{
	"name":"hhar03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"128147208 MGMT; (RefSeq) methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"128145846 ALKBH2; (RefSeq) DNA oxidative demethylase ALKBH2 isoform X1\tK10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]"
				},
				{
					"name":"128139479 ALKBH3; (RefSeq) alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1\tK10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]"
				},
				{
					"name":"128139277 ASCC3; (RefSeq) activating signal cointegrator 1 complex subunit 3 isoform X1\tK18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]"
				},
				{
					"name":"128149521 deoxyribodipyrimidine photo-lyase-like\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"128146355 UNG; (RefSeq) uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"128136694 CCNO; (RefSeq) LOW QUALITY PROTEIN: cyclin-O\tK10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]"
					},
					{
						"name":"128143634 TDG; (RefSeq) G\/T mismatch-specific thymine DNA glycosylase isoform X1\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"128134918 MPG; (RefSeq) DNA-3-methyladenine glycosylase\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"128151814 SMUG1; (RefSeq) single-strand selective monofunctional uracil DNA glycosylase\tK10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]"
					},
					{
						"name":"128147716 MUTYH; (RefSeq) adenine DNA glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"128137528 MBD4; (RefSeq) methyl-CpG-binding domain protein 4 isoform X1\tK10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]"
					},
					{
						"name":"128137038 OGG1; (RefSeq) N-glycosylase\/DNA lyase\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"128151365 NEIL1; (RefSeq) endonuclease 8-like 1 isoform X1\tK10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"128152197 NEIL2; (RefSeq) endonuclease 8-like 2 isoform X1\tK10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"128138170 NEIL3; (RefSeq) endonuclease 8-like 3 isoform X1\tK10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"128134582 NTHL1; (RefSeq) endonuclease III-like protein 1 isoform X1\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"128138031 APEX1; (RefSeq) LOW QUALITY PROTEIN: DNA-(apurinic or apyrimidinic site) endonuclease\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"128149934 POLD2; (RefSeq) LOW QUALITY PROTEIN: DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"128153404 POLD3; (RefSeq) DNA polymerase delta subunit 3 isoform X1\tK03504 POLD3; DNA polymerase delta subunit 3"
						},
						{
							"name":"128152831 POLD4; (RefSeq) DNA polymerase delta subunit 4\tK03505 POLD4; DNA polymerase delta subunit 4"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"128146408 POLE; (RefSeq) DNA polymerase epsilon catalytic subunit A\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"128140158 POLE2; (RefSeq) DNA polymerase epsilon subunit 2\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						},
						{
							"name":"128154379 POLE3; (RefSeq) DNA polymerase epsilon subunit 3\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
						},
						{
							"name":"128148293 DNA polymerase epsilon subunit 4-like\tK03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"128150375 PCNA; (RefSeq) proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"128153101 FEN1; (RefSeq) flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors",
					"children":[
					{
						"name":"128150267 POLB; (RefSeq) DNA polymerase beta\tK02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"128153288 XNDC1N; (RefSeq) protein XNDC1N isoform X1\tK10803 XRCC1; DNA-repair protein XRCC1"
					},
					{
						"name":"128148731 LIG3; (RefSeq) DNA ligase 3\tK10776 LIG3; DNA ligase 3 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"128139880 TDP1; (RefSeq) tyrosyl-DNA phosphodiesterase 1 isoform X1\tK10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]"
					},
					{
						"name":"128136772 APTX; (RefSeq) aprataxin\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"128140437 APLF; (RefSeq) aprataxin and PNK-like factor isoform X1\tK13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]"
					},
					{
						"name":"128153338 HMGB1; (RefSeq) high mobility group protein B1\tK10802 HMGB1; high mobility group protein B1"
					},
					{
						"name":"128147032 POLL; (RefSeq) DNA polymerase lambda isoform X1\tK03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"128150192 PARP1; (RefSeq) poly [ADP-ribose] polymerase 1\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
					},
					{
						"name":"128137782 PARP3; (RefSeq) protein mono-ADP-ribosyltransferase PARP3\tK10798 PARP3_4; protein mono-ADP-ribosyltransferase 3\/4 [EC:2.4.2.-]"
					},
					{
						"name":"128153592 PARP4; (RefSeq) LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP4\tK10798 PARP3_4; protein mono-ADP-ribosyltransferase 3\/4 [EC:2.4.2.-]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"128136566 XPC; (RefSeq) DNA repair protein complementing XP-C cells\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"128136583 RAD23B; (RefSeq) UV excision repair protein RAD23 homolog B isoform X1\tK10839 RAD23; UV excision repair protein RAD23"
						},
						{
							"name":"128146999 RAD23A; (RefSeq) UV excision repair protein RAD23 homolog A\tK10839 RAD23; UV excision repair protein RAD23"
						},
						{
							"name":"128153920 CETN2; (RefSeq) centrin-2\tK10840 CETN2; centrin-2"
						},
						{
							"name":"128153921 uncharacterized protein LOC128153921\tK10840 CETN2; centrin-2"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"128143232 RBX1; (RefSeq) E3 ubiquitin-protein ligase RBX1\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"128135145 CUL4A; (RefSeq) cullin-4A\tK10609 CUL4; cullin 4"
						},
						{
							"name":"128154019 CUL4B; (RefSeq) cullin-4B isoform X1\tK10609 CUL4; cullin 4"
						},
						{
							"name":"128153079 DDB1; (RefSeq) DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						},
						{
							"name":"128139510 DDB2; (RefSeq) DNA damage-binding protein 2 isoform X1\tK10140 DDB2; DNA damage-binding protein 2"
						}
						]
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"128150058 LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1-like\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"128136674 POLR2B; (RefSeq) DNA-directed RNA polymerase II subunit RPB2 isoform X1\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"128145536 POLR2C; (RefSeq) DNA-directed RNA polymerase II subunit RPB3\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"128149464 POLR2D; (RefSeq) DNA-directed RNA polymerase II subunit RPB4\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"128147969 POLR2E; (RefSeq) DNA-directed RNA polymerases I, II, and III subunit RPABC1\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"128142685 POLR2F; (RefSeq) DNA-directed RNA polymerases I, II, and III subunit RPABC2\tK03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2"
						},
