{
	"name":"ecoo02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"ECRM13514_3610 ygbT; CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"ECRM13514_3609 ygbF; CRISPR-associated protein, Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"ECRM13514_3616 ygbB; CRISPR-associated helicase Cas3, protein\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors",
				"children":[
				{
					"name":"ECRM13514_3614 cse1; CRISPR-associated protein, Cse1 family\tK19123 casA; CRISPR system Cascade subunit CasA"
				},
				{
					"name":"ECRM13514_3613 cse2; CRISPR-associated protein, Cse2 family\tK19046 casB; CRISPR system Cascade subunit CasB"
				},
				{
					"name":"ECRM13514_3612 cse4; CRISPR-associated protein, Cse4 family\tK19124 casC; CRISPR system Cascade subunit CasC"
				},
				{
					"name":"ECRM13514_3611 cse3; CRISPR-associated protein, Cse3 family\tK19126 casE; CRISPR system Cascade subunit CasE"
				}
				]
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"ECRM13514_2427 Type I restriction-modification system, restriction subunit R\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"ECRM13514_2430 Type I restriction-modification system, specificity subunit S\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"ECRM13514_2431 Type I restriction-modification system, DNA-methyltransferase subunit M\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"ECRM13514_4331 dam; Methyl-directed repair DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"ECRM13514_2047 DNA methyl transferase, phage-associated\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"ECRM13514_4215 yhdJ; Adenine-specific methyltransferase\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"ECRM13514_5730 Adenine-specific methyltransferase\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"ECRM13514_2517 dcm; DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"ECRM13514_4994 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"ECRM13514_5820 hypothetical protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"ECRM13514_2869 putative Dnase\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"ECRM13514_5223 putative DNase\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok",
				"children":[
				{
					"name":"ECRM13514_1231 hypothetical protein\tK18920 hokA; protein HokA"
				},
				{
					"name":"ECRM13514_2466 hypothetical protein\tK18920 hokA; protein HokA"
				},
				{
					"name":"ECRM13514_3114 hypothetical protein\tK18920 hokA; protein HokA"
				},
				{
					"name":"ECRM13514_4555 small toxic polypeptide\tK18920 hokA; protein HokA"
				},
				{
					"name":"ECRM13514_6031 hypothetical protein\tK18920 hokA; protein HokA"
				},
				{
					"name":"ECRM13514_0601 HokE protein\tK18922 hokE; protein HokE"
				}
				]
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl",
				"children":[
				{
					"name":"ECRM13514_1583 hypothetical protein\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"ECRM13514_4527 hypothetical protein\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				}
				]
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA",
				"children":[
				{
					"name":"ECRM13514_1776 ydaC; Phage protein\tK19780 ralA; antisense regulator of RalR protein"
				}
				]
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"ECRM13514_3641 chpA; Programmed cell death toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"ECRM13514_3642 chpR; Programmed cell death antitoxin\tK07172 mazE; antitoxin MazE"
				}
				]
			},
			{
				"name":"ChpB-ChpS",
				"children":[
				{
					"name":"ECRM13514_4359 pemK; Programmed cell death toxin PemK\tK18841 chpB; mRNA interferase ChpB [EC:3.1.-.-]"
				},
				{
					"name":"ECRM13514_5489 chpB; Programmed cell death toxin ChpB\tK18841 chpB; mRNA interferase ChpB [EC:3.1.-.-]"
				},
				{
					"name":"ECRM13514_4358 hypothetical protein\tK18842 chpS; antitoxin ChpS"
				},
				{
					"name":"ECRM13514_5488 chpS; Programmed cell death antitoxin ChpS\tK18842 chpS; antitoxin ChpS"
				}
				]
			},
			{
				"name":"YhaV-PrlF",
				"children":[
				{
					"name":"ECRM13514_4091 yhaV; Uncharacterized protein yhaV\tK19155 yhaV; toxin YhaV [EC:3.1.-.-]"
				},
				{
					"name":"ECRM13514_4090 sohA; SohA suppressor protein\tK19156 prlF; antitoxin PrlF"
				}
				]
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"ECRM13514_5500 hypothetical protein\tK18918 relB; RHH-type transcriptional regulator, rel operon repressor \/ antitoxin RelB"
				}
				]
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"ECRM13514_2737 YoeB toxin protein\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"ECRM13514_2738 YefM protein (antitoxin to YoeB)\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"ECRM13514_1885 hipB; HipB protein\tK15773 hipB; HTH-type transcriptional regulator \/ antitoxin HipB"
				}
				]
			},
			{
				"name":"HicA-HicB",
				"children":[
				{
					"name":"ECRM13514_1961 hypothetical protein\tK18843 hicB; antitoxin HicB"
				}
				]
