{
	"name":"gla03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors",
					"children":[
					{
						"name":"GL50803_0022338 mRNA cap guanine-N7 methyltransferase\tK00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]"
					},
					{
						"name":"GL50803_0017308 mRNA capping enzyme alpha subunit\tK00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]"
					},
					{
						"name":"GL50803_00103058 putative Methyltransferase\tK14589 CMTR1; cap1 methyltransferase [EC:2.1.1.57]"
					}
					]
				},
				{
					"name":"Cap binding complex"
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)"
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)"
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex",
					"children":[
					{
						"name":"GL50803_0013225 Zinc finger domain\tK14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4"
					},
					{
						"name":"GL50803_0014545 Serine\/threonine protein phosphatase PP1 isozyme 7\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"GL50803_0014568 Ser\/Thr protein phosphatase PP1-alpha 2 catalytic subunit\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex",
					"children":[
					{
						"name":"GL50803_0015042 Cleavage stimulation factor 50K chain\tK14406 CSTF1; cleavage stimulation factor subunit 1"
					}
					]
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors",
					"children":[
					{
						"name":"GL50803_0012164 putative Small nuclear ribonucleoprotein Sm D3\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"GL50803_0062597 putative SnRNP Sm-like protein\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"GL50803_004954 LSM domain-containing protein\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					}
					]
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex",
					"children":[
					{
						"name":"GL50803_007717 Transcription elongation factor Spt4\tK15171 SUPT4H1; transcription elongation factor SPT4"
					}
					]
				},
				{
					"name":"N6-methyltransferase complex"
				},
				{
					"name":"Poly(A) addition factors"
				},
				{
					"name":"Negative regulators of mRNA 3' end processing"
				}
				]
			},
			{
				"name":"Other processing factors"
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex"
				},
				{
					"name":"TREX complex"
				},
				{
					"name":"TREX-2 complex",
					"children":[
					{
						"name":"GL50803_00104685 Centrin\tK16466 CETN3; centrin-3"
					}
					]
				},
				{
					"name":"Nuclear pore complex",
					"children":[
					{
						"name":"GL50803_00112787 hypothetical protein\tK09291 TPR; nucleoprotein TPR"
					},
					{
						"name":"GL50803_00102890 putative WD-repeat family protein\tK14298 RAE1; mRNA export factor"
					},
					{
						"name":"GL50803_00112408 Nuclear pore complex subunit\tK14312 NUP155; nuclear pore complex protein Nup155"
					},
					{
						"name":"GL50803_00104685 Centrin\tK16466 CETN3; centrin-3"
					}
					]
				},
				{
					"name":"Ran-mediated transport factors",
					"children":[
					{
						"name":"GL50803_0015869 GTP-binding nuclear protein RAN\/TC4\tK07936 RAN; GTP-binding nuclear protein Ran"
					},
					{
						"name":"GL50803_0016867 AAA family ATPase\tK13525 VCP; transitional endoplasmic reticulum ATPase"
					},
					{
						"name":"GL50803_006724 putative Nuclear transport factor 2\tK28773 NUTF2; nuclear transport factor 2"
					}
					]
				},
				{
					"name":"eIF4F and regulatory proteins",
					"children":[
					{
						"name":"GL50803_007990 Eukaryotic initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"GL50803_0010255 putative Translation initiation factor eIF-4A\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"GL50803_0013156 Eukaryotic initiation factor 4A\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"GL50803_0015048 ATP-dependent RNA helicase-like protein\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]"
					}
					]
				},
				{
					"name":"APOBEC1-ACF complex"
				},
				{
					"name":"Other transport factors",
					"children":[
					{
						"name":"GL50803_005892 Pelo protein\tK06965 PELO; protein pelota"
					},
					{
						"name":"GL50803_006283 Helicase\tK18655 DDX19; ATP-dependent RNA helicase DDX19\/DBP5 [EC:5.6.2.7]"
					}
					]
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex",
					"children":[
					{
						"name":"GL50803_0017190 Eukaryotic peptide chain release factor subunit 1\tK03265 ETF1; peptide chain release factor subunit 1"
					},
					{
						"name":"GL50803_0017460 Selenocysteine-specific translation elongation factor\tK03267 ERF3; peptide chain release factor subunit 3"
					},
					{
						"name":"GL50803_0013452 Regulator of nonsense transcripts 1-like protein\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]"
					}
					]
				},
				{
					"name":"Protein phosphatase 2A",
					"children":[
					{
						"name":"GL50803_007439 Ser\/Thr phosphatase 2A regulatory subunit A\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A"
					},
					{
						"name":"GL50803_0032398 Protein phosphatase PP2A regulatory subunit B\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B"
					},
					{
						"name":"GL50803_004079 Protein phosphatase PP2A regulatory subunit B\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B"
					},
					{
						"name":"GL50803_0017157 Protein phosphatase 2A regulary subunit B\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''"
					},
					{
						"name":"GL50803_0017538 Phosphoprotein phosphatase 2A regulatory subunit\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''"
					},
					{
						"name":"GL50803_009894 putative Protein phosphatase 2A regulatory subunit\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''"
					},
					{
						"name":"GL50803_0016443 Protein phosphatase 2A B' regulatory subunit Wdb1\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'"
					}
					]
				},
				{
					"name":"Other surveillance factors"