						{
							"name":"128149439 POLR2H; (RefSeq) DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"128138173 POLR2I; (RefSeq) DNA-directed RNA polymerase II subunit RPB9\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"128152321 POLR2L; (RefSeq) DNA-directed RNA polymerases I, II, and III subunit RPABC5\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						},
						{
							"name":"128149385 DNA-directed RNA polymerase II subunit RPB11-a\tK03008 RPB11; DNA-directed RNA polymerase II subunit RPB11"
						},
						{
							"name":"128142355 POLR2K; (RefSeq) DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform X1\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"128143232 RBX1; (RefSeq) E3 ubiquitin-protein ligase RBX1\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"128135145 CUL4A; (RefSeq) cullin-4A\tK10609 CUL4; cullin 4"
						},
						{
							"name":"128154019 CUL4B; (RefSeq) cullin-4B isoform X1\tK10609 CUL4; cullin 4"
						},
						{
							"name":"128153079 DDB1; (RefSeq) DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						},
						{
							"name":"128137538 ERCC8; (RefSeq) DNA excision repair protein ERCC-8 isoform X1\tK10570 ERCC8; DNA excision repair protein ERCC-8"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"128146892 ERCC6; (RefSeq) DNA excision repair protein ERCC-6\tK10841 ERCC6; DNA excision repair protein ERCC-6"
						},
						{
							"name":"128138947 UVSSA; (RefSeq) UV-stimulated scaffold protein A\tK23720 UVSSA; UV-stimulated scaffold protein A"
						},
						{
							"name":"128147006 ELOF1; (RefSeq) transcription elongation factor 1 homolog\tK25829 ELOF1; transcription elongation factor 1"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"128143865 ERCC3; (RefSeq) general transcription and DNA repair factor IIH helicase subunit XPB isoform X1\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"128138126 ERCC2; (RefSeq) LOW QUALITY PROTEIN: general transcription and DNA repair factor IIH helicase subunit XPD\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"128152349 GTF2H1; (RefSeq) general transcription factor IIH subunit 1 isoform X1\tK03141 TFIIH1; transcription initiation factor TFIIH subunit 1"
					},
					{
						"name":"128137070 GTF2H2; (RefSeq) general transcription factor IIH subunit 2 isoform X1\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"128146412 GTF2H3; (RefSeq) general transcription factor IIH subunit 3 isoform X1\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"128140584 GTF2H5; (RefSeq) general transcription factor IIH subunit 5 isoform X1\tK10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit"
					},
					{
						"name":"128136842 CDK7; (RefSeq) cyclin-dependent kinase 7 isoform X1\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"128136377 CCNH; (RefSeq) cyclin-H isoform X1\tK06634 CCNH; cyclin H"
					},
					{
						"name":"128140069 MNAT1; (RefSeq) CDK-activating kinase assembly factor MAT1 isoform X1\tK10842 MNAT1; CDK-activating kinase assembly factor MAT1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"128149276 RPA1; (RefSeq) replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"128152401 RPA2; (RefSeq) replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"128148086 RPA3; (RefSeq) replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"128136891 XPA; (RefSeq) DNA repair protein complementing XP-A cells\tK10847 XPA; DNA-repair protein complementing XP-A cells"
					},
					{
						"name":"128138092 ERCC1; (RefSeq) DNA excision repair protein ERCC-1\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"128135031 ERCC4; (RefSeq) DNA repair endonuclease XPF\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"128141121 ERCC5; (RefSeq) DNA excision repair protein ERCC-5 isoform X1\tK10846 ERCC5; DNA excision repair protein ERCC-5"
					},
					{
						"name":"128146802 MMS19; (RefSeq) MMS19 nucleotide excision repair protein homolog isoform X1\tK15075 MET18; DNA repair\/transcription protein MET18\/MMS19"
					},
					{
						"name":"128146638 CCDC117; (RefSeq) coiled-coil domain-containing protein 117 isoform X1\tK27967 CCDC117; coiled-coil domain-containing protein 117"
					},
					{
						"name":"128149917 CIAO1; (RefSeq) probable cytosolic iron-sulfur protein assembly protein CIAO1\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"128145835 CIAO2B; (RefSeq) cytosolic iron-sulfur assembly component 2B\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"128151504 CIAO2A; (RefSeq) cytosolic iron-sulfur assembly component 2A isoform X1\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"128148774 CUL3; (RefSeq) cullin-3\tK03869 CUL3; cullin 3"
					},
					{
						"name":"128153251 CUL5; (RefSeq) cullin-5 isoform X1\tK10612 CUL5; cullin 5"
					},
					{
						"name":"128141781 ELOC; (RefSeq) elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"128146752 ELOB; (RefSeq) elongin-B\tK03873 ELOB; elongin-B"
					},
					{
						"name":"128151904 elongin-A-like isoform X1\tK15076 ELOA; elongin-A"
					},
					{
						"name":"128152687 ELOA; (RefSeq) elongin-A isoform X1\tK15076 ELOA; elongin-A"
					},
					{
						"name":"128136139 ubiquitin-associated protein 2-like isoform X1\tK26545 UBAP2; ubiquitin-associated protein 2"
					},
					{
						"name":"128136878 ubiquitin-associated protein 2-like isoform X1\tK26545 UBAP2; ubiquitin-associated protein 2"
					},
					{
						"name":"128145588 UBAP2L; (RefSeq) ubiquitin-associated protein 2-like isoform X1\tK26545 UBAP2; ubiquitin-associated protein 2"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"128150172 MSH2; (RefSeq) DNA mismatch repair protein Msh2\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"128136732 MSH3; (RefSeq) DNA mismatch repair protein Msh3\tK08736 MSH3; DNA mismatch repair protein MSH3"
					},
					{
						"name":"128150497 MSH6; (RefSeq) DNA mismatch repair protein Msh6 isoform X1\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"128143756 PMS1; (RefSeq) PMS1 protein homolog 1 isoform X1\tK10864 PMS1; DNA mismatch repair protein PMS1"
					},
					{
						"name":"128144326 MLH1; (RefSeq) DNA mismatch repair protein Mlh1 isoform X1\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"128134547 PMS2; (RefSeq) mismatch repair endonuclease PMS2\tK10858 PMS2; DNA mismatch repair protein PMS2"
					},
					{
						"name":"128139810 DNA mismatch repair protein Mlh3 isoform X1\tK08739 MLH3; DNA mismatch repair protein MLH3"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"128149934 POLD2; (RefSeq) LOW QUALITY PROTEIN: DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"128153404 POLD3; (RefSeq) DNA polymerase delta subunit 3 isoform X1\tK03504 POLD3; DNA polymerase delta subunit 3"
					},
					{