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB",
				"children":[
				{
					"name":"ECRM13514_1733 pspC; Phage shock protein C\tK03973 pspC; phage shock protein C"
				},
				{
					"name":"ECRM13514_1732 pspB; Phage shock protein B\tK03970 pspB; phage shock protein B"
				}
				]
			},
			{
				"name":"CcdB-CcdA",
				"children":[
				{
					"name":"ECRM13514_0051 ccdB; CcdB toxin protein\tK19163 ccdB; toxin CcdB"
				},
				{
					"name":"ECRM13514_0050 ccdA; CcdA protein (antitoxin to CcdB)\tK19164 ccdA; antitoxin CcdA"
				}
				]
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"ECRM13514_3566 hypothetical protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"ECRM13514_4045 hypothetical protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"ECRM13514_3564 Putative cytoplasmic protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"ECRM13514_4044 ygjM; Putative cytoplasmic protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"ECRM13514_0360 ybaQ; HigA protein (antitoxin to HigB)\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"ECRM13514_1925 yddM; HigA protein (antitoxin to HigB)\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"ECRM13514_2601 hypothetical protein\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA",
				"children":[
				{
					"name":"ECRM13514_3923 ygiU; Toxin mRNA interferase YgiU\tK13651 mqsR; motility quorum-sensing regulator \/ GCU-specific mRNA interferase toxin"
				},
				{
					"name":"ECRM13514_3922 ygiT; Antitoxin YgiT\tK13655 mqsA; HTH-type transcriptional regulator \/ antitoxin MqsA"
				}
				]
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"ECRM13514_5788 vagD; plasmid maintenance protein VagD\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"ECRM13514_5789 vagC; plasmid maintenance protein VagC\tK18829 mvpT; antitoxin VapB"
				}
				]
			},
			{
				"name":"PezT-PezA",
				"children":[
				{
					"name":"ECRM13514_5156 putative enolase\tK16214 pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]"
				}
				]
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"ECRM13514_5517 yjgK; Protein YjgK, linked to biofilm formation\tK19334 tabA; biofilm protein TabA"
				},
				{
					"name":"ECRM13514_0883 hypothetical protein\tK13650 mcbA; MqsR-controlled colanic acid and biofilm protein A"
				},
				{
					"name":"ECRM13514_1350 bssS; Putative cytoplasmic protein\tK12148 bssS; biofilm regulator BssS"
				},
				{
					"name":"ECRM13514_0913 bssR; Biofilm regulator bssR\tK19688 bssR; biofilm regulator BssR"
				},
				{
					"name":"ECRM13514_1405 ycfR; Putative outer membrane protein\tK12151 bhsA; multiple stress resistance protein BhsA"
				},
				{
					"name":"ECRM13514_0099 ftsZ; Cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"ECRM13514_4203 mreB; Rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"ECRM13514_3920 parC; Topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"ECRM13514_3931 parE; Topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"ECRM13514_3225 gltX; Glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU",
				"children":[
				{
					"name":"ECRM13514_1312 yeeV; YeeV toxin protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"ECRM13514_2647 yeeV_2; YeeV toxin protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"ECRM13514_3968 yeeV_3; YeeV toxin protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"ECRM13514_1311 yeeU; YeeU protein (antitoxin to YeeV)\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				},
				{
					"name":"ECRM13514_2646 yeeU_2; YeeU protein (antitoxin to YeeV)\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				},
				{
					"name":"ECRM13514_3969 yeeU_3; YeeU protein (antitoxin to YeeV)\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				}
				]
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"ECRM13514_3754 Putative inner membrane protein\tK19168 cptA; toxin CptA"
				},
				{
					"name":"ECRM13514_3755 ygfY; YgfY\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS",
				"children":[
				{
					"name":"ECRM13514_5345 hypothetical protein\tK18839 ghoT; toxin GhoT"
				},
				{
					"name":"ECRM13514_5344 hypothetical protein\tK18840 ghoS; antitoxin GhoS"
				}
				]
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein",
				"children":[
				{
					"name":"ECRM13514_1954 hypothetical protein\tK28274 ortT; orphan toxin OrtT"
				}
				]
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB",
				"children":[
				{
					"name":"ECRM13514_0383 hha; hemolysin expression modulating protein\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"ECRM13514_5362 Putative hemolysin expression modulating protein\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"ECRM13514_0382 ybaJ; Putative cytoplasmic protein\tK19162 tomB; hha toxicity modulator TomB"
				}
				]
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"ECRM13514_3362 yfhO; Cysteine desulfurase, IscS subfamily\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}