{
	"name":"hmh03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"116482001 MGMT; methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"116477972 ALKBH2; DNA oxidative demethylase ALKBH2 isoform X1\tK10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]"
				},
				{
					"name":"116476330 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1\tK10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]"
				},
				{
					"name":"116470184 ASCC3; activating signal cointegrator 1 complex subunit 3 isoform X1\tK18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"116477971 UNG; uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"116462564 CCNO; cyclin-O\tK10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]"
					},
					{
						"name":"116478023 TDG; G\/T mismatch-specific thymine DNA glycosylase isoform X1\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"116462624 MPG; DNA-3-methyladenine glycosylase isoform X1\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"116480975 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1\tK10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]"
					},
					{
						"name":"116473085 MUTYH; adenine DNA glycosylase isoform X1\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"116466784 MBD4; methyl-CpG-binding domain protein 4 isoform X1\tK10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]"
					},
					{
						"name":"116466719 OGG1; N-glycosylase\/DNA lyase isoform X3\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"116463625 uncharacterized protein LOC116463625\tK10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"116482407 NEIL1; endonuclease 8-like 1 isoform X6\tK10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"116473817 NEIL2; endonuclease 8-like 2 isoform X1\tK10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"116466047 NEIL3; endonuclease 8-like 3 isoform X1\tK10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"116462652 NTHL1; endonuclease III-like protein 1 isoform X1\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"116484591 APEX1; DNA-(apurinic or apyrimidinic site) endonuclease\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					},
					{
						"name":"116811721 APEX2; DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X1\tK10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"116478111 DNA polymerase delta catalytic subunit isoform X1\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"116470546 LOW QUALITY PROTEIN: DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"116812493 POLD2; DNA polymerase delta subunit 2 isoform X1\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"116476685 POLD3; DNA polymerase delta subunit 3 isoform X1\tK03504 POLD3; DNA polymerase delta subunit 3"
						},
						{
							"name":"116469073 POLD4; DNA polymerase delta subunit 4 isoform X1\tK03505 POLD4; DNA polymerase delta subunit 4"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"116477657 POLE; DNA polymerase epsilon catalytic subunit A isoform X1\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"116456184 POLE2; DNA polymerase epsilon subunit 2 isoform X1\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						},
						{
							"name":"116475574 POLE3; DNA polymerase epsilon subunit 3\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
						},
						{
							"name":"116483456 POLE4; DNA polymerase epsilon subunit 4 isoform X2\tK03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"116461198 PCNA; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"116811050 proliferating cell nuclear antigen-like\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"116468865 FEN1; flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"116478268 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors",
					"children":[
					{
						"name":"116461830 POLB; DNA polymerase beta isoform X1\tK02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"116480030 XRCC1; DNA repair protein XRCC1 isoform X1\tK10803 XRCC1; DNA-repair protein XRCC1"
					},
					{
						"name":"116474488 LIG3; DNA ligase 3 isoform X3\tK10776 LIG3; DNA ligase 3 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"116484486 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X1\tK10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]"
					},
					{
						"name":"116458480 APTX; aprataxin isoform X1\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"116483573 APLF; aprataxin and PNK-like factor isoform X1\tK13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]"
					},
					{
						"name":"116478175 PNKP; bifunctional polynucleotide phosphatase\/kinase isoform X3\tK08073 PNKP; bifunctional polynucleotide phosphatase\/kinase [EC:3.1.3.32 2.7.1.78]"
					},
					{
						"name":"116467106 HMGB1; high mobility group protein B1\tK10802 HMGB1; high mobility group protein B1"
					},
					{
						"name":"116484740 POLL; DNA polymerase lambda isoform X1\tK03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"116458110 PARP1; poly [ADP-ribose] polymerase 1 isoform X1\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
					},
					{
						"name":"116484595 PARP2; poly [ADP-ribose] polymerase 2 isoform X1\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
					},
					{
						"name":"116467147 PARP4; protein mono-ADP-ribosyltransferase PARP4 isoform X1\tK10798 PARP3_4; protein mono-ADP-ribosyltransferase 3\/4 [EC:2.4.2.-]"
					},
					{
						"name":"116473419 PARP3; protein mono-ADP-ribosyltransferase PARP3 isoform X2\tK10798 PARP3_4; protein mono-ADP-ribosyltransferase 3\/4 [EC:2.4.2.-]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"116466767 XPC; DNA repair protein complementing XP-C cells isoform X1\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"116475512 RAD23B; UV excision repair protein RAD23 homolog B\tK10839 RAD23; UV excision repair protein RAD23"
						},
						{
							"name":"116478556 RAD23A; UV excision repair protein RAD23 homolog A isoform X1\tK10839 RAD23; UV excision repair protein RAD23"
						},
						{
							"name":"116464852 CETN2; centrin-2\tK10840 CETN2; centrin-2"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"116458544 RBX1; E3 ubiquitin-protein ligase RBX1\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"116467581 CUL4A; cullin-4A isoform X1\tK10609 CUL4; cullin 4"
						},
						{
							"name":"116812008 CUL4B; cullin-4B isoform X3\tK10609 CUL4; cullin 4"
						},
						{
							"name":"116468851 DDB1; DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						},
						{
							"name":"116476282 DDB2; DNA damage-binding protein 2 isoform X1\tK10140 DDB2; DNA damage-binding protein 2"
						}
						]
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"116459477 POLR2A; DNA-directed RNA polymerase II subunit RPB1\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"116476581 POLR2B; DNA-directed RNA polymerase II subunit RPB2\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"116471303 POLR2C; DNA-directed RNA polymerase II subunit RPB3\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"116462957 POLR2D; DNA-directed RNA polymerase II subunit RPB4\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"116464931 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"116459400 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X1\tK03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2"
						},
						{
							"name":"116468902 POLR2G; DNA-directed RNA polymerase II subunit RPB7 isoform X1\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
						},
						{
