{
	"name":"eck03036",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Sister chromatid cohesion proteins",
			"children":[
			{
				"name":"Cohesin complex"
			},
			{
				"name":"Adherin complex"
			},
			{
				"name":"CTF18-RFC complex"
			},
			{
				"name":"Fork protection complex"
			},
			{
				"name":"55LCC heterohexameric ATPase complex"
			},
			{
				"name":"Other sister chromatid cohesion factors"
			}
			]
		},
		{
			"name":"Meiosis-specific proteins",
			"children":[
			{
				"name":"Cohesin complex and associated proteins"
			},
			{
				"name":"Synaptonemal complex"
			},
			{
				"name":"DSB formation-related proteins"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Nucleosome assembly factors",
			"children":[
			{
				"name":"Histones"
			},
			{
				"name":"Histone chaperones",
				"children":[
				{
					"name":"Nucleoplasmins"
				},
				{
					"name":"NAPs (Nucleosome assembly proteins)"
				},
				{
					"name":"CAF-1"
				},
				{
					"name":"FACT complex"
				},
				{
					"name":"Other Histone chaperones and regulators"
				}
				]
			},
			{
				"name":"HMG (high mobility group) proteins"
			}
			]
		},
		{
			"name":"Histone modification proteins",
			"children":[
			{
				"name":"HATs (histone acetyltransferases)"
			},
			{
				"name":"HAT complexes",
				"children":[
				{
					"name":"PCAF complex"
				},
				{
					"name":"STAGA complex"
				},
				{
					"name":"TFTC complex"
				},
				{
					"name":"TIP60 complex"
				},
				{
					"name":"HBO1 complex"
				},
				{
					"name":"MOZ\/MORF complex"
				},
				{
					"name":"SAGA complex"
				},
				{
					"name":"SLIK complex"
				},
				{
					"name":"ADA-HAT complex"
				},
				{
					"name":"HAT-A2 complex"
				},
				{
					"name":"ATAC complex"
				},
				{
					"name":"HATB complex"
				},
				{
					"name":"NSL complex"
				},
				{
					"name":"MSL complex"
				},
				{
					"name":"NuA3 complex"
				},
				{
					"name":"NuA4 complex"
				},
				{
					"name":"SAS complex"
				}
				]
			},
			{
				"name":"HDACs (histone deacetylases)",
				"children":[
				{
					"name":"Class I HDACs"
				},
				{
					"name":"Class II HDACs"
				},
				{
					"name":"SIRTs (sirtuins, class III HDACs)"
				},
				{
					"name":"Class IV HDACs"
				}
				]
			},
			{
				"name":"HDAC complexes",
				"children":[
				{
					"name":"Sin3A-HDAC complex"
				},
				{
					"name":"BRAF-HDAC complex"
				},
				{
					"name":"REST complex"
				},
				{
					"name":"SHIP complex"
				},
				{
					"name":"MiDAC complex"
				},
				{
					"name":"SMART complex"
				},
				{
					"name":"Other HDAC associated proteins"
				}
				]
			},
			{
				"name":"HMTs (histone methyltransferases)",
				"children":[
				{
					"name":"HKMTs (histone lysine methyltransferases)"
				},
				{
					"name":"PRMTs (protein arginine metyltransferases)"
				}
				]
			},
			{
				"name":"HMT complexes",
				"children":[
				{
					"name":"COMPASS\/SET1 complex"
				},
				{
					"name":"COMPASS\/SET1 complex (yeast)"
				},
				{
					"name":"MLL-HCF complex"
				},
				{
					"name":"MLL3\/MLL4 complex"
				},
				{
					"name":"Dot1-containing complex"
				},
				{
					"name":"CHTOP-methylosome complex"
				}
				]
			},
			{
				"name":"Histone demethylases"
			},
			{
				"name":"Polycomb repressive complex (PRC) and associated proteins",
				"children":[
				{
					"name":"Canonical PRC1 (PRC1.2\/1.4)",
					"children":[
					{
						"name":"PRC1.4 specific proteins"
					}
					]
				},
				{
					"name":"Noncanonical PRC1 (PRC1.1)"
				},
				{
					"name":"Noncanonical PRC1 (PRC1.3\/1.5)"
				},
				{
					"name":"Noncanonical PRC1 (PRC1.6)"
				},
				{
					"name":"PRC2.1"
				},
				{
					"name":"PRC2.2"
				},
				{
					"name":"PR-DUB complex"
				},
				{
					"name":"Other PRC associated proteins"
				}
				]
			},
			{
				"name":"Sir proteins"
