{
	"name":"eax01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]",
				"children":[
				{
					"name":"AAHF05_23030 broad-spectrum class A beta-lactamase TEM-1\tK18698 blaTEM; beta-lactamase class A TEM [EC:3.5.2.6]"
				},
				{
					"name":"AAHF05_24050 broad-spectrum class A beta-lactamase TEM-1\tK18698 blaTEM; beta-lactamase class A TEM [EC:3.5.2.6]"
				},
				{
					"name":"AAHF05_24595 broad-spectrum class A beta-lactamase TEM-1\tK18698 blaTEM; beta-lactamase class A TEM [EC:3.5.2.6]"
				},
				{
					"name":"AAHF05_25030 extended-spectrum class A beta-lactamase SHV-12\tK18699 blaSHV; beta-lactamase class A SHV [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]",
				"children":[
				{
					"name":"AAHF05_01940 blaACT; (GenBank) ACT family cephalosporin-hydrolyzing class C beta-lactamase\tK19215 blaACT_MIR; beta-lactamase class C ACT\/MIR [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases",
				"children":[
				{
					"name":"AAHF05_23700 aac(3)-IIg; (GenBank) aminoglycoside N-acetyltransferase AAC(3)-IIg\tK00662 aacC; aminoglycoside 3-N-acetyltransferase [EC:2.3.1.81]"
				},
				{
					"name":"AAHF05_23720 aac(6')-IIc; (GenBank) aminoglycoside N-acetyltransferase AAC(6')-IIc\tK19301 aac6-II; aminoglycoside 6'-N-acetyltransferase II [EC:2.3.1.82]"
				}
				]
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"AAHF05_04465 aminoglycoside O-phosphotransferase APH(3')-Ia\tK19272 aph3-I; aminoglycoside 3'-phosphotransferase I [EC:2.7.1.95]"
				},
				{
					"name":"AAHF05_11100 aminoglycoside O-phosphotransferase APH(3')-Ia\tK19272 aph3-I; aminoglycoside 3'-phosphotransferase I [EC:2.7.1.95]"
				},
				{
					"name":"AAHF05_13545 aminoglycoside O-phosphotransferase APH(3')-Ia\tK19272 aph3-I; aminoglycoside 3'-phosphotransferase I [EC:2.7.1.95]"
				},
				{
					"name":"AAHF05_23470 aminoglycoside O-phosphotransferase APH(3')-Ia\tK19272 aph3-I; aminoglycoside 3'-phosphotransferase I [EC:2.7.1.95]"
				},
				{
					"name":"AAHF05_24430 aminoglycoside O-phosphotransferase APH(3')-Ia\tK19272 aph3-I; aminoglycoside 3'-phosphotransferase I [EC:2.7.1.95]"
				},
				{
					"name":"AAHF05_24645 aminoglycoside O-phosphotransferase APH(3')-Ia\tK19272 aph3-I; aminoglycoside 3'-phosphotransferase I [EC:2.7.1.95]"
				},
				{
					"name":"AAHF05_23645 aph(3'')-Ib; (GenBank) aminoglycoside O-phosphotransferase APH(3'')-Ib\tK10673 strA; streptomycin 3\\\"-kinase [EC:2.7.1.87]"
				},
				{
					"name":"AAHF05_23640 aminoglycoside O-phosphotransferase APH(6)-Id\tK04343 strB; streptomycin 6-kinase [EC:2.7.1.72]"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"AAHF05_23080 tet(D); (GenBank) tetracycline efflux MFS transporter Tet(D)\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"AAHF05_06800 MFS transporter\tK08160 mdfA; MFS transporter, DHA1 family, multidrug\/chloramphenicol efflux transport protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"AAHF05_05385 catA; (GenBank) type A chloramphenicol O-acetyltransferase\tK19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28]"
				},
				{
					"name":"AAHF05_23065 type A-2 chloramphenicol O-acetyltransferase CatII\tK19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase",
				"children":[
				{
					"name":"AAHF05_23675 sul1; (GenBank) sulfonamide-resistant dihydropteroate synthase Sul1\tK18974 sul1; dihydropteroate synthase type 1 [EC:2.5.1.15]"
				},
				{
					"name":"AAHF05_25005 sul1; (GenBank) sulfonamide-resistant dihydropteroate synthase Sul1\tK18974 sul1; dihydropteroate synthase type 1 [EC:2.5.1.15]"
				}
				]
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases",
				"children":[
				{
					"name":"AAHF05_23660 dfrA19; (GenBank) trimethoprim-resistant dihydrofolate reductase DfrA19\tK19644 dfrA19; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]"
				}
				]
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"AAHF05_11550 MFS transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other",
				"children":[
				{
					"name":"AAHF05_24995 quinolone resistance pentapeptide repeat protein QnrA1\tK18555 qnr; fluoroquinolone resistance protein"
				}
				]
