{
	"name":"hcv02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"FTV88_2899 cas1; type I-D CRISPR-associated endonuclease Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"FTV88_2898 cas2; CRISPR-associated endoribonuclease Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"FTV88_2906 type I-D CRISPR-associated helicase Cas3'\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"FTV88_2890 edewey\tK19085 csa1; CRISPR-associated protein Csa1"
				},
				{
					"name":"FTV88_2894 CRISPR-associated negative auto-regulator DevR\/Csa2 protein\tK19075 cst2; CRISPR-associated protein Cst2"
				},
				{
					"name":"FTV88_2900 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"FTV88_2901 hypothetical protein\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"FTV88_2900 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"FTV88_2900 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"FTV88_2902 cas5d; type I-D CRISPR-associated protein Cas5\/Csc1\tK19120 csc1; CRISPR-associated protein Csc1"
				},
				{
					"name":"FTV88_2903 cas7d; type I-D CRISPR-associated protein Cas7\/Csc2\tK19121 csc2; CRISPR-associated protein Csc2"
				},
				{
					"name":"FTV88_2905 csc3; type I-D CRISPR-associated protein Cas10d\/Csc3\tK19122 csc3; CRISPR-associated protein Csc3"
				},
				{
					"name":"FTV88_2900 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"FTV88_2901 hypothetical protein\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"FTV88_2900 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"FTV88_0652 hsdR; type I site-specific deoxyribonuclease, HsdR family protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"FTV88_0123 hsdS; type I restriction enzyme, S subunit\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"FTV88_0124 hsdM; type I restriction-modification system, M subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"FTV88_2374 dam; DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"FTV88_1533 DNA (cytosine-5-)-methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"FTV88_1576 DNA (cytosine-5-)-methyltransferase family protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"FTV88_1939 Type III restriction enzyme, res subunit\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"FTV88_1938 Site-specific DNA-methyltransferase\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"FTV88_1188 HNH endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"FTV88_1532 HNH endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"FTV88_1942 AAA family ATPase\tK07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]"
			},
			{
				"name":"FTV88_1960 GTPase subunit of restriction endonuclease, putative\tK07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]"
			},
			{
				"name":"FTV88_1969 5-methylcytosine-specific restriction enzyme B\tK07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]"
			},
			{
				"name":"FTV88_1370 restriction endonuclease\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"FTV88_3033 mazF; Transcriptional modulator of MazE\/toxin, MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"FTV88_2238 AbrB\/MazE\/SpoVT family DNA-binding domain-containing protein\tK07172 mazE; antitoxin MazE"
				},
				{
					"name":"FTV88_3034 CopG family transcriptional regulator\tK07723 ndoAI; CopG family transcriptional regulator \/ antitoxin EndoAI"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA"
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"FTV88_1760 Cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"FTV88_3354 Cell division protein ftsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"FTV88_1023 mreB; rod-shaped determining protein\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"FTV88_1115 cell shape determining, MreB\/Mrl family protein\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA",
				"children":[
				{
					"name":"FTV88_2757 hypothetical protein\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"FTV88_2861 hypothetical protein\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"FTV88_2860 nucleotidyltransferase domain protein\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				}
				]
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"FTV88_0533 nifS; cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}