{
	"name":"fhw02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"RN87_05765 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"RN87_08950 type I-B CRISPR-associated endonuclease Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"RN87_05770 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"RN87_08945 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"RN87_08960 CRISPR-associated helicase Cas3\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"RN87_08970 type I-B CRISPR-associated protein Cas7\/Cst2\/DevR\tK19075 cst2; CRISPR-associated protein Cst2"
				},
				{
					"name":"RN87_08955 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"RN87_08965 CRISPR-associated protein Cas5\tK19090 cas5t; CRISPR-associated protein Cas5t"
				},
				{
					"name":"RN87_08980 CRISPR-associated endoribonuclease Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"RN87_08955 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"RN87_08955 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"RN87_08955 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"RN87_08980 CRISPR-associated endoribonuclease Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"RN87_08955 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins",
				"children":[
				{
					"name":"RN87_05730 type III-A CRISPR-associated protein Cas10\/Csm1\tK07016 csm1; CRISPR-associated protein Csm1"
				}
				]
			},
			{
				"name":"Subtype III-A factors",
				"children":[
				{
					"name":"RN87_05735 type III-A CRISPR-associated protein Csm2\tK19138 csm2; CRISPR-associated protein Csm2"
				},
				{
					"name":"RN87_05740 type III-A CRISPR-associated RAMP protein Csm3\tK09002 csm3; CRISPR-associated protein Csm3"
				},
				{
					"name":"RN87_05745 type III-A CRISPR-associated RAMP protein Csm4\tK19139 csm4; CRISPR-associated protein Csm4"
				},
				{
					"name":"RN87_05750 type III-A CRISPR-associated RAMP protein Csm5\tK19140 csm5; CRISPR-associated protein Csm5"
				}
				]
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"RN87_04400 DEAD\/DEAH box helicase\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"RN87_06210 restriction endonuclease subunit R\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"RN87_04370 hypothetical protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"RN87_04375 restriction endonuclease subunit S\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"RN87_06190 hypothetical protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"RN87_04360 restriction endonuclease\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"RN87_06185 DNA methyltransferase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases"
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"RN87_06670 type III restriction endonuclease subunit R\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"RN87_06660 cytosine methyltransferase\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"RN87_03465 GTPase\tK07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]"
			},
			{
				"name":"RN87_11060 McrB domain protein\tK07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]"
			},
			{
				"name":"RN87_03470 restriction endonuclease\tK19147 mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC"
			},
			{
				"name":"RN87_11055 restriction endonuclease\tK19147 mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"RN87_08490 addiction module toxin RelE\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"RN87_11730 hypothetical protein\tK06218 relE; mRNA interferase RelE\/StbE"
				}
				]
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"RN87_02185 damage-inducible protein J\tK07473 dinJ; DNA-damage-inducible protein J"
				},
				{
					"name":"RN87_07710 acyltransferase\tK07473 dinJ; DNA-damage-inducible protein J"
				},
				{
					"name":"RN87_10755 damage-inducible protein J\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"RN87_03715 addiction module protein\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"RN87_10760 toxin YoeB\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"RN87_11160 hypothetical protein\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"RN87_03710 prevent-host-death protein\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"RN87_00850 virulence factor\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA",
				"children":[
				{
					"name":"RN87_10340 zeta-toxin\tK16214 pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]"
				},
				{
					"name":"RN87_11715 zeta-toxin\tK16214 pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]"
				}
				]
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"RN87_04205 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"RN87_04530 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"RN87_03905 rod-share determining protein MreBH\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"RN87_07060 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"RN87_05080 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"RN87_01745 cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}