{
	"name":"halg03036",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Sister chromatid cohesion proteins",
			"children":[
			{
				"name":"Cohesin complex"
			},
			{
				"name":"Adherin complex"
			},
			{
				"name":"CTF18-RFC complex"
			},
			{
				"name":"Fork protection complex"
			},
			{
				"name":"55LCC heterohexameric ATPase complex"
			},
			{
				"name":"Other sister chromatid cohesion factors"
			}
			]
		},
		{
			"name":"Meiosis-specific proteins",
			"children":[
			{
				"name":"Cohesin complex and associated proteins"
			},
			{
				"name":"Synaptonemal complex"
			},
			{
				"name":"DSB formation-related proteins"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Nucleosome assembly factors",
			"children":[
			{
				"name":"Histones"
			},
			{
				"name":"Histone chaperones",
				"children":[
				{
					"name":"Nucleoplasmins"
				},
				{
					"name":"NAPs (Nucleosome assembly proteins)"
				},
				{
					"name":"CAF-1"
				},
				{
					"name":"FACT complex"
				},
				{
					"name":"Other Histone chaperones and regulators"
				}
				]
			},
			{
				"name":"HMG (high mobility group) proteins"
			}
			]
		},
		{
			"name":"Histone modification proteins",
			"children":[
			{
				"name":"HATs (histone acetyltransferases)"
			},
			{
				"name":"HAT complexes",
				"children":[
				{
					"name":"PCAF complex"
				},
				{
					"name":"STAGA complex"
				},
				{
					"name":"TFTC complex"
				},
				{
					"name":"TIP60 complex"
				},
				{
					"name":"HBO1 complex"
				},
				{
					"name":"MOZ\/MORF complex"
				},
				{
					"name":"SAGA complex"
				},
				{
					"name":"SLIK complex"
				},
				{
					"name":"ADA-HAT complex"
				},
				{
					"name":"HAT-A2 complex"
				},
				{
					"name":"ATAC complex"
				},
				{
					"name":"HATB complex"
				},
				{
					"name":"NSL complex"
				},
				{
					"name":"MSL complex"
				},
				{
					"name":"NuA3 complex"
				},
				{
					"name":"NuA4 complex"
				},
				{
					"name":"SAS complex"
				}
				]
			},
			{
				"name":"HDACs (histone deacetylases)",
				"children":[
				{
					"name":"Class I HDACs"
				},
				{
					"name":"Class II HDACs"
				},
				{
					"name":"SIRTs (sirtuins, class III HDACs)"
				},
				{
					"name":"Class IV HDACs"
				}
				]
			},
			{
				"name":"HDAC complexes",
				"children":[
				{
					"name":"Sin3A-HDAC complex"
				},
				{
					"name":"BRAF-HDAC complex"
				},
				{
					"name":"REST complex"
				},
				{
					"name":"SHIP complex"
				},
				{
					"name":"MiDAC complex"
				},
				{
					"name":"SMART complex"
				},
				{
					"name":"Other HDAC associated proteins"
				}
				]
			},
			{
				"name":"HMTs (histone methyltransferases)",
				"children":[
				{
					"name":"HKMTs (histone lysine methyltransferases)"
				},
				{
					"name":"PRMTs (protein arginine metyltransferases)"
				}
				]
			},
			{
				"name":"HMT complexes",
				"children":[
				{
					"name":"COMPASS\/SET1 complex"
				},
				{
					"name":"COMPASS\/SET1 complex (yeast)"
				},
				{
					"name":"MLL-HCF complex"
				},
				{
					"name":"MLL3\/MLL4 complex"
				},
				{
					"name":"Dot1-containing complex"
				},
				{
					"name":"CHTOP-methylosome complex"
				}
				]
			},
			{
				"name":"Histone demethylases"
			},
			{
				"name":"Polycomb repressive complex (PRC) and associated proteins",
				"children":[
				{
					"name":"Canonical PRC1 (PRC1.2\/1.4)",
					"children":[
					{
						"name":"PRC1.4 specific proteins"
					}
					]
				},
				{
					"name":"Noncanonical PRC1 (PRC1.1)"
				},
				{
					"name":"Noncanonical PRC1 (PRC1.3\/1.5)"
				},
				{
					"name":"Noncanonical PRC1 (PRC1.6)"
				},
				{
					"name":"PRC2.1"
				},
				{
					"name":"PRC2.2"
				},
				{
					"name":"PR-DUB complex"
				},
				{
					"name":"Other PRC associated proteins"
				}
				]
			},
			{
				"name":"Sir proteins"
			},
			{
				"name":"Other histone modification proteins"
			}
			]
		},
		{
			"name":"Chromosome condensation proteins",
			"children":[
			{
				"name":"Condensin I"
			},
			{
				"name":"Condensin II"
			},
			{
				"name":"Other regulators of chromosome condensation"
			}
			]
		},
		{
