{
	"name":"etw02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"ECSP_3703 ygbT; conserved protein\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"ECSP_3702 ygbF; predicted protein\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"ECSP_3709 ygcB; predicted helicase\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors",
				"children":[
				{
					"name":"ECSP_3708 hypothetical protein\tK19123 casA; CRISPR system Cascade subunit CasA"
				},
				{
					"name":"ECSP_3707 predicted protein\tK19046 casB; CRISPR system Cascade subunit CasB"
				},
				{
					"name":"ECSP_3706 predicted protein\tK19124 casC; CRISPR system Cascade subunit CasC"
				},
				{
					"name":"ECSP_3705 hypothetical protein\tK19125 casD; CRISPR system Cascade subunit CasD"
				},
				{
					"name":"ECSP_3704 hypothetical protein\tK19126 casE; CRISPR system Cascade subunit CasE"
				}
				]
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"ECSP_5432 putative restriction modification enzyme R subunit (endonuclease)\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"ECSP_5430 putative restriction modification enzyme S subunit\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"ECSP_5431 putative restriction modification enzyme M subunit (methylase)\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"ECSP_4336 dam; DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"ECSP_1671 putative DNA adenine methyltransferase encoded by prophage CP-933O\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"ECSP_1742 DNA methylase\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"ECSP_4231 yhdJ; predicted methyltransferase\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"ECSP_6044 hypothetical protein\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"ECSP_2565 dcm; DNA cytosine methylase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"ECSP_1458 HNH endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"ECSP_2108 HNH endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"ECSP_2712 restriction endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok",
				"children":[
				{
					"name":"ECSP_1260 predicted protein\tK18920 hokA; protein HokA"
				},
				{
					"name":"ECSP_4553 hokA; toxic polypeptide, small\tK18920 hokA; protein HokA"
				},
				{
					"name":"ECSP_6064 flmA; small toxic polypeptide\tK18921 hokB; protein HokB"
				},
				{
					"name":"ECSP_0016 mokC; regulatory peptide\tK18919 hokC_D; protein HokC\/D"
				},
				{
					"name":"ECSP_1097 putative cell killing protein encoded within cryptic prophage CP-933M\tK18919 hokC_D; protein HokC\/D"
				},
				{
					"name":"ECSP_1442 putative Gef-like protein encoded by prophage CP-933N\tK18919 hokC_D; protein HokC\/D"
				},
				{
					"name":"ECSP_1664 putative killer protein encoded by prophage CP-933O\tK18919 hokC_D; protein HokC\/D"
				},
				{
					"name":"ECSP_2125 mokP; putative cell killing protein encoded within cryptic prophage CP-933P\tK18919 hokC_D; protein HokC\/D"
				},
				{
					"name":"ECSP_0634 predicted protein\tK18922 hokE; protein HokE"
				},
				{
					"name":"ECSP_0635 hokE; toxic polypeptide, small\tK18922 hokE; protein HokE"
				},
				{
					"name":"ECSP_3710 predicted protein\tK18922 hokE; protein HokE"
				}
				]
			},
			{
				"name":"SymE-SymR",
				"children":[
				{
					"name":"ECSP_5429 yjiW; conserved protein\tK19048 symE; toxic protein SymE"
				}
				]
			},
			{
				"name":"Ldr-Rdl",
				"children":[
				{
					"name":"ECSP_1606 ldrA; toxic polypeptide, small\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"ECSP_1607 ldrB; toxic polypeptide, small\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				},
				{
					"name":"ECSP_4529 ldrD; toxic polypeptide, small\tK18862 ldrA_B_C_D; small toxic polypeptide LdrA\/B\/C\/D"
				}
				]
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA",
				"children":[
				{
					"name":"ECSP_2735 hypothetical protein\tK19779 ralR; endodeoxyribonuclease RalR [EC:3.1.-.-]"
				}
				]
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"ECSP_3734 chpA; toxin of the ChpA-ChpR toxin-antitoxin system, endoribonuclease\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"ECSP_3735 chpR; antitoxin of the ChpA-ChpR toxin-antitoxin system\tK07172 mazE; antitoxin MazE"
				}
				]
			},
			{
				"name":"ChpB-ChpS",
				"children":[
				{
					"name":"ECSP_5326 chpB; toxin of the ChpB-ChpS toxin-antitoxin system\tK18841 chpB; mRNA interferase ChpB [EC:3.1.-.-]"
				},
				{
					"name":"ECSP_5325 chpS; antitoxin of the ChpB-ChpS toxin-antitoxin system\tK18842 chpS; antitoxin ChpS"
				}
				]
			},
			{
				"name":"YhaV-PrlF",
				"children":[
				{
					"name":"ECSP_4101 yhaV; conserved protein\tK19155 yhaV; toxin YhaV [EC:3.1.-.-]"
				},
				{
					"name":"ECSP_4100 sohA; predicted regulator\tK19156 prlF; antitoxin PrlF"
				}
				]
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"ECSP_0257 hypothetical protein\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"ECSP_0258 dinJ; predicted antitoxin of YafQ-DinJ toxin-antitoxin system\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"ECSP_1994 hipA; regulator with hipB\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"HicA-HicB",