							"name":"116479907 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"116478942 POLR2I; DNA-directed RNA polymerase II subunit RPB9 isoform X1\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"116466605 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						},
						{
							"name":"116811000 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a isoform X1\tK03008 RPB11; DNA-directed RNA polymerase II subunit RPB11"
						},
						{
							"name":"116462054 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						},
						{
							"name":"116467257 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						},
						{
							"name":"116813469 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 isoform X2\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"116458544 RBX1; E3 ubiquitin-protein ligase RBX1\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"116467581 CUL4A; cullin-4A isoform X1\tK10609 CUL4; cullin 4"
						},
						{
							"name":"116812008 CUL4B; cullin-4B isoform X3\tK10609 CUL4; cullin 4"
						},
						{
							"name":"116468851 DDB1; DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"116460897 DNA excision repair protein ERCC-6 isoform X1\tK10841 ERCC6; DNA excision repair protein ERCC-6"
						},
						{
							"name":"116456829 UVSSA; UV-stimulated scaffold protein A\tK23720 UVSSA; UV-stimulated scaffold protein A"
						},
						{
							"name":"116478492 ELOF1; transcription elongation factor 1 homolog\tK25829 ELOF1; transcription elongation factor 1"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"116462991 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB isoform X1\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"116483356 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"116476455 GTF2H1; general transcription factor IIH subunit 1 isoform X1\tK03141 TFIIH1; transcription initiation factor TFIIH subunit 1"
					},
					{
						"name":"116462607 general transcription factor IIH subunit 2 isoform X2\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"116477728 GTF2H3; general transcription factor IIH subunit 3 isoform X1\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"116460092 GTF2H4; general transcription factor IIH subunit 4\tK03144 TFIIH4; transcription initiation factor TFIIH subunit 4"
					},
					{
						"name":"116473395 GTF2H5; general transcription factor IIH subunit 5\tK10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit"
					},
					{
						"name":"116462488 CDK7; cyclin-dependent kinase 7 isoform X1\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"116471024 CCNH; cyclin-H isoform X1\tK06634 CCNH; cyclin H"
					},
					{
						"name":"116456135 MNAT1; CDK-activating kinase assembly factor MAT1 isoform X1\tK10842 MNAT1; CDK-activating kinase assembly factor MAT1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"116458899 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X3\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"116813156 RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"116459670 LOW QUALITY PROTEIN: replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"116813697 RPA3; replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"116465674 RPA4; replication protein A 30 kDa subunit\tK10741 RPA4; replication factor A4"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"116475306 XPA; DNA repair protein complementing XP-A cells\tK10847 XPA; DNA-repair protein complementing XP-A cells"
					},
					{
						"name":"116483759 ERCC1; DNA excision repair protein ERCC-1 isoform X3\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"116462382 ERCC4; DNA repair endonuclease XPF isoform X1\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"116467542 ERCC5; DNA excision repair protein ERCC-5 isoform X1\tK10846 ERCC5; DNA excision repair protein ERCC-5"
					},
					{
						"name":"116478268 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"116456408 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1\tK15075 MET18; DNA repair\/transcription protein MET18\/MMS19"
					},
					{
						"name":"116459427 CCDC117; coiled-coil domain-containing protein 117 isoform X1\tK27967 CCDC117; coiled-coil domain-containing protein 117"
					},
					{
						"name":"116483514 CIAO1; probable cytosolic iron-sulfur protein assembly protein CIAO1\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"116471364 CIAO2B; cytosolic iron-sulfur assembly component 2B\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"116482424 CIAO2A; cytosolic iron-sulfur assembly component 2A isoform X1\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"116810179 CUL3; cullin-3 isoform X1\tK03869 CUL3; cullin 3"
					},
					{
						"name":"116476895 CUL5; cullin-5\tK10612 CUL5; cullin 5"
					},
					{
						"name":"116457087 elongin-C-like\tK03872 ELOC; elongin-C"
					},
					{
						"name":"116468348 elongin-C-like\tK03872 ELOC; elongin-C"
					},
					{
						"name":"116481514 elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"116483116 elongin-C-like\tK03872 ELOC; elongin-C"
					},
					{
						"name":"116813327 ELOC; elongin-C isoform X1\tK03872 ELOC; elongin-C"
					},
					{
						"name":"116459822 elongin-B-like\tK03873 ELOB; elongin-B"
					},
					{
						"name":"116462586 ELOB; elongin-B\tK03873 ELOB; elongin-B"
					},
					{
						"name":"116477167 elongin-B-like\tK03873 ELOB; elongin-B"
					},
					{
						"name":"131384252 elongin-B-like\tK03873 ELOB; elongin-B"
					},
					{
						"name":"116813067 ELOA; elongin-A\tK15076 ELOA; elongin-A"
					},
					{
						"name":"116459198 UBAP2; ubiquitin-associated protein 2 isoform X1\tK26545 UBAP2; ubiquitin-associated protein 2"
					},
					{
						"name":"116469363 UBAP2L; ubiquitin-associated protein 2-like isoform X1\tK26545 UBAP2; ubiquitin-associated protein 2"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"116482978 MSH2; DNA mismatch repair protein Msh2 isoform X1\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"116471049 MSH3; DNA mismatch repair protein Msh3\tK08736 MSH3; DNA mismatch repair protein MSH3"
					},
					{
						"name":"116483948 MSH6; DNA mismatch repair protein Msh6 isoform X1\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"116810545 PMS1; PMS1 protein homolog 1 isoform X1\tK10864 PMS1; DNA mismatch repair protein PMS1"
					},
					{
						"name":"116473677 MLH1; DNA mismatch repair protein Mlh1 isoform X2\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"116810313 PMS2; mismatch repair endonuclease PMS2\tK10858 PMS2; DNA mismatch repair protein PMS2"
					},
					{
						"name":"116484843 MLH3; DNA mismatch repair protein Mlh3 isoform X1\tK08739 MLH3; DNA mismatch repair protein MLH3"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"116478111 DNA polymerase delta catalytic subunit isoform X1\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
					},
					{
						"name":"116470546 LOW QUALITY PROTEIN: DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"116812493 POLD2; DNA polymerase delta subunit 2 isoform X1\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"116476685 POLD3; DNA polymerase delta subunit 3 isoform X1\tK03504 POLD3; DNA polymerase delta subunit 3"
					},
					{
