{
	"name":"elu02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"UM146_13150 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"UM146_13145 CRISPR-associated helicase Cas3 family protein\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors",
				"children":[
				{
					"name":"UM146_13140 CRISPR-associated protein, Csy1 family\tK19127 csy1; CRISPR-associated protein Csy1"
				},
				{
					"name":"UM146_13125 hypothetical protein\tK19129 csy3; CRISPR-associated protein Csy3"
				},
				{
					"name":"UM146_13120 hypothetical protein\tK19130 csy4; CRISPR-associated endonuclease Csy4 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"UM146_22485 hsdR; type I restriction enzyme EcoKI subunit R\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"UM146_22475 EcoKI restriction-modification system protein HsdS\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"UM146_22480 DNA methylase M\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"UM146_16990 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"UM146_00055 putative methyltransferase\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"UM146_10675 putative DNA adenine methyltransferase (DNA methylase) from phage origin\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"UM146_24356 putative methylase\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"UM146_07385 DNA cytosine methylase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"UM146_21920 DNA-cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"UM146_03440 putative endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"UM146_22490 methylated adenine and cytosine restriction protein\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok",
				"children":[
				{
					"name":"UM146_17955 small toxic polypeptide\tK18920 hokA; protein HokA"
				},
				{
					"name":"UM146_24266 small toxic polypeptide\tK18921 hokB; protein HokB"
				},
				{
					"name":"UM146_10700 putative prophage maintenance protein\tK18919 hokC_D; protein HokC\/D"
				},
				{
					"name":"UM146_22855 regulatory protein MokC for HokC\tK18919 hokC_D; protein HokC\/D"
				},
				{
					"name":"UM146_02785 Small toxic membrane polypeptide\tK18922 hokE; protein HokE"
				},
				{
					"name":"UM146_14600 regulatory peptide MokC\tK18922 hokE; protein HokE"
				}
				]
			},
			{
				"name":"SymE-SymR",
				"children":[
				{
					"name":"UM146_22470 endoribonuclease SymE\tK19048 symE; toxic protein SymE"
				}
				]
			},
			{
				"name":"Ldr-Rdl",
				"children":[
				{
					"name":"UM146_10980 hypothetical protein\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"UM146_17850 toxic polypeptide, small\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"UM146_17855 toxic polypeptide, small\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"UM146_17860 toxic polypeptide, small\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				}
				]
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"UM146_02660 toxin ChpA\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"UM146_02655 antitoxin MazE\tK07172 mazE; antitoxin MazE"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"UM146_06710 hypothetical protein\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"UM146_06705 antitoxin YefM\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"UM146_09430 regulator with HipB\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				},
				{
					"name":"UM146_21265 hypothetical protein\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				},
				{
					"name":"UM146_09425 DNA-binding transcriptional regulator HipB\tK15773 hipB; HTH-type transcriptional regulator \/ antitoxin HipB"
				}
				]
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN",
				"children":[
				{
					"name":"UM146_16050 putative toxin YafO\tK19160 yafO; mRNA interferase YafO [EC:3.1.-.-]"
				},
				{
					"name":"UM146_16055 putative antitoxin of the YafO-YafN toxin-antitoxin system\tK19161 yafN; antitoxin YafN"
				}
				]
			},
			{
				"name":"PspC-PspB",
				"children":[
				{
					"name":"UM146_10245 DNA-binding transcriptional activator PspC\tK03973 pspC; phage shock protein C"
				},
				{
					"name":"UM146_10250 pspB; phage shock protein B\tK03970 pspB; phage shock protein B"
				}
				]
			},
			{
				"name":"CcdB-CcdA",
				"children":[
				{
					"name":"UM146_23035 putative toxin of gyrase inhibiting toxin-antitoxin system\tK19163 ccdB; toxin CcdB"
				},
				{
					"name":"UM146_24451 plasmid maintenance protein CcdB\tK19163 ccdB; toxin CcdB"
				},
				{
					"name":"UM146_23025 putative antitoxin of gyrase inhibiting toxin-antitoxin system\tK19164 ccdA; antitoxin CcdA"
				},
				{
					"name":"UM146_24456 plasmid maintenance protein CcdA\tK19164 ccdA; antitoxin CcdA"
				}
				]
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"UM146_09645 hypothetical protein\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"UM146_14935 putative RelE\/ParE family protein, cytotoxic translational repressor of toxin-antitoxin stability system\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"UM146_03005 putative HTH-type transcriptional regulator ygjM\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"UM146_09650 predicted DNA-binding transcriptional regulator\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"UM146_14930 XRE family plasmid maintenance system antidote protein\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"UM146_14200 hypothetical protein\tK19334 tabA; biofilm protein TabA"
				},
				{
					"name":"UM146_21525 hypothetical protein\tK19334 tabA; biofilm protein TabA"
				},
				{
					"name":"UM146_13615 hypothetical protein\tK13650 mcbA; MqsR-controlled colanic acid and biofilm protein A"
				},
				{
					"name":"UM146_12030 bssS; biofilm formation regulatory protein BssS\tK12148 bssS; biofilm regulator BssS"
				},
				{
					"name":"UM146_13470 bssR; biofilm formation regulatory protein BssR\tK19688 bssR; biofilm regulator BssR"
				},
				{
					"name":"UM146_11760 putative secreted protein\tK12151 bhsA; multiple stress resistance protein BhsA"
				},
				{
					"name":"UM146_23260 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"UM146_00155 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"UM146_01245 DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"UM146_01155 DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"UM146_04610 gltX; glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU",
				"children":[
				{
					"name":"UM146_06770 CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"UM146_12180 hypothetical protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"UM146_22195 hypothetical protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"UM146_06775 hypothetical protein\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				},
				{
					"name":"UM146_12185 hypothetical protein\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				},
				{
					"name":"UM146_22190 hypothetical protein\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				}
				]
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"UM146_02040 hypothetical protein\tK19168 cptA; toxin CptA"
				},
				{
					"name":"UM146_02035 hypothetical protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS",
				"children":[
				{
					"name":"UM146_20880 hypothetical protein\tK18839 ghoT; toxin GhoT"
				},
				{
					"name":"UM146_20875 hypothetical protein\tK18840 ghoS; antitoxin GhoS"
				}
				]
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein",
				"children":[
				{
					"name":"UM146_09800 hypothetical protein\tK28274 ortT; orphan toxin OrtT"
				}
				]
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB",
				"children":[
				{
					"name":"UM146_15060 modulator of gene expression, with H-NS\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"UM146_24036 putative regulator\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"UM146_15055 hypothetical protein\tK19162 tomB; hha toxicity modulator TomB"
				}
				]
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"UM146_04050 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}