{
	"name":"ftu03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"FTT_1518 ogt; Methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"FTT_0846 deoxyribodipyrimidine photolyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"FTT_1578c ung; Uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"FTT_0666c Methylpurine-DNA glycosylase family protein\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"FTT_0648c nth; Endonuclease III\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex"
					},
					{
						"name":"DNA polymerase epsilon complex"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex"
					},
					{
						"name":"Cul4-DDB2 complex"
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex"
					},
					{
						"name":"Cul4-CSA complex"
					},
					{
						"name":"Other TCR factor"
					}
					]
				},
				{
					"name":"TFIIH complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Other NER factors"
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"MutL homologs"
				},
				{
					"name":"DNA polymerase delta complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other MMR factors"
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex"
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex"
				},
				{
					"name":"BRCA complex"
				},
				{
					"name":"RecA family proteins"
				},
				{
					"name":"Rad52 family proteins"
				},
				{
					"name":"Rad54 family proteins"
				},
				{
					"name":"RecQ family DNA helicases"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Protein phosphatase 4"
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex"
				},
				{
					"name":"Other HR factors"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex"
				},
				{
					"name":"MRX complex"
				},
				{
					"name":"DNA Ligase 4 complex"
				},
				{
					"name":"X-family DNA polymerases"
				},
				{
					"name":"Other NHEJ factors"
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors"
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"B-family DNA polymerases"
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group"
			},
			{
				"name":"Other TLS factors"
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex"
			},
			{
				"name":"HRAD17(Rad24)-RFC complex"
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex"
			},
			{
				"name":"FPC (fork protection complex)"
			},
			{
				"name":"Triple T complex"
			},
			{
				"name":"BAG6-UBL4A-GET4 complex"
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases"
			},
			{
				"name":"Nucleases"
			},
			{
				"name":"Helicases"
			},
			{
				"name":"PSO4 complex"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"FTT_0823 MutT protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"FTT_0984c mutT; Mutator protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"FTT_0319 dut; dUTP pyrophosphatase (Deoxyuridine 5'-triphosphate nucleotidohydrolase)\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"FTT_1518 ogt; Methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"FTT_0846 deoxyribodipyrimidine photolyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				},
				{
					"name":"FTT_0847 conserved hypothetical protein\tK06876 phrB; (6-4)DNA photolyase [EC:4.1.99.13]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"FTT_1578c ung; Uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"FTT_0666c Methylpurine-DNA glycosylase family protein\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"FTT_0693c mutM; Formamidopyrimidine-DNA glycosylase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"FTT_0648c nth; Endonuclease III\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"FTT_0959c xthA; Exodeoxyribonuclease III\tK01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"RecJ",
					"children":[
					{
						"name":"FTT_0478c recJ; Single-stranded-DNA-specific exonuclease\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"FTT_1387c ligN; DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"DNA polymerase I",
					"children":[
					{
						"name":"FTT_0111 polA; DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"FTT_1312c uvrA; DNA excision repair enzyme, subunit A (UvrABC system protein A), ABC transporter, ATP-binding protein\tK03701 uvrA; excinuclease ABC subunit A"
					},
					{
						"name":"FTT_1199c uvrB; DNA excision repair enzyme, subunit B (UvrABC system protein B)\tK03702 uvrB; excinuclease ABC subunit B"
					},
					{
						"name":"FTT_0777 uvrC; DNA excision repair enzyme, subunit C (UvrABC system protein A)\tK03703 uvrC; excinuclease ABC subunit C"
					},
					{
						"name":"FTT_0121 uvrD; DNA helicase II\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"FTT_0111 polA; DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					},
					{
						"name":"FTT_1387c ligN; DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)",
						"children":[
						{
							"name":"FTT_0144 rpoB; DNA-directed RNA polymerase beta chain\tK03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]"
						},
						{
							"name":"FTT_0145 rpoC; DNA-directed RNA polymerase, beta subunit\tK03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]"
						},
						{
							"name":"FTT_0350 rpoA1; DNA-directed RNA polymerase, alpha subunit\tK03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]"
						},
						{
							"name":"FTT_1442c rpoA2; DNA-directed RNA polymerase, alpha subunit\tK03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]"
						},
						{
							"name":"FTT_0703 rpoZ; DNA-directed RNA polymerase omega subunit\tK03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]"
						}
						]
					},
					{
						"name":"TRCF (transcription-repair coupling factor)",
						"children":[
						{
							"name":"FTT_0644c mfd; Transcription-repair coupling factor,ATP-dependent\tK03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]"
						}
						]
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"FTT_1499 muts; DNA mismatch repair protein MutS\tK03555 mutS; DNA mismatch repair protein MutS"
					}
					]
				},
				{
					"name":"Molecular matchmaker",
					"children":[
					{
						"name":"FTT_0486 mutL; DNA mismatch repair protein\tK03572 mutL; DNA mismatch repair protein MutL"
					}
					]
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases",
					"children":[
					{
						"name":"FTT_1200c sbcB; Exodeoxyribonuclease I\tK01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]"
					},
					{
						"name":"FTT_1190c xseA; Exodeoxyribonuclease VII large subunit\tK03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]"
					}
					]
				},