						"name":"116469073 POLD4; DNA polymerase delta subunit 4 isoform X1\tK03505 POLD4; DNA polymerase delta subunit 4"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"116458899 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X3\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"116813156 RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"116459670 LOW QUALITY PROTEIN: replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"116813697 RPA3; replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"116465674 RPA4; replication protein A 30 kDa subunit\tK10741 RPA4; replication factor A4"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"116456946 RFC1; replication factor C subunit 1 isoform X1\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"116479945 RFC4; replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"116811587 RFC2; replication factor C subunit 2 isoform X1\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"116467089 RFC3; replication factor C subunit 3 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"116477853 RFC5; replication factor C subunit 5 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"116461198 PCNA; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"116811050 proliferating cell nuclear antigen-like\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"116457277 EXO1; exonuclease 1 isoform X1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"116467106 HMGB1; high mobility group protein B1\tK10802 HMGB1; high mobility group protein B1"
					},
					{
						"name":"116478268 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"116482168 WDR76; WD repeat-containing protein 76 isoform X1\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"116476824 MRE11; double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"116470837 RAD50; DNA repair protein RAD50 isoform X1\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					},
					{
						"name":"116813398 NBN; nibrin isoform X1\tK10867 NBN; nibrin"
					}
					]
				},
				{
					"name":"BRCA1-core complex",
					"children":[
					{
						"name":"116474903 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"116810342 BARD1; BRCA1-associated RING domain protein 1 isoform X1\tK10683 BARD1; BRCA1-associated RING domain protein 1"
					}
					]
				},
				{
					"name":"BRCA1-A complex",
					"children":[
					{
						"name":"116474903 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"116464303 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X1\tK20774 FAM175A; BRCA1-A complex subunit Abraxas"
					},
					{
						"name":"116471903 UIMC1; BRCA1-A complex subunit RAP80 isoform X2\tK20775 UIMC1; BRCA1-A complex subunit RAP80"
					},
					{
						"name":"116478660 BABAM1; BRISC and BRCA1-A complex member 1\tK20776 BABAM; BRISC and BRCA1-A complex member 1"
					},
					{
						"name":"116480498 BABAM2; BRISC and BRCA1-A complex member 2 isoform X1\tK12173 BRE; BRCA1-A complex subunit BRE"
					},
					{
						"name":"116471919 LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
					},
					{
						"name":"116811225 BRCC3; lys-63-specific deubiquitinase BRCC36\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
					}
					]
				},
				{
					"name":"BRCA1-B complex",
					"children":[
					{
						"name":"116474903 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"116474316 BRIP1; Fanconi anemia group J protein\tK15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]"
					},
					{
						"name":"116462113 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
					}
					]
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"116474903 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"116468674 RBBP8; DNA endonuclease RBBP8 isoform X1\tK20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]"
					},
					{
						"name":"116476824 MRE11; double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"116470837 RAD50; DNA repair protein RAD50 isoform X1\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					},
					{
						"name":"116813398 NBN; nibrin isoform X1\tK10867 NBN; nibrin"
					}
					]
				},
				{
					"name":"BRCA complex",
					"children":[
					{
						"name":"116474903 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"116467095 BRCA2; breast cancer type 2 susceptibility protein isoform X1\tK08775 BRCA2; breast cancer 2 susceptibility protein"
					},
					{
						"name":"116471142 PALB2; partner and localizer of BRCA2 isoform X1\tK10897 PALB2; partner and localizer of BRCA2"
					},
					{
						"name":"116481623 RAD51; DNA repair protein RAD51 homolog 1 isoform X1\tK04482 RAD51; DNA repair protein RAD51"
					}
					]
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"116481623 RAD51; DNA repair protein RAD51 homolog 1 isoform X1\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"116484509 RAD51B; DNA repair protein RAD51 homolog 2 isoform X1\tK10869 RAD51L1; RAD51-like protein 1"
					},
					{
						"name":"116474407 RAD51C; DNA repair protein RAD51 homolog 3\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"116474492 RAD51D; DNA repair protein RAD51 homolog 4 isoform X4\tK10871 RAD51L3; RAD51-like protein 3"
					},
					{
						"name":"116809725 XRCC2; DNA repair protein XRCC2\tK10879 XRCC2; DNA-repair protein XRCC2"
					},
					{
						"name":"116456099 XRCC3; DNA repair protein XRCC3 isoform X1\tK10880 XRCC3; DNA-repair protein XRCC3"
					}
					]
				},
				{
					"name":"Rad52 family proteins",
					"children":[
					{
						"name":"116472516 RAD52; DNA repair protein RAD52 homolog isoform X1\tK10873 RAD52; DNA repair and recombination protein RAD52"
					},
					{
						"name":"116474511 RDM1; RAD52 motif-containing protein 1\tK10874 RDM1; RAD52 motif-containing protein 1"
					}
					]
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"116473110 RAD54L; DNA repair and recombination protein RAD54-like isoform X1\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					},
					{
						"name":"116473425 RAD54L2; helicase ARIP4\tK10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]"
					},
					{
						"name":"116813423 RAD54B; DNA repair and recombination protein RAD54B isoform X1\tK10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"116472761 RECQL; ATP-dependent DNA helicase Q1\tK10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]"
					},
					{
						"name":"116461714 WRN; bifunctional 3'-5' exonuclease\/ATP-dependent helicase WRN isoform X1\tK10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]"
					},
					{
						"name":"116463316 recQ-like DNA helicase BLM isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"116463647 recQ-like DNA helicase BLM isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"116813711 RECQL4; ATP-dependent DNA helicase Q4 isoform X1\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
					},
					{
						"name":"116484058 RECQL5; ATP-dependent DNA helicase Q5 isoform X1\tK10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"116463316 recQ-like DNA helicase BLM isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"116463647 recQ-like DNA helicase BLM isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"116459122 TOP3B; DNA topoisomerase 3-beta-1 isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"116484032 TOP3A; DNA topoisomerase 3-alpha isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"116475196 RMI1; recQ-mediated genome instability protein 1\tK10990 RMI1; RecQ-mediated genome instability protein 1"
					},
					{
						"name":"116462555 RMI2; recQ-mediated genome instability protein 2\tK15365 RMI2; RecQ-mediated genome instability protein 2"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"116458899 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X3\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"116813156 RPA2; LOW QUALITY PROTEIN: replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"116459670 LOW QUALITY PROTEIN: replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"116813697 RPA3; replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"116465674 RPA4; replication protein A 30 kDa subunit\tK10741 RPA4; replication factor A4"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"116470236 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit isoform X1\tK15423 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"116463300 LOW QUALITY PROTEIN: serine\/threonine-protein phosphatase 4 regulatory subunit 1-like\tK15424 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1"
