{
	"name":"hmc03000",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Basic leucine zipper (bZIP)",
			"children":[
			{
				"name":"AP-1(-like) components, Jun"
			},
			{
				"name":"AP-1(-like) components, Fos"
			},
			{
				"name":"AP-1(-like) components, Maf"
			},
			{
				"name":"AP-1(-like) components, NF-E2"
			},
			{
				"name":"AP-1(-like) components, Fungal regulators"
			},
			{
				"name":"AP-1(-like) components, CRE-BP\/ATF"
			},
			{
				"name":"CREB"
			},
			{
				"name":"C\/EBP-like factors"
			},
			{
				"name":"bZIP\/PAR"
			},
			{
				"name":"Plant bZIP factors"
			},
			{
				"name":"ZIP only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix (bHLH)",
			"children":[
			{
				"name":"Ubiquitous (class A) factors"
			},
			{
				"name":"Myogenic transcription factors"
			},
			{
				"name":"Achaete-Scute"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Lymphoid factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesodermal Twist-like factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, HEN"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesp"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Atonal"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Pancreatic factors"
			},
			{
				"name":"Hairy, Hairy\/E(SPL)"
			},
			{
				"name":"Hairy, Fungal regulators"
			},
			{
				"name":"Factors with PAS domain"
			},
			{
				"name":"Yabby"
			},
			{
				"name":"INO"
			},
			{
				"name":"HLH domain only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix\/leucine zipper (bHLH-ZIP)",
			"children":[
			{
				"name":"Ubiquitous bHLH-ZIP factors"
			},
			{
				"name":"Cell cycle controlling factors, Myc"
			},
			{
				"name":"Cell cycle controlling factors, Mad\/Max"
			},
			{
				"name":"Other bHLH-ZIP factors"
			}
			]
		},
		{
			"name":"Other basic domains",
			"children":[
			{
				"name":"NF-1"
			},
			{
				"name":"RF-X"
			},
			{
				"name":"AP-2 (bHSH)"
			}
			]
		},
		{
			"name":"Zinc finger",
			"children":[
			{
				"name":"Cys4 thyroid hormone receptor-like"
			},
			{
				"name":"Cys4 hepatocyte nuclear factor 4-like"
			},
			{
				"name":"Cys4 estrogen receptor-like"
			},
			{
				"name":"Cys4 nerve growth factor IB-like"
			},
			{
				"name":"Cys4 Fushi tarazu-F1-like"
			},
			{
				"name":"Cys4 germ cell nuclear factor"
			},
			{
				"name":"Cys4 Knirps\/DAX1-like"
			},
			{
				"name":"Cys4 GATA-factors"
			},
			{
				"name":"Cys2His2 SP\/KLF family and related proteins"
			},
			{
				"name":"Cys2His2 GLI-like"
			},
			{
				"name":"Cys2His2 Snail"
			},
			{
				"name":"Cys2His2 BTB-ZF factors"
			},
			{
				"name":"Cys2His2 BED"
			},
			{
				"name":"Cys2His2 PRDM"
			},
			{
				"name":"Cys2His2 metabolic regulators in fungi"
			},
			{
				"name":"Cys2His2 others"
			},
			{
				"name":"Cys2HisCys zinc factors"
			},
			{
				"name":"Cys3His zinc factors"
			},
			{
				"name":"Cys2CysHis zinc factors"
			},
			{
				"name":"CXXC CpG-binding proteins"
			},
			{
				"name":"Cys6 metabolic regulators in fungi"
			},
			{
				"name":"Other zinc fingers"
			}
			]
		},
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"Homeo domain ANTP: HOXL"
			},
			{
				"name":"Homeo domain ANTP: NKL"
			},
			{
				"name":"Homeo domain Paired-related"
			},
			{
				"name":"Homeo domain LIM"
			},
			{
				"name":"Homeo domain POU"
			},
			{
				"name":"Homeo domain SINE"
			},
			{
				"name":"Homeo domain ZF"
			},
			{
				"name":"Homeo domain CUT"
			},
			{
				"name":"Homeo domain PROS"
			},
			{
				"name":"Homeo domain TALE"
			},
			{
				"name":"Homeo domain other"
			},
			{
				"name":"Fork head\/winged helix developmental regulators"
			},
			{
				"name":"Fork head\/winged helix tissue-specific regulators"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, E2F"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, DP"
			},
			{
				"name":"Fork head\/winged helix other regulators"
			},
			{
				"name":"Stork head\/winged helix factors"
			},
			{
				"name":"Heat shock factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-like factors"
			},
			{
				"name":"Tryptophan clusters Ets-type"
			},
			{
				"name":"Tryptophan clusters interferon-regulating factors"
			},
			{
				"name":"TEA domain"
			},
			{
				"name":"ARID"
			}
			]
		},
		{
			"name":"beta-Scaffold factors with minor groove contacts",
			"children":[
			{
				"name":"RHR (Rel homology region) Rel\/Ankyrin"
			},
			{
				"name":"RHR (Rel homology region) Ankyrin only"
