{
	"name":"dvu03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"DVU_0791 methylated-DNA--protein-cysteine methyltransferase, DNA-binding domain protein\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"DVU_0112 deoxyribodipyrimidine photolyase, putative\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"DVU_0393 ung; uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"DVU_0282 mutY; A\/G-specific adenine glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"DVU_0990 endonuclease III, putative\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex"
					},
					{
						"name":"DNA polymerase epsilon complex"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex"
					},
					{
						"name":"Cul4-DDB2 complex"
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex"
					},
					{
						"name":"Cul4-CSA complex"
					},
					{
						"name":"Other TCR factor"
					}
					]
				},
				{
					"name":"TFIIH complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Other NER factors"
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"MutL homologs"
				},
				{
					"name":"DNA polymerase delta complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other MMR factors"
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex"
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex"
				},
				{
					"name":"BRCA complex"
				},
				{
					"name":"RecA family proteins"
				},
				{
					"name":"Rad52 family proteins"
				},
				{
					"name":"Rad54 family proteins"
				},
				{
					"name":"RecQ family DNA helicases"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Protein phosphatase 4"
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex"
				},
				{
					"name":"Other HR factors"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex"
				},
				{
					"name":"MRX complex"
				},
				{
					"name":"DNA Ligase 4 complex"
				},
				{
					"name":"X-family DNA polymerases"
				},
				{
					"name":"Other NHEJ factors"
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors"
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"B-family DNA polymerases"
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group"
			},
			{
				"name":"Other TLS factors"
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex"
			},
			{
				"name":"HRAD17(Rad24)-RFC complex"
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex"
			},
			{
				"name":"FPC (fork protection complex)"
			},
			{
				"name":"Triple T complex"
			},
			{
				"name":"BAG6-UBL4A-GET4 complex"
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases"
			},
			{
				"name":"Nucleases"
			},
			{
				"name":"Helicases"
			},
			{
				"name":"PSO4 complex"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"DVU_2245 mutT\/nudix family protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"DVU_3051 mutT; mutator mutT protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"DVU_2348 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"DVU_0791 methylated-DNA--protein-cysteine methyltransferase, DNA-binding domain protein\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"DVU_0112 deoxyribodipyrimidine photolyase, putative\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"DVU_0393 ung; uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"DVU_0282 mutY; A\/G-specific adenine glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"DVU_0356 tag; DNA-3-methyladenine glycosylase I\tK01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]"
					},
					{
						"name":"DVU_3256 mutM; formamidopyrimidine-DNA glycosylase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"DVU_0990 endonuclease III, putative\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"DVU_3259 xth; exodeoxyribonuclease III\tK01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]"
					},
					{
						"name":"DVU_1224 nfo; endonuclease IV\tK01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]"
					}
					]
				},
				{
					"name":"RecJ",
					"children":[
					{
						"name":"DVU_0904 recJ; single-stranded-DNA-specific exonuclease RecJ\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"DVU_1608 ligA; DNA ligase, NAD-dependent\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"DVU_1987 uvrA; excinuclease ABC, A subunit\tK03701 uvrA; excinuclease ABC subunit A"
					},
					{
						"name":"DVU_1605 uvrB; excinuclease ABC, B subunit\tK03702 uvrB; excinuclease ABC subunit B"
					},
					{
						"name":"DVU_0801 uvrC; excinuclease ABC, C subunit\tK03703 uvrC; excinuclease ABC subunit C"
					},
					{