					},
					{
						"name":"116464115 serine\/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1\tK15424 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1"
					},
					{
						"name":"116468745 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1\tK15424 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1"
					},
					{
						"name":"116466661 PPP4R2; serine\/threonine-protein phosphatase 4 regulatory subunit 2 isoform X2\tK15425 PPP4R2; serine\/threonine-protein phosphatase 4 regulatory subunit 2"
					},
					{
						"name":"116484037 PPP4R3B; serine\/threonine-protein phosphatase 4 regulatory subunit 3B isoform X3\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					},
					{
						"name":"116484637 PPP4R3A; serine\/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					},
					{
						"name":"116811242 PPP4R3C; protein PPP4R3C\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					},
					{
						"name":"116484947 PPP4R4; serine\/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1\tK15426 PPP4R4; serine\/threonine-protein phosphatase 4 regulatory subunit 4"
					}
					]
				},
				{
					"name":"AP-5 complex",
					"children":[
					{
						"name":"116469015 AP5B1; AP-5 complex subunit beta-1\tK19022 AP5B1; AP-5 complex subunit beta-1"
					},
					{
						"name":"116456278 AP5M1; AP-5 complex subunit mu-1\tK19023 AP5M1; AP-5 complex subunit mu-1"
					},
					{
						"name":"116481193 LOW QUALITY PROTEIN: AP-5 complex subunit mu-1-like\tK19023 AP5M1; AP-5 complex subunit mu-1"
					},
					{
						"name":"116461436 AP5S1; AP-5 complex subunit sigma-1\tK19024 AP5S1; AP-5 complex subunit sigma-1"
					},
					{
						"name":"116810825 AP5Z1; AP-5 complex subunit zeta-1 isoform X1\tK19025 AP5Z1; AP-5 complex subunit zeta-1"
					}
					]
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"116475140 SMC5; structural maintenance of chromosomes protein 5 isoform X1\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"116480316 SMC6; structural maintenance of chromosomes protein 6 isoform X2\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"116480276 LRATD1; protein LRATD1\tK22805 FAM84A; protein FAM84A"
					},
					{
						"name":"116471165 NSMCE1; non-structural maintenance of chromosomes element 1 homolog\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
					},
					{
						"name":"116813585 NSMCE2; E3 SUMO-protein ligase NSE2 isoform X1\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
					},
					{
						"name":"116482448 NSMCE3; non-structural maintenance of chromosomes element 3 homolog\tK22823 NSMCE3; non-structural maintenance of chromosomes element 3"
					},
					{
						"name":"116482562 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A isoform X1\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					},
					{
						"name":"116478018 EID3; EP300-interacting inhibitor of differentiation 3\tK22826 EID3; EP300-interacting inhibitor of differentiation 3"
					},
					{
						"name":"116470996 SLF1; SMC5-SMC6 complex localization factor protein 1 isoform X1\tK26126 SLF1; SMC5-SMC6 complex localization factor protein 1"
					},
					{
						"name":"116484964 SLF2; SMC5-SMC6 complex localization factor protein 2 isoform X1\tK26127 SLF2; SMC5-SMC6 complex localization factor protein 2"
					},
					{
						"name":"116465274 SUMO-interacting motif-containing protein 1-like\tK28408 SIMC1; SUMO-interacting motif-containing protein 1"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"116474645 EME1; crossover junction endonuclease EME1 isoform X1\tK10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]"
					},
					{
						"name":"116462521 EME2; probable crossover junction endonuclease EME2\tK10883 EME2; crossover junction endonuclease EME2"
					},
					{
						"name":"116484498 EXD2; exonuclease 3'-5' domain-containing protein 2 isoform X1\tK20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]"
					},
					{
						"name":"116469018 MUS81; crossover junction endonuclease MUS81 isoform X1\tK08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]"
					},
					{
						"name":"116813839 SEM1; 26S proteasome complex subunit SEM1 isoform X1\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"116475714 SWI5; LOW QUALITY PROTEIN: DNA repair protein SWI5 homolog\tK10991 SWI5; DNA repair protein Swi5\/Sae3"
					},
					{
						"name":"116483915 SFR1; swi5-dependent recombination DNA repair protein 1 homolog\tK10992 SFR1; Swi5-dependent recombination DNA repair protein 1"
					},
					{
						"name":"116470225 SLX1A; structure-specific endonuclease subunit SLX1\tK15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]"
					},
					{
						"name":"116462750 SLX4; structure-specific endonuclease subunit SLX4 isoform X1\tK10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB\/POZ domain-containing protein 12)"
					},
					{
						"name":"116480317 GEN1; flap endonuclease GEN homolog 1 isoform X1\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"116482192 SPG11; spatacsin isoform X1\tK19026 SPG11; spatacsin"
					},
					{
						"name":"116484827 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1\tK19027 ZFYVE26; zinc finger FYVE domain-containing protein 26"
					},
					{
						"name":"116472555 RAD51AP1; RAD51-associated protein 1 isoform X1\tK20778 RAD51AP1; RAD51-associated protein 1"
					},
					{
						"name":"116457491 NUCKS1; nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1\tK28888 NUCKS1; nuclear ubiquitous casein and cyclin-dependent kinase substrate 1"
					},
					{
						"name":"116482263 MORF4L1; mortality factor 4-like protein 1\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"116460930 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1\tK22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]"
					},
					{
						"name":"116812446 FIGNL1; fidgetin-like protein 1 isoform X1\tK22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"
					},
					{
						"name":"116813311 SPIDR; DNA repair-scaffolding protein isoform X1\tK22806 SPIDR; DNA repair-scaffolding protein"
					},
					{
						"name":"116813587 LRATD2; protein LRATD2\tK22810 FAM84B; protein FAM84B"
					},
					{
						"name":"116810814 BRAT1; BRCA1-associated ATM activator 1 isoform X1\tK23112 BRAT1; BRCA1-associated ATM activator 1"
					},
					{
						"name":"116482274 CFAP410; cilia- and flagella-associated protein 410 isoform X1\tK23456 CFAP410; cilla- and flagella-associated protein"
					},
					{
						"name":"116484285 HDGFL2; hepatoma-derived growth factor-related protein 2\tK25065 HDGFL2; hepatoma-derived growth factor-related protein 2"
					},
					{
						"name":"116463822 zinc finger SWIM domain-containing protein 7 isoform X1\tK25770 ZSWIM7; zinc finger SWIM domain-containing protein 7"
					},
					{
						"name":"116463831 zinc finger SWIM domain-containing protein 7 isoform X1\tK25770 ZSWIM7; zinc finger SWIM domain-containing protein 7"
					},
					{
						"name":"116479431 SWSAP1; ATPase SWSAP1\tK25771 SWSAP1; ATPase SWSAP1"
					},
					{
						"name":"116476710 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X1\tK25790 EMSY; BRCA2-interacting transcriptional repressor EMSY"
