{
	"name":"efau01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases",
				"children":[
				{
					"name":"EFAU085_02347 aac(6')-Ii; Aminoglycoside resistance protein, Aac(6')-Ii\tK18815 aac6-I; aminoglycoside 6'-N-acetyltransferase I [EC:2.3.1.82]"
				}
				]
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases",
				"children":[
				{
					"name":"EFAU085_p3016 aadE; Streptomycin adenyltransferase\tK05593 aadK; aminoglycoside 6-adenylyltransferase [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"EFAU085_p3013 aphA; Aminoglycoside 3'-phosphotransferase\tK19299 aph3-III; aminoglycoside 3'-phosphotransferase III [EC:2.7.1.95]"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"EFAU085_01344 major facilitator superfamily transporter\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"EFAU085_00538 translation elongation factor G\tK18220 tetM; ribosomal protection tetracycline resistance protein"
				}
				]
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases",
				"children":[
				{
					"name":"EFAU085_p3012 erm; rRNA adenine N-6-methyltransferase\tK00561 ermC; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]"
				}
				]
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"EFAU085_02754 ABC transporter, ATP-binding protein\tK18231 msr; macrolide transport system ATP-binding\/permease protein"
				},
				{
					"name":"EFAU085_00578 ABC transporter ATP-binding protein\tK19350 lsa; lincosamide and streptogramin A transport system ATP-binding\/permease protein"
				},
				{
					"name":"EFAU085_p3023 drug resistance ABC transporter ATP-binding protein\tK19350 lsa; lincosamide and streptogramin A transport system ATP-binding\/permease protein"
				},
				{
					"name":"EFAU085_00478 transporter, major facilitator family protein\tK08217 mef; MFS transporter, DHA3 family, macrolide efflux protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"EFAU085_p3022 Lincosamide nucleotidyltransferase\tK18236 lnuB_F; lincosamide nucleotidyltransferase B\/F"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"EFAU085_01197 fosX; fosfomycin resistance protein FosX domain protein\tK21252 fosX; fosfomycin resistance protein FosX"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"EFAU085_00731 vanSB; sensor histidine kinase VanSB\tK18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]"
				},
				{
					"name":"EFAU085_00730 vanRB; DNA-binding response regulator VanRB\tK18344 vanRB; two-component system, OmpR family, response regulator VanR"
				},
				{
					"name":"EFAU085_00732 vanYB; VanY protein, D-alanyl-D-alanine carboxypeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"EFAU085_01219 serine-type D-Ala-D-Ala carboxypeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"EFAU085_00733 vanWB; vancomycin B-type resistance protein VanW\tK18346 vanW; vancomycin resistance protein VanW"
				},
				{
					"name":"EFAU085_00734 vanHB; VanH protein, D-specific alpha-keto acid dehydrogenase\tK18347 vanH; D-specific alpha-keto acid dehydrogenase [EC:1.1.1.-]"
				},
				{
					"name":"EFAU085_00735 vanB; Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase\tK15739 vanB; D-alanine---(R)-lactate ligase [EC:6.1.2.1]"
				},
				{
					"name":"EFAU085_00736 vanXB; D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]",
				"children":[
				{
					"name":"EFAU085_00673 D-alanine--poly(phosphoribitol) ligase subunit 1\tK03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]"
				},
				{
					"name":"EFAU085_00674 membrane bound O-acyl transferase\tK03739 dltB; membrane protein involved in D-alanine export"
				},
				{
					"name":"EFAU085_00675 D-alanine--poly(phosphoribitol) ligase subunit 2\tK14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]"
				},
				{
					"name":"EFAU085_00676 dltD; D-alanyl-lipoteichoic acid synthetase, DltD\tK03740 dltD; D-alanine transfer protein"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"EFAU085_01106 ysyl-tRNA synthetase\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				},
				{
					"name":"EFAU085_02724 hypothetical protein\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]"
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]"
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]"
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}