{
	"name":"gdu02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"P0S91_05075 cas1d; type I-D CRISPR-associated endonuclease Cas1d\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"P0S91_06770 cas1; CRISPR-associated endonuclease Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"P0S91_05080 cas2; CRISPR-associated endonuclease Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"P0S91_06765 cas2; CRISPR-associated endonuclease Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"P0S91_02975 cas3; CRISPR-associated helicase Cas3'\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				},
				{
					"name":"P0S91_05025 cas3; type I-D CRISPR-associated helicase Cas3'\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"P0S91_05070 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"P0S91_05065 cas6; CRISPR-associated endoribonuclease Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"P0S91_05070 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"P0S91_05070 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"P0S91_05055 cas5d; type I-D CRISPR-associated protein Cas5\/Csc1\tK19120 csc1; CRISPR-associated protein Csc1"
				},
				{
					"name":"P0S91_05050 cas7d; type I-D CRISPR-associated protein Cas7\/Csc2\tK19121 csc2; CRISPR-associated protein Csc2"
				},
				{
					"name":"P0S91_05045 cas10d; type I-D CRISPR-associated protein Cas10d\/Csc3\tK19122 csc3; CRISPR-associated protein Csc3"
				},
				{
					"name":"P0S91_05070 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"P0S91_05065 cas6; CRISPR-associated endoribonuclease Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors",
				"children":[
				{
					"name":"P0S91_02985 cas7u; type I-U CRISPR-associated RAMP protein Csb1\/Cas7u\tK19131 csb1; CRISPR-associated protein Csb1"
				},
				{
					"name":"P0S91_02990 csb2; type I-U CRISPR-associated protein Csb2\tK19132 csb2; CRISPR-associated protein Csb2"
				},
				{
					"name":"P0S91_02980 csx17; type I-U CRISPR-associated protein Csx17\tK19136 csx17; CRISPR-associated protein Csx17"
				}
				]
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"P0S91_05070 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors",
				"children":[
				{
					"name":"P0S91_06805 cas10; type III-B CRISPR-associated protein Cas10\/Cmr2\tK19076 cmr2; CRISPR-associated protein Cmr2"
				},
				{
					"name":"P0S91_06800 type III-B CRISPR module-associated Cmr3 family protein\tK09127 cmr3; CRISPR-associated protein Cmr3"
				},
				{
					"name":"P0S91_06795 cmr4; type III-B CRISPR module RAMP protein Cmr4\tK09000 cmr4; CRISPR-associated protein Cmr4"
				},
				{
					"name":"P0S91_06785 RAMP superfamily CRISPR-associated protein\tK19142 cmr6; CRISPR-associated protein Cmr6"
				}
				]
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"P0S91_01780 DEAD\/DEAH box helicase family protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"P0S91_20415 type I restriction endonuclease subunit R\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"P0S91_20850 type I restriction endonuclease\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"P0S91_01795 restriction endonuclease subunit S\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"P0S91_20430 restriction endonuclease subunit S\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"P0S91_20815 restriction endonuclease subunit S\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"P0S91_20785 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"P0S91_15685 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"P0S91_23785 DNA cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system"
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"P0S91_14015 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_17105 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_21890 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_22320 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_25915 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_14020 AbrB\/MazE\/SpoVT family DNA-binding domain-containing protein\tK07172 mazE; antitoxin MazE"
				},
				{
					"name":"P0S91_17100 AbrB\/MazE\/SpoVT family DNA-binding domain-containing protein\tK07172 mazE; antitoxin MazE"
				},
				{
					"name":"P0S91_08285 hypothetical protein\tK26986 mazE6; antitoxin MazE6"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF",
				"children":[
				{
					"name":"P0S91_17950 type II toxin-antitoxin system YhaV family toxin\tK19155 yhaV; toxin YhaV [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_24800 type II toxin-antitoxin system YhaV family toxin\tK19155 yhaV; toxin YhaV [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_26520 type II toxin-antitoxin system YhaV family toxin\tK19155 yhaV; toxin YhaV [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_17945 type II toxin-antitoxin system PrlF family antitoxin\tK19156 prlF; antitoxin PrlF"
				},
				{
					"name":"P0S91_26525 type II toxin-antitoxin system PrlF family antitoxin\tK19156 prlF; antitoxin PrlF"
				}
				]
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"P0S91_03000 type II toxin-antitoxin system RelE\/ParE family toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"P0S91_20505 type II toxin-antitoxin system RelE\/ParE family toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"P0S91_20500 type II toxin-antitoxin system Phd\/YefM family antitoxin\tK28297 relB_F; antitoxin RelB\/F"
				}
				]
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"P0S91_05770 Txe\/YoeB family addiction module toxin\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_20265 Txe\/YoeB family addiction module toxin\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_20260 type II toxin-antitoxin system prevent-host-death family antitoxin\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"P0S91_14520 type II toxin-antitoxin system RelE\/ParE family toxin\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"P0S91_14525 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"P0S91_00900 hypothetical protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"P0S91_17460 type II toxin-antitoxin system HigB family toxin\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_19915 type II toxin-antitoxin system HigB family toxin\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_18745 type II toxin-antitoxin system RelE\/ParE family toxin\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"P0S91_17465 transcriptional regulator\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"P0S91_19920 helix-turn-helix domain-containing protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"P0S91_06760 HigA family addiction module antitoxin\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"P0S91_18740 HigA family addiction module antitoxin\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"P0S91_21205 type II toxin-antitoxin system VapC family toxin\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"P0S91_20820 AbrB\/MazE\/SpoVT family DNA-binding domain-containing protein\tK18829 mvpT; antitoxin VapB"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"P0S91_10735 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"P0S91_06565 rod shape-determining protein\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"P0S91_03490 gltX; glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA",
				"children":[
				{
					"name":"P0S91_05035 nucleotidyltransferase domain-containing protein\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				}
				]
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"P0S91_02120 IscS subfamily cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"P0S91_11095 cysteine desulfurase family protein\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"P0S91_20680 dndC; DNA phosphorothioation system sulfurtransferase DndC\tK19170 dndC; DNA sulfur modification protein DndC"
			},
			{
				"name":"P0S91_20665 AAA family ATPase\tK19171 dndD; DNA sulfur modification protein DndD"
			},
			{
				"name":"P0S91_20695 dndD; DNA sulfur modification protein DndD\tK19171 dndD; DNA sulfur modification protein DndD"
			},
			{
				"name":"P0S91_20705 dndE; DNA sulfur modification protein DndE\tK19172 dndE; DNA sulfur modification protein DndE"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}