						"name":"128152831 POLD4; (RefSeq) DNA polymerase delta subunit 4\tK03505 POLD4; DNA polymerase delta subunit 4"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"128149276 RPA1; (RefSeq) replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"128152401 RPA2; (RefSeq) replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"128148086 RPA3; (RefSeq) replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"128138766 RFC1; (RefSeq) replication factor C subunit 1 isoform X1\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"128149056 RFC2; (RefSeq) replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"128149558 RFC4; (RefSeq) replication factor C subunit 4 isoform X1\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"128146579 RFC5; (RefSeq) replication factor C subunit 5 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"128153435 RFC3; (RefSeq) replication factor C subunit 3 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"128150375 PCNA; (RefSeq) proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"128150102 EXO1; (RefSeq) exonuclease 1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"128153338 HMGB1; (RefSeq) high mobility group protein B1\tK10802 HMGB1; high mobility group protein B1"
					},
					{
						"name":"128150874 WDR76; (RefSeq) WD repeat-containing protein 76\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"128153254 MRE11; (RefSeq) double-strand break repair protein MRE11 isoform X1\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"128155126 RAD50; (RefSeq) DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					},
					{
						"name":"128141831 NBN; (RefSeq) nibrin isoform X1\tK10867 NBN; nibrin"
					}
					]
				},
				{
					"name":"BRCA1-core complex",
					"children":[
					{
						"name":"128141042 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"128144399 BARD1; (RefSeq) BRCA1-associated RING domain protein 1\tK10683 BARD1; BRCA1-associated RING domain protein 1"
					}
					]
				},
				{
					"name":"BRCA1-A complex",
					"children":[
					{
						"name":"128141042 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"128134599 ABRAXAS1; (RefSeq) BRCA1-A complex subunit Abraxas 1 isoform X1\tK20774 FAM175A; BRCA1-A complex subunit Abraxas"
					},
					{
						"name":"128154921 UIMC1; (RefSeq) BRCA1-A complex subunit RAP80 isoform X1\tK20775 UIMC1; BRCA1-A complex subunit RAP80"
					},
					{
						"name":"128148500 BABAM1; (RefSeq) LOW QUALITY PROTEIN: BRISC and BRCA1-A complex member 1\tK20776 BABAM; BRISC and BRCA1-A complex member 1"
					},
					{
						"name":"128150291 BABAM2; (RefSeq) BRISC and BRCA1-A complex member 2 isoform X1\tK12173 BRE; BRCA1-A complex subunit BRE"
					},
					{
						"name":"128153865 BRCC3; (RefSeq) lys-63-specific deubiquitinase BRCC36 isoform X1\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
					}
					]
				},
				{
					"name":"BRCA1-B complex",
					"children":[
					{
						"name":"128141042 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"128148759 BRIP1; (RefSeq) Fanconi anemia group J protein isoform X1\tK15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]"
					},
					{
						"name":"128145167 TOPBP1; (RefSeq) DNA topoisomerase 2-binding protein 1\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
					}
					]
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"128141042 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"128142336 RBBP8; (RefSeq) DNA endonuclease RBBP8 isoform X1\tK20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]"
					},
					{
						"name":"128153254 MRE11; (RefSeq) double-strand break repair protein MRE11 isoform X1\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"128155126 RAD50; (RefSeq) DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					},
					{
						"name":"128141831 NBN; (RefSeq) nibrin isoform X1\tK10867 NBN; nibrin"
					}
					]
				},
				{
					"name":"BRCA complex",
					"children":[
					{
						"name":"128141042 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"128153214 BRCA2; (RefSeq) breast cancer type 2 susceptibility protein isoform X1\tK08775 BRCA2; breast cancer 2 susceptibility protein"
					},
					{
						"name":"128134633 PALB2; (RefSeq) partner and localizer of BRCA2 isoform X1\tK10897 PALB2; partner and localizer of BRCA2"
					},
					{
						"name":"128153046 RAD51; (RefSeq) DNA repair protein RAD51 homolog 1\tK04482 RAD51; DNA repair protein RAD51"
					}
					]
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"128153046 RAD51; (RefSeq) DNA repair protein RAD51 homolog 1\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"128139664 RAD51B; (RefSeq) DNA repair protein RAD51 homolog 2 isoform X1\tK10869 RAD51L1; RAD51-like protein 1"
					},
					{
						"name":"128148911 RAD51C; (RefSeq) DNA repair protein RAD51 homolog 3 isoform X1\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"128149416 RAD51D; (RefSeq) DNA repair protein RAD51 homolog 4 isoform X1\tK10871 RAD51L3; RAD51-like protein 3"
					},
					{
						"name":"128150710 XRCC2; (RefSeq) DNA repair protein XRCC2\tK10879 XRCC2; DNA-repair protein XRCC2"
					},
					{
						"name":"128140010 XRCC3; (RefSeq) DNA repair protein XRCC3 isoform X1\tK10880 XRCC3; DNA-repair protein XRCC3"
					}
					]
				},
				{
					"name":"Rad52 family proteins",
					"children":[
					{
						"name":"128142742 RAD52; (RefSeq) DNA repair protein RAD52 homolog isoform X1\tK10873 RAD52; DNA repair and recombination protein RAD52"
					},
					{
						"name":"128140781 RDM1; (RefSeq) RAD52 motif-containing protein 1 isoform X1\tK10874 RDM1; RAD52 motif-containing protein 1"
					}
					]
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"128147935 RAD54L; (RefSeq) DNA repair and recombination protein RAD54-like\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					},
					{
						"name":"128136505 RAD54L2; (RefSeq) helicase ARIP4 isoform X1\tK10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]"
					},
					{
						"name":"128142376 RAD54B; (RefSeq) DNA repair and recombination protein RAD54B\tK10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"128142750 RECQL; (RefSeq) ATP-dependent DNA helicase Q1 isoform X1\tK10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]"
					},
					{
						"name":"128153514 WRN; (RefSeq) bifunctional 3'-5' exonuclease\/ATP-dependent helicase WRN isoform X1\tK10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]"
					},
					{
						"name":"128151302 BLM; (RefSeq) recQ-like DNA helicase BLM isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"128141743 RECQL4; (RefSeq) LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
					},
					{
						"name":"128151545 RECQL5; (RefSeq) ATP-dependent DNA helicase Q5 isoform X1\tK10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"128151302 BLM; (RefSeq) recQ-like DNA helicase BLM isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"128134519 TOP3A; (RefSeq) DNA topoisomerase 3-alpha\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"128146581 TOP3B; (RefSeq) DNA topoisomerase 3-beta-1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"128136574 RMI1; (RefSeq) recQ-mediated genome instability protein 1\tK10990 RMI1; RecQ-mediated genome instability protein 1"
					},
					{
