{
	"name":"fkr03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"NCS57_00692100 Methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"NCS57_00156200 Deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"NCS57_00134700 Uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"NCS57_00139100 UDG domain-containing protein\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"NCS57_00759200 Adenine DNA glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"NCS57_00586600 DNA-(apurinic or apyrimidinic site) lyase\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"NCS57_00318700 ENDO3c domain-containing protein\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"NCS57_00739200 Endonuclease III-like protein\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"NCS57_00048300 AP-endonuc-2 domain-containing protein\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					},
					{
						"name":"NCS57_00440500 Endo\/exonuclease\/phosphatase domain-containing protein\tK10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"NCS57_01127800 DNA polymerase\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"NCS57_01126700 hypothetical protein\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"NCS57_00839300 DNA polymerase delta subunit 3\tK03504 POLD3; DNA polymerase delta subunit 3"
						},
						{
							"name":"NCS57_00576900 hypothetical protein\tK03505 POLD4; DNA polymerase delta subunit 4"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"NCS57_00580300 DNA polymerase epsilon catalytic subunit\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"NCS57_00727300 DNA polymerase epsilon subunit B\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"NCS57_00078100 Proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"NCS57_00702000 Flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"NCS57_01039600 DNA ligase\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"NCS57_00240400 hypothetical protein\tK10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]"
					},
					{
						"name":"NCS57_01124200 hypothetical protein\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"NCS57_00181300 hypothetical protein\tK08073 PNKP; bifunctional polynucleotide phosphatase\/kinase [EC:3.1.3.32 2.7.1.78]"
					},
					{
						"name":"NCS57_01171200 Poly [ADP-ribose] polymerase\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"NCS57_00229300 AN1-type domain-containing protein\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"NCS57_00381100 hypothetical protein\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"NCS57_00614700 UV excision repair protein RAD23\tK10839 RAD23; UV excision repair protein RAD23"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"NCS57_00890400 RING-box protein 1\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"NCS57_00231200 DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"NER4 complex",
						"children":[
						{
							"name":"NCS57_01168100 hypothetical protein\tK15083 RAD16; DNA repair protein RAD16"
						}
						]
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"NCS57_00134100 DNA-directed RNA polymerase II subunit RPB1\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"NCS57_00895800 DNA-directed RNA polymerase II subunit RPB2\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"NCS57_00036700 RPOLD domain-containing protein\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"NCS57_00071100 RPOL4c domain-containing protein\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"NCS57_00255500 DNA-directed RNA polymerases I, II, and III subunit RPABC1\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"NCS57_00634500 hypothetical protein\tK03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2"
						},
						{
							"name":"NCS57_00061800 hypothetical protein\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
						},
						{
							"name":"NCS57_00837200 DNA-directed RNA polymerases I, II, and III subunit RPABC3\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"NCS57_00654000 hypothetical protein\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"NCS57_00136700 DNA-directed RNA polymerases I, II, and III subunit RPABC5\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						},
						{
							"name":"NCS57_01136000 RNA-pol-L-2 domain-containing protein\tK03008 RPB11; DNA-directed RNA polymerase II subunit RPB11"
						},
						{
							"name":"NCS57_00822100 hypothetical protein\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"NCS57_00890400 RING-box protein 1\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"NCS57_00231200 DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						},
						{
							"name":"NCS57_00738200 hypothetical protein\tK10570 ERCC8; DNA excision repair protein ERCC-8"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"NCS57_00885700 Transcription-coupled repair protein CSB\/RAD26\tK10841 ERCC6; DNA excision repair protein ERCC-6"
						},
						{
							"name":"NCS57_01110700 Transcription elongation factor 1-like protein\tK25829 ELOF1; transcription elongation factor 1"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"NCS57_00166600 DNA helicase\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"NCS57_00622600 DNA helicase\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"NCS57_01049300 General transcription and DNA repair factor IIH helicase subunit XPD\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"NCS57_01050800 hypothetical protein\tK03141 TFIIH1; transcription initiation factor TFIIH subunit 1"
					},
					{