			"name":"Centromeric chromatin formation proteins",
			"children":[
			{
				"name":"Kinetochore proteins",
				"children":[
				{
					"name":"Centromere proteins"
				},
				{
					"name":"CPC (chromosomal passenger complex)"
				},
				{
					"name":"KMN network proteins",
					"children":[
					{
						"name":"MIS12 complex"
					},
					{
						"name":"NDC80 complex"
					}
					]
				},
				{
					"name":"Mis6 complex"
				},
				{
					"name":"COMA complex"
				},
				{
					"name":"NMS complex",
					"children":[
					{
						"name":"NDC80 complex"
					},
					{
						"name":"MIND kinetochore complex"
					}
					]
				},
				{
					"name":"MIS16-MIS18 complex"
				},
				{
					"name":"DASH complex"
				},
				{
					"name":"CBF3 complex"
				},
				{
					"name":"Others"
				}
				]
			},
			{
				"name":"SAC (spindle assembly checkpoint) factors",
				"children":[
				{
					"name":"Core SAC proteins"
				},
				{
					"name":"Motor proteins",
					"children":[
					{
						"name":"RZZ complex"
					},
					{
						"name":"Dynein complex"
					}
					]
				},
				{
					"name":"Protein kinases"
				},
				{
					"name":"Others"
				}
				]
			},
			{
				"name":"Other centromeric chromatin formation proteins",
				"children":[
				{
					"name":"Shugoshin"
				},
				{
					"name":"PP2A (protein phosphatase 2A)"
				}
				]
			}
			]
		},
		{
			"name":"Heterochromatin formation proteins",
			"children":[
			{
				"name":"HP1 (heterochromatin protein 1)"
			},
			{
				"name":"MBPs (metylated DNA binding proteins)"
			},
			{
				"name":"Other heterochromatin formation proteins"
			}
			]
		},
		{
			"name":"Gene silencing",
			"children":[
			{
				"name":"RISC (RNA-induced silencing complex)"
			},
			{
				"name":"piRNA pathway"
			},
			{
				"name":"RNA interference (RNAi) pathway",
				"children":[
				{
					"name":"RITS (RNA-induced transcriptional silencing) complex"
				},
				{
					"name":"RDRC (RNA-directed RNA polymerase complex)"
				},
				{
					"name":"Other RNAi proteins"
				}
				]
			},
			{
				"name":"microRNA pathway",
				"children":[
				{
					"name":"Microprocessor complex"
				},
				{
					"name":"RISC loading complex"
				},
				{
					"name":"Other miRNA pathway proteins"
				}
				]
			},
			{
				"name":"Transposable elements"
			}
			]
		},
		{
			"name":"Centrosome formation proteins",
			"children":[
			{
				"name":"Centriole proteins"
			},
			{
				"name":"Pericentriolar materials (PCM)",
				"children":[
				{
					"name":"Centriolar satellite"
				},
				{
					"name":"Other PCM proteins"
				}
				]
			},
			{
				"name":"Cyclins"
			},
			{
				"name":"Kinases and associated factors",
				"children":[
				{
					"name":"Kinase associated protein"
				}
				]
			},
			{
				"name":"Microtubules and associated factors",
				"children":[
				{
					"name":"gamma-tubulin ring complex"
				},
				{
					"name":"Other tubulins"
				},
				{
					"name":"Dynactin complex"
				},
				{
					"name":"BRISC complex"
				},
				{
					"name":"Microtubule-associated proteins"
				}
				]
			},
			{
				"name":"Augmin complex"
			},
			{
				"name":"Centrosome duplication proteins",
				"children":[
				{
					"name":"Centriole replication proteins"
				},
				{
					"name":"Regulators of centriole replication"
				},
				{
					"name":"Other centrosome duplication proteins"
				}
				]
			},
			{
				"name":"Nde1-Su48 complex"
			},
			{
				"name":"LINC complex"
			},
			{
				"name":"3M complex"
			},
			{
				"name":"Gypsy chromatin insulator complex"
			},
			{
				"name":"Other centrosome associated proteins",
				"children":[
				{
					"name":"HUG10_00595 hypothetical protein\tK09142 SPOUT1; methyltransferase [EC:2.1.1.-]"
				}
				]
			},
			{
				"name":"Spindle formation proteins",
				"children":[
				{
					"name":"HUG10_06620 ATP-dependent DNA helicase\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
				},
				{
					"name":"HUG10_13335 ATP-dependent DNA helicase\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
				}
				]
			}
			]
		},
		{
			"name":"Sister chromatid separation proteins",
			"children":[
			{
				"name":"Securin and associated proteins"