						"name":"128134727 RMI2; (RefSeq) recQ-mediated genome instability protein 2\tK15365 RMI2; RecQ-mediated genome instability protein 2"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"128149276 RPA1; (RefSeq) replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"128152401 RPA2; (RefSeq) replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"128148086 RPA3; (RefSeq) replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"128136010 PPP4C; (RefSeq) LOW QUALITY PROTEIN: serine\/threonine-protein phosphatase 4 catalytic subunit\tK15423 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"128141660 serine\/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1\tK15424 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1"
					},
					{
						"name":"128142103 PPP4R1; (RefSeq) serine\/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1\tK15424 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1"
					},
					{
						"name":"128136823 PPP4R2; (RefSeq) serine\/threonine-protein phosphatase 4 regulatory subunit 2\tK15425 PPP4R2; serine\/threonine-protein phosphatase 4 regulatory subunit 2"
					},
					{
						"name":"128139893 PPP4R3A; (RefSeq) serine\/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					},
					{
						"name":"128140366 PPP4R3B; (RefSeq) serine\/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					},
					{
						"name":"128139921 PPP4R4; (RefSeq) serine\/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1\tK15426 PPP4R4; serine\/threonine-protein phosphatase 4 regulatory subunit 4"
					}
					]
				},
				{
					"name":"AP-5 complex",
					"children":[
					{
						"name":"128140100 AP5M1; (RefSeq) AP-5 complex subunit mu-1\tK19023 AP5M1; AP-5 complex subunit mu-1"
					},
					{
						"name":"128139028 AP5S1; (RefSeq) AP-5 complex subunit sigma-1\tK19024 AP5S1; AP-5 complex subunit sigma-1"
					},
					{
						"name":"128134715 AP5Z1; (RefSeq) AP-5 complex subunit zeta-1 isoform X1\tK19025 AP5Z1; AP-5 complex subunit zeta-1"
					}
					]
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"128136866 SMC5; (RefSeq) structural maintenance of chromosomes protein 5 isoform X1\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"128151664 SMC6; (RefSeq) structural maintenance of chromosomes protein 6\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"128151978 LRATD1; (RefSeq) protein LRATD1\tK22805 FAM84A; protein FAM84A"
					},
					{
						"name":"128134588 NSMCE1; (RefSeq) non-structural maintenance of chromosomes element 1 homolog isoform X1\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
					},
					{
						"name":"128141910 NSMCE2; (RefSeq) E3 SUMO-protein ligase NSE2\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
					},
					{
						"name":"128137981 non-structural maintenance of chromosomes element 3 homolog\tK22823 NSMCE3; non-structural maintenance of chromosomes element 3"
					},
					{
						"name":"128146717 NSMCE4A; (RefSeq) non-structural maintenance of chromosomes element 4 homolog A\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					},
					{
						"name":"128137011 SLF1; (RefSeq) SMC5-SMC6 complex localization factor protein 1 isoform X1\tK26126 SLF1; SMC5-SMC6 complex localization factor protein 1"
					},
					{
						"name":"128147547 SLF2; (RefSeq) SMC5-SMC6 complex localization factor protein 2 isoform X1\tK26127 SLF2; SMC5-SMC6 complex localization factor protein 2"
					},
					{
						"name":"128154916 SIMC1; (RefSeq) SUMO-interacting motif-containing protein 1 isoform X1\tK28408 SIMC1; SUMO-interacting motif-containing protein 1"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"128150839 EME1; (RefSeq) crossover junction endonuclease EME1 isoform X1\tK10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]"
					},
					{
						"name":"128134762 EME2; (RefSeq) LOW QUALITY PROTEIN: probable crossover junction endonuclease EME2\tK10883 EME2; crossover junction endonuclease EME2"
					},
					{
						"name":"128139656 EXD2; (RefSeq) exonuclease 3'-5' domain-containing protein 2 isoform X1\tK20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]"
					},
					{
						"name":"128148160 SEM1; (RefSeq) 26S proteasome complex subunit SEM1\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"128154163 SWI5; (RefSeq) DNA repair protein SWI5 homolog\tK10991 SWI5; DNA repair protein Swi5\/Sae3"
					},
					{
						"name":"128147134 SFR1; (RefSeq) swi5-dependent recombination DNA repair protein 1 homolog\tK10992 SFR1; Swi5-dependent recombination DNA repair protein 1"
					},
					{
						"name":"128134920 SLX4; (RefSeq) structure-specific endonuclease subunit SLX4 isoform X1\tK10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB\/POZ domain-containing protein 12)"
					},
					{
						"name":"128151908 GEN1; (RefSeq) flap endonuclease GEN homolog 1 isoform X1\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"128151499 SPG11; (RefSeq) spatacsin isoform X1\tK19026 SPG11; spatacsin"
					},
					{
						"name":"128139671 ZFYVE26; (RefSeq) zinc finger FYVE domain-containing protein 26 isoform X1\tK19027 ZFYVE26; zinc finger FYVE domain-containing protein 26"
					},
					{
						"name":"128142608 RAD51AP1; (RefSeq) RAD51-associated protein 1\tK20778 RAD51AP1; RAD51-associated protein 1"
					},
					{
						"name":"128154316 NUCKS1; (RefSeq) nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1\tK28888 NUCKS1; nuclear ubiquitous casein and cyclin-dependent kinase substrate 1"
					},
					{
						"name":"128150789 MORF4L1; (RefSeq) mortality factor 4-like protein 1 isoform X1\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"128143743 SAMHD1; (RefSeq) deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1\tK22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]"
					},
					{
						"name":"128142191 FIGNL1; (RefSeq) fidgetin-like protein 1\tK22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"
					},
					{
						"name":"128141800 SPIDR; (RefSeq) DNA repair-scaffolding protein isoform X1\tK22806 SPIDR; DNA repair-scaffolding protein"
					},
					{
						"name":"128142132 LRATD2; (RefSeq) protein LRATD2\tK22810 FAM84B; protein FAM84B"
					},
					{
						"name":"128134792 BRAT1; (RefSeq) BRCA1-associated ATM activator 1 isoform X1\tK23112 BRAT1; BRCA1-associated ATM activator 1"
					},
					{
						"name":"128149401 CFAP410; (RefSeq) cilia- and flagella-associated protein 410\tK23456 CFAP410; cilla- and flagella-associated protein"
					},
					{
						"name":"128148217 HDGFL2; (RefSeq) hepatoma-derived growth factor-related protein 2 isoform X1\tK25065 HDGFL2; hepatoma-derived growth factor-related protein 2"
					},
					{
						"name":"128148830 ZSWIM7; (RefSeq) zinc finger SWIM domain-containing protein 7 isoform X1\tK25770 ZSWIM7; zinc finger SWIM domain-containing protein 7"
					},
					{
						"name":"128153277 EMSY; (RefSeq) BRCA2-interacting transcriptional repressor EMSY isoform X1\tK25790 EMSY; BRCA2-interacting transcriptional repressor EMSY"
					},
					{
						"name":"128145264 HSF2BP; (RefSeq) heat shock factor 2-binding protein isoform X1\tK25791 HSF2BP; heat shock factor 2-binding protein"
					},
					{