						"name":"NCS57_00574000 General transcription and DNA repair factor IIH\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"NCS57_00694900 General transcription and DNA repair factor IIH subunit TFB4\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"NCS57_00370000 RNA polymerase II transcription factor B subunit 2\tK03144 TFIIH4; transcription initiation factor TFIIH subunit 4"
					},
					{
						"name":"NCS57_00752200 General transcription and DNA repair factor IIH subunit TFB5\tK10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit"
					},
					{
						"name":"NCS57_01116000 [RNA-polymerase]-subunit kinase\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"NCS57_01273700 Cyclin-C-2 domain-containing protein\tK06634 CCNH; cyclin H"
					},
					{
						"name":"NCS57_01220400 RNA polymerase II transcription factor B subunit 3\tK10842 MNAT1; CDK-activating kinase assembly factor MAT1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"NCS57_00748200 Replication protein A subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"NCS57_00251800 hypothetical protein\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"NCS57_00995500 hypothetical protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"NCS57_00018500 XPA-C domain-containing protein\tK10847 XPA; DNA-repair protein complementing XP-A cells"
					},
					{
						"name":"NCS57_00300300 hypothetical protein\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"NCS57_00423100 ERCC4 domain-containing protein\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"NCS57_00135500 hypothetical protein\tK10846 ERCC5; DNA excision repair protein ERCC-5"
					},
					{
						"name":"NCS57_01039600 DNA ligase\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"NCS57_01024100 MMS19 nucleotide excision repair protein\tK15075 MET18; DNA repair\/transcription protein MET18\/MMS19"
					},
					{
						"name":"NCS57_01050600 hypothetical protein\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"NCS57_00113800 CULLIN-2 domain-containing protein\tK03869 CUL3; cullin 3"
					},
					{
						"name":"NCS57_00120300 Elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"NCS57_00071800 hypothetical protein\tK15077 ELA1; elongin-A"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"NCS57_00557400 DNA mismatch repair protein msh-2\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"NCS57_00593500 DNA mismatch repair protein\tK08736 MSH3; DNA mismatch repair protein MSH3"
					},
					{
						"name":"NCS57_01103000 DNA mismatch repair protein\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"NCS57_00252200 DNA-mis-repair domain-containing protein\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"NCS57_01243400 hypothetical protein\tK10858 PMS2; DNA mismatch repair protein PMS2"
					},
					{
						"name":"NCS57_00018800 MutL-C domain-containing protein\tK08739 MLH3; DNA mismatch repair protein MLH3"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"NCS57_01127800 DNA polymerase\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
					},
					{
						"name":"NCS57_01126700 hypothetical protein\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"NCS57_00839300 DNA polymerase delta subunit 3\tK03504 POLD3; DNA polymerase delta subunit 3"
					},
					{
						"name":"NCS57_00576900 hypothetical protein\tK03505 POLD4; DNA polymerase delta subunit 4"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"NCS57_00748200 Replication protein A subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"NCS57_00251800 hypothetical protein\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"NCS57_00995500 hypothetical protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"NCS57_00117800 Replication factor C subunit 1\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"NCS57_00062900 Replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"NCS57_01131000 Replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"NCS57_00117600 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"NCS57_00576400 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"NCS57_00078100 Proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"NCS57_00585900 Exonuclease 1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"NCS57_01039600 DNA ligase\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"NCS57_00524200 DNA damage-binding protein CMR1\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"NCS57_00012300 Double-strand break repair protein\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"NCS57_00147800 AAA-23 domain-containing protein\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"NCS57_00012300 Double-strand break repair protein\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"NCS57_00147800 AAA-23 domain-containing protein\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA complex"
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"NCS57_00124100 RECA-2 domain-containing protein\tK10958 RAD57; DNA repair protein RAD57"
					}
					]
				},
				{
					"name":"Rad52 family proteins",
					"children":[
					{
						"name":"NCS57_00744500 hypothetical protein\tK10873 RAD52; DNA repair and recombination protein RAD52"
					}
					]
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"NCS57_00546700 DNA repair protein rhp54\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"NCS57_00094200 hypothetical protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"NCS57_00094200 hypothetical protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"NCS57_00631200 DNA topoisomerase\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"NCS57_00559200 DUF1767 domain-containing protein\tK15364 NCE4; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"NCS57_00748200 Replication protein A subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"NCS57_00251800 hypothetical protein\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"NCS57_00995500 hypothetical protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"NCS57_00236500 SMK-1 domain-containing protein\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					}