					},
					{
						"name":"116482150 HSF2BP; heat shock factor 2-binding protein isoform X3\tK25791 HSF2BP; heat shock factor 2-binding protein"
					},
					{
						"name":"116469903 MMS22L; protein MMS22-like isoform X2\tK26125 MMS22L; protein MMS22-like"
					},
					{
						"name":"116813879 TONSL; tonsoku-like protein\tK09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2"
					},
					{
						"name":"116456623 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1\tK27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1"
					},
					{
						"name":"116478037 PARPBP; PCNA-interacting partner isoform X1\tK27412 PARPBP; PCNA-interacting partner"
					},
					{
						"name":"116475371 HROB; homologous recombination OB-fold protein\tK27803 HROB; homologous recombination OB-fold protein"
					},
					{
						"name":"116460843 MCM8; DNA helicase MCM8 isoform X1\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
					},
					{
						"name":"116471461 MCM9; DNA helicase MCM9\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
					},
					{
						"name":"116480654 HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1\tK15047 HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1"
					},
					{
						"name":"116468896 HNRNPUL2; heterogeneous nuclear ribonucleoprotein U-like protein 2\tK28611 HNRNPUL2; heterogeneous nuclear ribonucleoprotein U-like protein 2"
					},
					{
						"name":"116471949 MRNIP; MRN complex-interacting protein isoform X1\tK28623 MRNIP; MRN complex-interacting protein"
					},
					{
						"name":"116811929 RADX; RPA-related protein RADX\tK29002 RADX; RPA-related protein RADX"
					},
					{
						"name":"116473453 RBM6; RNA-binding protein 6 isoform X1\tK29038 RBM6; RNA-binding protein 6"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex",
					"children":[
					{
						"name":"116458940 XRCC6; X-ray repair cross-complementing protein 6\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"116478673 LOW QUALITY PROTEIN: X-ray repair cross-complementing protein 6-like\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"116810328 XRCC5; X-ray repair cross-complementing protein 5 isoform X2\tK10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2"
					},
					{
						"name":"116813310 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
					}
					]
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"116476824 MRE11; double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"116470837 RAD50; DNA repair protein RAD50 isoform X1\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"116467554 LIG4; DNA ligase 4 isoform X1\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					},
					{
						"name":"116471034 XRCC4; DNA repair protein XRCC4 isoform X2\tK10886 XRCC4; DNA-repair protein XRCC4"
					},
					{
						"name":"116810277 NHEJ1; non-homologous end-joining factor 1 isoform X1\tK10980 NHEJ1; non-homologous end-joining factor 1"
					}
					]
				},
				{
					"name":"X-family DNA polymerases",
					"children":[
					{
						"name":"116484740 POLL; DNA polymerase lambda isoform X1\tK03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"116812495 POLM; DNA-directed DNA\/RNA polymerase mu isoform X2\tK03513 POLM; DNA polymerase mu [EC:2.7.7.7]"
					},
					{
						"name":"116456795 DNTT; DNA nucleotidylexotransferase isoform X1\tK00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]"
					},
					{
						"name":"116461830 POLB; DNA polymerase beta isoform X1\tK02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]"
					}
					]
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"116458480 APTX; aprataxin isoform X1\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"116483573 APLF; aprataxin and PNK-like factor isoform X1\tK13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]"
					},
					{
						"name":"116470735 DCLRE1C; protein artemis isoform X1\tK10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]"
					},
					{
						"name":"116459950 TDP2; tyrosyl-DNA phosphodiesterase 2\tK19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]"
					},
					{
						"name":"116468703 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1\tK23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1"
					},
					{
						"name":"116484172 PWWP3A; PWWP domain-containing DNA repair factor 3A isoform X1\tK23386 PWWP3; PWWP domain-containing DNA repair factor 3"
					},
					{
						"name":"116811364 PWWP3B; PWWP domain-containing DNA repair factor 3B\tK23386 PWWP3; PWWP domain-containing DNA repair factor 3"
					},
					{
						"name":"116475899 PAXX; protein PAXX isoform X1\tK25772 PAXX; protein PAXX"
					},
					{
						"name":"116814387 CYREN; cell cycle regulator of non-homologous end joining isoform X1\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"116462673 JMJD8; jmjC domain-containing protein 8 isoform X2\tK25792 JMJD8; jumonji domain-containing protein 8"
					},
					{
						"name":"116461102 SHLD1; shieldin complex subunit 1 isoform X1\tK26128 SHLD1; shieldin complex subunit 1"
					},
					{
						"name":"116460645 SHLD2; shieldin complex subunit 2 isoform X1\tK26129 SHLD2; shieldin complex subunit 2"
					},
					{
						"name":"116814483 LOW QUALITY PROTEIN: shieldin complex subunit 2-like\tK26129 SHLD2; shieldin complex subunit 2"
					},
					{
						"name":"116462552 SHLD3; shieldin complex subunit 3\tK26130 SHLD3; shieldin complex subunit 3"
					},
					{
						"name":"116456867 BEND4; BEN domain-containing protein 4 isoform X1\tK27845 BEND4; BEN domain-containing protein 4"
					},
					{
						"name":"116472583 IFFO1; non-homologous end joining factor IFFO1 isoform X1\tK28738 IFFO; non-homologous end joining factor IFFO"
					},
					{
						"name":"116813002 IFFO2; intermediate filament family orphan 2 isoform X1\tK28738 IFFO; non-homologous end joining factor IFFO"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex",
					"children":[
					{
						"name":"116470680 FANCA; Fanconi anemia group A protein isoform X1\tK10888 FANCA; fanconi anemia group A protein"
					},
					{
						"name":"116475277 FANCC; Fanconi anemia group C protein\tK10890 FANCC; fanconi anemia group C protein"
					},
					{
						"name":"116460386 FANCE; Fanconi anemia group E protein isoform X1\tK10892 FANCE; fanconi anemia group E protein"
					},
					{
						"name":"116476424 FANCF; Fanconi anemia group F protein\tK10893 FANCF; fanconi anemia group F protein"
					},
					{
						"name":"116475050 FANCG; Fanconi anemia group G protein isoform X1\tK10894 FANCG; fanconi anemia group G protein"
					},
					{
						"name":"116484047 FANCL; E3 ubiquitin-protein ligase FANCL isoform X1\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
					},
					{
						"name":"116484723 FANCM; Fanconi anemia group M protein\tK10896 FANCM; fanconi anemia group M protein"
					},
					{
						"name":"116478848 FAAP24; Fanconi anemia core complex-associated protein 24\tK10898 FAAP24; fanconi anemia-associated protein"
					},
					{
						"name":"116483337 FAAP100; Fanconi anemia core complex-associated protein 100 isoform X1\tK10993 FAAP100; fanconi anemia core complex 100 kDa subunit"
					}
					]
				},
				{
					"name":"FA core complex binding factors",
					"children":[
					{
						"name":"116479977 HES1; transcription factor HES-1\tK06054 HES1; hairy and enhancer of split 1"
					},
					{
						"name":"116812901 CENPS; centromere protein S isoform X3\tK11511 APITD1; centromere protein S"
					},
					{
						"name":"116482995 CENPX; centromere protein X isoform X1\tK15360 STRA13; centromere protein X"