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex",
					"children":[
					{
						"name":"GL50803_0016602 hypothetical protein\tK14844 PUF6; pumilio homology domain family member 6"
					}
					]
				},
				{
					"name":"Factors that have mRNA localization signals"
				},
				{
					"name":"Trans-acting binding proteins",
					"children":[
					{
						"name":"GL50803_00112304 Elongation factor 1-alpha\tK03231 EEF1A; elongation factor 1-alpha"
					},
					{
						"name":"GL50803_00112312 Elongation factor 1-alpha\tK03231 EEF1A; elongation factor 1-alpha"
					},
					{
						"name":"GL50803_0012102 Elongation factor 1-gamma\tK03233 EEF1G; elongation factor 1-gamma"
					}
					]
				},
				{
					"name":"Other mRNA localization factors"
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule",
					"children":[
					{
						"name":"GL50803_007990 Eukaryotic initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"GL50803_0013452 Regulator of nonsense transcripts 1-like protein\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]"
					},
					{
						"name":"GL50803_0015048 ATP-dependent RNA helicase-like protein\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]"
					},
					{
						"name":"GL50803_002098 putative ATP-dependent RNA helicase p54\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]"
					}
					]
				},
				{
					"name":"P-body specific factors",
					"children":[
					{
						"name":"GL50803_0018713 putative U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"GL50803_0022112 putative U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3"
					},
					{
						"name":"GL50803_00103676 Alpha-tubulin 1\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"GL50803_00112079 Alpha-tubulin\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"GL50803_008061 Not1 N-terminal domain, CCR4-Not complex component-containing protein\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3"
					},
					{
						"name":"GL50803_008427 putative Transcriptional repressor NOT4Hp\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
					},
					{
						"name":"GL50803_0010606 CCR4-NOT transcription complex, subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"GL50803_008209 CCR4-NOT transcription complex, subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"GL50803_009912 putative Ribonuclease\tK18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-]"
					}
					]
				},
				{
					"name":"Stress granule specific factors",
					"children":[
					{
						"name":"GL50803_0015495 RNA recognition motif-containing protein\tK03253 EIF3B; translation initiation factor 3 subunit B"
					},
					{
						"name":"GL50803_0010255 putative Translation initiation factor eIF-4A\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"GL50803_0013156 Eukaryotic initiation factor 4A\tK03257 EIF4A; translation initiation factor 4A"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex",
					"children":[
					{
						"name":"GL50803_002098 putative ATP-dependent RNA helicase p54\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]"
					}
					]
				},
				{
					"name":"Lsm complex",
					"children":[
					{
						"name":"GL50803_0018713 putative U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"GL50803_0022112 putative U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3"
					}
					]
				},
				{
					"name":"5' exonucleases",
					"children":[
					{
						"name":"GL50803_0024133 5'-3' exoribonuclease 2\tK12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]"
					}
					]
				},
				{
					"name":"Other 5'-3' decay factors"
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors",
					"children":[
					{
						"name":"GL50803_0033022 Exosome complex exonuclease RRP4\tK03679 RRP4; exosome complex component RRP4"
					},
					{
						"name":"GL50803_001890 3' exoribonuclease, putative\tK12590 RRP46; exosome complex component RRP46"
					}
					]
				},
				{
					"name":"Exosome cofactors",
					"children":[
					{
						"name":"GL50803_00112718 Mitotic control protein dis3\tK12585 DIS3; exosome complex exonuclease DIS3\/RRP44 [EC:3.1.13.-]"
					}
					]
				},
				{
					"name":"TRAMP complex",
					"children":[
					{
						"name":"GL50803_0016285 Topoisomerase I-related protein\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]"
					},
					{
						"name":"GL50803_007081 hypothetical protein\tK12597 AIR1_2; protein AIR1\/2"
					},
					{
						"name":"GL50803_0017146 Helicase\tK12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"Ski complex"
				},
				{
					"name":"Ccr4-NOT complex",
					"children":[
					{
						"name":"GL50803_008061 Not1 N-terminal domain, CCR4-Not complex component-containing protein\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3"
					},
					{
						"name":"GL50803_008427 putative Transcriptional repressor NOT4Hp\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
					},
					{
						"name":"GL50803_0010606 CCR4-NOT transcription complex, subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"GL50803_008209 CCR4-NOT transcription complex, subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					}
					]
				},
				{
					"name":"Pan complex"
				},
				{
					"name":"Other 3'-5' decay factors"
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases"
				},
				{
					"name":"Helicases",
					"children":[
					{
						"name":"GL50803_009266 putative Sgs1 DNA helicase\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"GL50803_0011118 Enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones"
				},
				{
					"name":"Others"
				},
				{
					"name":"Bacterial Small RNA Regulators"
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome",
					"children":[
					{
						"name":"GL50803_0033022 Exosome complex exonuclease RRP4\tK03679 RRP4; exosome complex component RRP4"
					}
					]
				},
				{
					"name":"Cofactors"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}