						"name":"128139290 MMS22L; (RefSeq) protein MMS22-like\tK26125 MMS22L; protein MMS22-like"
					},
					{
						"name":"128142319 TONSL; (RefSeq) LOW QUALITY PROTEIN: tonsoku-like protein\tK09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2"
					},
					{
						"name":"128138845 BOD1L1; (RefSeq) biorientation of chromosomes in cell division protein 1-like 1 isoform X1\tK27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1"
					},
					{
						"name":"128143198 PARPBP; (RefSeq) PCNA-interacting partner\tK27412 PARPBP; PCNA-interacting partner"
					},
					{
						"name":"128140834 HROB; (RefSeq) homologous recombination OB-fold protein isoform X1\tK27803 HROB; homologous recombination OB-fold protein"
					},
					{
						"name":"128141117 MCM8; (RefSeq) DNA helicase MCM8\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
					},
					{
						"name":"128139174 MCM9; (RefSeq) DNA helicase MCM9\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
					},
					{
						"name":"128134511 MRNIP; (RefSeq) MRN complex-interacting protein isoform X1\tK28623 MRNIP; MRN complex-interacting protein"
					},
					{
						"name":"128153744 RADX; (RefSeq) RPA-related protein RADX\tK29002 RADX; RPA-related protein RADX"
					},
					{
						"name":"128136382 RBM6; (RefSeq) RNA-binding protein 6 isoform X1\tK29038 RBM6; RNA-binding protein 6"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex",
					"children":[
					{
						"name":"128142957 XRCC6; (RefSeq) X-ray repair cross-complementing protein 6\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"128143942 XRCC5; (RefSeq) X-ray repair cross-complementing protein 5 isoform X1\tK10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2"
					},
					{
						"name":"128142532 PRKDC; (RefSeq) DNA-dependent protein kinase catalytic subunit isoform X1\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
					}
					]
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"128153254 MRE11; (RefSeq) double-strand break repair protein MRE11 isoform X1\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"128155126 RAD50; (RefSeq) DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"128141105 LIG4; (RefSeq) DNA ligase 4\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					},
					{
						"name":"128136370 XRCC4; (RefSeq) DNA repair protein XRCC4 isoform X1\tK10886 XRCC4; DNA-repair protein XRCC4"
					},
					{
						"name":"128144427 NHEJ1; (RefSeq) non-homologous end-joining factor 1\tK10980 NHEJ1; non-homologous end-joining factor 1"
					}
					]
				},
				{
					"name":"X-family DNA polymerases",
					"children":[
					{
						"name":"128147032 POLL; (RefSeq) DNA polymerase lambda isoform X1\tK03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"128147533 DNTT; (RefSeq) DNA nucleotidylexotransferase\tK00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]"
					},
					{
						"name":"128150267 POLB; (RefSeq) DNA polymerase beta\tK02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]"
					}
					]
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"128136772 APTX; (RefSeq) aprataxin\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"128140437 APLF; (RefSeq) aprataxin and PNK-like factor isoform X1\tK13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]"
					},
					{
						"name":"128142863 DCLRE1C; (RefSeq) protein artemis\tK10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]"
					},
					{
						"name":"128141931 TDP2; (RefSeq) tyrosyl-DNA phosphodiesterase 2\tK19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]"
					},
					{
						"name":"128142511 SMCHD1; (RefSeq) structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1\tK23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1"
					},
					{
						"name":"128148071 PWWP3A; (RefSeq) PWWP domain-containing DNA repair factor 3A\tK23386 PWWP3; PWWP domain-containing DNA repair factor 3"
					},
					{
						"name":"128154544 PAXX; (RefSeq) protein PAXX isoform X1\tK25772 PAXX; protein PAXX"
					},
					{
						"name":"128135425 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135629 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135634 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135640 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135658 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135671 LOW QUALITY PROTEIN: cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135672 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135673 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135674 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135677 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135678 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135681 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135682 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135683 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128135687 cell cycle regulator of non-homologous end joining-like\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"128134773 JMJD8; (RefSeq) jmjC domain-containing protein 8\tK25792 JMJD8; jumonji domain-containing protein 8"
					},
					{
						"name":"128140485 SHLD1; (RefSeq) shieldin complex subunit 1 isoform X1\tK26128 SHLD1; shieldin complex subunit 1"
					},
					{
						"name":"128146895 SHLD2; (RefSeq) shieldin complex subunit 2 isoform X1\tK26129 SHLD2; shieldin complex subunit 2"
					},
					{
						"name":"128137655 SHLD3; (RefSeq) shieldin complex subunit 3\tK26130 SHLD3; shieldin complex subunit 3"
					},
					{
						"name":"128138752 BEND4; (RefSeq) BEN domain-containing protein 4 isoform X1\tK27845 BEND4; BEN domain-containing protein 4"
					},
					{
						"name":"128143961 IFFO2; (RefSeq) intermediate filament family orphan 2 isoform X1\tK28738 IFFO; non-homologous end joining factor IFFO"
					},
					{
						"name":"128144873 IFFO1; (RefSeq) LOW QUALITY PROTEIN: non-homologous end joining factor IFFO1\tK28738 IFFO; non-homologous end joining factor IFFO"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex",
					"children":[
					{
						"name":"128145792 FANCA; (RefSeq) Fanconi anemia group A protein\tK10888 FANCA; fanconi anemia group A protein"
					},
					{
						"name":"128135283 FANCB; (RefSeq) Fanconi anemia group B protein\tK10889 FANCB; fanconi anemia group B protein"
					},
					{
						"name":"128137646 FANCC; (RefSeq) Fanconi anemia group C protein\tK10890 FANCC; fanconi anemia group C protein"
					},
					{
						"name":"128154336 FANCE; (RefSeq) Fanconi anemia group E protein isoform X1\tK10892 FANCE; fanconi anemia group E protein"
					},
					{
						"name":"128152763 FANCF; (RefSeq) Fanconi anemia group F protein\tK10893 FANCF; fanconi anemia group F protein"
					},
					{
						"name":"128137352 FANCG; (RefSeq) Fanconi anemia group G protein isoform X1\tK10894 FANCG; fanconi anemia group G protein"
					},
					{
						"name":"128140374 FANCL; (RefSeq) E3 ubiquitin-protein ligase FANCL isoform X1\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
					},
					{