					},
					{
						"name":"116457617 UBE2T; ubiquitin-conjugating enzyme E2 T isoform X1\tK13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"116463316 recQ-like DNA helicase BLM isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"116463647 recQ-like DNA helicase BLM isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"116459122 TOP3B; DNA topoisomerase 3-beta-1 isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"116484032 TOP3A; DNA topoisomerase 3-alpha isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"116475196 RMI1; recQ-mediated genome instability protein 1\tK10990 RMI1; RecQ-mediated genome instability protein 1"
					},
					{
						"name":"116462555 RMI2; recQ-mediated genome instability protein 2\tK15365 RMI2; RecQ-mediated genome instability protein 2"
					}
					]
				},
				{
					"name":"FANCD2-I complex",
					"children":[
					{
						"name":"116466728 Fanconi anemia group D2 protein isoform X1\tK10891 FANCD2; fanconi anemia group D2 protein"
					},
					{
						"name":"116482142 FANCI; Fanconi anemia group I protein isoform X1\tK10895 FANCI; fanconi anemia group I protein"
					}
					]
				},
				{
					"name":"Downstream FA components",
					"children":[
					{
						"name":"116474903 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"116467095 BRCA2; breast cancer type 2 susceptibility protein isoform X1\tK08775 BRCA2; breast cancer 2 susceptibility protein"
					},
					{
						"name":"116474316 BRIP1; Fanconi anemia group J protein\tK15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]"
					},
					{
						"name":"116471142 PALB2; partner and localizer of BRCA2 isoform X1\tK10897 PALB2; partner and localizer of BRCA2"
					}
					]
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"116482640 FAN1; fanconi-associated nuclease 1\tK15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]"
					},
					{
						"name":"116481623 RAD51; DNA repair protein RAD51 homolog 1 isoform X1\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"116474407 RAD51C; DNA repair protein RAD51 homolog 3\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"116462245 TELO2; telomere length regulation protein TEL2 homolog\tK11137 TELO2; telomere length regulation protein"
					},
					{
						"name":"116457511 USP1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1\tK11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]"
					},
					{
						"name":"116473647 WDR48; WD repeat-containing protein 48 isoform X1\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6",
					"children":[
					{
						"name":"116475656 PPP6C; serine\/threonine-protein phosphatase 6 catalytic subunit isoform X1\tK15498 PPP6C; serine\/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"116479212 PPP6R1; serine\/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1\tK15499 PPP6R1; serine\/threonine-protein phosphatase 6 regulatory subunit 1"
					},
					{
						"name":"116458993 PPP6R2; serine\/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1\tK15500 PPP6R2; serine\/threonine-protein phosphatase 6 regulatory subunit 2"
					},
					{
						"name":"116469104 PPP6R3; serine\/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1\tK15501 PPP6R3; serine\/threonine-protein phosphatase 6 regulatory subunit 3"
					},
					{
						"name":"116462046 ANKRD28; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1\tK15502 ANKRD28; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A"
					},
					{
						"name":"116810503 ANKRD44; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1\tK15503 ANKRD44; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B"
					},
					{
						"name":"116480917 ANKRD52; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C\tK15504 ANKRD52; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C"
					}
					]
				},
				{
					"name":"Ubiquitin ligases",
					"children":[
					{
						"name":"116459640 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X1\tK10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]"
					},
					{
						"name":"116479994 RNF168; E3 ubiquitin-protein ligase RNF168\tK20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]"
					},
					{
						"name":"116476689 RNF169; E3 ubiquitin-protein ligase RNF169\tK20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]"
					},
					{
						"name":"116482387 HERC2; E3 ubiquitin-protein ligase HERC2\tK10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"116459051 WRAP53; telomerase Cajal body protein 1 isoform X1\tK23314 WRAP53; telomerase Cajal body protein 1"
					},
					{
						"name":"116475915 TPRN; taperin\tK24164 TPRN; taperin"
					},
					{
						"name":"116810940 ZCWPW1; zinc finger CW-type PWWP domain protein 1 isoform X2\tK24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1"
					},
					{
						"name":"116457050 WDR70; WD repeat-containing protein 70\tK24752 WDR70; WD repeat-containing protein 70"
					},
					{
						"name":"116482168 WDR76; WD repeat-containing protein 76 isoform X1\tK24755 WDR76; WD repeat-containing protein 76"
					},
					{
						"name":"116466790 HMCES; abasic site processing protein HMCES\tK28434 HMCES; abasic site processing protein HMCES"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"116459985 POLH; DNA polymerase eta isoform X1\tK03509 POLH; DNA polymerase eta [EC:2.7.7.7]"
				},
				{
					"name":"116466269 LOW QUALITY PROTEIN: DNA polymerase iota-like\tK03510 POLI; DNA polymerase iota [EC:2.7.7.7]"
				},
				{
					"name":"116468529 POLI; DNA polymerase iota isoform X1\tK03510 POLI; DNA polymerase iota [EC:2.7.7.7]"
				},
				{
					"name":"116462469 POLK; DNA polymerase kappa isoform X1\tK03511 POLK; DNA polymerase kappa [EC:2.7.7.7]"
				},
				{
					"name":"116483803 REV1; DNA repair protein REV1 isoform X1\tK03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases",
				"children":[
				{
					"name":"116470974 REV3L; DNA polymerase zeta catalytic subunit isoform X1\tK02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"A-family DNA polymerase",
				"children":[
				{
					"name":"116456683 POLN; DNA polymerase nu\tK16618 POLN; DNA polymerase nu [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"116811997 UBE2A; ubiquitin-conjugating enzyme E2 A isoform X1\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"116471509 UBE2B; ubiquitin-conjugating enzyme E2 B\tK10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]"
				},
				{
					"name":"116466696 RAD18; E3 ubiquitin-protein ligase RAD18 isoform X2\tK10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"
				},
				{
					"name":"116481119 HLTF; helicase-like transcription factor isoform X1\tK15711 SMARCA3; SWI\/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]"
				},
				{
					"name":"116461373 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 isoform X2\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"116476637 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 variant 1-like\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"116811176 ubiquitin-conjugating enzyme E2 variant 1\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"116813308 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 isoform X1\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"116460102 ubiquitin-conjugating enzyme E2 N\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				},
				{
					"name":"116479096 UBE2N; ubiquitin-conjugating enzyme E2 N\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"116461198 PCNA; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"116811050 proliferating cell nuclear antigen-like\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"116482417 PCLAF; PCNA-associated factor isoform X1\tK28763 PCLAF; PCNA-associated factor"