					]
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"NCS57_00412700 Structural maintenance of chromosomes protein 5\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"NCS57_00550400 SMC-N domain-containing protein\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"NCS57_00268000 Non-structural maintenance of chromosomes element 1-like protein\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
					},
					{
						"name":"NCS57_00388300 SP-RING-type domain-containing protein\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
					},
					{
						"name":"NCS57_00404200 Non-structural maintenance of chromosomes element 4\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"NCS57_00011200 ERCC4 domain-containing protein\tK10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]"
					},
					{
						"name":"NCS57_00070300 Crossover junction endonuclease MUS81\tK08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]"
					},
					{
						"name":"NCS57_00816600 putative 26S proteasome complex subunit sem-1\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"NCS57_01172300 Structure-specific endonuclease subunit SLX1\tK15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]"
					},
					{
						"name":"NCS57_01060500 hypothetical protein\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"NCS57_00577800 Chromatin modification-related protein EAF3\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"NCS57_00549000 AAA domain-containing protein\tK22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"
					},
					{
						"name":"NCS57_00131000 hypothetical protein\tK22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]"
					},
					{
						"name":"NCS57_00094600 ATP-dependent DNA helicase\tK14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex",
					"children":[
					{
						"name":"NCS57_01235800 ATP-dependent DNA helicase II subunit 1\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"NCS57_00630600 ATP-dependent DNA helicase II subunit 2\tK10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2"
					}
					]
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"NCS57_00012300 Double-strand break repair protein\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"NCS57_00147800 AAA-23 domain-containing protein\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"NCS57_00878400 DNA ligase\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					},
					{
						"name":"NCS57_01141700 DNA-LIGASE-A3 domain-containing protein\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"X-family DNA polymerases",
					"children":[
					{
						"name":"NCS57_00086900 DNA polymerase lambda\tK10981 POL4; DNA polymerase IV [EC:2.7.7.7]"
					},
					{
						"name":"NCS57_01246200 DNA polymerase\tK10981 POL4; DNA polymerase IV [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"NCS57_01124200 hypothetical protein\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"NCS57_00973500 hypothetical protein\tK19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]"
					},
					{
						"name":"NCS57_01297000 Endo\/exonuclease\/phosphatase domain-containing protein\tK19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors",
					"children":[
					{
						"name":"NCS57_01126300 hypothetical protein\tK11511 APITD1; centromere protein S"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"NCS57_00094200 hypothetical protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"NCS57_00631200 DNA topoisomerase\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"NCS57_00559200 DUF1767 domain-containing protein\tK15364 NCE4; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"NCS57_00586200 Fanconi-associated nuclease\tK15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]"
					},
					{
						"name":"NCS57_00113200 Telomere-reg-2 domain-containing protein\tK11137 TELO2; telomere length regulation protein"
					},
					{
						"name":"NCS57_01055300 hypothetical protein\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"NCS57_00230800 hypothetical protein\tK23314 WRAP53; telomerase Cajal body protein 1"
					},
					{
						"name":"NCS57_00619500 hypothetical protein\tK24752 WDR70; WD repeat-containing protein 70"
					},
					{
						"name":"NCS57_00524200 DNA damage-binding protein CMR1\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"NCS57_00444300 hypothetical protein\tK03509 POLH; DNA polymerase eta [EC:2.7.7.7]"
				},
				{
					"name":"NCS57_00561900 UmuC domain-containing protein\tK03510 POLI; DNA polymerase iota [EC:2.7.7.7]"
				},
				{
					"name":"NCS57_00041200 DNA polymerase kappa\tK03511 POLK; DNA polymerase kappa [EC:2.7.7.7]"
				},
				{
					"name":"NCS57_00079900 DNA repair protein REV1\tK03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases",
				"children":[
				{
					"name":"NCS57_00441400 DNA polymerase\tK02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"NCS57_00246400 hypothetical protein\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"NCS57_00839200 Postreplication repair E3 ubiquitin-protein ligase RAD18\tK10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"
				},
				{
					"name":"NCS57_00868400 DNA repair protein RAD5\tK15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]"
				},
				{
					"name":"NCS57_00265000 hypothetical protein\tK15711 SMARCA3; SWI\/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]"
				},
				{
