{
	"name":"eff03000",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Basic leucine zipper (bZIP)",
			"children":[
			{
				"name":"AP-1(-like) components, Jun"
			},
			{
				"name":"AP-1(-like) components, Fos"
			},
			{
				"name":"AP-1(-like) components, Maf"
			},
			{
				"name":"AP-1(-like) components, NF-E2"
			},
			{
				"name":"AP-1(-like) components, Fungal regulators"
			},
			{
				"name":"AP-1(-like) components, CRE-BP\/ATF"
			},
			{
				"name":"CREB"
			},
			{
				"name":"C\/EBP-like factors"
			},
			{
				"name":"bZIP\/PAR"
			},
			{
				"name":"Plant bZIP factors"
			},
			{
				"name":"ZIP only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix (bHLH)",
			"children":[
			{
				"name":"Ubiquitous (class A) factors"
			},
			{
				"name":"Myogenic transcription factors"
			},
			{
				"name":"Achaete-Scute"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Lymphoid factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesodermal Twist-like factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, HEN"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesp"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Atonal"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Pancreatic factors"
			},
			{
				"name":"Hairy, Hairy\/E(SPL)"
			},
			{
				"name":"Hairy, Fungal regulators"
			},
			{
				"name":"Factors with PAS domain"
			},
			{
				"name":"Yabby"
			},
			{
				"name":"INO"
			},
			{
				"name":"HLH domain only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix\/leucine zipper (bHLH-ZIP)",
			"children":[
			{
				"name":"Ubiquitous bHLH-ZIP factors"
			},
			{
				"name":"Cell cycle controlling factors, Myc"
			},
			{
				"name":"Cell cycle controlling factors, Mad\/Max"
			},
			{
				"name":"Other bHLH-ZIP factors"
			}
			]
		},
		{
			"name":"Other basic domains",
			"children":[
			{
				"name":"NF-1"
			},
			{
				"name":"RF-X"
			},
			{
				"name":"AP-2 (bHSH)"
			}
			]
		},
		{
			"name":"Zinc finger",
			"children":[
			{
				"name":"Cys4 thyroid hormone receptor-like"
			},
			{
				"name":"Cys4 hepatocyte nuclear factor 4-like"
			},
			{
				"name":"Cys4 estrogen receptor-like"
			},
			{
				"name":"Cys4 nerve growth factor IB-like"
			},
			{
				"name":"Cys4 Fushi tarazu-F1-like"
			},
			{
				"name":"Cys4 germ cell nuclear factor"
			},
			{
				"name":"Cys4 Knirps\/DAX1-like"
			},
			{
				"name":"Cys4 GATA-factors"
			},
			{
				"name":"Cys2His2 SP\/KLF family and related proteins"
			},
			{
				"name":"Cys2His2 GLI-like"
			},
			{
				"name":"Cys2His2 Snail"
			},
			{
				"name":"Cys2His2 BTB-ZF factors"
			},
			{
				"name":"Cys2His2 BED"
			},
			{
				"name":"Cys2His2 PRDM"
			},
			{
				"name":"Cys2His2 metabolic regulators in fungi"
			},
			{
				"name":"Cys2His2 others"
			},
			{
				"name":"Cys2HisCys zinc factors"
			},
			{
				"name":"Cys3His zinc factors"
			},
			{
				"name":"Cys2CysHis zinc factors"
			},
			{
				"name":"CXXC CpG-binding proteins",
				"children":[
				{
					"name":"skT53_14650 hypothetical protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"skT53_14660 hypothetical protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"skT53_17970 DNA methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Cys6 metabolic regulators in fungi"
			},
			{
				"name":"Other zinc fingers"
			}
			]
		},
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"Homeo domain ANTP: HOXL"
			},
			{
				"name":"Homeo domain ANTP: NKL"
			},
			{
				"name":"Homeo domain Paired-related"
			},
			{
				"name":"Homeo domain LIM"
			},
			{
				"name":"Homeo domain POU"
			},
			{
				"name":"Homeo domain SINE"
			},
			{
				"name":"Homeo domain ZF"
			},
			{
				"name":"Homeo domain CUT"
			},
			{
				"name":"Homeo domain PROS"
			},
			{
				"name":"Homeo domain TALE"
			},
			{
				"name":"Homeo domain other"
			},
			{
				"name":"Fork head\/winged helix developmental regulators"
			},
			{