			},
			{
				"name":"RHR (Rel homology region) NF-AT"
			},
			{
				"name":"STAT"
			},
			{
				"name":"p53"
			},
			{
				"name":"MADS-box regulators of differentiation, MEF-2"
			},
			{
				"name":"MADS-box regulators of differentiation, Homeotic genes"
			},
			{
				"name":"MADS-box regulators of differentiation, Yeast regulators"
			},
			{
				"name":"MADS-box responders to external signals"
			},
			{
				"name":"SAND domain-containing proteins"
			},
			{
				"name":"TATA-binding proteins"
			},
			{
				"name":"HMG SOX"
			},
			{
				"name":"HMG TCF-1"
			},
			{
				"name":"HMG TOX"
			},
			{
				"name":"HMG2-related"
			},
			{
				"name":"UBF"
			},
			{
				"name":"Other HMG box factors"
			},
			{
				"name":"Heteromeric CCAAT factors"
			},
			{
				"name":"Grainyhead"
			},
			{
				"name":"Cold-shock domain factors, DbpA-like"
			},
			{
				"name":"Cold-shock domain factors, YB-1\/DbpB-like"
			},
			{
				"name":"Cold-shock domain factors, FRG Y2-like"
			},
			{
				"name":"Runt"
			},
			{
				"name":"MYRF"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"HMGI(Y)"
			},
			{
				"name":"NUPR"
			},
			{
				"name":"Pocket domain Rb"
			},
			{
				"name":"Pocket domain CBP"
			},
			{
				"name":"T-box"
			},
			{
				"name":"DMRT"
			},
			{
				"name":"LRRFIP"
			},
			{
				"name":"TCP"
			},
			{
				"name":"AP2\/ERF"
			},
			{
				"name":"WRKY"
			},
			{
				"name":"LOB"
			},
			{
				"name":"GRAS"
			},
			{
				"name":"NAC"
			},
			{
				"name":"Copper-fist proteins fungal regulators"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"AraC family",
				"children":[
				{
					"name":"HYPMC_1777 Transcriptional regulator, AraC family\tK18991 mtrA; AraC family transcriptional regulator, activator of mtrCDE"
				},
				{
					"name":"HYPMC_0133 protein of unknown function\tK07506 K07506; AraC family transcriptional regulator"
				},
				{
					"name":"HYPMC_1271 Transcriptional regulator (fragment)\tK07506 K07506; AraC family transcriptional regulator"
				},
				{
					"name":"HYPMC_3590 protein of unknown function\tK07506 K07506; AraC family transcriptional regulator"
				},
				{
					"name":"HYPMC_3803 ada; fused DNA-binding transcriptional dual regulator; O6-methylguanine-DNA methyltransferase\tK10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response \/ methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"HYPMC_1872 transcriptional regulator, AraC family\tK21826 gbdR; AraC family transcriptional regulator, glycine betaine-responsive activator"
				}
				]
			},
			{
				"name":"LysR family",
				"children":[
				{
					"name":"HYPMC_0053 Transcriptional regulator, LysR family\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"HYPMC_1535 putative transcriptional regulator\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"HYPMC_2257 putative HTH-type transcriptional activator AmpR\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"HYPMC_0765 oxyR; putative hydrogen peroxide-inducible genes activator\tK04761 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator"
				},
				{
					"name":"HYPMC_4852 oxyR; Hydrogen peroxide-inducible genes activator\tK04761 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator"
				},
				{
					"name":"HYPMC_0150 cysB; HTH-type transcriptional regulator cysB (Cys regulon transcriptional activator)\tK13635 cbl; LysR family transcriptional regulator, cys regulon transcriptional activator"
				},
				{
					"name":"HYPMC_0721 cysB; HTH-type transcriptional regulator cysB (Cys regulon transcriptional activator)\tK13635 cbl; LysR family transcriptional regulator, cys regulon transcriptional activator"
				},
				{
					"name":"HYPMC_3412 cbl; HTH-type transcriptional regulator cbl\tK13635 cbl; LysR family transcriptional regulator, cys regulon transcriptional activator"
				},
				{
					"name":"HYPMC_0427 yhjC; Uncharacterized HTH-type transcriptional regulator yhjC\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"HYPMC_0654 Transcriptional regulator protein\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"HYPMC_3460 putative Nitrogen assimilation regulatory protein nac\tK19338 nac; LysR family transcriptional regulator, nitrogen assimilation regulatory protein"
				},
				{
					"name":"HYPMC_1184 Transcriptional regulator, LysR family\tK23773 hdfR; LysR family transcriptional regulator, flagellar master operon regulator"
				}
				]
			},
			{
				"name":"DeoR family",
				"children":[
				{
