{
	"name":"hco04147",
	"children":[
	{
		"name":"Exosomal proteins",
		"children":[
		{
			"name":"Proteins found in most exosomes",
			"children":[
			{
				"name":"LOKO_00864 htpG; Chaperone protein HtpG\tK04079 HSP90A; molecular chaperone HtpG"
			},
			{
				"name":"LOKO_02922 eno; Enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
			},
			{
				"name":"LOKO_00930 gap; Glyceraldehyde-3-phosphate dehydrogenase\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]"
			},
			{
				"name":"LOKO_03469 gap2; Glyceraldehyde-3-phosphate dehydrogenase 2\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]"
			},
			{
				"name":"LOKO_00037 pgk; Phosphoglycerate kinase\tK00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]"
			},
			{
				"name":"LOKO_03185 pykA_3; Pyruvate kinase II\tK00873 PK; pyruvate kinase [EC:2.7.1.40]"
			},
			{
				"name":"LOKO_00454 Membrane dipeptidase (Peptidase family M19)\tK01273 DPEP; membrane dipeptidase [EC:3.4.13.19]"
			}
			]
		},
		{
			"name":"Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)",
			"children":[
			{
				"name":"LOKO_01607 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"LOKO_03440 dnaK; Chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"LOKO_00784 pgi_1; Glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"LOKO_03485 pgi_2; Glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"LOKO_02849 guaB; Inosine-5'-monophosphate dehydrogenase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]"
			},
			{
				"name":"LOKO_00115 tuf1; Elongation factor Tu\tK02358 tuf; elongation factor Tu"
			},
			{
				"name":"LOKO_02198 HIT-like protein\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
			}
			]
		},
		{
			"name":"Exosomal proteins of oligodendrocytes"
		},
		{
			"name":"Exosomal proteins of cortical neuronal cells"
		},
		{
			"name":"Exosomal proteins of microglial cells"
		},
		{
			"name":"Exosomal proteins of epithelial cells"
		},
		{
			"name":"Exosomal proteins of hepatic cells"
		},
		{
			"name":"Exosomal proteins of breast milk",
			"children":[
			{
				"name":"LOKO_01120 lcfB_2; Long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"LOKO_02599 fadD_2; Long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"LOKO_03639 fadD_3; Long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"LOKO_03107 Na+\/Pi-cotransporter\tK14683 SLC34A; solute carrier family 34 (sodium-dependent phosphate cotransporter)"
			}
			]
		},
		{
			"name":"Exosomal proteins of other body fluids (saliva and urine)",
			"children":[
			{
				"name":"LOKO_01607 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"LOKO_02577 thlA_1; Acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"LOKO_03382 pcaF_2; Beta-ketoadipyl-CoA thiolase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"LOKO_03413 thlA_2; Acetyl-CoA acetyltransferase\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"LOKO_03638 bktB; Beta-ketothiolase BktB\tK00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]"
			},
			{
				"name":"LOKO_00046 ahcY; Adenosylhomocysteinase\tK01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]"
			},
			{
				"name":"LOKO_00645 adk; Adenylate kinase\tK00939 adk; adenylate kinase [EC:2.7.4.3]"
			},
			{
				"name":"LOKO_02055 apt; Adenine phosphoribosyltransferase\tK00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]"
			},
			{
				"name":"LOKO_03494 argH1; Argininosuccinate lyase 1\tK01755 argH; argininosuccinate lyase [EC:4.3.2.1]"
			},
			{
				"name":"LOKO_02743 argG; Argininosuccinate synthase\tK01940 argG; argininosuccinate synthase [EC:6.3.4.5]"
			},
			{
				"name":"LOKO_00399 D-hydantoinase\tK01464 DPYS; dihydropyrimidinase [EC:3.5.2.2]"
			},
			{
				"name":"LOKO_02063 glpK_1; Glycerol kinase\tK00864 glpK; glycerol kinase [EC:2.7.1.30]"
			},
			{
				"name":"LOKO_00022 glnA_1; Glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"LOKO_01143 puuA_1; Gamma-glutamylputrescine synthetase PuuA\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"LOKO_02564 puuA_2; Gamma-glutamylputrescine synthetase PuuA\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"LOKO_03033 glnA_2; Glutamine synthetase\tK01915 glnA; glutamine synthetase [EC:6.3.1.2]"
			},
			{
				"name":"LOKO_00784 pgi_1; Glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"LOKO_03485 pgi_2; Glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"LOKO_02953 hemB; Delta-aminolevulinic acid dehydratase\tK01698 hemB; porphobilinogen synthase [EC:4.2.1.24]"
			},
			{
				"name":"LOKO_00080 hpd; 4-hydroxyphenylpyruvate dioxygenase\tK00457 HPD; 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]"
			},
			{
