{
	"name":"hds03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"HSR122_0373 ada; Methylated DNA-protein cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"HSR122_2636 phrB3; Deoxyribodipyrimidine photolyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"HSR122_0620 mutY; A\/G-specific DNA glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"HSR122_1411 alkA; 3-methyladenine DNA glycosylase\/8-oxoguanine DNAglycosylase\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"HSR122_1140 nth; EndoIII-related endonuclease\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"HSR122_1850 nth2; EndoIII-related endonuclease\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex"
					},
					{
						"name":"DNA polymerase epsilon complex"
					},
					{
						"name":"HSR122_0065 dnaN; DNA polymerase sliding clamp subunit (PCNA-like protein)\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"HSR122_0973 fen1; 5'-3' exonuclease\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"HSR122_0475 cDC9; ATP-dependent DNA ligase\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex"
					},
					{
						"name":"Cul4-DDB2 complex"
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex"
					},
					{
						"name":"Cul4-CSA complex"
					},
					{
						"name":"Other TCR factor"
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"HSR122_1718 xpb; ssDNA-dependent ATPase, helicase superfamily II\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"HSR122_0902 dinG; Rad3-related DNA helicase\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"HSR122_1687 dinG2; Rad3-related DNA helicase\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"HSR122_0301 rpa1; Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit or related ssDNA-binding protein\tK07466 RFA1; replication factor A1"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"HSR122_0475 cDC9; ATP-dependent DNA ligase\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"MutL homologs"
				},
				{
					"name":"DNA polymerase delta complex"
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"HSR122_0301 rpa1; Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit or related ssDNA-binding protein\tK07466 RFA1; replication factor A1"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"HSR122_0065 dnaN; DNA polymerase sliding clamp subunit (PCNA-like protein)\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"HSR122_0475 cDC9; ATP-dependent DNA ligase\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex"
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex"
				},
				{
					"name":"BRCA complex"
				},
				{
					"name":"RecA family proteins"
				},
				{
					"name":"Rad52 family proteins"
				},
				{
					"name":"Rad54 family proteins"
				},
				{
					"name":"RecQ family DNA helicases"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"HSR122_0301 rpa1; Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit or related ssDNA-binding protein\tK07466 RFA1; replication factor A1"
					}
					]
				},
				{
					"name":"Protein phosphatase 4"
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex"
				},
				{
					"name":"Other HR factors"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex"
				},
				{
					"name":"MRX complex"
				},
				{
					"name":"DNA Ligase 4 complex"
				},
				{
					"name":"X-family DNA polymerases"
				},
				{
					"name":"Other NHEJ factors"
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors"
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"B-family DNA polymerases"
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group"
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"HSR122_0065 dnaN; DNA polymerase sliding clamp subunit (PCNA-like protein)\tK04802 PCNA; proliferating cell nuclear antigen"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex"
			},
			{
				"name":"HRAD17(Rad24)-RFC complex"
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex"
			},
			{
				"name":"FPC (fork protection complex)"
			},
			{
				"name":"Triple T complex"
			},
			{
				"name":"BAG6-UBL4A-GET4 complex"
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases"
			},
			{
				"name":"Nucleases"
			},
			{
				"name":"Helicases"
			},
			{
				"name":"PSO4 complex"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"HSR122_1281 NUDIX family hydrolase\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"HSR122_2515 dcd2; Deoxycytidine deaminase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"HSR122_0373 ada; Methylated DNA-protein cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"HSR122_2636 phrB3; Deoxyribodipyrimidine photolyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				},
				{
					"name":"HSR122_1351 Uncharacterized protein\tK06876 phrB; (6-4)DNA photolyase [EC:4.1.99.13]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"HSR122_2903 Uracil-DNA glycosylase\tK21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"HSR122_3015 Uracil-DNA glycosylase\tK21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"HSR122_0620 mutY; A\/G-specific DNA glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"HSR122_1140 nth; EndoIII-related endonuclease\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"HSR122_1850 nth2; EndoIII-related endonuclease\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"HSR122_3060 nfo; Endonuclease IV\tK01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]"
					},
					{
						"name":"HSR122_1922 nfi; Deoxyinosine 3'endonuclease (endonuclease V)\tK05982 nfi; deoxyribonuclease V [EC:3.1.21.7]"
					},
					{
						"name":"HSR122_2904 Endonuclease V-like protein\tK09120 dU; endonuclease dU"
					}
					]
				},
				{
					"name":"RecJ",
					"children":[
					{