			},
			{
				"name":"Other histone modification proteins"
			}
			]
		},
		{
			"name":"Chromosome condensation proteins",
			"children":[
			{
				"name":"Condensin I"
			},
			{
				"name":"Condensin II"
			},
			{
				"name":"Other regulators of chromosome condensation"
			}
			]
		},
		{
			"name":"Centromeric chromatin formation proteins",
			"children":[
			{
				"name":"Kinetochore proteins",
				"children":[
				{
					"name":"Centromere proteins"
				},
				{
					"name":"CPC (chromosomal passenger complex)"
				},
				{
					"name":"KMN network proteins",
					"children":[
					{
						"name":"MIS12 complex"
					},
					{
						"name":"NDC80 complex"
					}
					]
				},
				{
					"name":"Mis6 complex"
				},
				{
					"name":"COMA complex"
				},
				{
					"name":"NMS complex",
					"children":[
					{
						"name":"NDC80 complex"
					},
					{
						"name":"MIND kinetochore complex"
					}
					]
				},
				{
					"name":"MIS16-MIS18 complex"
				},
				{
					"name":"DASH complex"
				},
				{
					"name":"CBF3 complex"
				},
				{
					"name":"Others"
				}
				]
			},
			{
				"name":"SAC (spindle assembly checkpoint) factors",
				"children":[
				{
					"name":"Core SAC proteins"
				},
				{
					"name":"Motor proteins",
					"children":[
					{
						"name":"RZZ complex"
					},
					{
						"name":"Dynein complex"
					}
					]
				},
				{
					"name":"Protein kinases"
				},
				{
					"name":"Others"
				}
				]
			},
			{
				"name":"Other centromeric chromatin formation proteins",
				"children":[
				{
					"name":"Shugoshin"
				},
				{
					"name":"PP2A (protein phosphatase 2A)"
				}
				]
			}
			]
		},
		{
			"name":"Heterochromatin formation proteins",
			"children":[
			{
				"name":"HP1 (heterochromatin protein 1)"
			},
			{
				"name":"MBPs (metylated DNA binding proteins)"
			},
			{
				"name":"Other heterochromatin formation proteins",
				"children":[
				{
					"name":"EC55989_2182 dcm; DNA cytosine methylase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Gene silencing",
			"children":[
			{
				"name":"RISC (RNA-induced silencing complex)"
			},
			{
				"name":"piRNA pathway"
			},
			{
				"name":"RNA interference (RNAi) pathway",
				"children":[
				{
					"name":"RITS (RNA-induced transcriptional silencing) complex"
				},
				{
					"name":"RDRC (RNA-directed RNA polymerase complex)"
				},
				{
					"name":"Other RNAi proteins"
				}
				]
			},
			{
				"name":"microRNA pathway",
				"children":[
				{
					"name":"Microprocessor complex",
					"children":[
					{
						"name":"EC55989_2855 rnc; RNase III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					}
					]
				},
				{
					"name":"RISC loading complex"
				},
				{
					"name":"Other miRNA pathway proteins"
				}
				]
			},
			{
				"name":"Transposable elements"
			}
			]
		},
		{
			"name":"Centrosome formation proteins",
			"children":[
			{
				"name":"Centriole proteins"
			},
			{
				"name":"Pericentriolar materials (PCM)",
				"children":[
				{
					"name":"Centriolar satellite"
				},
				{
					"name":"Other PCM proteins"
				}
				]
			},
			{
				"name":"Cyclins"
			},
			{
				"name":"Kinases and associated factors",
				"children":[
				{
					"name":"Kinase associated protein"
				}
				]
			},
			{
				"name":"Microtubules and associated factors",
				"children":[
				{
					"name":"gamma-tubulin ring complex"
				},
				{
					"name":"Other tubulins"
				},
				{
					"name":"Dynactin complex"
				},
				{
					"name":"BRISC complex"
				},
				{
					"name":"Microtubule-associated proteins"
				}
				]
			},
			{
				"name":"Augmin complex"
			},
			{
				"name":"Centrosome duplication proteins",
				"children":[
				{
					"name":"Centriole replication proteins"
				},
				{
					"name":"Regulators of centriole replication"
				},
				{
					"name":"Other centrosome duplication proteins"
