{
	"name":"eok03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors"
				},
				{
					"name":"Cap binding complex"
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)"
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)"
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex"
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex"
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors"
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex"
				},
				{
					"name":"N6-methyltransferase complex"
				},
				{
					"name":"Poly(A) addition factors"
				},
				{
					"name":"Negative regulators of mRNA 3' end processing"
				}
				]
			},
			{
				"name":"Other processing factors"
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex"
				},
				{
					"name":"TREX complex"
				},
				{
					"name":"TREX-2 complex"
				},
				{
					"name":"Nuclear pore complex"
				},
				{
					"name":"Ran-mediated transport factors"
				},
				{
					"name":"eIF4F and regulatory proteins"
				},
				{
					"name":"APOBEC1-ACF complex"
				},
				{
					"name":"Other transport factors"
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex"
				},
				{
					"name":"Protein phosphatase 2A"
				},
				{
					"name":"Other surveillance factors"
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex"
				},
				{
					"name":"Factors that have mRNA localization signals"
				},
				{
					"name":"Trans-acting binding proteins"
				},
				{
					"name":"Other mRNA localization factors"
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule"
				},
				{
					"name":"P-body specific factors"
				},
				{
					"name":"Stress granule specific factors"
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex"
				},
				{
					"name":"Lsm complex"
				},
				{
					"name":"5' exonucleases"
				},
				{
					"name":"Other 5'-3' decay factors"
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors"
				},
				{
					"name":"Exosome cofactors"
				},
				{
					"name":"TRAMP complex"
				},
				{
					"name":"Ski complex"
				},
				{
					"name":"Ccr4-NOT complex"
				},
				{
					"name":"Pan complex"
				},
				{
					"name":"Other 3'-5' decay factors"
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases",
					"children":[
					{
						"name":"G2583_1343 rne; Ribonuclease, Rne\/Rng family\tK08300 rne; ribonuclease E [EC:3.1.26.12]"
					},
					{
						"name":"G2583_3966 rng; Ribonuclease G\tK08301 rng; ribonuclease G [EC:3.1.26.-]"
					},
					{
						"name":"G2583_3148 rnc; Ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					},
					{
						"name":"G2583_5006 rnr; Putative enzyme\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
					},
					{
						"name":"G2583_4989 orn; Oligoribonuclease\tK13288 orn; oligoribonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Helicases",
					"children":[
					{
						"name":"G2583_4573 rhlB; ATP-dependent RNA helicase RhlB\tK03732 rhlB; ATP-dependent RNA helicase RhlB [EC:5.6.2.7]"
					},
					{
						"name":"G2583_1025 rhlE; ATP-dependent RNA helicase RhlE\tK11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7]"
					},
					{
						"name":"G2583_3886 deaD; Cold-shock DEAD-box protein A\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]"
					},
					{
						"name":"G2583_4622 recQ; ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"G2583_3431 eno; Enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					},
					{
						"name":"G2583_3888 pnp; Polynucleotide phosphorylase\/polyadenylase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
					},
					{
						"name":"G2583_4576 rho; Transcription termination factor rho\tK03628 rho; transcription termination factor Rho"
					},
					{
						"name":"G2583_4720 pfkA; 6-phosphofructokinase isozyme 1\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"G2583_0014 dnaK; Chaperone protein dnaK\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"G2583_4970 groL; 60 kDa chaperonin 1\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					},
