{
	"name":"eac03000",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Basic leucine zipper (bZIP)",
			"children":[
			{
				"name":"AP-1(-like) components, Jun"
			},
			{
				"name":"AP-1(-like) components, Fos"
			},
			{
				"name":"AP-1(-like) components, Maf"
			},
			{
				"name":"AP-1(-like) components, NF-E2"
			},
			{
				"name":"AP-1(-like) components, Fungal regulators"
			},
			{
				"name":"AP-1(-like) components, CRE-BP\/ATF"
			},
			{
				"name":"CREB"
			},
			{
				"name":"C\/EBP-like factors"
			},
			{
				"name":"bZIP\/PAR"
			},
			{
				"name":"Plant bZIP factors"
			},
			{
				"name":"ZIP only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix (bHLH)",
			"children":[
			{
				"name":"Ubiquitous (class A) factors"
			},
			{
				"name":"Myogenic transcription factors"
			},
			{
				"name":"Achaete-Scute"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Lymphoid factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesodermal Twist-like factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, HEN"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesp"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Atonal"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Pancreatic factors"
			},
			{
				"name":"Hairy, Hairy\/E(SPL)"
			},
			{
				"name":"Hairy, Fungal regulators"
			},
			{
				"name":"Factors with PAS domain"
			},
			{
				"name":"Yabby"
			},
			{
				"name":"INO"
			},
			{
				"name":"HLH domain only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix\/leucine zipper (bHLH-ZIP)",
			"children":[
			{
				"name":"Ubiquitous bHLH-ZIP factors"
			},
			{
				"name":"Cell cycle controlling factors, Myc"
			},
			{
				"name":"Cell cycle controlling factors, Mad\/Max"
			},
			{
				"name":"Other bHLH-ZIP factors"
			}
			]
		},
		{
			"name":"Other basic domains",
			"children":[
			{
				"name":"NF-1"
			},
			{
				"name":"RF-X"
			},
			{
				"name":"AP-2 (bHSH)"
			}
			]
		},
		{
			"name":"Zinc finger",
			"children":[
			{
				"name":"Cys4 thyroid hormone receptor-like"
			},
			{
				"name":"Cys4 hepatocyte nuclear factor 4-like"
			},
			{
				"name":"Cys4 estrogen receptor-like"
			},
			{
				"name":"Cys4 nerve growth factor IB-like"
			},
			{
				"name":"Cys4 Fushi tarazu-F1-like"
			},
			{
				"name":"Cys4 germ cell nuclear factor"
			},
			{
				"name":"Cys4 Knirps\/DAX1-like"
			},
			{
				"name":"Cys4 GATA-factors"
			},
			{
				"name":"Cys2His2 SP\/KLF family and related proteins"
			},
			{
				"name":"Cys2His2 GLI-like"
			},
			{
				"name":"Cys2His2 Snail"
			},
			{
				"name":"Cys2His2 BTB-ZF factors"
			},
			{
				"name":"Cys2His2 BED"
			},
			{
				"name":"Cys2His2 PRDM"
			},
			{
				"name":"Cys2His2 metabolic regulators in fungi"
			},
			{
				"name":"Cys2His2 others"
			},
			{
				"name":"Cys2HisCys zinc factors"
			},
			{
				"name":"Cys3His zinc factors"
			},
			{
				"name":"Cys2CysHis zinc factors"
			},
			{
				"name":"CXXC CpG-binding proteins",
				"children":[
				{
					"name":"EAL2_c04870 scrFIBM; modification methylase ScrFIB\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"EAL2_c04920 hphIAM; modification methylase HphIA\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"EAL2_c04940 bspRIM; modification methylase BspRI\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Cys6 metabolic regulators in fungi"
			},
			{
				"name":"Other zinc fingers"
			}
			]
		},
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"Homeo domain ANTP: HOXL"
			},
			{
				"name":"Homeo domain ANTP: NKL"
			},
			{
				"name":"Homeo domain Paired-related"
			},
			{
				"name":"Homeo domain LIM"
			},
			{
				"name":"Homeo domain POU"
			},
			{
				"name":"Homeo domain SINE"
			},
			{
				"name":"Homeo domain ZF"
			},
			{
				"name":"Homeo domain CUT"
			},
			{
				"name":"Homeo domain PROS"
			},
			{
				"name":"Homeo domain TALE"
			},
			{
				"name":"Homeo domain other"
			},
			{
				"name":"Fork head\/winged helix developmental regulators"
			},
			{
				"name":"Fork head\/winged helix tissue-specific regulators"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, E2F"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, DP"
			},
			{
				"name":"Fork head\/winged helix other regulators"
			},
			{
				"name":"Stork head\/winged helix factors"
			},
			{
				"name":"Heat shock factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-like factors"
			},
			{
				"name":"Tryptophan clusters Ets-type"
			},
			{
				"name":"Tryptophan clusters interferon-regulating factors"
			},
			{