				}
				]
			},
			{
				"name":"Nde1-Su48 complex"
			},
			{
				"name":"LINC complex"
			},
			{
				"name":"3M complex"
			},
			{
				"name":"Gypsy chromatin insulator complex"
			},
			{
				"name":"Other centrosome associated proteins",
				"children":[
				{
					"name":"EC55989_3465 yqiK; conserved hypothetical protein\tK07192 FLOT; flotillin"
				}
				]
			},
			{
				"name":"Spindle formation proteins"
			}
			]
		},
		{
			"name":"Sister chromatid separation proteins",
			"children":[
			{
				"name":"Securin and associated proteins"
			},
			{
				"name":"Separase"
			},
			{
				"name":"APC\/C complex"
			},
			{
				"name":"Aurora kinases",
				"children":[
				{
					"name":"Regulators of Aurora kinases"
				}
				]
			},
			{
				"name":"TACC proteins"
			},
			{
				"name":"Polo kinases"
			},
			{
				"name":"Early mitotic inhibitors"
			}
			]
		},
		{
			"name":"Chromatin remodeling factors",
			"children":[
			{
				"name":"BAF complex"
			},
			{
				"name":"PBAF complex"
			},
			{
				"name":"GBAF(ncBAF) complex"
			},
			{
				"name":"CHRAC complex"
			},
			{
				"name":"RSF complex"
			},
			{
				"name":"WICH complex"
			},
			{
				"name":"B-WICH complex"
			},
			{
				"name":"NORC complex"
			},
			{
				"name":"BRF complex"
			},
			{
				"name":"NuRD complex"
			},
			{
				"name":"NuRF complex"
			},
			{
				"name":"NuRF complex (fruit fly)"
			},
			{
				"name":"CERF complex"
			},
			{
				"name":"SRCAP complex"
			},
			{
				"name":"INO80 complex"
			},
			{
				"name":"INO80 complex (yeast)"
			},
			{
				"name":"RSC complex"
			},
			{
				"name":"SWI\/SNF complex"
			},
			{
				"name":"SWR1 complex"
			},
			{
				"name":"ASTRA complex"
			},
			{
				"name":"Other chromatin remodeling factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Nucleoid associated proteins",
			"children":[
			{
				"name":"HNS (histone-like nucleoid structuring protein)",
				"children":[
				{
					"name":"EC55989_1332 hns; global nucleic acid-binding transcriptional dual regulator H-NS\tK03746 hns; DNA-binding protein H-NS"
				},
				{
					"name":"EC55989_2937 stpA; DNA binding protein, nucleoid-associated\tK11685 stpA; DNA-binding protein StpA"
				}
				]
			},
			{
				"name":"HU (heat unstable protein)",
				"children":[
				{
					"name":"EC55989_4485 hupA; HU, DNA-binding transcriptional regulator, alpha subunit\tK05787 hupA; DNA-binding protein HU-alpha"
				},
				{
					"name":"EC55989_0454 hupB; HU, DNA-binding transcriptional regulator, beta subunit\tK03530 hupB; DNA-binding protein HU-beta"
				}
				]
			},
			{
				"name":"IHF (integration host factor)",
				"children":[
				{
					"name":"EC55989_1880 ihfA; integration host factor (IHF), DNA-binding protein, alpha subunit\tK04764 ihfA; integration host factor subunit alpha"
				},
				{
					"name":"EC55989_0957 ihfB; integration host factor (IHF), DNA-binding protein, beta subunit\tK05788 ihfB; integration host factor subunit beta"
				}
				]
			},
			{
				"name":"Other nucleoid associated proteins",
				"children":[
				{
					"name":"EC55989_1110 cbpA; curved DNA-binding protein, DnaJ homologue that functions as a co-chaperone of DnaK\tK05516 cbpA; curved DNA-binding protein"
				},
				{
					"name":"EC55989_1109 cbpM; modulator of CbpA co-chaperone\tK18997 cbpM; chaperone modulatory protein CbpM"
				},
				{
					"name":"EC55989_5058 rob; DNA-binding transcriptional activator\tK05804 rob; AraC family transcriptional regulator, mar-sox-rob regulon activator"
				},
				{
					"name":"EC55989_4171 dnaA; chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator\tK02313 dnaA; chromosomal replication initiator protein"
				},
				{
					"name":"EC55989_3569 yraO; DnaA initiator-associating factor for replication initiation\tK12961 diaA; DnaA initiator-associating protein"
				},
				{
