{
	"name":"ear03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III"
			},
			{
				"name":"Cytochrome c oxidase"
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase"
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"CCG33137 Translation initiation factor 2\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"CCG30499 Translation initiation factor 3\tK02520 infC; translation initiation factor IF-3"
				},
				{
					"name":"CCG31653 Translation elongation factor Ts\tK02357 tsf; elongation factor Ts"
				},
				{
					"name":"CCG32380 Translation elongation factor Tu\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"CCG32999 Translation elongation factor Tu\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"CCG29206 Translation elongation factor G\tK02355 fusA; elongation factor G"
				},
				{
					"name":"CCG32998 Translation elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP"
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"CCG33938 GTP-binding protein Era\tK03595 era; GTPase"
				},
				{
					"name":"CCG30312 Tyrosyl-tRNA synthetase (EC 6.1.1.1) ## cluster 1\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"CCG31192 Leucyl-tRNA synthetase (EC 6.1.1.4)\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"CCG29426 Aspartyl-tRNA synthetase (EC 6.1.1.12)\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"CCG29418 Arginyl-tRNA synthetase (EC 6.1.1.19)\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors",
				"children":[
				{
					"name":"CCG32000 Nuclease precursor (EC 3.1.30.2)\tK01173 ENDOG; endonuclease G, mitochondrial"
				}
				]
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"CCG28696 Single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"CCG32292 Single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors"
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex"
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"CCG31643 Outer membrane protein assembly factor YaeT precursor\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex"
			},
			{
				"name":"TIM8\/13 complex"
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex"
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex"
			},
			{
				"name":"TIM23 complex"
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors"
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"CCG31843 Chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"CCG33894 Heat shock protein GrpE\tK03687 GRPE; molecular chaperone GrpE"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"CCG32210 Heat shock protein 60 family chaperone GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"CCG32211 Heat shock protein 60 family co-chaperone GroES\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"CCG31842 Chaperone protein DnaJ\tK03686 dnaJ; molecular chaperone DnaJ"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"CCG29206 Translation elongation factor G\tK02355 fusA; elongation factor G"
				},
				{
					"name":"CCG32998 Translation elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"CCG33964 Cysteine desulfurase (EC 2.8.1.7), IscS subfamily\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"CCG31843 Chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"CCG33967 Chaperone protein HscB\tK04082 hscB; molecular chaperone HscB"
				},
				{
					"name":"CCG30329 Probable monothiol glutaredoxin ydhD\tK07390 grxD; monothiol glutaredoxin"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis"
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors",
				"children":[
				{
					"name":"CCG29128 Scaffold protein for [4Fe-4S] cluster assembly ApbC, MRP-like\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				}
				]
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors"
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"CCG31435 Heme O synthase, protoheme IX farnesyltransferase (EC 2.5.1.-) COX10-CtaB\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"CCG32594 Inner membrane protein translocase component YidC, long form\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				}
				]
			},
			{
				"name":"Complex-V assembly factors"
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors"
			},
			{
				"name":"Actin cytoskeleton organization"
			},
			{
				"name":"Mitochondrial movement"
			},
			{
				"name":"Retention of mitochondria"
			},
			{
				"name":"Morphogenesis factors"
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins"
			},
			{
				"name":"Parkin-dependent mechanism factors"
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"CCG31376 Chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors"
			}
			]
		}
		]
	}
	]
}