					"name":"HYPMC_4004 Transcriptional regulator, DeoR family\tK02444 glpR; DeoR family transcriptional regulator, glycerol-3-phosphate regulon repressor"
				},
				{
					"name":"HYPMC_3929 putative glycerol-3-phosphate regulon repressor\tK22103 glcR; DeoR family transcriptional regulator, carbon catabolite repression regulator"
				}
				]
			},
			{
				"name":"LacI family"
			},
			{
				"name":"GntR family",
				"children":[
				{
					"name":"HYPMC_3542 Transcriptional regulator, GntR family\tK03710 K03710; GntR family transcriptional regulator"
				},
				{
					"name":"HYPMC_0465 GntR domain protein\tK05799 pdhR; GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex"
				},
				{
					"name":"HYPMC_0238 Transcriptional regulator, GntR family\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				}
				]
			},
			{
				"name":"TetR\/AcrR family",
				"children":[
				{
					"name":"HYPMC_3040 putative Transcriptional regulator, TetR family\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				},
				{
					"name":"HYPMC_3043 Transcriptional regulator, TetR family\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				},
				{
					"name":"HYPMC_3208 Transcriptional regulator, TetR family\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				},
				{
					"name":"HYPMC_4282 putative transcriptional regulator, TetR family\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				}
				]
			},
			{
				"name":"Lrp\/AsnC family",
				"children":[
				{
					"name":"HYPMC_2765 bkdR; Bkd operon transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"HYPMC_2317 putative transcriptional regulator, AsnC\/Lrp family\tK05800 decR; Lrp\/AsnC family transcriptional regulator, cysteine-sensing transcriptional activator"
				}
				]
			},
			{
				"name":"LuxR family"
			},
			{
				"name":"MarR family",
				"children":[
				{
					"name":"HYPMC_4400 transcriptional regulator, MarR family\tK06075 slyA; MarR family transcriptional regulator, transcriptional regulator for hemolysin"
				},
				{
					"name":"HYPMC_0205 Transcriptional regulator, MarR family\tK22296 nicR; MarR family transcriptional regulator, lower aerobic nicotinate degradation pathway regulator"
				},
				{
					"name":"HYPMC_4628 Transcriptional regulator, MarR family\tK22489 hosA; MarR family transcriptional regulator, temperature-dependent positive regulator of motility"
				}
				]
			},
			{
				"name":"MerR family"
			},
			{
				"name":"Fur family",
				"children":[
				{
					"name":"HYPMC_4777 Ferric uptake regulator, Fur family\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator"
				},
				{
					"name":"HYPMC_0930 Transcriptional regulator, Fur family\tK09823 zur; Fur family transcriptional regulator, zinc uptake regulator"
				},
				{
					"name":"HYPMC_4092 putative Fe2+\/Zn2+ uptake regulation protein\tK09823 zur; Fur family transcriptional regulator, zinc uptake regulator"
				},
				{
					"name":"HYPMC_2234 irr; Iron transcriptional regulator protein\tK09826 irr; Fur family transcriptional regulator, iron response regulator"
				},
				{
					"name":"HYPMC_3636 Ferric uptake regulator family, Irr-like protein (modular protein)\tK09826 irr; Fur family transcriptional regulator, iron response regulator"
				},
				{
					"name":"HYPMC_4753 Ferric uptake regulator family, Irr-like protein\tK09826 irr; Fur family transcriptional regulator, iron response regulator"
				}
				]
			},
			{
				"name":"IclR family",
				"children":[
				{
					"name":"HYPMC_0188 Transcriptional regulator, IclR-family\tK13641 iclR; IclR family transcriptional regulator, acetate operon repressor"
				}
				]
			},
			{
				"name":"CRP\/FNR family",
				"children":[
				{
					"name":"HYPMC_0229 Transcriptional regulator, Crp\/Fnr family\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				},
				{
					"name":"HYPMC_0663 Transcriptional regulator, Crp\/Fnr family\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				},
				{
					"name":"HYPMC_1730 conserved protein of unknown function\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				},
				{
					"name":"HYPMC_0081 Cyclic nucleotide-binding protein\tK01420 fnr; CRP\/FNR family transcriptional regulator, anaerobic regulatory protein"
				},
				{
					"name":"HYPMC_0673 Transcriptional regulator, Crp\/Fnr family\tK01420 fnr; CRP\/FNR family transcriptional regulator, anaerobic regulatory protein"
				},
				{
					"name":"HYPMC_1351 putative transcriptional regulator, Crp\/Fnr family\tK01420 fnr; CRP\/FNR family transcriptional regulator, anaerobic regulatory protein"