						"name":"DVU_0156 ATP-dependent DNA helicase, UvrD\/REP family\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"DVU_1608 ligA; DNA ligase, NAD-dependent\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)",
						"children":[
						{
							"name":"DVU_2928 rpoB; DNA-directed RNA polymerase, beta subunit\tK03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]"
						},
						{
							"name":"DVU_2929 rpoC; DNA-directed RNA polymerase, beta prime subunit\tK03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]"
						},
						{
							"name":"DVU_1329 rpoA; DNA-directed RNA polymerase, alpha subunit\tK03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]"
						},
						{
							"name":"DVU_3242 rpoZ; DNA-directed RNA polymerase, omega subunit\tK03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]"
						}
						]
					},
					{
						"name":"TRCF (transcription-repair coupling factor)",
						"children":[
						{
							"name":"DVU_1903 mfd; transcription-repair coupling factor\tK03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]"
						}
						]
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"DVU_1649 mutS; DNA mismatch repair protein MutS\tK03555 mutS; DNA mismatch repair protein MutS"
					},
					{
						"name":"DVU_1790 MutS2 family protein\tK07456 mutS2; DNA mismatch repair protein MutS2"
					}
					]
				},
				{
					"name":"Molecular matchmaker",
					"children":[
					{
						"name":"DVU_0483 DNA mismatch repair protein MutL, putative\tK03572 mutL; DNA mismatch repair protein MutL"
					}
					]
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases",
					"children":[
					{
						"name":"DVU_1346 xseA; exodeoxyribonuclease VII, large subunit\tK03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]"
					},
					{
						"name":"DVU_1348 xseB; exodeoxyribonuclease VII, small subunit\tK03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]"
					}
					]
				},
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"DVU_1353 dnaE; DNA polymerase III, alpha subunit\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"DVU_0002 dnaN; DNA polymerase III, beta subunit\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"DVU_1194 hypothetical protein\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"DVU_3203 DNA polymerase III, delta prime subunit, putative\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"DVU_0443 exonulcease, putative\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"DVU_3198 DNA polymerase III, gamma and tau subunits, putative\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"DVU_1608 ligA; DNA ligase, NAD-dependent\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"DVU_0156 ATP-dependent DNA helicase, UvrD\/REP family\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"DVU_2222 ssb; single-strand binding protein\tK03111 ssb; single-strand DNA-binding protein"
					},
					{
						"name":"DVU_2843 DNA mismatch endonuclease Vsr, putative\tK07458 vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins",
					"children":[
					{
						"name":"DVU_0895 helicase, RecD\/TraA family\tK03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]"
					},
					{
						"name":"DVU_1090 recA; recA protein\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"DVU_2256 ruvA; Holliday junction DNA helicase RuvA\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"DVU_2255 ruvB; Holliday junction DNA helicase RuvB\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					},
					{
						"name":"DVU_2258 ruvC; crossover junction endodeoxyribonuclease RuvC\tK01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]"
					},
					{
						"name":"DVU_1284 priA; primosomal protein n'\tK04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]"
					},
					{
						"name":"DVU_0070 Ser\/Thr protein phosphatase family protein\tK03547 sbcD; DNA repair protein SbcD\/Mre11"
					}
					]
				},
				{
					"name":"RecFOR pathway proteins",
					"children":[
					{
						"name":"DVU_1090 recA; recA protein\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"DVU_1590 radA; DNA repair protein RadA\tK04485 radA; DNA repair protein RadA\/Sms"
					},
					{
						"name":"DVU_0904 recJ; single-stranded-DNA-specific exonuclease RecJ\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
					},
					{
						"name":"DVU_1899 DNA repair protein RecO, putative\tK03584 recO; DNA repair protein RecO (recombination protein O)"
					},
					{
						"name":"DVU_3200 recR; recombination protein RecR\tK06187 recR; recombination protein RecR"
					},
					{