				"name":"TEA domain"
			},
			{
				"name":"ARID"
			}
			]
		},
		{
			"name":"beta-Scaffold factors with minor groove contacts",
			"children":[
			{
				"name":"RHR (Rel homology region) Rel\/Ankyrin"
			},
			{
				"name":"RHR (Rel homology region) Ankyrin only"
			},
			{
				"name":"RHR (Rel homology region) NF-AT"
			},
			{
				"name":"STAT"
			},
			{
				"name":"p53"
			},
			{
				"name":"MADS-box regulators of differentiation, MEF-2"
			},
			{
				"name":"MADS-box regulators of differentiation, Homeotic genes"
			},
			{
				"name":"MADS-box regulators of differentiation, Yeast regulators"
			},
			{
				"name":"MADS-box responders to external signals"
			},
			{
				"name":"SAND domain-containing proteins"
			},
			{
				"name":"TATA-binding proteins"
			},
			{
				"name":"HMG SOX"
			},
			{
				"name":"HMG TCF-1"
			},
			{
				"name":"HMG TOX"
			},
			{
				"name":"HMG2-related"
			},
			{
				"name":"UBF"
			},
			{
				"name":"Other HMG box factors"
			},
			{
				"name":"Heteromeric CCAAT factors"
			},
			{
				"name":"Grainyhead"
			},
			{
				"name":"Cold-shock domain factors, DbpA-like"
			},
			{
				"name":"Cold-shock domain factors, YB-1\/DbpB-like"
			},
			{
				"name":"Cold-shock domain factors, FRG Y2-like"
			},
			{
				"name":"Runt"
			},
			{
				"name":"MYRF"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"HMGI(Y)"
			},
			{
				"name":"NUPR"
			},
			{
				"name":"Pocket domain Rb"
			},
			{
				"name":"Pocket domain CBP"
			},
			{
				"name":"T-box"
			},
			{
				"name":"DMRT"
			},
			{
				"name":"LRRFIP"
			},
			{
				"name":"TCP"
			},
			{
				"name":"AP2\/ERF"
			},
			{
				"name":"WRKY"
			},
			{
				"name":"LOB"
			},
			{
				"name":"GRAS"
			},
			{
				"name":"NAC"
			},
			{
				"name":"Copper-fist proteins fungal regulators"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"AraC family"
			},
			{
				"name":"LysR family"
			},
			{
				"name":"DeoR family",
				"children":[
				{
					"name":"EAL2_c14220 ccpN; transcriptional repressor CcpN\tK23774 ccpN; DeoR family transcriptional regulator, catabolite repression regulator"
				}
				]
			},
			{
				"name":"LacI family",
				"children":[
				{
					"name":"EAL2_c09550 ccpA; glucose-resistance amylase regulator\tK02529 galR; LacI family transcriptional regulator, galactose operon repressor"
				},
				{
					"name":"EAL2_c14070 regA; HTH-type transcriptional regulator RegA\tK02529 galR; LacI family transcriptional regulator, galactose operon repressor"
				}
				]
			},
			{
				"name":"GntR family",
				"children":[
				{
					"name":"EAL2_c03420 transcriptional regulator, GntR family\tK07979 ytrA; GntR family transcriptional regulator"
				}
				]
			},
			{
				"name":"TetR\/AcrR family"
			},
			{
				"name":"Lrp\/AsnC family",
				"children":[
				{
					"name":"EAL2_808p01190 transcriptional regulator, AsnC family\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"EAL2_808p07680 putative HTH-type transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				}
				]
			},
			{
				"name":"LuxR family"
			},
			{
				"name":"MarR family"
			},
			{
				"name":"MerR family"
			},
			{
				"name":"Fur family",
				"children":[
				{
					"name":"EAL2_c12570 fur; ferric uptake regulation protein Fur\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator"
				},
				{
					"name":"EAL2_c02730 ferric uptake regulator, Fur family\tK09825 perR; Fur family transcriptional regulator, peroxide stress response regulator"
				}
				]
			},
			{
				"name":"IclR family",
				"children":[
				{
					"name":"EAL2_808p04940 yagI; putative HTH-type transcriptional regulator YagI\tK19333 kdgR; IclR family transcriptional regulator, KDG regulon repressor"
				}
				]
			},
			{
				"name":"CRP\/FNR family"
			},
			{
				"name":"Rrf2 family",
				"children":[
				{
					"name":"EAL2_808p06390 cymR; HTH-type transcriptional regulator CymR\tK17472 cymR; Rrf2 family transcriptional regulator, cysteine metabolism repressor"
				},
				{
					"name":"EAL2_c12480 cymR; HTH-type transcriptional regulator CymR\tK17472 cymR; Rrf2 family transcriptional regulator, cysteine metabolism repressor"
				}
				]
			},
			{
				"name":"ArsR family",
				"children":[
				{
					"name":"EAL2_808p05220 arsR; arsenical resistance operon repressor\tK03892 arsR; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor"
				},
				{
					"name":"EAL2_808p05350 transcriptional regulator, ArsR family\tK03892 arsR; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor"
				},
				{