					"name":"EC55989_1015 yccV; DNA-binding protein, hemimethylated\tK11940 hspQ; heat shock protein HspQ"
				},
				{
					"name":"EC55989_0856 dps; Fe-binding and storage protein\tK04047 dps; starvation-inducible DNA-binding protein"
				},
				{
					"name":"EC55989_3675 fis; global DNA-binding transcriptional dual regulator\tK03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein"
				},
				{
					"name":"EC55989_4727 hfq; HF-I, host factor for RNA phage Q beta replication\tK03666 hfq; host factor-I protein"
				},
				{
					"name":"EC55989_3203 argP; DNA-binding transcriptional activator, replication initiation inhibitor\tK05596 argP; LysR family transcriptional regulator, arginine and lysine transport system\/DNA replication regulator"
				},
				{
					"name":"EC55989_0934 lrp; DNA-binding transcriptional dual regulator, leucine-binding\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"EC55989_2440 yejK; nucleotide associated protein\tK06899 ndpA; nucleoid-associated protein"
				}
				]
			}
			]
		},
		{
			"name":"Chromosome partitioning proteins",
			"children":[
			{
				"name":"MukBEF complex",
				"children":[
				{
					"name":"EC55989_0970 mukB; fused chromosome partitioning protein: putative nucleotide hydrolase; conserved hypothetical protein; conserved protein\tK03632 mukB; chromosome partition protein MukB"
				},
				{
					"name":"EC55989_0969 mukE; protein involved in chromosome partitioning\tK03804 mukE; chromosome partition protein MukE"
				},
				{
					"name":"EC55989_0968 mukF; Involved in chromosome partioning, Ca2+ binding protein\tK03633 mukF; chromosome partition protein MukF"
				}
				]
			},
			{
				"name":"Condensin-like complex"
			},
			{
				"name":"Divisome proteins",
				"children":[
				{
					"name":"EC55989_0090 ftsA; ATP-binding cell division protein involved in recruitment of FtsK to Z ring\tK03590 ftsA; cell division protein FtsA"
				},
				{
					"name":"EC55989_3020 ftsB; cell division protein\tK05589 ftsB; cell division protein FtsB"
				},
				{
					"name":"EC55989_3871 ftsE; transporter subunit: ATP-binding component of ABC superfamily\tK09812 ftsE; cell division transport system ATP-binding protein"
				},
				{
					"name":"EC55989_0080 ftsI; transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3)\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]"
				},
				{
					"name":"EC55989_0935 ftsK; DNA-binding membrane protein required for chromosome resolution and partitioning\tK03466 ftsK; DNA segregation ATPase FtsK\/SpoIIIE, S-DNA-T family"
				},
				{
					"name":"EC55989_0079 ftsL; membrane bound cell division protein at septum containing leucine zipper motif\tK03586 ftsL; cell division protein FtsL"
				},
				{
					"name":"EC55989_4411 ftsN; essential cell division protein\tK03591 ftsN; cell division protein FtsN"
				},
				{
					"name":"EC55989_0089 ftsQ; membrane anchored protein involved in growth of wall at septum\tK03589 ftsQ; cell division protein FtsQ"
				},
				{
					"name":"EC55989_0085 ftsW; integral membrane protein involved in stabilizing FstZ ring during cell division\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
				},
				{
					"name":"EC55989_3870 ftsX; transporter subunit: membrane component of ABC superfamily\tK09811 ftsX; cell division transport system permease protein"
				},
				{
					"name":"EC55989_0091 ftsZ; GTP-binding tubulin-like cell division protein\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"EC55989_2702 zipA; cell division protein involved in Z ring assembly\tK03528 zipA; cell division protein ZipA"
				},
				{
					"name":"EC55989_3198 zapA; protein that localizes to the cytokinetic ring\tK09888 zapA; cell division protein ZapA"
				},
				{
					"name":"EC55989_4406 yiiU; conserved hypothetical protein\tK09892 zapB; cell division protein ZapB"
				},
				{
