{
	"name":"dto03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)"
			},
			{
				"name":"CDK (cyclin dependent kinase)"
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)"
			},
			{
				"name":"GINS complex"
			},
			{
				"name":"Other initiation factors"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex"
			},
			{
				"name":"DNA polymerase epsilon complex"
			},
			{
				"name":"DNA polymerase delta complex"
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)"
			},
			{
				"name":"RPA (replication protein A)"
			},
			{
				"name":"RFC (replication factor C)"
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"TOL2_C32600 rnhA; RnhA: ribonuclease H\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				}
				]
			},
			{
				"name":"Other elongation factors"
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"TOL2_C04110 dcm; Dcm: DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors"
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex"
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"Dyskerin complex"
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"Sm core complex"
				}
				]
			},
			{
				"name":"ELG1-RFC complex"
			},
			{
				"name":"MRN complex"
			},
			{
				"name":"Other termination factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"TOL2_C13640 hupA; HupA: DNA-binding protein HU 1\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"TOL2_C30160 DNA-binding protein, histone family\tK04764 ihfA; integration host factor subunit alpha"
				},
				{
					"name":"TOL2_C42650 ihfA; IhfA: integration host factor, alpha subunit\tK04764 ihfA; integration host factor subunit alpha"
				},
				{
					"name":"TOL2_C13280 hup; Hup: DNA-binding protein, histone family\tK05788 ihfB; integration host factor subunit beta"
				},
				{
					"name":"TOL2_C36020 histone family DNA-binding protein\tK05788 ihfB; integration host factor subunit beta"
				},
				{
					"name":"TOL2_C22890 dnaA; DnaA: chromosomal replication initiator protein\tK02313 dnaA; chromosomal replication initiator protein"
				},
				{
					"name":"TOL2_C22860 dnaB; DnaB: replicative DNA helicase\tK02314 dnaB; replicative DNA helicase [EC:5.6.2.3]"
				},
				{
					"name":"TOL2_C23570 dnaG2; DnaG2: DNA primase\tK02316 dnaG; DNA primase [EC:2.7.7.101]"
				},
				{
					"name":"TOL2_C30650 phage P4 alpha helicase\/primase zinc-binding domain protein\tK02316 dnaG; DNA primase [EC:2.7.7.101]"
				},
				{
					"name":"TOL2_C41130 ssb; Ssb: singel-stranded DNA-binding protein, helix-destabilizing\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"TOL2_C21170 dnaE; DnaE: DNA-directed DNA polymerase III, alpha subunit\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"TOL2_C00010 dnaN; DnaN: DNA polymerase III, beta chain\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"TOL2_C21020 holA; HolA: putative DNA-directed DNA polymerase III, delta subunit\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"TOL2_C13270 holB; HolB: putative DNA-directed DNA polymerase III, delta subunit\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"TOL2_C31550 putative exonuclease modulated with PAS domain\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"TOL2_C13420 dnaX; DnaX: DNA polymerase III, subunit gamma\/tau\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"TOL2_C32600 rnhA; RnhA: ribonuclease H\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"TOL2_C33560 rnhB; RnhB: ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"TOL2_C38880 polA; PolA: DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					},
					{
						"name":"TOL2_C22180 ligA; LigA: DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"TOL2_C32600 rnhA; RnhA: ribonuclease H\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"TOL2_C33560 rnhB; RnhB: ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"TOL2_C35050 gyrA; GyrA: DNA gyrase, subunit A\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
			},
			{
				"name":"TOL2_C00020 gyrB; GyrB: DNA gyrase, subunit B\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
			},
			{
				"name":"TOL2_C14470 parC; ParC: DNA topoisomerase 4, subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
			},
			{
				"name":"TOL2_C14480 parE; ParE: DNA topoisomerase 4, subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
			},
			{
				"name":"TOL2_C14380 topA; TopA: DNA topoisomerase 1\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
			}
			]
		}
		]
	}
	]
}