{
	"name":"esa02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"ESA_02832 hypothetical protein\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"ESA_02831 hypothetical protein\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"ESA_02838 hypothetical protein\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors",
				"children":[
				{
					"name":"ESA_02837 hypothetical protein\tK19123 casA; CRISPR system Cascade subunit CasA"
				},
				{
					"name":"ESA_02836 hypothetical protein\tK19046 casB; CRISPR system Cascade subunit CasB"
				},
				{
					"name":"ESA_02835 hypothetical protein\tK19124 casC; CRISPR system Cascade subunit CasC"
				},
				{
					"name":"ESA_02834 hypothetical protein\tK19125 casD; CRISPR system Cascade subunit CasD"
				},
				{
					"name":"ESA_02833 hypothetical protein\tK19126 casE; CRISPR system Cascade subunit CasE"
				}
				]
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"ESA_00617 hypothetical protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"ESA_00615 hypothetical protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"ESA_00614 hypothetical protein\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"ESA_04355 hypothetical protein\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"ESA_01237 hypothetical protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"ESA_pESA2p06562 hypothetical protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system"
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok",
				"children":[
				{
					"name":"ESA_00124 hypothetical protein\tK18921 hokB; protein HokB"
				},
				{
					"name":"ESA_02949 hypothetical protein\tK18921 hokB; protein HokB"
				}
				]
			},
			{
				"name":"SymE-SymR",
				"children":[
				{
					"name":"ESA_03423 hypothetical protein\tK19048 symE; toxic protein SymE"
				}
				]
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"ESA_00258 hypothetical protein\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"ESA_00257 hypothetical protein\tK18918 relB; RHH-type transcriptional regulator, rel operon repressor \/ antitoxin RelB"
				}
				]
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"ESA_pESA3p05543 hypothetical protein\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				},
				{
					"name":"ESA_pESA3p05544 hypothetical protein\tK15773 hipB; HTH-type transcriptional regulator \/ antitoxin HipB"
				}
				]
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB",
				"children":[
				{
					"name":"ESA_01600 hypothetical protein\tK03973 pspC; phage shock protein C"
				},
				{
					"name":"ESA_01599 hypothetical protein\tK03970 pspB; phage shock protein B"
				}
				]
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"ESA_04289 hypothetical protein\tK07341 doc; death on curing protein"
				},
				{
					"name":"ESA_04288 hypothetical protein\tK19165 phd; antitoxin Phd"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"ESA_01887 hypothetical protein\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"ESA_02143 hypothetical protein\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"ESA_02144 hypothetical protein\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"ESA_01886 hypothetical protein\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"ESA_02142 hypothetical protein\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"ESA_03454 hypothetical protein\tK19334 tabA; biofilm protein TabA"
				},
				{
					"name":"ESA_03474 hypothetical protein\tK19334 tabA; biofilm protein TabA"
				},
				{
					"name":"ESA_02288 hypothetical protein\tK12148 bssS; biofilm regulator BssS"
				},
				{
					"name":"ESA_02232 hypothetical protein\tK12151 bhsA; multiple stress resistance protein BhsA"
				},
				{
					"name":"ESA_03243 hypothetical protein\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"ESA_03638 hypothetical protein\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"ESA_00382 hypothetical protein\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"ESA_00378 hypothetical protein\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"ESA_00841 hypothetical protein\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"ESA_00435 hypothetical protein\tK19168 cptA; toxin CptA"
				},
				{
					"name":"ESA_00434 hypothetical protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein",
				"children":[
				{
					"name":"ESA_01669 hypothetical protein\tK28274 ortT; orphan toxin OrtT"
				}
				]
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB",
				"children":[
				{
					"name":"ESA_02810 hypothetical protein\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"ESA_02809 hypothetical protein\tK19162 tomB; hha toxicity modulator TomB"
				}
				]
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA",
				"children":[
				{
					"name":"ESA_01402 RyeB RNA\tK28181 sdsR; small regulatory RNA SdsR"
				},
				{
					"name":"ESA_01403 SraC\/RyeA RNA\tK28182 ryeA; small antisense RNA RyeA"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"ESA_00721 hypothetical protein\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}