					"name":"EC55989_0995 ycbW; conserved hypothetical protein\tK18657 zapC; cell division protein ZapC"
				},
				{
					"name":"EC55989_0096 yacF; conserved hypothetical protein\tK18778 zapD; cell division protein ZapD"
				},
				{
					"name":"EC55989_3645 yhcM; conserved hypothetical protein; putative nucleoside triphosphate hydrolase domain\tK06916 zapE; cell division protein ZapE"
				},
				{
					"name":"EC55989_4766 ytfB; putative cell envelope opacity-associated protein\tK07269 ytfB; cell division protein YtfB"
				},
				{
					"name":"EC55989_2724 amiA; N-acetylmuramoyl-l-alanine amidase I\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]"
				},
				{
					"name":"EC55989_3093 amiC; N-acetylmuramoyl-L-alanine amidase\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]"
				},
				{
					"name":"EC55989_4724 amiB; N-acetylmuramoyl-l-alanine amidase II\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]"
				},
				{
					"name":"EC55989_0476 acrA; multidrug efflux system\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Inhibitors of FtsZ assembly",
				"children":[
				{
					"name":"EC55989_1269 minC; cell division inhibitor\tK03610 minC; septum site-determining protein MinC"
				},
				{
					"name":"EC55989_1268 minD; membrane ATPase of the MinC-MinD-MinE system\tK03609 minD; septum site-determining protein MinD"
				},
				{
					"name":"EC55989_1267 minE; cell division topological specificity factor\tK03608 minE; cell division topological specificity factor"
				},
				{
					"name":"EC55989_1007 sulA; SOS cell division inhibitor\tK13053 sulA; cell division inhibitor SulA"
				},
				{
					"name":"EC55989_4106 ttk; division inhibitor\tK05501 slmA; TetR\/AcrR family transcriptional regulator"
				}
				]
			},
			{
				"name":"Other chromosome partitioning proteins",
				"children":[
				{
					"name":"EC55989_0674 seqA; regulatory protein for replication initiation\tK03645 seqA; negative modulator of initiation of replication"
				},
				{
					"name":"EC55989_3664 mreB; cell wall structural complex MreBCD, actin-like component MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"EC55989_3663 mreC; cell wall structural complex MreBCD transmembrane component MreC\tK03570 mreC; rod shape-determining protein MreC"
				},
				{
					"name":"EC55989_3661 mreD; cell wall structural complex MreBCD transmembrane component MreD\tK03571 mreD; rod shape-determining protein MreD"
				},
				{
					"name":"EC55989_0626 mrdB; cell wall shape-determining protein\tK05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
				},
				{
					"name":"EC55989_3436 parC; DNA topoisomerase IV, subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"EC55989_3446 parE; DNA topoisomerase IV, subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"EC55989_4216 gidA; glucose-inhibited cell-division protein\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"EC55989_4215 gidB; methyltransferase, SAM-dependent methyltransferase, glucose-inhibited cell-division protein\tK03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]"
				},
				{
					"name":"EC55989_4285 xerC; site-specific tyrosine recombinase\tK03733 xerC; integrase\/recombinase XerC"
				},
				{
					"name":"EC55989_3180 xerD; site-specific tyrosine recombinase\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"EC55989_2368 mrp; antiporter inner membrane protein\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				},
				{
					"name":"EC55989_3767 fic; stationary-phase protein, cell division\tK04095 fic; cell filamentation protein, protein adenylyltransferase [EC:2.7.7.108]"
				},
				{
					"name":"EC55989_4912 Putative Filamentation induced by cAMP protein Fic\tK04095 fic; cell filamentation protein, protein adenylyltransferase [EC:2.7.7.108]"
				},
				{
					"name":"EC55989_4340 yihA; GTP-binding protein\tK03978 engB; GTP-binding protein"
				}
				]
			}
			]
		}
		]
	}
	]
}