			},
			{
				"name":"Separase"
			},
			{
				"name":"APC\/C complex"
			},
			{
				"name":"Aurora kinases",
				"children":[
				{
					"name":"Regulators of Aurora kinases"
				}
				]
			},
			{
				"name":"TACC proteins"
			},
			{
				"name":"Polo kinases"
			},
			{
				"name":"Early mitotic inhibitors"
			}
			]
		},
		{
			"name":"Chromatin remodeling factors",
			"children":[
			{
				"name":"BAF complex"
			},
			{
				"name":"PBAF complex"
			},
			{
				"name":"GBAF(ncBAF) complex"
			},
			{
				"name":"CHRAC complex"
			},
			{
				"name":"RSF complex"
			},
			{
				"name":"WICH complex"
			},
			{
				"name":"B-WICH complex"
			},
			{
				"name":"NORC complex"
			},
			{
				"name":"BRF complex"
			},
			{
				"name":"NuRD complex"
			},
			{
				"name":"NuRF complex"
			},
			{
				"name":"NuRF complex (fruit fly)"
			},
			{
				"name":"CERF complex"
			},
			{
				"name":"SRCAP complex"
			},
			{
				"name":"INO80 complex"
			},
			{
				"name":"INO80 complex (yeast)"
			},
			{
				"name":"RSC complex"
			},
			{
				"name":"SWI\/SNF complex"
			},
			{
				"name":"SWR1 complex"
			},
			{
				"name":"ASTRA complex"
			},
			{
				"name":"Other chromatin remodeling factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Nucleoid associated proteins",
			"children":[
			{
				"name":"HNS (histone-like nucleoid structuring protein)",
				"children":[
				{
					"name":"HUG10_17920 NFYB\/HAP3 family transcription factor subunit\tK24450 hmf; DNA-binding protein"
				}
				]
			},
			{
				"name":"HU (heat unstable protein)"
			},
			{
				"name":"IHF (integration host factor)"
			},
			{
				"name":"Other nucleoid associated proteins",
				"children":[
				{
					"name":"HUG10_03550 DNA starvation\/stationary phase protection protein\tK04047 dps; starvation-inducible DNA-binding protein"
				},
				{
					"name":"HUG10_18880 dps; DNA starvation\/stationary phase protection protein Dps\tK04047 dps; starvation-inducible DNA-binding protein"
				},
				{
					"name":"HUG10_12080 non-histone chromosomal MC1 family protein\tK28135 mc1; chromosomal protein MC1"
				}
				]
			}
			]
		},
		{
			"name":"Chromosome partitioning proteins",
			"children":[
			{
				"name":"MukBEF complex"
			},
			{
				"name":"Condensin-like complex",
				"children":[
				{
					"name":"HUG10_02045 smc; chromosome segregation protein SMC\tK03529 smc; chromosome segregation protein"
				},
				{
					"name":"HUG10_02050 segregation\/condensation protein A\tK05896 scpA; segregation and condensation protein A"
				}
				]
			},
			{
				"name":"Divisome proteins",
				"children":[
				{
					"name":"HUG10_13975 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"HUG10_16730 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				}
				]
			},
			{
				"name":"Inhibitors of FtsZ assembly",
				"children":[
				{
					"name":"HUG10_05095 CDP-4-keto-6-deoxy-D-glucose-3-dehydrase\tK03609 minD; septum site-determining protein MinD"
				},
				{
					"name":"HUG10_13765 chromosome partitioning protein ParA\tK03609 minD; septum site-determining protein MinD"
				},
				{
					"name":"HUG10_14140 P-loop NTPase\tK03609 minD; septum site-determining protein MinD"
				},
				{
					"name":"HUG10_15035 AAA family ATPase\tK03609 minD; septum site-determining protein MinD"
				},
				{
					"name":"HUG10_18200 P-loop NTPase\tK03609 minD; septum site-determining protein MinD"
				}
				]
			},
			{
				"name":"Other chromosome partitioning proteins",
				"children":[
				{
					"name":"HUG10_19390 ParA family protein\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"HUG10_20820 ParA family protein\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"HUG10_05230 tyrosine-type recombinase\/integrase\tK03733 xerC; integrase\/recombinase XerC"
				},
				{
					"name":"HUG10_11600 site-specific integrase\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"HUG10_03250 Mrp\/NBP35 family ATP-binding protein\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				},
				{
					"name":"HUG10_18330 Fic family protein\tK04095 fic; cell filamentation protein, protein adenylyltransferase [EC:2.7.7.108]"
				}
				]
			}
			]
		}
		]
	}
	]
}