				"name":"Fork head\/winged helix tissue-specific regulators"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, E2F"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, DP"
			},
			{
				"name":"Fork head\/winged helix other regulators"
			},
			{
				"name":"Stork head\/winged helix factors"
			},
			{
				"name":"Heat shock factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-like factors"
			},
			{
				"name":"Tryptophan clusters Ets-type"
			},
			{
				"name":"Tryptophan clusters interferon-regulating factors"
			},
			{
				"name":"TEA domain"
			},
			{
				"name":"ARID"
			}
			]
		},
		{
			"name":"beta-Scaffold factors with minor groove contacts",
			"children":[
			{
				"name":"RHR (Rel homology region) Rel\/Ankyrin"
			},
			{
				"name":"RHR (Rel homology region) Ankyrin only"
			},
			{
				"name":"RHR (Rel homology region) NF-AT"
			},
			{
				"name":"STAT"
			},
			{
				"name":"p53"
			},
			{
				"name":"MADS-box regulators of differentiation, MEF-2"
			},
			{
				"name":"MADS-box regulators of differentiation, Homeotic genes"
			},
			{
				"name":"MADS-box regulators of differentiation, Yeast regulators"
			},
			{
				"name":"MADS-box responders to external signals"
			},
			{
				"name":"SAND domain-containing proteins"
			},
			{
				"name":"TATA-binding proteins"
			},
			{
				"name":"HMG SOX"
			},
			{
				"name":"HMG TCF-1"
			},
			{
				"name":"HMG TOX"
			},
			{
				"name":"HMG2-related"
			},
			{
				"name":"UBF"
			},
			{
				"name":"Other HMG box factors"
			},
			{
				"name":"Heteromeric CCAAT factors"
			},
			{
				"name":"Grainyhead"
			},
			{
				"name":"Cold-shock domain factors, DbpA-like"
			},
			{
				"name":"Cold-shock domain factors, YB-1\/DbpB-like"
			},
			{
				"name":"Cold-shock domain factors, FRG Y2-like"
			},
			{
				"name":"Runt"
			},
			{
				"name":"MYRF"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"HMGI(Y)"
			},
			{
				"name":"NUPR"
			},
			{
				"name":"Pocket domain Rb"
			},
			{
				"name":"Pocket domain CBP"
			},
			{
				"name":"T-box"
			},
			{
				"name":"DMRT"
			},
			{
				"name":"LRRFIP"
			},
			{
				"name":"TCP"
			},
			{
				"name":"AP2\/ERF"
			},
			{
				"name":"WRKY"
			},
			{
				"name":"LOB"
			},
			{
				"name":"GRAS"
			},
			{
				"name":"NAC"
			},
			{
				"name":"Copper-fist proteins fungal regulators"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"AraC family"
			},
			{
				"name":"LysR family",
				"children":[
				{
					"name":"skT53_06890 LysR family transcriptional regulator\tK21900 cysL; LysR family transcriptional regulator, transcriptional activator of the cysJI operon"
				},
				{
					"name":"skT53_15640 LysR family transcriptional regulator\tK21900 cysL; LysR family transcriptional regulator, transcriptional activator of the cysJI operon"
				}
				]
			},
			{
				"name":"DeoR family",
				"children":[
				{
					"name":"skT53_27280 sporulation transcriptional regulator SpoIIID\tK06283 spoIIID; putative DeoR family transcriptional regulator, stage III sporulation protein D"
				},
				{
					"name":"skT53_11950 ccpN; transcriptional repressor CcpN\tK23774 ccpN; DeoR family transcriptional regulator, catabolite repression regulator"
				}
				]
			},
			{
				"name":"LacI family",
				"children":[
				{
					"name":"skT53_03330 catabolite control protein A\tK02529 galR; LacI family transcriptional regulator, galactose operon repressor"
				}
				]
			},
			{
				"name":"GntR family",
				"children":[
				{
					"name":"skT53_26900 hypothetical protein\tK03710 K03710; GntR family transcriptional regulator"
				},
				{
					"name":"skT53_05330 hypothetical protein\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				}
				]
			},
			{
				"name":"TetR\/AcrR family",
				"children":[
				{
					"name":"skT53_17140 hypothetical protein\tK13770 ysiA; TetR\/AcrR family transcriptional regulator, fatty acid metabolism regulator protein"
				}
				]
			},
			{
				"name":"Lrp\/AsnC family"
			},
			{
				"name":"LuxR family",
				"children":[