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"FTT_0402 dnaE; DNA polymerase III alpha subunit\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"FTT_0002 dnaN; DNA polymerase III, beta chain\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"FTT_0298 holC; DNA polymerase III (CHI subunit) protein\tK02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]"
					},
					{
						"name":"FTT_0197c holA; DNA polymerase III, delta subunit\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"FTT_0460 holB; DNA polymerase III, delta prime subunit\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"FTT_0548 dnaQ; DNA polymerase III, epsilon subunit\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"FTT_0190c dnaX; DNA polymerase III, gamma\/tau subunits\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"FTT_1387c ligN; DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"FTT_0121 uvrD; DNA helicase II\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"FTT_1752 ssb; Single-strand binding protein\tK03111 ssb; single-strand DNA-binding protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins",
					"children":[
					{
						"name":"FTT_1394c recB; Exodeoxyribonuclease V beta chain\tK03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]"
					},
					{
						"name":"FTT_1397c recC; Exodeoxyribonuclease V gamma chain\tK03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]"
					},
					{
						"name":"FTT_1393c recD; Exodeoxyribonuclease V, alpha subunit\tK03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]"
					},
					{
						"name":"FTT_1750 recA; Recombinase A protein\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"FTT_0658 ruvA; holliday junction DNA helicase, subunit A\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"FTT_1013c ruvB; holliday junction DNA helicase, subunit B\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					},
					{
						"name":"FTT_0656 ruvC; holliday junction endodeoxyribonuclease\tK01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]"
					},
					{
						"name":"FTT_0215 priA; Primosomal protein N'\tK04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]"
					},
					{
						"name":"FTT_1200c sbcB; Exodeoxyribonuclease I\tK01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]"
					}
					]
				},
				{
					"name":"RecFOR pathway proteins",
					"children":[
					{
						"name":"FTT_1750 recA; Recombinase A protein\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"FTT_0873c radA; DNA repair protein radA\tK04485 radA; DNA repair protein RadA\/Sms"
					},
					{
						"name":"FTT_0762c recF; DNA replication and repair protein recF\tK03629 recF; DNA replication and repair protein RecF"
					},
					{
						"name":"FTT_1601c recG; ATP-dependent DNA helicase RecG\tK03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]"
					},
					{
						"name":"FTT_0478c recJ; Single-stranded-DNA-specific exonuclease\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
					},
					{
						"name":"FTT_1224c recO; DNA repair protein recO\tK03584 recO; DNA repair protein RecO (recombination protein O)"
					},
					{
						"name":"FTT_0809c recR; Recombination protein recR\tK06187 recR; recombination protein RecR"
					},
					{
						"name":"FTT_0886 DNA repair protein recN\tK03631 recN; DNA repair protein RecN (Recombination protein N)"
					},
					{
						"name":"FTT_1084c rdgC; recombination associated protein\tK03554 rdgC; recombination associated protein RdgC"
					},
					{
						"name":"FTT_0658 ruvA; holliday junction DNA helicase, subunit A\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"FTT_1013c ruvB; holliday junction DNA helicase, subunit B\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					},
					{
						"name":"FTT_0656 ruvC; holliday junction endodeoxyribonuclease\tK01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]"
					}
					]
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator",
						"children":[
						{
							"name":"FTT_1575c gyrA; DNA gyrase, subunit A\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
						},
						{
							"name":"FTT_0510 gyrB; DNA gyrase subunit B\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
						},
						{
							"name":"FTT_0906c topA; DNA topoisomerase I\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
						}
						]
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"FTT_0627 hupB; Histone-like protein HU form B\tK03530 hupB; DNA-binding protein HU-beta"
						}
						]
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway",
						"children":[
						{
							"name":"FTT_0478c recJ; Single-stranded-DNA-specific exonuclease\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
						},
						{
							"name":"FTT_1224c recO; DNA repair protein recO\tK03584 recO; DNA repair protein RecO (recombination protein O)"
						},
						{
							"name":"FTT_0809c recR; Recombination protein recR\tK06187 recR; recombination protein RecR"
						},
						{
							"name":"FTT_1387c ligN; DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
						}
						]
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"FTT_1200c sbcB; Exodeoxyribonuclease I\tK01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]"
						},
						{
							"name":"FTT_1312c uvrA; DNA excision repair enzyme, subunit A (UvrABC system protein A), ABC transporter, ATP-binding protein\tK03701 uvrA; excinuclease ABC subunit A"
						},
						{
							"name":"FTT_1199c uvrB; DNA excision repair enzyme, subunit B (UvrABC system protein B)\tK03702 uvrB; excinuclease ABC subunit B"
						}
						]
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"FTT_1750 recA; Recombinase A protein\tK03553 recA; recombination protein RecA"
				},
				{
					"name":"FTT_0886 DNA repair protein recN\tK03631 recN; DNA repair protein RecN (Recombination protein N)"
				},
				{
					"name":"FTT_1752 ssb; Single-strand binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"FTT_1751 recX; Regulatory protein recX\tK03565 recX; regulatory protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases",
				"children":[
				{
					"name":"FTT_1087c rep; ATP-dependent DNA helicase\tK03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"FTT_0823 MutT protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"FTT_0984c mutT; Mutator protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"FTT_0319 dut; dUTP pyrophosphatase (Deoxyuridine 5'-triphosphate nucleotidohydrolase)\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"FTT_0534c nrdA; Ribonucleoside-diphosphate reductase, alpha subunit\tK00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]"
				},
				{
					"name":"FTT_0532c grxC; Biofunctional protein, glutaredoxin 3 protein\/Ribonucleoside-diphosphate reductase, beta subunit\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}