						"name":"128140166 FANCM; (RefSeq) Fanconi anemia group M protein isoform X1\tK10896 FANCM; fanconi anemia group M protein"
					},
					{
						"name":"128146101 FAAP24; (RefSeq) Fanconi anemia core complex-associated protein 24\tK10898 FAAP24; fanconi anemia-associated protein"
					},
					{
						"name":"128151227 FAAP100; (RefSeq) LOW QUALITY PROTEIN: Fanconi anemia core complex-associated protein 100\tK10993 FAAP100; fanconi anemia core complex 100 kDa subunit"
					}
					]
				},
				{
					"name":"FA core complex binding factors",
					"children":[
					{
						"name":"128144523 HES4; (RefSeq) transcription factor HES-4 isoform X1\tK06054 HES1; hairy and enhancer of split 1"
					},
					{
						"name":"128149545 HES1; (RefSeq) LOW QUALITY PROTEIN: transcription factor HES-1\tK06054 HES1; hairy and enhancer of split 1"
					},
					{
						"name":"128143935 CENPS; (RefSeq) centromere protein S\tK11511 APITD1; centromere protein S"
					},
					{
						"name":"128151067 CENPX; (RefSeq) centromere protein X\tK15360 STRA13; centromere protein X"
					},
					{
						"name":"128154442 UBE2T; (RefSeq) ubiquitin-conjugating enzyme E2 T\tK13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"128151302 BLM; (RefSeq) recQ-like DNA helicase BLM isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"128134519 TOP3A; (RefSeq) DNA topoisomerase 3-alpha\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"128146581 TOP3B; (RefSeq) DNA topoisomerase 3-beta-1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"128136574 RMI1; (RefSeq) recQ-mediated genome instability protein 1\tK10990 RMI1; RecQ-mediated genome instability protein 1"
					},
					{
						"name":"128134727 RMI2; (RefSeq) recQ-mediated genome instability protein 2\tK15365 RMI2; RecQ-mediated genome instability protein 2"
					}
					]
				},
				{
					"name":"FANCD2-I complex",
					"children":[
					{
						"name":"128137105 FANCD2; (RefSeq) Fanconi anemia group D2 protein isoform X1\tK10891 FANCD2; fanconi anemia group D2 protein"
					},
					{
						"name":"128150943 FANCI; (RefSeq) Fanconi anemia group I protein isoform X1\tK10895 FANCI; fanconi anemia group I protein"
					}
					]
				},
				{
					"name":"Downstream FA components",
					"children":[
					{
						"name":"128141042 BRCA1; (RefSeq) breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"128153214 BRCA2; (RefSeq) breast cancer type 2 susceptibility protein isoform X1\tK08775 BRCA2; breast cancer 2 susceptibility protein"
					},
					{
						"name":"128148759 BRIP1; (RefSeq) Fanconi anemia group J protein isoform X1\tK15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]"
					},
					{
						"name":"128134633 PALB2; (RefSeq) partner and localizer of BRCA2 isoform X1\tK10897 PALB2; partner and localizer of BRCA2"
					}
					]
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"128151002 FAN1; (RefSeq) fanconi-associated nuclease 1 isoform X1\tK15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]"
					},
					{
						"name":"128153046 RAD51; (RefSeq) DNA repair protein RAD51 homolog 1\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"128148911 RAD51C; (RefSeq) DNA repair protein RAD51 homolog 3 isoform X1\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"128134745 TELO2; (RefSeq) telomere length regulation protein TEL2 homolog isoform X1\tK11137 TELO2; telomere length regulation protein"
					},
					{
						"name":"128148610 USP1; (RefSeq) ubiquitin carboxyl-terminal hydrolase 1\tK11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]"
					},
					{
						"name":"128150869 WDR48; (RefSeq) WD repeat-containing protein 48\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6",
					"children":[
					{
						"name":"128154809 PPP6C; (RefSeq) serine\/threonine-protein phosphatase 6 catalytic subunit\tK15498 PPP6C; serine\/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"128143291 PPP6R2; (RefSeq) serine\/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1\tK15500 PPP6R2; serine\/threonine-protein phosphatase 6 regulatory subunit 2"
					},
					{
						"name":"128152299 serine\/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1\tK15501 PPP6R3; serine\/threonine-protein phosphatase 6 regulatory subunit 3"
					},
					{
						"name":"128153058 serine\/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1\tK15501 PPP6R3; serine\/threonine-protein phosphatase 6 regulatory subunit 3"
					},
					{
						"name":"128146916 ANKRD28; (RefSeq) serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1\tK15502 ANKRD28; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A"
					},
					{
						"name":"128143889 ANKRD44; (RefSeq) serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1\tK15503 ANKRD44; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B"
					},
					{
						"name":"128152093 ANKRD52; (RefSeq) serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C\tK15504 ANKRD52; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C"
					}
					]
				},
				{
					"name":"Ubiquitin ligases",
					"children":[
					{
						"name":"128149108 RNF168; (RefSeq) E3 ubiquitin-protein ligase RNF168\tK20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]"
					},
					{
						"name":"128153313 RNF169; (RefSeq) E3 ubiquitin-protein ligase RNF169\tK20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]"
					},
					{
						"name":"128135259 HERC2; (RefSeq) E3 ubiquitin-protein ligase HERC2 isoform X1\tK10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"128150406 WRAP53; (RefSeq) LOW QUALITY PROTEIN: telomerase Cajal body protein 1\tK23314 WRAP53; telomerase Cajal body protein 1"
					},
					{
						"name":"128154287 TPRN; (RefSeq) taperin isoform X1\tK24164 TPRN; taperin"
					},
					{
						"name":"128136368 WDR70; (RefSeq) WD repeat-containing protein 70\tK24752 WDR70; WD repeat-containing protein 70"
					},
					{
						"name":"128150874 WDR76; (RefSeq) WD repeat-containing protein 76\tK24755 WDR76; WD repeat-containing protein 76"
					},
					{
						"name":"128136490 HMCES; (RefSeq) abasic site processing protein HMCES\tK28434 HMCES; abasic site processing protein HMCES"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"128149816 POLH; (RefSeq) DNA polymerase eta\tK03509 POLH; DNA polymerase eta [EC:2.7.7.7]"
				},
				{
					"name":"128136764 POLI; (RefSeq) DNA polymerase iota isoform X1\tK03510 POLI; DNA polymerase iota [EC:2.7.7.7]"
				},
				{
					"name":"128137057 POLK; (RefSeq) DNA polymerase kappa isoform X1\tK03511 POLK; DNA polymerase kappa [EC:2.7.7.7]"
				},
				{
					"name":"128135083 REV1; (RefSeq) DNA repair protein REV1 isoform X1\tK03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases",
				"children":[
				{
					"name":"128139203 REV3L; (RefSeq) DNA polymerase zeta catalytic subunit isoform X1\tK02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"A-family DNA polymerase",
				"children":[
				{