				},
				{
					"name":"HYPMC_3128 putative transcriptional regulator, Crp\/Fnr family\tK01420 fnr; CRP\/FNR family transcriptional regulator, anaerobic regulatory protein"
				},
				{
					"name":"HYPMC_3279 protein of unknown function\tK01420 fnr; CRP\/FNR family transcriptional regulator, anaerobic regulatory protein"
				},
				{
					"name":"HYPMC_3244 Transcriptional regulator, Crp\/Fnr family (fragment)\tK13642 ftrB; CRP\/FNR family transcriptional regulator, transcriptional activator FtrB"
				},
				{
					"name":"HYPMC_3243 Putative transcriptional regulator (modular protein)\tK21564 nnrR; CRP\/FNR family transcriptional regulator, nitrogen oxide reductase regulator"
				}
				]
			},
			{
				"name":"Rrf2 family",
				"children":[
				{
					"name":"HYPMC_0595 Transcriptional regulator, BadM\/Rrf2 family\tK13772 rirA; Rrf2 family transcriptional regulator, iron-responsive regulator"
				}
				]
			},
			{
				"name":"ArsR family",
				"children":[
				{
					"name":"HYPMC_3071 arsR; transcriptional regulator, ArsR family\tK03892 arsR; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor"
				}
				]
			},
			{
				"name":"XRE family"
			},
			{
				"name":"PadR family"
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"HYPMC_2884 Biotin\/acetyl-CoA-carboxylase ligase\tK03524 birA; BirA family transcriptional regulator, biotin operon repressor \/ biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]"
				},
				{
					"name":"HYPMC_0476 acxR; acetone carboxylase transcriptional regulator\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"HYPMC_3697 nifA; Nif-specific regulatory protein\tK02584 nifA; Nif-specific regulatory protein"
				},
				{
					"name":"HYPMC_3979 putative two-component sigma-54 specific transcriptional regulator; with N-terminal response receiver, GAF and ATPase domains\tK02584 nifA; Nif-specific regulatory protein"
				},
				{
					"name":"HYPMC_3799 putative transcriptional regulator, ModE family\tK02019 modE; molybdate transport system regulatory protein"
				}
				]
			}
			]
		},
		{
			"name":"Ribbon-helix-helix",
			"children":[
			{
				"name":"CopG family",
				"children":[
				{
					"name":"HYPMC_3057 Transcriptional regulator, CopG family (modular protein)\tK07722 nikR; CopG family transcriptional regulator, nickel-responsive regulator"
				}
				]
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"HYPMC_1107 Delta-1-pyrroline-5-carboxylate dehydrogenase\tK13821 putA; RHH-type transcriptional regulator, proline utilization regulon repressor \/ proline dehydrogenase \/ delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]"
				}
				]
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"BglG family"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"HYPMC_2516 conserved protein of unknown function\tK21600 csoR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor"
				},
				{
					"name":"HYPMC_4415 BolA-like protein\tK05527 bolA; BolA family transcriptional regulator, general stress-responsive regulator"
				},
				{
					"name":"HYPMC_4546 parB; chromosome-partitioning protein parB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"HYPMC_4405 Transcriptional regulator, CarD family\tK07736 carD; CarD family transcriptional regulator, regulator of rRNA transcription"
				},
				{
					"name":"HYPMC_3131 NusG antitermination factor\tK05785 rfaH; transcriptional antiterminator RfaH"
				},
				{
					"name":"HYPMC_4702 hrcA; Heat-inducible transcription repressor HrcA\tK03705 hrcA; heat-inducible transcriptional repressor"
				},
				{
					"name":"HYPMC_2024 putative Phage transcriptional regulator, AlpA\tK07733 alpA; prophage regulatory protein"
				},
				{
					"name":"HYPMC_4247 protein of unknown function\tK07733 alpA; prophage regulatory protein"
				},
				{
					"name":"HYPMC_4174 conserved protein of unknown function\tK07735 algH; putative transcriptional regulator"
				},
				{
					"name":"HYPMC_1392 Transcriptional regulator, TraR\/DksA family\tK06204 dksA; RNA polymerase-binding transcription factor"
				},
				{
					"name":"HYPMC_2773 transcriptional regulator NrdR\tK07738 nrdR; transcriptional repressor NrdR"
				},
				{
					"name":"HYPMC_0327 mraZ; Protein MraZ\tK03925 mraZ; transcriptional regulator MraZ"
				},
				{
					"name":"HYPMC_2697 Sel1 domain protein repeat-containing protein\tK25885 exoR; exopolysaccharide production negative regulator"
				}
				]
			}
			]
		}
		]
	}
	]
}