				{
					"name":"skT53_34950 gerE; spore germination protein GerE\tK01994 gerE; LuxR family transcriptional regulator, transcriptional regulator of spore coat protein"
				}
				]
			},
			{
				"name":"MarR family"
			},
			{
				"name":"MerR family",
				"children":[
				{
					"name":"skT53_01800 glnR_1; HTH-type transcriptional regulator GlnR\tK03713 glnR; MerR family transcriptional regulator, glutamine synthetase repressor"
				},
				{
					"name":"skT53_07020 glnR_2; HTH-type transcriptional regulator GlnR\tK03713 glnR; MerR family transcriptional regulator, glutamine synthetase repressor"
				},
				{
					"name":"skT53_22610 merR-2; Hg(II)-responsive transcriptional regulator\tK08365 merR; MerR family transcriptional regulator, mercuric resistance operon regulatory protein"
				},
				{
					"name":"skT53_19000 MerR family transcriptional regulator\tK11923 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"skT53_33910 transcriptional regulator\tK11923 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"skT53_16260 MerR family transcriptional regulator\tK21902 yfmP; MerR family transcriptional regulator, repressor of the yfmOP operon"
				}
				]
			},
			{
				"name":"Fur family",
				"children":[
				{
					"name":"skT53_08130 transcriptional repressor\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator"
				},
				{
					"name":"skT53_09780 zurR; transcriptional regulator ZurR\tK02076 zurR; Fur family transcriptional regulator, zinc uptake regulator"
				},
				{
					"name":"skT53_34460 perR; peroxide-responsive transcriptional repressor PerR\tK09825 perR; Fur family transcriptional regulator, peroxide stress response regulator"
				}
				]
			},
			{
				"name":"IclR family",
				"children":[
				{
					"name":"skT53_25850 IclR family transcriptional regulator\tK19333 kdgR; IclR family transcriptional regulator, KDG regulon repressor"
				},
				{
					"name":"skT53_25940 IclR family transcriptional regulator\tK19333 kdgR; IclR family transcriptional regulator, KDG regulon repressor"
				},
				{
					"name":"skT53_32020 IclR family transcriptional regulator\tK19333 kdgR; IclR family transcriptional regulator, KDG regulon repressor"
				},
				{
					"name":"skT53_32070 IclR family transcriptional regulator\tK19333 kdgR; IclR family transcriptional regulator, KDG regulon repressor"
				},
				{
					"name":"skT53_33880 IclR family transcriptional regulator\tK19333 kdgR; IclR family transcriptional regulator, KDG regulon repressor"
				}
				]
			},
			{
				"name":"CRP\/FNR family",
				"children":[
				{
					"name":"skT53_00670 cyclic nucleotide-binding protein\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				}
				]
			},
			{
				"name":"Rrf2 family",
				"children":[
				{
					"name":"skT53_12880 transcriptional regulator\tK17472 cymR; Rrf2 family transcriptional regulator, cysteine metabolism repressor"
				},
				{
					"name":"skT53_20470 AsnC family transcriptional regulator\tK17472 cymR; Rrf2 family transcriptional regulator, cysteine metabolism repressor"
				}
				]
			},
			{
				"name":"ArsR family",
				"children":[
				{
					"name":"skT53_13210 hypothetical protein\tK03892 arsR; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor"
				},
				{
					"name":"skT53_10340 transcriptional regulator\tK26993 sdpR; ArsR family transcriptional regulator, repressor of sdpIR and other operons"
				}
				]
			},
			{
				"name":"XRE family"
			},
			{
				"name":"PadR family",
				"children":[
				{
					"name":"skT53_06490 PadR family transcriptional regulator\tK10947 K10947; PadR family transcriptional regulator"
				},
				{
					"name":"skT53_24360 PadR family transcriptional regulator\tK10947 K10947; PadR family transcriptional regulator"
				}
				]
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"skT53_35610 mntR; transcriptional regulator MntR\tK11924 mntR; DtxR family transcriptional regulator, manganese transport regulator"
				},
				{
