{
	"name":"edw02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"QY76_14840 phoR; phosphate regulon sensor protein\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"QY76_14845 transcriptional regulator PhoB\tK07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)",
			"children":[
			{
				"name":"QY76_09925 sensor protein PhoQ\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
			},
			{
				"name":"QY76_09930 transcriptional regulator\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
			}
			]
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)",
			"children":[
			{
				"name":"QY76_04085 envZ; osmolarity sensor protein\tK07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]"
			},
			{
				"name":"QY76_04080 ompR; osmolarity response regulator\tK07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR"
			}
			]
		},
		{
			"name":"RstB-RstA",
			"children":[
			{
				"name":"QY76_11375 sensor protein RstB\tK07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]"
			},
			{
				"name":"QY76_11380 transcriptional regulator\tK07661 rstA; two-component system, OmpR family, response regulator RstA"
			}
			]
		},
		{
			"name":"CpxA-CpxR (envelope stress response)",
			"children":[
			{
				"name":"QY76_03315 cpxA; two-component sensor protein\tK07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]"
			},
			{
				"name":"QY76_03320 transcriptional regulator\tK07662 cpxR; two-component system, OmpR family, response regulator CpxR"
			}
			]
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)",
			"children":[
			{
				"name":"QY76_16935 DNA-binding protein\tK07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB"
			}
			]
		},
		{
			"name":"BaeS-BaeR (envelope stress response)",
			"children":[
			{
				"name":"QY76_14905 histidine kinase\tK07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]"
			},
			{
				"name":"QY76_14910 transcriptional regulator\tK07664 baeR; two-component system, OmpR family, response regulator BaeR"
			}
			]
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)",
			"children":[
			{
				"name":"QY76_00935 sensor protein BasS\/PmrB\tK07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3]"
			},
			{
				"name":"QY76_00930 XRE family transcriptional regulator\tK07771 basR; two-component system, OmpR family, response regulator BasR"
			}
			]
		},
		{
			"name":"CusS-CusR (copper tolerance)",
			"children":[
			{
				"name":"QY76_11765 histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
			},
			{
				"name":"QY76_11760 transcriptional regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			}
			]
		},
		{
			"name":"QseC-QseB (quorum sensing)",
			"children":[
			{
				"name":"QY76_00675 sensor protein QseC\tK07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]"
			},
			{
				"name":"QY76_00670 transcriptional regulator\tK07666 qseB; two-component system, OmpR family, response regulator QseB"
			}
			]
		},
		{
			"name":"KdpD-KdpE (potassium transport)",
			"children":[
			{
				"name":"QY76_07500 sensor protein KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			},
			{
				"name":"QY76_07495 transcriptional regulator\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE"
			}
			]
		},
		{
			"name":"TorS-TorR (TMAO respiration)",
			"children":[
			{
				"name":"QY76_01385 histidine kinase\tK07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3]"
			},
			{
				"name":"QY76_01395 chemotaxis protein CheY\tK07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR"
			}
			]
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)",
			"children":[
			{
				"name":"QY76_00255 aerobic respiration control sensor protein ArcB\tK07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]"
			},
			{
				"name":"QY76_00080 TorR family transcriptional regulator\tK07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA"
			}
			]
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)"
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR"
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)"
		},
		{
			"name":"NarQ-NarP (nitrate respiration)",
			"children":[
			{
				"name":"QY76_14695 nitrate\/nitrite sensor protein NarQ\tK07674 narQ; two-component system, NarL family, nitrate\/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]"
			},
			{
				"name":"QY76_14700 transcriptional regulator NarP\tK07685 narP; two-component system, NarL family, nitrate\/nitrite response regulator NarP"
			}
			]
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)",
			"children":[
			{
				"name":"QY76_03505 histidine kinase\tK07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]"
			},
			{
				"name":"QY76_03500 transcriptional regulator\tK07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA"
			}
			]
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)",
			"children":[
			{
				"name":"QY76_08675 histidine kinase\tK07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]"
			},
			{
				"name":"QY76_08685 tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase\tK07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3]"
			},
			{
				"name":"QY76_08680 transcriptional regulator\tK07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB"
			}
			]
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)",
			"children":[
			{
				"name":"QY76_06930 histidine kinase\tK07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]"
			},
			{
				"name":"QY76_09995 sirA; response regulator\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			}
			]
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)"
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)"
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)",
			"children":[
			{
				"name":"QY76_01695 dpiB; histidine kinase\tK07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]"
			},
			{
				"name":"QY76_01690 dpiA; two-component response regulator DpiA\tK07702 dpiA; two-component system, CitB family, response regulator CitB"
			}
			]
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)"
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)",
			"children":[
			{
				"name":"QY76_03755 histidine kinase\tK27882 btsS; two-component system, LytTR family, low-concentration pyruvate sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"QY76_06130 response regulator\tK27883 btsR; two-component system, LytTR family, low-concentration pyruvate response regulator"
			}
			]
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)",
			"children":[
			{
				"name":"QY76_05305 membrane protein\tK27884 pyrS; two-component system, LytTR family, high-concentration pyruvate sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"QY76_05310 LytTR family transcriptional regulator\tK27885 pyrR; two-component system, LytTR family, high-concentration pyruvate response regulator"
			}
			]
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)",
			"children":[
			{
				"name":"QY76_03080 glnL; nitrogen regulation protein NR(II)\tK07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]"
			},
			{
				"name":"QY76_03075 glnG; nitrogen regulation protein NR(I)\tK07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG"
			}
			]
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)"
		},
		{
			"name":"HydH-HydG (metal tolerance)"
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)",
			"children":[
			{
				"name":"QY76_10215 histidine kinase\tK07710 atoS; two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3]"
			},
			{
				"name":"QY76_10210 transcriptional regulator\tK07714 atoC; two-component system, NtrC family, response regulator AtoC"
			}
			]
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)"
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)",
			"children":[
			{
				"name":"QY76_16455 histidine kinase\tK07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]"
			},
			{
				"name":"QY76_16445 response regulator GlrR\tK07715 glrR; two-component system, NtrC family, response regulator GlrR"
			}
			]
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)",
			"children":[
			{
				"name":"QY76_13315 histidine kinase\tK08475 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3]"
			},
			{
				"name":"QY76_13320 transcriptional regulator\tK08476 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA"
			}
			]
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)"
		},
		{
			"name":"KinB-AlgB (alginate production)"
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"QY76_13235 chemotaxis protein CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"QY76_13205 chemotaxis protein CheY\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"QY76_13210 chemotaxis protein\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)"
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)"
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)"
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)"
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)"
		},
		{
			"name":"SsrA-SsrB",
			"children":[
			{
				"name":"QY76_15740 histidine kinase\tK14978 ssrA; two-component system, LuxR family, secretion system sensor histidine kinase SsrA"
			},
			{
				"name":"QY76_15735 regulator\tK14979 ssrB; two-component system, LuxR family, secretion system response regulator SsrB"
			}
			]
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)"
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)"
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)"
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)"
		},
		{
			"name":"PdtaS-PdtaR"
		},
		{
			"name":"NasS-NasT"
		},
		{
			"name":"Unclassified"
		}
		]
	}
	]
}