{
	"name":"hin03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III"
			},
			{
				"name":"Cytochrome c oxidase"
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase"
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"HI_1284 translation initiation factor 2 (infB)\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"HI_1318 translation initiation factor 3 (infC)\tK02520 infC; translation initiation factor IF-3"
				},
				{
					"name":"HI_0914 elongation factor Ts (tsf)\tK02357 tsf; elongation factor Ts"
				},
				{
					"name":"HI_0578 elongation factor Tu (tufA)\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"HI_0632 elongation factor Tu (tufB)\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"HI_0579 elongation factor G (fusA)\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP"
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"HI_0013 GTP-binding protein (era)\tK03595 era; GTPase"
				},
				{
					"name":"HI_1610 tyrosyl tRNA synthetase (tyrS)\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"HI_0921 leucyl-tRNA synthetase (leuS)\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"HI_0317 aspartyl-tRNA synthetase (aspS)\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"HI_1583 arginyl-tRNA synthetase (argS)\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors"
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"HI_0250 single-stranded DNA binding protein (ssb)\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors"
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex"
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"HI_0917 protective surface antigen D15\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex"
			},
			{
				"name":"TIM8\/13 complex"
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex"
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex"
			},
			{
				"name":"TIM23 complex"
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors"
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"HI_1237 heat shock protein 70 (dnaK)\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"HI_0071 heat shock protein (grpE)\tK03687 GRPE; molecular chaperone GrpE"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"HI_0543 heat shock protein (groEL)\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"HI_0542 chaperonin (groES)\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"HI_1238 heat shock protein (dnaJ)\tK03686 dnaJ; molecular chaperone DnaJ"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"HI_0579 elongation factor G (fusA)\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"HI_0378 nifS protein (nifS)\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"HI_1237 heat shock protein 70 (dnaK)\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"HI_0375 conserved hypothetical protein\tK04082 hscB; molecular chaperone HscB"
				},
				{
					"name":"HI_1165 conserved hypothetical protein\tK07390 grxD; monothiol glutaredoxin"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis"
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors",
				"children":[
				{
					"name":"HI_1277 ATP-binding protein (mrp)\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				}
				]
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors"
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"HI_1001 inner membrane protein, 60 kDa (yidC)\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				}
				]
			},
			{
				"name":"Complex-V assembly factors"
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors"
			},
			{
				"name":"Actin cytoskeleton organization"
			},
			{
				"name":"Mitochondrial movement"
			},
			{
				"name":"Retention of mitochondria"
			},
			{
				"name":"Morphogenesis factors"
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins"
			},
			{
				"name":"Parkin-dependent mechanism factors"
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"HI_0104 heat shock protein (htpG)\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors"
			}
			]
		}
		]
	}
	]
}