					"name":"EAL2_c07130 ziaR; transcriptional repressor smtB\tK21903 cadC; ArsR family transcriptional regulator, lead\/cadmium\/zinc\/bismuth-responsive transcriptional repressor"
				},
				{
					"name":"EAL2_c02470 sdpR; transcriptional repressor SdpR\tK26993 sdpR; ArsR family transcriptional regulator, repressor of sdpIR and other operons"
				}
				]
			},
			{
				"name":"XRE family",
				"children":[
				{
					"name":"EAL2_808p06720 ydcN; putative HTH-type transcriptional regulator YdcN\tK23779 sutR; XRE family transcriptional regulator, regulator of sulfur utilization"
				}
				]
			},
			{
				"name":"PadR family"
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"EAL2_c17930 birA; bifunctional protein BirA\tK03524 birA; BirA family transcriptional regulator, biotin operon repressor \/ biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]"
				},
				{
					"name":"EAL2_c02090 purR; Pur operon repressor\tK09685 purR; HTH-type transcriptional regulator, purine operon repressor"
				},
				{
					"name":"EAL2_808p04820 acoR; acetoin dehydrogenase operon transcriptional activator AcoR\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"EAL2_c19250 stc; signal-transduction and transcriptional-control protein Stc\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"EAL2_c17620 rex; redox-sensing transcriptional repressor Rex\tK01926 rex; redox-sensing transcriptional repressor"
				},
				{
					"name":"EAL2_c12450 codY; GTP-sensing transcriptional pleiotropic repressor CodY\tK03706 codY; transcriptional pleiotropic repressor"
				},
				{
					"name":"EAL2_c05600 hypothetical protein\tK07727 K07727; putative transcriptional regulator"
				},
				{
					"name":"EAL2_c06190 hypothetical protein\tK07727 K07727; putative transcriptional regulator"
				},
				{
					"name":"EAL2_c13880 hypothetical protein\tK07727 K07727; putative transcriptional regulator"
				},
				{
					"name":"EAL2_c10820 hypothetical protein\tK07729 K07729; putative transcriptional regulator"
				}
				]
			}
			]
		},
		{
			"name":"Ribbon-helix-helix",
			"children":[
			{
				"name":"CopG family",
				"children":[
				{
					"name":"EAL2_c03980 hypothetical protein\tK07723 ndoAI; CopG family transcriptional regulator \/ antitoxin EndoAI"
				}
				]
			},
			{
				"name":"Other families"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"BglG family"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"EAL2_c09820 hypothetical protein\tK21600 csoR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor"
				},
				{
					"name":"EAL2_808p07150 pucR; purine catabolism regulatory protein PucR\tK09684 pucR; PucR family transcriptional regulator, purine catabolism regulatory protein"
				},
				{
					"name":"EAL2_c17100 sugar diacid utilization regulator\tK09684 pucR; PucR family transcriptional regulator, purine catabolism regulatory protein"
				},
				{
					"name":"EAL2_c01990 transcriptional regulator, AbrB family\tK06284 abrB; AbrB family transcriptional regulator, transcriptional pleiotropic regulator of transition state genes"
				},
				{
					"name":"EAL2_808p00080 integrating conjugative element\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"EAL2_c06580 ParB family protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"EAL2_c21760 hypothetical protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"EAL2_c22200 parB; chromosome-partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"EAL2_808p00140 glpP; glycerol uptake operon antiterminator regulatory protein GlpP\tK02443 glpP; glycerol uptake operon antiterminator"
				},
				{
					"name":"EAL2_c12060 argR; arginine repressor\tK03402 argR; transcriptional regulator of arginine metabolism"
				},
				{
					"name":"EAL2_c14440 hrcA; heat-inducible transcription repressor HrcA\tK03705 hrcA; heat-inducible transcriptional repressor"
				},
				{
					"name":"EAL2_c00370 tenI; regulatory protein TenI\tK10810 tenI; thiazole tautomerase (transcriptional regulator TenI) [EC:5.3.99.10]"
				},
				{
					"name":"EAL2_c01190 transcriptional regulator CtsR\tK03708 ctsR; transcriptional regulator of stress and heat shock response"
				},
				{
					"name":"EAL2_c14830 pyrR; bifunctional protein PyrR\tK02825 pyrR; pyrimidine operon attenuation protein \/ uracil phosphoribosyltransferase [EC:2.4.2.9]"
				},
				{
					"name":"EAL2_c10540 nrdR; transcriptional repressor NrdR\tK07738 nrdR; transcriptional repressor NrdR"
				},
				{
					"name":"EAL2_808p06060 hutP; Hut operon positive regulatory protein HutP\tK09683 hutP; hut operon positive regulatory protein"
				}
				]
			}
			]
		}
		]
	}
	]
}