{
	"name":"eln01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]",
				"children":[
				{
					"name":"NRG857_30085 beta-lactamase\tK18698 blaTEM; beta-lactamase class A TEM [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases",
				"children":[
				{
					"name":"NRG857_30102 Streptomycin 3''-adenylyltransferase\tK00984 aadA; streptomycin 3\\\"-adenylyltransferase [EC:2.7.7.47]"
				}
				]
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"NRG857_30096 aminoglycoside resistance protein A\tK10673 strA; streptomycin 3\\\"-kinase [EC:2.7.1.87]"
				},
				{
					"name":"NRG857_30097 strB; aminoglycoside resistance protein StrB\tK04343 strB; streptomycin 6-kinase [EC:2.7.1.72]"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"NRG857_30067 tetA; tetracycline resistance protein A\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"NRG857_03790 multidrug efflux system protein\tK08160 mdfA; MFS transporter, DHA1 family, multidrug\/chloramphenicol efflux transport protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"NRG857_30123 macrolide 2'-phosphotransferase II protein MphB\tK06979 mph; macrolide phosphotransferase"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"NRG857_30075 Chloramphenicol acetyltransferase\tK19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase",
				"children":[
				{
					"name":"NRG857_30104 dihydropteroate synthase\tK18974 sul1; dihydropteroate synthase type 1 [EC:2.5.1.15]"
				},
				{
					"name":"NRG857_30095 dihydropteroate synthase\tK18824 sul2; dihydropteroate synthase type 2 [EC:2.5.1.15]"
				}
				]
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases",
				"children":[
				{
					"name":"NRG857_30100 dihydrofolate reductase type I DhfrA1\tK18589 dfrA1; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]"
				}
				]
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"NRG857_02560 sensor kinase CusS\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"NRG857_02565 DNA-binding transcriptional activator CusR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"NRG857_07480 two component heavy metal response transcriptional regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]"
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]",
				"children":[
				{
					"name":"NRG857_05450 sensor protein PhoQ\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
				},
				{
					"name":"NRG857_05455 DNA-binding transcriptional regulator PhoP\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				}
				]
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"NRG857_02190 multidrug efflux system\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"NRG857_06635 predicted multidrug-efflux transport protein precursor\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"NRG857_02185 multidrug efflux system protein AcrB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"NRG857_06640 multidrug efflux protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"NRG857_06645 outer membrane efflux lipoprotein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"NRG857_10850 multidrug resistance outer membrane protein MdtQ\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"NRG857_06645 outer membrane efflux lipoprotein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"NRG857_10850 multidrug resistance outer membrane protein MdtQ\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"NRG857_06645 outer membrane efflux lipoprotein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"NRG857_10850 multidrug resistance outer membrane protein MdtQ\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"NRG857_02325 DNA-binding transcriptional regulator CueR\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"NRG857_16195 DNA-binding transcriptional regulator EnvR\tK18140 envR; TetR\/AcrR family transcriptional regulator, acrEF\/envCD operon repressor"
				},
				{
					"name":"NRG857_16200 cytoplasmic membrane lipoprotein\tK18141 acrE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"NRG857_16205 multidrug efflux system protein\tK18142 acrF; multidrug efflux pump"
				},
				{
					"name":"NRG857_15110 tolC; outer membrane channel protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"NRG857_11905 DNA-binding transcriptional activator EvgA\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
				},
				{
					"name":"NRG857_17455 multidrug efflux system protein MdtE\tK18898 mdtE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"NRG857_17460 multidrug transporter, RpoS-dependent\tK18899 mdtF; multidrug efflux pump"
				},
				{
					"name":"NRG857_15110 tolC; outer membrane channel protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]",
				"children":[
				{
					"name":"NRG857_07555 DNA-binding transcriptional activator MarA\tK13632 marA; AraC family transcriptional regulator, mar-sox-rob regulon activator"
				},
				{
					"name":"NRG857_04245 outer membrane protein F\tK09476 ompF; outer membrane pore protein F"
				},
				{
					"name":"NRG857_09815 Outer membrane protein N precursor (porin)\tK09476 ompF; outer membrane pore protein F"
				}
				]
			}
			]
		}
		]
	}
	]
}