						"name":"DVU_2463 recN; DNA repair protein RecN\tK03631 recN; DNA repair protein RecN (Recombination protein N)"
					},
					{
						"name":"DVU_2459 hypothetical protein\tK03554 rdgC; recombination associated protein RdgC"
					},
					{
						"name":"DVU_2256 ruvA; Holliday junction DNA helicase RuvA\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"DVU_2255 ruvB; Holliday junction DNA helicase RuvB\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					},
					{
						"name":"DVU_2258 ruvC; crossover junction endodeoxyribonuclease RuvC\tK01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]"
					}
					]
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor",
					"children":[
					{
						"name":"DVUA0134 cas1; CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
					}
					]
				},
				{
					"name":"Archaeal homologous recombinant proteins",
					"children":[
					{
						"name":"DVU_0070 Ser\/Thr protein phosphatase family protein\tK03547 sbcD; DNA repair protein SbcD\/Mre11"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator",
						"children":[
						{
							"name":"DVU_0004 gyrA; DNA gyrase, A subunit\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
						},
						{
							"name":"DVU_0003 gyrB; DNA gyrase, B subunit\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
						},
						{
							"name":"DVU_3389 topA; DNA topoisomerase I\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
						}
						]
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"DVUA0004 DNA-binding protein HU, putative\tK03530 hupB; DNA-binding protein HU-beta"
						},
						{
							"name":"DVU_0764 hup-2; DNA-binding protein HU\tK03530 hupB; DNA-binding protein HU-beta"
						},
						{
							"name":"DVU_1134 hupB; DNA-binding protein HU, beta subunit\tK03530 hupB; DNA-binding protein HU-beta"
						},
						{
							"name":"DVU_1795 hup-3; DNA-binding protein HU\tK03530 hupB; DNA-binding protein HU-beta"
						},
						{
							"name":"DVU_3187 hup-4; DNA-binding protein HU\tK03530 hupB; DNA-binding protein HU-beta"
						}
						]
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway",
						"children":[
						{
							"name":"DVU_0904 recJ; single-stranded-DNA-specific exonuclease RecJ\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
						},
						{
							"name":"DVU_1899 DNA repair protein RecO, putative\tK03584 recO; DNA repair protein RecO (recombination protein O)"
						},
						{
							"name":"DVU_3200 recR; recombination protein RecR\tK06187 recR; recombination protein RecR"
						},
						{
							"name":"DVU_1608 ligA; DNA ligase, NAD-dependent\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
						}
						]
					},
					{
						"name":"Facilitator",
						"children":[
						{
							"name":"DVU_0396 hup-1; DNA-binding protein HU\tK04764 ihfA; integration host factor subunit alpha"
						},
						{
							"name":"DVU_1864 DNA-binding protein HU, beta subunit, putative\tK05788 ihfB; integration host factor subunit beta"
						},
						{
							"name":"DVU_2973 integration host factor, beta subunit\tK05788 ihfB; integration host factor subunit beta"
						}
						]
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"DVU_1987 uvrA; excinuclease ABC, A subunit\tK03701 uvrA; excinuclease ABC subunit A"
						},
						{
							"name":"DVU_1605 uvrB; excinuclease ABC, B subunit\tK03702 uvrB; excinuclease ABC subunit B"
						}
						]
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"DVU_0071 dinP; DNA polymerase IV\tK02346 dinB; DNA polymerase IV [EC:2.7.7.7]"
				},
				{
					"name":"DVU_2906 umuC; umuC protein\tK03502 umuC; DNA polymerase V"
				},
				{
					"name":"DVU_2907 umuD; umuD protein\tK03503 umuD; DNA polymerase V [EC:3.4.21.-]"
				}
				]
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"DVU_1090 recA; recA protein\tK03553 recA; recombination protein RecA"
				},
				{
					"name":"DVU_2463 recN; DNA repair protein RecN\tK03631 recN; DNA repair protein RecN (Recombination protein N)"
				},
				{
					"name":"DVU_2222 ssb; single-strand binding protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"DVU_2245 mutT\/nudix family protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"DVU_3051 mutT; mutator mutT protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"DVU_2348 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"DVU_3379 ribonucleoside-diphosphate reductase\tK00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"DVU_0506 DHH family protein\tK06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]"
				}
				]
			}
			]
		}
		]
	}
	]
}