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"AAHF05_11180 Cu(+)\/Ag(+) sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"AAHF05_23605 pcoS; (GenBank) copper resistance membrane spanning protein PcoS\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"AAHF05_23955 pcoS; (GenBank) copper resistance membrane spanning protein PcoS\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"AAHF05_11175 copper\/silver response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"AAHF05_23960 pcoR; (GenBank) copper response regulator transcription factor PcoR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"AAHF05_24030 silR; (GenBank) copper\/silver response regulator transcription factor SilR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"AAHF05_11315 ddpX; (GenBank) D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]",
				"children":[
				{
					"name":"AAHF05_07585 AMP-binding protein\tK03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]"
				},
				{
					"name":"AAHF05_07590 MBOAT family O-acyltransferase\tK03739 dltB; membrane protein involved in D-alanine export"
				},
				{
					"name":"AAHF05_07580 acyl carrier protein\tK14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]"
				},
				{
					"name":"AAHF05_07600 D-alanyl-lipoteichoic acid biosynthesis protein DltD\tK03740 dltD; D-alanine transfer protein"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]",
				"children":[
				{
					"name":"AAHF05_08800 phoQ; (GenBank) two-component system sensor histidine kinase PhoQ\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
				},
				{
					"name":"AAHF05_08805 phoP; (GenBank) two-component system response regulator PhoP\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				}
				]
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"AAHF05_05025 acrA; (GenBank) multidrug efflux RND transporter periplasmic adaptor subunit AcrA\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AAHF05_05020 acrB; (GenBank) multidrug efflux RND transporter permease subunit AcrB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AAHF05_14855 mdtQ; (GenBank) multidrug resistance outer membrane protein MdtQ\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"AAHF05_14855 mdtQ; (GenBank) multidrug resistance outer membrane protein MdtQ\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"AAHF05_14855 mdtQ; (GenBank) multidrug resistance outer membrane protein MdtQ\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"AAHF05_05125 cueR; (GenBank) Cu(I)-responsive transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]",
				"children":[
				{
					"name":"AAHF05_12040 ATP-binding protein\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
				},
				{
					"name":"AAHF05_12045 response regulator\tK18144 adeR; two-component system, OmpR family, response regulator AdeR"
				},
				{
					"name":"AAHF05_12060 multidrug efflux RND transporter permease subunit\tK18146 adeB; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"AAHF05_20330 envR; (GenBank) acrEF\/envCD operon transcriptional regulator\tK18140 envR; TetR\/AcrR family transcriptional regulator, acrEF\/envCD operon repressor"
				},
				{
					"name":"AAHF05_20335 efflux RND transporter periplasmic adaptor subunit\tK18141 acrE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AAHF05_20340 efflux RND transporter permease subunit\tK18142 acrF; multidrug efflux pump"
				},
				{
					"name":"AAHF05_19220 tolC; (GenBank) outer membrane channel protein TolC\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"AAHF05_19220 tolC; (GenBank) outer membrane channel protein TolC\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"AAHF05_13925 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"AAHF05_11550 MFS transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]",
				"children":[
				{
					"name":"AAHF05_10940 marA; (GenBank) MDR efflux pump AcrAB transcriptional activator MarA\tK13632 marA; AraC family transcriptional regulator, mar-sox-rob regulon activator"
				},
				{
					"name":"AAHF05_07375 porin\tK09476 ompF; outer membrane pore protein F"
				},
				{
					"name":"AAHF05_13825 porin\tK09476 ompF; outer membrane pore protein F"
				}
				]
			}
			]
		}
		]
	}
	]
}