				"children":[
				{
					"name":"ECSP_1917 yncN; predicted protein\tK07339 hicA; mRNA interferase HicA [EC:3.1.-.-]"
				},
				{
					"name":"ECSP_1918 ydcQ; predicted DNA-binding transcriptional regulator\tK18843 hicB; antitoxin HicB"
				}
				]
			},
			{
				"name":"YafO-YafN",
				"children":[
				{
					"name":"ECSP_0267 yafO; predicted toxin of the YafO-YafN toxin-antitoxin system\tK19160 yafO; mRNA interferase YafO [EC:3.1.-.-]"
				},
				{
					"name":"ECSP_0266 yafN; predicted antitoxin of the YafO-YafN toxin-antitoxin system\tK19161 yafN; antitoxin YafN"
				}
				]
			},
			{
				"name":"PspC-PspB",
				"children":[
				{
					"name":"ECSP_1831 pspC; psp operon regulatory protein\tK03973 pspC; phage shock protein C"
				},
				{
					"name":"ECSP_1830 pspB; psp operon regulatory protein\tK03970 pspB; phage shock protein B"
				}
				]
			},
			{
				"name":"CcdB-CcdA",
				"children":[
				{
					"name":"ECSP_0053 putative toxin of gyrase inhibiting toxin-antitoxin system\tK19163 ccdB; toxin CcdB"
				},
				{
					"name":"ECSP_6035 ccdB; plasmid maintenance protein\tK19163 ccdB; toxin CcdB"
				},
				{
					"name":"ECSP_0052 putative antitoxin of gyrase inhibiting toxin-antitoxin system\tK19164 ccdA; antitoxin CcdA"
				},
				{
					"name":"ECSP_6032 ccdA; plasmid maintenance protein\tK19164 ccdA; antitoxin CcdA"
				}
				]
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"ECSP_0476 hypothetical protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"ECSP_0475 hypothetical protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"ECSP_4057 ygjN; conserved protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"ECSP_4056 ygjM; predicted DNA-binding transcriptional regulator\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"ECSP_0550 ybaQ; predicted DNA-binding transcriptional regulator\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"ECSP_1961 yddM; predicted DNA-binding transcriptional regulator\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"ECSP_5353 yjgK; conserved protein\tK19334 tabA; biofilm protein TabA"
				},
				{
					"name":"ECSP_0903 ybiM; predicted protein\tK13650 mcbA; MqsR-controlled colanic acid and biofilm protein A"
				},
				{
					"name":"ECSP_1361 bssS; regulator of biofilm formation\tK12148 bssS; biofilm regulator BssS"
				},
				{
					"name":"ECSP_0936 putative receptor\tK19688 bssR; biofilm regulator BssR"
				},
				{
					"name":"ECSP_1414 ycfR; predicted protein\tK12151 bhsA; multiple stress resistance protein BhsA"
				},
				{
					"name":"ECSP_0098 ftsZ; GTP-binding tubulin-like cell division protein\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"ECSP_4219 mreB; cell wall structural complex MreBCD, actin-like component MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"ECSP_3995 parC; DNA topoisomerase IV, subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"ECSP_4009 parE; DNA topoisomerase IV, subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"ECSP_3350 gltX; glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU",
				"children":[
				{
					"name":"ECSP_1329 hypothetical protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"ECSP_2676 yeeV; CP4-44 prophage; toxin of the YeeV-YeeU toxin-antitoxin system\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"ECSP_4656 hypothetical protein\tK18837 cbtA; cytoskeleton-binding toxin CbtA and related proteins"
				},
				{
					"name":"ECSP_1328 putative structural protein\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				},
				{
					"name":"ECSP_2675 yeeU; CP4-44 prophage; antitoxin of the YeeV-YeeU toxin-antitoxin system\tK18838 cbeA; cytoskeleton bundling-enhancing protein CbeA and related proteins"
				}
				]
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"ECSP_3864 ygfX; predicted protein\tK19168 cptA; toxin CptA"
				},
				{
					"name":"ECSP_3865 ygfY; conserved protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS",
				"children":[
				{
					"name":"ECSP_5228 yjdO; predicted protein\tK18839 ghoT; toxin GhoT"
				},
				{
					"name":"ECSP_5227 yjdK; predicted protein\tK18840 ghoS; antitoxin GhoS"
				}
				]
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein",
				"children":[
				{
					"name":"ECSP_1926 ydcX; predicted inner membrane protein\tK28274 ortT; orphan toxin OrtT"
				},
				{
					"name":"ECSP_3832 predicted protein\tK28274 ortT; orphan toxin OrtT"
				}
				]
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB",
				"children":[
				{
					"name":"ECSP_0527 hha; hemolysin expression modulating protein\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"ECSP_6079 hemolysin expression-modulating protein\tK05839 hha; haemolysin expression modulating protein"
				},
				{
					"name":"ECSP_0528 ybaJ; predicted protein\tK19162 tomB; hha toxicity modulator TomB"
				}
				]
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"ECSP_3474 iscS; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}