						"name":"HSR122_2551 recJ_Cdc45; Single-stranded DNA-specific exonuclease RecJ\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"HSR122_1767 lig; NAD-dependent DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"HSR122_0177 uvrA; Excinuclease ABC subunit A, ATPase\tK03701 uvrA; excinuclease ABC subunit A"
					},
					{
						"name":"HSR122_2133 uvrB; Excinuclease ABC subunit B, helicase\tK03702 uvrB; excinuclease ABC subunit B"
					},
					{
						"name":"HSR122_0251 uvrC; Excinuclease ABC subunit C\tK03703 uvrC; excinuclease ABC subunit C"
					},
					{
						"name":"HSR122_0169 uvrD; Superfamily I DNA and RNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"HSR122_1767 lig; NAD-dependent DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"HSR122_0467 mutS; Mismatch repair ATPase (MutS family)\tK03555 mutS; DNA mismatch repair protein MutS"
					},
					{
						"name":"HSR122_0522 mutS-2; Mismatch repair ATPase (MutS family)\tK03555 mutS; DNA mismatch repair protein MutS"
					},
					{
						"name":"HSR122_0904 mutS2; DNA structure-specific ATPase involved in suppression of recombination, MutS family\tK07456 mutS2; DNA mismatch repair protein MutS2"
					},
					{
						"name":"HSR122_1364 mutS2-2; DNA structure-specific ATPase involved in suppression of recombination, MutS family\tK07456 mutS2; DNA mismatch repair protein MutS2"
					}
					]
				},
				{
					"name":"Molecular matchmaker",
					"children":[
					{
						"name":"HSR122_1660 mutL; DNA mismatch repair enzyme (predicted ATPase)\tK03572 mutL; DNA mismatch repair protein MutL"
					}
					]
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"HSR122_1767 lig; NAD-dependent DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"HSR122_0169 uvrD; Superfamily I DNA and RNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins",
					"children":[
					{
						"name":"HSR122_2108 sbcC; ATPase involved in DNA repair, SbcC\tK03546 sbcC; DNA repair protein SbcC\/Rad50"
					},
					{
						"name":"HSR122_2107 sbcD; DNA repair exonuclease, SbcD\tK03547 sbcD; DNA repair protein SbcD\/Mre11"
					}
					]
				},
				{
					"name":"RecFOR pathway proteins",
					"children":[
					{
						"name":"HSR122_2551 recJ_Cdc45; Single-stranded DNA-specific exonuclease RecJ\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor",
					"children":[
					{
						"name":"HSR122_2058 cas1; CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
					}
					]
				},
				{
					"name":"Archaeal homologous recombinant proteins",
					"children":[
					{
						"name":"HSR122_2854 recA2; RecA\/RadA recombinase\tK04483 radA; DNA repair protein RadA"
					},
					{
						"name":"HSR122_2014 recA; RecA\/RadA recombinase\tK04484 radB; DNA repair protein RadB"
					},
					{
						"name":"HSR122_2985 Holliday junction resolvase, archaeal type\tK03552 hjr; holliday junction resolvase [EC:3.1.21.10]"
					},
					{
						"name":"HSR122_2108 sbcC; ATPase involved in DNA repair, SbcC\tK03546 sbcC; DNA repair protein SbcC\/Rad50"
					},
					{
						"name":"HSR122_2107 sbcD; DNA repair exonuclease, SbcD\tK03547 sbcD; DNA repair protein SbcD\/Mre11"
					},
					{
						"name":"HSR122_2760 bRR22; Replicative superfamily II helicase\tK03726 helS; ATP-dependent DNA helicase [EC:5.6.2.4]"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator",
						"children":[
						{
							"name":"HSR122_2666 gyrA; Type IIA topoisomerase (DNA gyrase\/topo II, topoisomerase IV), A subunit\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
						},
						{
							"name":"HSR122_2665 gyrB; Type IIA topoisomerase (DNA gyrase\/topo II, topoisomerase IV), B subunit\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
						},
						{
							"name":"HSR122_0107 Topoisomerase DNA binding C4 zinc finger fused to uncharacterized N-terminal domain often associated with RecB-like endonuclease\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
						},
						{
							"name":"HSR122_2738 topA; Topoisomerase IA\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
						}
						]
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway",
						"children":[
						{
							"name":"HSR122_2551 recJ_Cdc45; Single-stranded DNA-specific exonuclease RecJ\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
						},
						{
							"name":"HSR122_1767 lig; NAD-dependent DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
						}
						]
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"HSR122_0177 uvrA; Excinuclease ABC subunit A, ATPase\tK03701 uvrA; excinuclease ABC subunit A"
						},
						{
							"name":"HSR122_2133 uvrB; Excinuclease ABC subunit B, helicase\tK03702 uvrB; excinuclease ABC subunit B"
						}
						]
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"HSR122_1962 dpo4; Family Y DNA polymerase\tK04479 dbh; DNA polymerase IV (archaeal DinB-like DNA polymerase) [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"Other SOS response factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase",
				"children":[
				{
					"name":"HSR122_1925 pol4; DNA polymerase IV (family X)\tK02347 polX; DNA polymerase (family X)"
				}
				]
			},
			{
				"name":"DNA helicases",
				"children":[
				{
					"name":"HSR122_0266 lhr; Lhr-like helicase\tK03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]"
				},
				{
					"name":"HSR122_1801 lhr2; Lhr-like helicase\tK03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"HSR122_1281 NUDIX family hydrolase\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"HSR122_2515 dcd2; Deoxycytidine deaminase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"HSR122_1387 nrdA; Ribonucleotide reductase, alpha subunit\tK00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"HSR122_0363 Protein, predicted to be involved in DNA repair\tK22585 nreA; DNA repair protein NreA"
				}
				]
			}
			]
		}
		]
	}
	]
}