				"name":"LOKO_00071 Putative pterin-4-alpha-carbinolamine dehydratase\tK01724 PCBD; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]"
			},
			{
				"name":"LOKO_01319 Putative pterin-4-alpha-carbinolamine dehydratase\tK01724 PCBD; 4a-hydroxytetrahydrobiopterin dehydratase [EC:4.2.1.96]"
			},
			{
				"name":"LOKO_00324 hprA; Glycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"LOKO_00382 serA_1; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"LOKO_00963 serA_2; D-3-phosphoglycerate dehydrogenase\tK00058 serA; D-3-phosphoglycerate dehydrogenase \/ 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]"
			},
			{
				"name":"LOKO_01215 purH; Bifunctional purine biosynthesis protein PurH\tK00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase \/ IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]"
			}
			]
		},
		{
			"name":"Exosomal proteins of breast cancer cells",
			"children":[
			{
				"name":"LOKO_01120 lcfB_2; Long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"LOKO_02599 fadD_2; Long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"LOKO_03639 fadD_3; Long-chain-fatty-acid--CoA ligase\tK01897 ACSL; long-chain-fatty-acid---CoA ligase [EC:6.2.1.3]"
			},
			{
				"name":"LOKO_01551 lpdA_1; Dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]"
			},
			{
				"name":"LOKO_02798 lpd; Dihydrolipoyl dehydrogenase\tK00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]"
			},
			{
				"name":"LOKO_02144 etfA_4; Electron transfer flavoprotein subunit alpha\tK03522 fixB; electron transfer flavoprotein alpha subunit"
			},
			{
				"name":"LOKO_02323 zwf; Glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"LOKO_02849 guaB; Inosine-5'-monophosphate dehydrogenase\tK00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]"
			},
			{
				"name":"LOKO_03440 dnaK; Chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"LOKO_01607 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"LOKO_00115 tuf1; Elongation factor Tu\tK02358 tuf; elongation factor Tu"
			}
			]
		},
		{
			"name":"Exosomal proteins of ovarian cancer cells"
		},
		{
			"name":"Exosomal proteins of colorectal cancer cells",
			"children":[
			{
				"name":"LOKO_01607 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"LOKO_00784 pgi_1; Glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"LOKO_03485 pgi_2; Glucose-6-phosphate isomerase\tK01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]"
			},
			{
				"name":"LOKO_02323 zwf; Glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"LOKO_03440 dnaK; Chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
			},
			{
				"name":"LOKO_03424 tpiA; Triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			},
			{
				"name":"LOKO_00115 tuf1; Elongation factor Tu\tK02358 tuf; elongation factor Tu"
			}
			]
		},
		{
			"name":"Exosomal proteins of pancreatic cancer cells"
		},
		{
			"name":"Exosomal proteins of bladder cancer cells",
			"children":[
			{
				"name":"LOKO_01607 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
			},
			{
				"name":"LOKO_02323 zwf; Glucose-6-phosphate 1-dehydrogenase\tK00036 G6PD; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]"
			},
			{
				"name":"LOKO_03424 tpiA; Triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			}
			]
		},
		{
			"name":"Exosomal proteins of melanoma cells",
			"children":[
			{
				"name":"LOKO_03424 tpiA; Triosephosphate isomerase\tK01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]"
			}
			]
		},
		{
			"name":"Exosomal proteins of other cancer cells",
			"children":[
			{
				"name":"LOKO_03595 blc; Outer membrane lipoprotein Blc precursor\tK03098 APOD; apolipoprotein D and lipocalin family protein"
			}
			]
		}
		]
	},
	{
		"name":"Exosomal RNA",
		"children":[
		{
			"name":"Exosomal RNA of haemopoietic cells"
		},
		{
			"name":"Exosomal RNA of muscle cells"
		},
		{
			"name":"Exosomal RNA of hepatic cells"
		},
		{
			"name":"Exosomal RNA of pancreatic cells"
		},
		{
			"name":"Exosomal RNA of neural cells"
		},
		{
			"name":"Exosomal RNA of breast milk"
		},
		{
			"name":"Exosomal RNA of saliva"
		},
		{
			"name":"Exosomal RNA of breast cancer cells"
		},
		{
			"name":"Exosomal RNA of ovarian cancer cells"
		},
		{
			"name":"Exosomal RNA of colorectal cancer cells"
		},
		{
			"name":"Exosomal RNA of hepatic cancer cells"
		},
		{
			"name":"Exosomal RNA of renal carcinoma cells"
		},
		{
			"name":"Exosomal RNA of pancreatic cancer cells"
		},
		{
			"name":"Exosomal RNA of melanoma cells"
		},
		{
			"name":"Exosomal RNA of lung cancer cells"
		},
		{
			"name":"Exosomal RNA of other cancer cells"
		}
		]
	}
	]
}