					"name":"128138927 POLN; (RefSeq) DNA polymerase nu\tK16618 POLN; DNA polymerase nu [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"128153636 UBE2A; (RefSeq) ubiquitin-conjugating enzyme E2 A isoform X1\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"128155044 UBE2B; (RefSeq) ubiquitin-conjugating enzyme E2 B isoform X1\tK10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]"
				},
				{
					"name":"128137120 RAD18; (RefSeq) E3 ubiquitin-protein ligase RAD18 isoform X1\tK10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"
				},
				{
					"name":"128149640 HLTF; (RefSeq) helicase-like transcription factor isoform X1\tK15711 SMARCA3; SWI\/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]"
				},
				{
					"name":"128141806 UBE2V2; (RefSeq) ubiquitin-conjugating enzyme E2 variant 2 isoform X1\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"128142155 UBE2V1; (RefSeq) ubiquitin-conjugating enzyme E2 variant 1 isoform X1\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"128135558 UBE2N; (RefSeq) ubiquitin-conjugating enzyme E2 N\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"128150375 PCNA; (RefSeq) proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"128151294 PCLAF; (RefSeq) PCNA-associated factor\tK28763 PCLAF; PCNA-associated factor"
				},
				{
					"name":"128143198 PARPBP; (RefSeq) PCNA-interacting partner\tK27412 PARPBP; PCNA-interacting partner"
				},
				{
					"name":"128149809 SPRTN; (RefSeq) DNA-dependent metalloprotease SPRTN\tK24051 SPRTN; SprT-like domain-contaning protein Spartan"
				},
				{
					"name":"128153644 GCNA; (RefSeq) germ cell nuclear acidic protein isoform X1\tK26957 GCNA; germ cell nuclear acidic protein"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"128152879 RAD9A; (RefSeq) cell cycle checkpoint control protein RAD9A\tK10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]"
				},
				{
					"name":"128145611 RAD9B; (RefSeq) cell cycle checkpoint control protein RAD9B isoform X1\tK10995 RAD9B; cell cycle checkpoint control protein RAD9B"
				},
				{
					"name":"128145388 HUS1; (RefSeq) checkpoint protein HUS1\tK10903 HUS1; HUS1 checkpoint protein"
				},
				{
					"name":"128136221 RAD1; (RefSeq) cell cycle checkpoint protein RAD1\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"128137411 RAD17; (RefSeq) cell cycle checkpoint protein RAD17 isoform X1\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"128149056 RFC2; (RefSeq) replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"128149558 RFC4; (RefSeq) replication factor C subunit 4 isoform X1\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"128146579 RFC5; (RefSeq) replication factor C subunit 5 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"128153435 RFC3; (RefSeq) replication factor C subunit 3 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"128136221 RAD1; (RefSeq) cell cycle checkpoint protein RAD1\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"128152088 TIMELESS; (RefSeq) protein timeless homolog isoform X1\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				},
				{
					"name":"128150732 TIPIN; (RefSeq) TIMELESS-interacting protein isoform X1\tK10998 TIPIN; replication fork protection complex subunit TIPIN\/Csm3\/Swi3"
				},
				{
					"name":"128152850 CLSPN; (RefSeq) claspin isoform X1\tK25773 CLSPN; claspin"
				}
				]
			},
			{
				"name":"Triple T complex",
				"children":[
				{
					"name":"128134745 TELO2; (RefSeq) telomere length regulation protein TEL2 homolog isoform X1\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"128139942 TTI1; (RefSeq) TELO2-interacting protein 1 homolog isoform X1\tK20403 TTI1; TELO2-interacting protein 1"
				},
				{
					"name":"128150303 TTI2; (RefSeq) TELO2-interacting protein 2 isoform X1\tK23115 TTI2; TELO2-interacting protein 2"
				}
				]
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"128135816 BAG6; (RefSeq) LOW QUALITY PROTEIN: large proline-rich protein BAG6\tK23390 BAG6; large proline-rich protein BAG6"
				},
				{
					"name":"128134785 GET4; (RefSeq) Golgi to ER traffic protein 4 homolog isoform X1\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex",
				"children":[
				{
					"name":"128145915 INTS3; (RefSeq) integrator complex subunit 3\tK13140 INTS3; integrator complex subunit 3 (SOSS complex subunit A)"
				},
				{
					"name":"128144222 NABP1; (RefSeq) SOSS complex subunit B2 isoform X1\tK28889 NABP; SOSS complex subunit B"
				},
				{
					"name":"128152132 NABP2; (RefSeq) LOW QUALITY PROTEIN: SOSS complex subunit B1\tK28889 NABP; SOSS complex subunit B"
				},
				{
					"name":"128136461 INIP; (RefSeq) SOSS complex subunit C\tK28890 INIP; SOSS complex subunit C"
				}
				]
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"128148761 ATR; (RefSeq) serine\/threonine-protein kinase ATR isoform X1\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]"
				},
				{
					"name":"128137817 ATRIP; (RefSeq) ATR-interacting protein isoform X1\tK10905 ATRIP; ATR interacting protein"
				},
				{
					"name":"128140448 ETAA1; (RefSeq) ewing's tumor-associated antigen 1\tK28856 ETAA1; Ewing's tumor-associated antigen 1"
				},
				{
					"name":"128153250 ATM; (RefSeq) serine-protein kinase ATM isoform X1\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"128141511 CHEK1; (RefSeq) serine\/threonine-protein kinase Chk1\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]"
				},
				{
					"name":"128146634 CHEK2; (RefSeq) serine\/threonine-protein kinase Chk2 isoform X1\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]"
				},
				{
					"name":"128151729 CDC25A; (RefSeq) M-phase inducer phosphatase 1 isoform X1\tK06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]"
				},
				{
					"name":"128139026 CDC25B; (RefSeq) LOW QUALITY PROTEIN: M-phase inducer phosphatase 2\tK05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]"
				},
				{
					"name":"128141911 YWHAZ; (RefSeq) 14-3-3 protein zeta\/delta\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"128142725 YWHAB; (RefSeq) 14-3-3 protein beta\/alpha\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"128151830 YWHAQ; (RefSeq) 14-3-3 protein theta\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"128145931 YWHAH; (RefSeq) 14-3-3 protein eta\tK16198 YWHAG_H; 14-3-3 protein gamma\/eta"
				},
				{
					"name":"128149078 YWHAG; (RefSeq) 14-3-3 protein gamma\tK16198 YWHAG_H; 14-3-3 protein gamma\/eta"
				},
				{
					"name":"128149042 YWHAE; (RefSeq) 14-3-3 protein epsilon isoform X1\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"128152641 NAV2; (RefSeq) neuron navigator 2 isoform X1\tK19483 NAV2; neuron navigator 2 [EC:5.6.2.4]"
				},
				{
					"name":"128142633 WEE2; (RefSeq) wee1-like protein kinase 2\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
				},
				{
					"name":"128152998 WEE1; (RefSeq) wee1-like protein kinase isoform X1\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
				},
				{
					"name":"128148771 PER2; (RefSeq) period circadian protein homolog 2 isoform X1\tK02633 PER2; period circadian protein 2"
				},
				{
					"name":"128143939 PER3; (RefSeq) period circadian protein homolog 3 isoform X1\tK21945 PER3; period circadian protein 3"
