{
	"name":"efe04147",
	"children":[
	{
		"name":"Exosomal proteins",
		"children":[
		{
			"name":"Proteins found in most exosomes",
			"children":[
			{
				"name":"EFER_2544 htpG; molecular chaperone HSP90 family\tK04079 HSP90A; molecular chaperone HtpG"
			},
			{
				"name":"EFER_3880 htpG; Hsp90xo molecular chaperone\tK04079 HSP90A; molecular chaperone HtpG"
			},
			{
				"name":"EFER_0285 eno; enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
			},
			{
				"name":"EFER_1293 gapA; glyceraldehyde-3-phosphate dehydrogenase A\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]"
			},
			{
				"name":"EFER_1585 gapC; glyceraldehyde-3-phosphate dehydrogenase C\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]"
			},
			{
				"name":"EFER_2858 pgk; phosphoglycerate kinase\tK00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]"
			},
			{
				"name":"EFER_1218 pykA; pyruvate kinase II\tK00873 PK; pyruvate kinase [EC:2.7.1.40]"
			},
			{
				"name":"EFER_1376 pykF; pyruvate kinase I\tK00873 PK; pyruvate kinase [EC:2.7.1.40]"
			},
			{
				"name":"EFER_3336 ppiA; peptidyl-prolyl cis-trans isomerase A (rotamase A)\tK03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]"
			},
			{
				"name":"EFER_2994 yqiK; conserved hypothetical protein\tK07192 FLOT; flotillin"
			}
			]
		},
		{
			"name":"Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)",
			"children":[
			{
				"name":"EFER_4195 groL; Cpn60 chaperonin GroEL, large subunit of GroESL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"EFER_0010 dnaK; chaperone Hsp70, co-chaperone with DnaJ\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"EFER_4117 pgi; glucosephosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"EFER_0667 guaB; IMP dehydrogenase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]"
			},
			{
				"name":"EFER_3309 tufA; protein chain elongation factor EF-Tu (duplicate of tufB)\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"EFER_3774 tufB; protein chain elongation factor EF-Tu (duplicate of tufA)\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"EFER_1825 hinT; purine nucleoside phosphoramidase\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
			}
			]
		},
		{
			"name":"Exosomal proteins of oligodendrocytes"
		},
		{
			"name":"Exosomal proteins of cortical neuronal cells"
		},
		{
			"name":"Exosomal proteins of microglial cells"
		},
		{
			"name":"Exosomal proteins of epithelial cells",
			"children":[
			{
				"name":"EFER_4154 Putative malate\/L-lactate dehydrogenases\tK00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]"
			}
			]
		},
		{
			"name":"Exosomal proteins of hepatic cells",
			"children":[
			{
				"name":"EFER_0765 yfeH; putative sodium\/bile acid symporter family (mazG-like)\tK14347 SLC10A7; solute carrier family 10 (sodium\/bile acid cotransporter), member 7"
			}
			]
		},
		{
			"name":"Exosomal proteins of breast milk",
			"children":[
			{
				"name":"EFER_1275 fadD; acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"EFER_4154 Putative malate\/L-lactate dehydrogenases\tK00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]"
			}
			]
		},
		{
			"name":"Exosomal proteins of other body fluids (saliva and urine)",
			"children":[
			{
				"name":"EFER_4195 groL; Cpn60 chaperonin GroEL, large subunit of GroESL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"EFER_0935 atoB; acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"EFER_2775 yqeF; Acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"EFER_0523 adk; adenylate kinase\tK00939 adk; adenylate kinase [EC:2.7.4.3]"
			},
			{
				"name":"EFER_2548 apt; adenine phosphoribosyltransferase\tK00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]"
			},
			{
				"name":"EFER_3803 argH; argininosuccinate lyase\tK01755 argH; argininosuccinate lyase [EC:4.3.2.1]"
			},
			{
				"name":"EFER_3150 argG; argininosuccinate synthetase\tK01940 argG; argininosuccinate synthase [EC:6.3.4.5]"
			},
			{
				"name":"EFER_4310 fbp; fructose-1,6-bisphosphatase I\tK03841 FBP; fructose-1,6-bisphosphatase I [EC:3.1.3.11]"
			},
			{
				"name":"EFER_2352 galK; galactokinase\tK00849 galK; galactokinase [EC:2.7.1.6]"
			},
			{
				"name":"EFER_3409 glgB; 1,4-alpha-glucan branching enzyme\tK00700 GBE1; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]"
			},
			{
				"name":"EFER_2517 Glycerol kinase 2 (ATP:glycerol 3-phosphotransferase 2) (Glycerokinase 2) (GK 2)\tK00864 glpK; glycerol kinase [EC:2.7.1.30]"
			},
			{
				"name":"EFER_3847 glpK; glycerol kinase\tK00864 glpK; glycerol kinase [EC:2.7.1.30]"
			},
			{
				"name":"EFER_3903 glnA; glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"EFER_4117 pgi; glucosephosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"EFER_2650 hemB; porphobilinogen synthase\tK01698 hemB; porphobilinogen synthase [EC:4.2.1.24]"
			},
			{
				"name":"EFER_2640 phoA; bacterial alkaline phosphatase\tK01077 ALP; alkaline phosphatase [EC:3.1.3.1]"
			},
			{