					"name":"NCS57_00295900 UBC core domain-containing protein\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"NCS57_00416700 hypothetical protein\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"NCS57_00078100 Proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"NCS57_00545000 SprT-like domain-containing protein\tK26957 GCNA; germ cell nuclear acidic protein"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"NCS57_00877400 DNA repair protein rad9\tK10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]"
				},
				{
					"name":"NCS57_01153600 Checkpoint protein\tK10903 HUS1; HUS1 checkpoint protein"
				},
				{
					"name":"NCS57_00161100 hypothetical protein\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"NCS57_00086500 hypothetical protein\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"NCS57_00062900 Replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"NCS57_01131000 Replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"NCS57_00117600 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"NCS57_00576400 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"NCS57_00161100 hypothetical protein\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"NCS57_01136400 Topoisomerase 1-associated factor 1\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				},
				{
					"name":"NCS57_00451200 Chromosome segregation in meiosis protein\tK10998 TIPIN; replication fork protection complex subunit TIPIN\/Csm3\/Swi3"
				},
				{
					"name":"NCS57_00731800 MRC1 domain-containing protein\tK11272 MRC1; mediator of replication checkpoint protein 1"
				}
				]
			},
			{
				"name":"Triple T complex",
				"children":[
				{
					"name":"NCS57_00113200 Telomere-reg-2 domain-containing protein\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"NCS57_01027400 hypothetical protein\tK20403 TTI1; TELO2-interacting protein 1"
				}
				]
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"NCS57_00566600 hypothetical protein\tK23388 UBL4; ubiquitin-like protein 4"
				},
				{
					"name":"NCS57_01132100 hypothetical protein\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"NCS57_00420700 Non-specific serine\/threonine protein kinase\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]"
				},
				{
					"name":"NCS57_01032700 Serine\/threonine-protein kinase Tel1\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"NCS57_00032700 hypothetical protein\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]"
				},
				{
					"name":"NCS57_00092700 M-phase inducer phosphatase\tK02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]"
				},
				{
					"name":"NCS57_00057700 hypothetical protein\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"NCS57_00598700 hypothetical protein\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"NCS57_00755200 Protein kinase domain-containing protein\tK03114 SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]"
				},
				{
					"name":"NCS57_01046700 hypothetical protein\tK24664 FKH; forkhead protein FKH"
				},
				{
					"name":"NCS57_00681000 hypothetical protein\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"NCS57_00563800 Sde2-N-Ubi domain-containing protein\tK25059 SDE2; replication stress response regulator SDE2"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases"
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"NCS57_00113600 hypothetical protein\tK15340 DCLRE1A; DNA cross-link repair 1A protein"
				},
				{
					"name":"NCS57_00224100 hypothetical protein\tK17815 EXO5; exonuclease V [EC:3.1.-.-]"
				},
				{
					"name":"NCS57_00407000 hypothetical protein\tK05986 NUCS; nuclease S1 [EC:3.1.30.1]"
				}
				]
			},
			{
				"name":"Helicases",
				"children":[
				{
					"name":"NCS57_00755900 hypothetical protein\tK20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]"
				}
				]
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"NCS57_00865400 Pre-mRNA-processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"NCS57_00261800 Pre-mRNA-splicing factor cef-1\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"NCS57_00728500 hypothetical protein\tK12861 BCAS2; pre-mRNA-splicing factor SPF27"
				},
				{
					"name":"NCS57_00049500 Pre-mRNA-splicing factor prp46\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"NCS57_01213500 Nudix hydrolase domain-containing protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"NCS57_00077900 hypothetical protein\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"NCS57_00571000 Ribonucleoside-diphosphate reductase\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"NCS57_01044300 Ribonucleoside-diphosphate reductase small chain\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"NCS57_00692100 Methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"NCS57_00156200 Deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"NCS57_00134700 Uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"NCS57_00751100 hypothetical protein\tK01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]"
					},
					{
						"name":"NCS57_00759200 Adenine DNA glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"NCS57_00388600 DNA-(apurinic or apyrimidinic site) lyase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"NCS57_00318700 ENDO3c domain-containing protein\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"NCS57_00739200 Endonuclease III-like protein\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"NCS57_00393300 DNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"NCS57_00393300 DNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"NCS57_01213500 Nudix hydrolase domain-containing protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"NCS57_00077900 hypothetical protein\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}