					{
						"name":"G2583_4999 hfq; RNA-binding protein Hfq\tK03666 hfq; host factor-I protein"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"G2583_3024 ppk; Polyphosphate kinase\tK00937 ppk1; polyphosphate kinase [EC:2.7.4.1]"
					},
					{
						"name":"G2583_0147 pcnB; Poly(A) polymerase\tK00970 pcnB; poly(A) polymerase [EC:2.7.7.19]"
					},
					{
						"name":"G2583_3484 nudH; RNA pyrophosphohydrolase ((Di)nucleoside polyphosphate hydrolase)\tK08311 nudH; putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]"
					},
					{
						"name":"G2583_3344 csrA; Carbon storage regulator-like protein\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"G2583_3971 csrD; Cyclic diguanylate phosphodiesterase (EAL) domain protein\tK18765 csrD; RNase E specificity factor CsrD"
					},
					{
						"name":"G2583_4736 rraA; Regulator of ribonuclease activity A\tK02553 rraA; regulator of ribonuclease activity A"
					},
					{
						"name":"G2583_5085 rraB; hypothetical protein\tK09893 rraB; regulator of ribonuclease activity B"
					},
					{
						"name":"G2583_3930 yhbJ; UPF0042 protein yhbJ\tK06958 rapZ; RNase adapter protein RapZ"
					},
					{
						"name":"G2583_1771 hrpA; HrpA-like helicase\tK03578 hrpA; ATP-dependent RNA helicase HrpA [EC:5.6.2.6]"
					},
					{
						"name":"G2583_0152 hrpB; ATP-dependent helicase HrpB\tK03579 hrpB; ATP-dependent RNA helicase HrpB [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"Bacterial Small RNA Regulators",
					"children":[
					{
						"name":"G2583_2405 dsrA; dsrA\tK18502 dsrA; small regulatory RNA DsrA"
					},
					{
						"name":"G2583_0594 sroB; sroB\tK18503 chiX; small regulatory RNA ChiX"
					},
					{
						"name":"G2583_3935 putative non-coding RNA\tK18504 arcZ; small regulatory RNA ArcZ"
					},
					{
						"name":"G2583_3087 putative non-coding RNA\tK15841 glmY; small regulatory RNA GlmY"
					},
					{
						"name":"G2583_4597 putative non-coding RNA\tK18505 glmZ; small regulatory RNA GlmZ"
					},
					{
						"name":"G2583_0074 putative non-coding RNA\tK18506 sgrS; small regulatory RNA SgrS"
					},
					{
						"name":"G2583_4143 putative non-coding RNA\tK18507 ryhB; small regulatory RNA RyhB"
					},
					{
						"name":"G2583_1077 rybB; rybB\tK18508 rybB; small regulatory RNA RybB"
					},
					{
						"name":"G2583_1780 putative non-coding RNA\tK18509 rydC; small regulatory RNA RydC"
					},
					{
						"name":"G2583_3335 sraD; sraD\tK18511 micA; small regulatory RNA MicA"
					},
					{
						"name":"G2583_1753 putative non-coding RNA\tK18512 micC; small regulatory RNA MicC"
					},
					{
						"name":"G2583_2757 micF; micF\tK18513 micF; small regulatory RNA MicF"
					},
					{
						"name":"G2583_3445 csrB; csrB\tK18515 csrB; small regulatory RNA CsrB"
					},
					{
						"name":"G2583_4665 putative non-coding RNA\tK18516 csrC; small regulatory RNA CsrC"
					},
					{
						"name":"G2583_1535 dicF4; dicF4\tK18517 dicF; small regulatory RNA DicF"
					},
					{
						"name":"G2583_2085 rprA; rprA\tK18518 rprA; small regulatory RNA RprA"
					},
					{
						"name":"G2583_2610 putative non-coding RNA\tK18520 cyaR; small regulatory RNA CyaR"
					},
					{
						"name":"G2583_3462 gcvB; gcvB\tK18521 gcvB; small regulatory RNA GcvB"
					},
					{
						"name":"G2583_3492 putative non-coding RNA\tK18522 omrA; small regulatory RNA OmrA"
					},
					{
						"name":"G2583_3493 putative non-coding RNA\tK18523 omrB; small regulatory RNA OmrB"
					},
					{
						"name":"G2583_4251 putative non-coding RNA\tK18525 gadY; small regulatory RNA GadY"
					},
					{
						"name":"G2583_4663 spf; spf\tK18527 spf; small regulatory RNA Spot 42"
					},
					{
						"name":"G2583_4773 oxyS; oxyS\tK18528 oxyS; small regulatory RNA OxyS"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome"
				},
				{
					"name":"Cofactors"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}