				"name":"EFER_2850 serA; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"EFER_3748 purH; fused IMP cyclohydrolase; phosphoribosylaminoimidazolecarboxamide formyltransferase\tK00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase \/ IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]"
			}
			]
		},
		{
			"name":"Exosomal proteins of breast cancer cells",
			"children":[
			{
				"name":"EFER_1275 fadD; acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"EFER_0137 lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]"
			},
			{
				"name":"EFER_4150 putative dihydrolipoyl dehydrogenase, E3 component (lpd-like)\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]"
			},
			{
				"name":"EFER_0050 fixB; putative electron transfer flavoprotein, NAD\/FAD-binding domain and ETFP adenine nucleotide-binding domain-like\tK03522 fixB; electron transfer flavoprotein alpha subunit"
			},
			{
				"name":"EFER_1221 zwf; glucose-6-phosphate dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"EFER_0667 guaB; IMP dehydrogenase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]"
			},
			{
				"name":"EFER_0010 dnaK; chaperone Hsp70, co-chaperone with DnaJ\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"EFER_4195 groL; Cpn60 chaperonin GroEL, large subunit of GroESL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"EFER_3309 tufA; protein chain elongation factor EF-Tu (duplicate of tufB)\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"EFER_3774 tufB; protein chain elongation factor EF-Tu (duplicate of tufA)\tK02358 tuf; elongation factor Tu"
			}
			]
		},
		{
			"name":"Exosomal proteins of ovarian cancer cells"
		},
		{
			"name":"Exosomal proteins of colorectal cancer cells",
			"children":[
			{
				"name":"EFER_4195 groL; Cpn60 chaperonin GroEL, large subunit of GroESL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"EFER_4117 pgi; glucosephosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"EFER_1221 zwf; glucose-6-phosphate dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"EFER_0010 dnaK; chaperone Hsp70, co-chaperone with DnaJ\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"EFER_0431 putative triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			},
			{
				"name":"EFER_3854 tpiA; triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			},
			{
				"name":"EFER_3309 tufA; protein chain elongation factor EF-Tu (duplicate of tufB)\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"EFER_3774 tufB; protein chain elongation factor EF-Tu (duplicate of tufA)\tK02358 tuf; elongation factor Tu"
			}
			]
		},
		{
			"name":"Exosomal proteins of pancreatic cancer cells"
		},
		{
			"name":"Exosomal proteins of bladder cancer cells",
			"children":[
			{
				"name":"EFER_4195 groL; Cpn60 chaperonin GroEL, large subunit of GroESL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"EFER_1221 zwf; glucose-6-phosphate dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"EFER_2354 gpmA; phosphoglyceromutase 1\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"
			},
			{
				"name":"EFER_0431 putative triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			},
			{
				"name":"EFER_3854 tpiA; triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			}
			]
		},
		{
			"name":"Exosomal proteins of melanoma cells",
			"children":[
			{
				"name":"EFER_2354 gpmA; phosphoglyceromutase 1\tK01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"
			},
			{
				"name":"EFER_0431 putative triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			},
			{
				"name":"EFER_3854 tpiA; triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			}
			]
		},
		{
			"name":"Exosomal proteins of other cancer cells",
			"children":[
			{
				"name":"EFER_2705 blc; Outer membrane lipoprotein blc precursor (LIPOCALIN) from bacteriophage origin\tK03098 APOD; apolipoprotein D and lipocalin family protein"
			},
			{
				"name":"EFER_4203 blc; outer membrane lipoprotein (lipocalin)\tK03098 APOD; apolipoprotein D and lipocalin family protein"
			}
			]
		}
		]
	},
	{
		"name":"Exosomal RNA",
		"children":[
		{
			"name":"Exosomal RNA of haemopoietic cells"
		},
		{
			"name":"Exosomal RNA of muscle cells"
		},
		{
			"name":"Exosomal RNA of hepatic cells"
		},
		{
			"name":"Exosomal RNA of pancreatic cells"
		},
		{
			"name":"Exosomal RNA of neural cells"
		},
		{
			"name":"Exosomal RNA of breast milk"
		},
		{
			"name":"Exosomal RNA of saliva"
		},
		{
			"name":"Exosomal RNA of breast cancer cells"
		},
		{
			"name":"Exosomal RNA of ovarian cancer cells"
		},
		{
			"name":"Exosomal RNA of colorectal cancer cells"
		},
		{
			"name":"Exosomal RNA of hepatic cancer cells"
		},
		{
			"name":"Exosomal RNA of renal carcinoma cells"
		},
		{
			"name":"Exosomal RNA of pancreatic cancer cells"
		},
		{
			"name":"Exosomal RNA of melanoma cells"
		},
		{
			"name":"Exosomal RNA of lung cancer cells"
		},
		{
			"name":"Exosomal RNA of other cancer cells"
		}
		]
	}
	]
}