				},
				{
					"name":"128153786 PLS3; (RefSeq) plastin-3 isoform X1\tK17336 PLS3; plastin-3"
				},
				{
					"name":"128151423 apoptosis-enhancing nuclease-like isoform X1\tK18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]"
				},
				{
					"name":"128148313 PLK3; (RefSeq) serine\/threonine-protein kinase PLK3\tK08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]"
				},
				{
					"name":"128136963 NEK4; (RefSeq) serine\/threonine-protein kinase Nek4 isoform X1\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"128137727 NEK1; (RefSeq) serine\/threonine-protein kinase Nek1 isoform X1\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"128141465 NEK5; (RefSeq) serine\/threonine-protein kinase Nek5 isoform X1\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"128146394 NEK10; (RefSeq) serine\/threonine-protein kinase Nek10 isoform X1\tK20879 NEK10; serine\/threonine-protein kinase Nek10 [EC:2.7.11.1]"
				},
				{
					"name":"128145093 DONSON; (RefSeq) protein downstream neighbor of Son\tK22422 DONSON; protein downstream neighbor of Son"
				},
				{
					"name":"128137023 KANK1; (RefSeq) KN motif and ankyrin repeat domain-containing protein 1 isoform X1\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"128147921 KANK3; (RefSeq) KN motif and ankyrin repeat domain-containing protein 3 isoform X1\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"128148120 KANK4; (RefSeq) KN motif and ankyrin repeat domain-containing protein 4 isoform X1\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"128149189 LOW QUALITY PROTEIN: schlafen family member 11-like\tK24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]"
				},
				{
					"name":"128141899 CHMP4C; (RefSeq) charged multivesicular body protein 4c\tK24782 CHMP4C; charged multivesicular body protein 4C"
				},
				{
					"name":"128138901 VPS4B; (RefSeq) vacuolar protein sorting-associated protein 4B\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"128146431 VPS4A; (RefSeq) vacuolar protein sorting-associated protein 4A isoform X1\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"128139550 ZFYVE19; (RefSeq) abscission\/NoCut checkpoint regulator\tK24778 ZFYVE19; abscission\/NoCut checkpoint regulator"
				},
				{
					"name":"128150288 SDE2; (RefSeq) splicing regulator SDE2\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"128142784 BLCAP; (RefSeq) bladder cancer-associated protein\tK29062 BLCAP; apoptosis inducing factor BLCAP"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases",
				"children":[
				{
					"name":"128145119 POLQ; (RefSeq) DNA polymerase theta\tK02349 POLQ; DNA polymerase theta [EC:2.7.7.7]"
				},
				{
					"name":"128149054 MYBBP1A; (RefSeq) myb-binding protein 1A isoform X1\tK02331 POL5; DNA polymerase phi [EC:2.7.7.7]"
				},
				{
					"name":"128138572 PRIMPOL; (RefSeq) DNA-directed primase\/polymerase protein isoform X1\tK22761 PRIMPOL; DNA-directed primase\/polymerase protein [EC:2.7.7.102 2.7.7.7]"
				}
				]
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"128147230 DCLRE1A; (RefSeq) DNA cross-link repair 1A protein isoform X1\tK15340 DCLRE1A; DNA cross-link repair 1A protein"
				},
				{
					"name":"128154385 DCLRE1B; (RefSeq) 5' exonuclease Apollo\tK15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]"
				},
				{
					"name":"128151155 ENDOV; (RefSeq) endonuclease V isoform X1\tK21813 ENDOV; endonuclease V [EC:3.1.26.-]"
				},
				{
					"name":"128144243 ZRANB3; (RefSeq) DNA annealing helicase and endonuclease ZRANB3 isoform X1\tK25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]"
				},
				{
					"name":"128148142 ANKLE1; (RefSeq) ankyrin repeat and LEM domain-containing protein 1\tK21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1"
				}
				]
			},
			{
				"name":"Helicases",
				"children":[
				{
					"name":"128134585 HELQ; (RefSeq) helicase POLQ-like isoform X1\tK19178 HELQ; POLQ-like helicase [EC:5.6.2.4]"
				},
				{
					"name":"128136389 ERCC6L2; (RefSeq) DNA excision repair protein ERCC-6-like 2 isoform X1\tK20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]"
				}
				]
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"128152631 PRPF19; (RefSeq) pre-mRNA-processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"128151900 CDC5L; (RefSeq) cell division cycle 5-like protein isoform X1\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"128154178 BCAS2; (RefSeq) pre-mRNA-splicing factor SPF27 isoform X1\tK12861 BCAS2; pre-mRNA-splicing factor SPF27"
				},
				{
					"name":"128137088 PLRG1; (RefSeq) pleiotropic regulator 1\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"128141422 NUDT15; (RefSeq) LOW QUALITY PROTEIN: nucleotide triphosphate diphosphatase NUDT15\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"128134750 NUDT1; (RefSeq) oxidized purine nucleoside triphosphate hydrolase isoform X1\tK17816 NUDT1; 8-oxo-dGTP diphosphatase \/ 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]"
				},
				{
					"name":"128150398 NUDT18; (RefSeq) LOW QUALITY PROTEIN: 8-oxo-dGDP phosphatase NUDT18\tK17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]"
				},
				{
					"name":"128151551 DUT; (RefSeq) deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"128153309 RRM1; (RefSeq) ribonucleoside-diphosphate reductase large subunit isoform X1\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"128142025 RRM2B; (RefSeq) ribonucleoside-diphosphate reductase subunit M2 B isoform X1\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				},
				{
					"name":"128152164 RRM2; (RefSeq) ribonucleoside-diphosphate reductase subunit M2\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"128147208 MGMT; (RefSeq) methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"128149521 deoxyribodipyrimidine photo-lyase-like\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"128146355 UNG; (RefSeq) uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"128151814 SMUG1; (RefSeq) single-strand selective monofunctional uracil DNA glycosylase\tK10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]"
					},
					{
						"name":"128134918 MPG; (RefSeq) DNA-3-methyladenine glycosylase\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"128147716 MUTYH; (RefSeq) adenine DNA glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"128134582 NTHL1; (RefSeq) endonuclease III-like protein 1 isoform X1\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors"
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"128142636 SSBP1; (RefSeq) single-stranded DNA-binding protein, mitochondrial isoform X1\tK03111 ssb; single-strand DNA-binding protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"128142636 SSBP1; (RefSeq) single-stranded DNA-binding protein, mitochondrial isoform X1\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"128141422 NUDT15; (RefSeq) LOW QUALITY PROTEIN: nucleotide triphosphate diphosphatase NUDT15\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"128151551 DUT; (RefSeq) deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}