					"name":"skT53_04080 birA; bifunctional ligase\/repressor BirA\tK03524 birA; BirA family transcriptional regulator, biotin operon repressor \/ biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]"
				},
				{
					"name":"skT53_11370 sigma-54-dependent Fis family transcriptional regulator\tK02688 prpR; transcriptional regulator, propionate catabolism operon regulatory protein"
				},
				{
					"name":"skT53_24010 purR; pur operon repressor\tK09685 purR; HTH-type transcriptional regulator, purine operon repressor"
				},
				{
					"name":"skT53_05930 sigma-54-dependent Fis family transcriptional regulator\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"skT53_10190 acoR_1; acetoin dehydrogenase operon transcriptional activator AcoR\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"skT53_16330 acoR_2; signal-transduction and transcriptional-control protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"skT53_18820 sigma-54-dependent Fis family transcriptional regulator\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"skT53_21100 sigma-54-dependent Fis family transcriptional regulator\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"skT53_31400 acoR_3; signal-transduction and transcriptional-control protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"skT53_04150 rex; redox-sensing transcriptional repressor Rex\tK01926 rex; redox-sensing transcriptional repressor"
				},
				{
					"name":"skT53_21880 codY; GTP-sensing transcriptional pleiotropic repressor CodY\tK03706 codY; transcriptional pleiotropic repressor"
				},
				{
					"name":"skT53_14190 hypothetical protein\tK07729 K07729; putative transcriptional regulator"
				}
				]
			}
			]
		},
		{
			"name":"Ribbon-helix-helix",
			"children":[
			{
				"name":"CopG family",
				"children":[
				{
					"name":"skT53_22010 ndoAI; antitoxin EndoAI\tK07723 ndoAI; CopG family transcriptional regulator \/ antitoxin EndoAI"
				}
				]
			},
			{
				"name":"Other families"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"BglG family"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"skT53_33460 hypothetical protein\tK21600 csoR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor"
				},
				{
					"name":"skT53_24170 AbrB family transcriptional regulator\tK06284 abrB; AbrB family transcriptional regulator, transcriptional pleiotropic regulator of transition state genes"
				},
				{
					"name":"skT53_23910 AbrB family transcriptional regulator\tK04769 spoVT; AbrB family transcriptional regulator, stage V sporulation protein T"
				},
				{
					"name":"skT53_24650 noc; nucleoid occlusion protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"skT53_24670 spo0J; stage 0 sporulation protein J\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"skT53_08900 argR; arginine repressor\tK03402 argR; transcriptional regulator of arginine metabolism"
				},
				{
					"name":"skT53_35880 hrcA; heat-inducible transcription repressor HrcA\tK03705 hrcA; heat-inducible transcriptional repressor"
				},
				{
					"name":"skT53_23560 CtsR family transcriptional regulator\tK03708 ctsR; transcriptional regulator of stress and heat shock response"
				},
				{
					"name":"skT53_19310 cggR; central glycolytic genes regulator\tK05311 cggR; central glycolytic genes regulator"
				},
				{
					"name":"skT53_03680 transcription attenuation protein MtrB\tK06285 mtrB; transcription attenuation protein (tryptophan RNA-binding attenuator protein)"
				},
				{
					"name":"skT53_10290 pyrR; bifunctional protein PyrR\tK02825 pyrR; pyrimidine operon attenuation protein \/ uracil phosphoribosyltransferase [EC:2.4.2.9]"
				},
				{
					"name":"skT53_19830 ylbO; hypothetical protein\tK06314 rsfA; prespore-specific regulator"
				},
				{
					"name":"skT53_32500 nrdR; transcriptional repressor NrdR\tK07738 nrdR; transcriptional repressor NrdR"
				},
				{
					"name":"skT53_10680 mraZ; transcriptional regulator MraZ\tK03925 mraZ; transcriptional regulator MraZ"
				}
				]
			}
			]
		}
		]
	}
	]
}