				},
				{
					"name":"116478037 PARPBP; PCNA-interacting partner isoform X1\tK27412 PARPBP; PCNA-interacting partner"
				},
				{
					"name":"116458041 SPRTN; DNA-dependent metalloprotease SPRTN isoform X1\tK24051 SPRTN; SprT-like domain-contaning protein Spartan"
				},
				{
					"name":"116811782 GCNA; germ cell nuclear acidic protein isoform X1\tK26957 GCNA; germ cell nuclear acidic protein"
				},
				{
					"name":"116475440 DPPA5; developmental pluripotency-associated 5 protein\tK28975 DPPA5; developmental pluripotency-associated protein 5"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"116469081 RAD9A; cell cycle checkpoint control protein RAD9A isoform X1\tK10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]"
				},
				{
					"name":"116477936 RAD9B; cell cycle checkpoint control protein RAD9B isoform X1\tK10995 RAD9B; cell cycle checkpoint control protein RAD9B"
				},
				{
					"name":"116460383 HUS1B; checkpoint protein HUS1B\tK10996 HUS1B; checkpoint protein HUS1B"
				},
				{
					"name":"116457058 RAD1; cell cycle checkpoint protein RAD1 isoform X1\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"116462489 RAD17; cell cycle checkpoint protein RAD17 isoform X1\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"116479945 RFC4; replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"116811587 RFC2; replication factor C subunit 2 isoform X1\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"116467089 RFC3; replication factor C subunit 3 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"116477853 RFC5; replication factor C subunit 5 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"116457058 RAD1; cell cycle checkpoint protein RAD1 isoform X1\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"116480907 TIMELESS; protein timeless homolog isoform X1\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				},
				{
					"name":"116481693 TIPIN; TIMELESS-interacting protein isoform X4\tK10998 TIPIN; replication fork protection complex subunit TIPIN\/Csm3\/Swi3"
				},
				{
					"name":"116472934 CLSPN; claspin isoform X1\tK25773 CLSPN; claspin"
				}
				]
			},
			{
				"name":"Triple T complex",
				"children":[
				{
					"name":"116462245 TELO2; telomere length regulation protein TEL2 homolog\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"116461016 TTI1; TELO2-interacting protein 1 homolog\tK20403 TTI1; TELO2-interacting protein 1"
				},
				{
					"name":"116461700 TTI2; TELO2-interacting protein 2 isoform X1\tK23115 TTI2; TELO2-interacting protein 2"
				}
				]
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"116460265 BAG6; large proline-rich protein BAG6 isoform X6\tK23390 BAG6; large proline-rich protein BAG6"
				},
				{
					"name":"116468362 UBL4B; ubiquitin-like protein 4B\tK23388 UBL4; ubiquitin-like protein 4"
				},
				{
					"name":"116812160 UBL4A; ubiquitin-like protein 4A\tK23388 UBL4; ubiquitin-like protein 4"
				},
				{
					"name":"116462950 GET4; Golgi to ER traffic protein 4 homolog isoform X2\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex",
				"children":[
				{
					"name":"116469382 INTS3; integrator complex subunit 3 isoform X1\tK13140 INTS3; integrator complex subunit 3 (SOSS complex subunit A)"
				},
				{
					"name":"116480919 NABP2; SOSS complex subunit B1\tK28889 NABP; SOSS complex subunit B"
				},
				{
					"name":"116810524 NABP1; SOSS complex subunit B2 isoform X2\tK28889 NABP; SOSS complex subunit B"
				},
				{
					"name":"116475553 INIP; SOSS complex subunit C isoform X1\tK28890 INIP; SOSS complex subunit C"
				},
				{
					"name":"116478237 LOW QUALITY PROTEIN: SOSS complex subunit C\tK28890 INIP; SOSS complex subunit C"
				}
				]
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"116462002 ATR; serine\/threonine-protein kinase ATR\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]"
				},
				{
					"name":"116473507 ATRIP; ATR-interacting protein isoform X1\tK10905 ATRIP; ATR interacting protein"
				},
				{
					"name":"116483319 ETAA1; ewing's tumor-associated antigen 1 isoform X1\tK28856 ETAA1; Ewing's tumor-associated antigen 1"
				},
				{
					"name":"116476898 ATM; serine-protein kinase ATM isoform X1\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"116459052 TP53; cellular tumor antigen p53\tK04451 TP53; tumor protein p53"
				},
				{
					"name":"116477131 CHEK1; serine\/threonine-protein kinase Chk1\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]"
				},
				{
					"name":"116458592 CHEK2; serine\/threonine-protein kinase Chk2\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]"
				},
				{
					"name":"116473518 CDC25A; M-phase inducer phosphatase 1 isoform X1\tK06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]"
				},
				{
					"name":"116461428 CDC25B; M-phase inducer phosphatase 2 isoform X1\tK05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]"
				},
				{
					"name":"116474369 LOW QUALITY PROTEIN: M-phase inducer phosphatase 2-like\tK05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]"
				},
				{
					"name":"116471552 CDC25C; M-phase inducer phosphatase 3 isoform X1\tK05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]"
				},
				{
					"name":"116461242 YWHAB; 14-3-3 protein beta\/alpha isoform X1\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"116468774 14-3-3 protein theta-like\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"116475043 LOW QUALITY PROTEIN: 14-3-3 protein zeta\/delta-like\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"116478498 YWHAZ; 14-3-3 protein zeta\/delta\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"116480214 YWHAQ; 14-3-3 protein theta\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"116810056 14-3-3 protein zeta\/delta-like\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"116459370 YWHAH; 14-3-3 protein eta\tK16198 YWHAG_H; 14-3-3 protein gamma\/eta"
				},
				{
					"name":"116811152 YWHAG; 14-3-3 protein gamma\tK16198 YWHAG_H; 14-3-3 protein gamma\/eta"
				},
				{
					"name":"116458285 YWHAE; 14-3-3 protein epsilon\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"116476433 NAV2; neuron navigator 2 isoform X1\tK19483 NAV2; neuron navigator 2 [EC:5.6.2.4]"
				},
				{
					"name":"116476351 LOW QUALITY PROTEIN: wee1-like protein kinase 2\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
				},
				{
					"name":"116476528 WEE1; wee1-like protein kinase isoform X2\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
				},
				{
					"name":"116814436 WEE2; wee1-like protein kinase 2\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
				},
				{
					"name":"116458635 PER1; period circadian protein homolog 1 isoform X1\tK21944 PER1; period circadian protein 1"
				},
				{
					"name":"116809367 PER2; period circadian protein homolog 2 isoform X1\tK02633 PER2; period circadian protein 2"
				},
				{
					"name":"116812866 PER3; period circadian protein homolog 3 isoform X1\tK21945 PER3; period circadian protein 3"
				},
				{
					"name":"116459774 MDC1; mediator of DNA damage checkpoint protein 1\tK20780 MDC1; mediator of DNA damage checkpoint protein 1"
				},
				{
					"name":"116811163 PLS3; plastin-3\tK17336 PLS3; plastin-3"
				},
				{
					"name":"116481701 AEN; apoptosis-enhancing nuclease isoform X3\tK18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]"
				},
				{
					"name":"116473073 PLK3; serine\/threonine-protein kinase PLK3\tK08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]"
				},
				{
					"name":"116483366 PLK5; LOW QUALITY PROTEIN: inactive serine\/threonine-protein kinase PLK5\tK19596 PLK5; inactive serine\/threonine-protein kinase PLK5"
				},
				{
					"name":"116466010 NEK1; serine\/threonine-protein kinase Nek1 isoform X1\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"116467312 NEK5; LOW QUALITY PROTEIN: serine\/threonine-protein kinase Nek5\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"116473385 NEK4; serine\/threonine-protein kinase Nek4 isoform X3\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"116473727 NEK10; serine\/threonine-protein kinase Nek10 isoform X1\tK20879 NEK10; serine\/threonine-protein kinase Nek10 [EC:2.7.11.1]"
				},
				{
					"name":"116461824 NEK11; serine\/threonine-protein kinase Nek11 isoform X1\tK20880 NEK11; serine\/threonine-protein kinase Nek11 [EC:2.7.11.1]"
				},
				{
					"name":"116482317 DONSON; protein downstream neighbor of Son isoform X1\tK22422 DONSON; protein downstream neighbor of Son"
				},
				{
					"name":"116457762 KANK4; KN motif and ankyrin repeat domain-containing protein 4 isoform X1\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"116458499 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"116478383 KANK3; KN motif and ankyrin repeat domain-containing protein 3\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"116478471 KANK2; KN motif and ankyrin repeat domain-containing protein 2 isoform X1\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"116457902 KLLN; killin\tK23389 KLLN; killin"
				},
				{
					"name":"116474501 SLFN11; schlafen family member 11\tK24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]"
				},
				{
					"name":"116813363 CHMP4C; charged multivesicular body protein 4c\tK24782 CHMP4C; charged multivesicular body protein 4C"
				},
				{
					"name":"116468491 VPS4B; vacuolar protein sorting-associated protein 4B\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"116471438 VPS4A; vacuolar protein sorting-associated protein 4A isoform X1\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"116481456 ZFYVE19; abscission\/NoCut checkpoint regulator\tK24778 ZFYVE19; abscission\/NoCut checkpoint regulator"
				},
				{
					"name":"116457583 SDE2; splicing regulator SDE2 isoform X1\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"116483195 KRCC1; lysine-rich coiled-coil protein 1\tK29003 KRCC1; lysine-rich coiled-coil protein 1"
				},
				{
					"name":"116460744 BLCAP; bladder cancer-associated protein\tK29062 BLCAP; apoptosis inducing factor BLCAP"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases",
				"children":[
				{
					"name":"116466883 POLQ; DNA polymerase theta isoform X4\tK02349 POLQ; DNA polymerase theta [EC:2.7.7.7]"
				},
				{
					"name":"116458304 MYBBP1A; myb-binding protein 1A isoform X1\tK02331 POL5; DNA polymerase phi [EC:2.7.7.7]"
				},
				{
					"name":"116466070 PRIMPOL; DNA-directed primase\/polymerase protein isoform X1\tK22761 PRIMPOL; DNA-directed primase\/polymerase protein [EC:2.7.7.102 2.7.7.7]"
				}
				]
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"116473508 TREX1; three-prime repair exonuclease 1\tK10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]"
				},
				{
					"name":"116812194 TREX2; three prime repair exonuclease 2 isoform X1\tK10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]"
				},
				{
					"name":"116483404 DCLRE1A; DNA cross-link repair 1A protein\tK15340 DCLRE1A; DNA cross-link repair 1A protein"
				},
				{
					"name":"116469580 DCLRE1B; 5' exonuclease Apollo\tK15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]"
				},
				{
					"name":"116473015 EXO5; exonuclease V\tK17815 EXO5; exonuclease V [EC:3.1.-.-]"
				},
				{
					"name":"116463786 endonuclease V isoform X2\tK21813 ENDOV; endonuclease V [EC:3.1.26.-]"
				},
				{
					"name":"116463798 endonuclease V isoform X2\tK21813 ENDOV; endonuclease V [EC:3.1.26.-]"
				},
				{
					"name":"116462925 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X2\tK25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]"
				},
				{
					"name":"116478661 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 isoform X1\tK21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1"
				}
				]
			},
			{
				"name":"Helicases",
				"children":[
				{
					"name":"116464737 HELQ; helicase POLQ-like isoform X1\tK19178 HELQ; POLQ-like helicase [EC:5.6.2.4]"
				},
				{
					"name":"116475281 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1\tK20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]"
				}
				]
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"116468843 PRPF19; pre-mRNA-processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"116459734 CDC5L; cell division cycle 5-like protein\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"116469572 BCAS2; pre-mRNA-splicing factor SPF27\tK12861 BCAS2; pre-mRNA-splicing factor SPF27"
				},
				{
					"name":"116465453 PLRG1; pleiotropic regulator 1\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"116467254 NUDT15; nucleotide triphosphate diphosphatase NUDT15\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"116463002 NUDT1; oxidized purine nucleoside triphosphate hydrolase\tK17816 NUDT1; 8-oxo-dGTP diphosphatase \/ 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]"
				},
				{
					"name":"116461765 NUDT18; LOW QUALITY PROTEIN: 8-oxo-dGDP phosphatase NUDT18\tK17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]"
				},
				{
					"name":"116482588 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X3\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"116813244 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"116476611 RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"116480222 RRM2; ribonucleoside-diphosphate reductase subunit M2\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				},
				{
					"name":"116813485 RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"116482001 MGMT; methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"116477971 UNG; uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"116480975 SMUG1; single-strand selective monofunctional uracil DNA glycosylase isoform X1\tK10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]"
					},
					{
						"name":"116462624 MPG; DNA-3-methyladenine glycosylase isoform X1\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"116473085 MUTYH; adenine DNA glycosylase isoform X1\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"116462652 NTHL1; endonuclease III-like protein 1 isoform X1\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors"
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"116474606 LOW QUALITY PROTEIN: single-stranded DNA-binding protein, mitochondrial\tK03111 ssb; single-strand DNA-binding protein"
					},
					{
						"name":"116814437 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1\tK03111 ssb; single-strand DNA-binding protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"116474606 LOW QUALITY PROTEIN: single-stranded DNA-binding protein, mitochondrial\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"116814437 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"116467254 NUDT15; nucleotide triphosphate diphosphatase NUDT15\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"116482588 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X3\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"116813244 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}