{
	"name":"hyp02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"A0257_03450 subtype I-B CRISPR-associated endonuclease Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"A0257_03445 CRISPR-associated endonuclease Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"A0257_03470 hypothetical protein\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"A0257_03455 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"A0257_03455 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"A0257_03455 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"A0257_03455 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"A0257_03455 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"A0257_22210 hypothetical protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"A0257_22205 hypothetical protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"A0257_22200 type I restriction endonuclease subunit M\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases",
				"children":[
				{
					"name":"A0257_21060 hypothetical protein\tK01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]"
				},
				{
					"name":"A0257_21935 hypothetical protein\tK01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]"
				}
				]
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"A0257_08045 adenine methyltransferase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"A0257_14570 cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"A0257_11710 hypothetical protein\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"A0257_11705 type III restriction endonuclease subunit M\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"A0257_03950 hypothetical protein\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"A0257_13215 hypothetical protein\tK07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]"
			},
			{
				"name":"A0257_13220 hypothetical protein\tK19147 mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"A0257_06060 PemK family transcriptional regulator\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"A0257_10375 transcriptional regulator\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"A0257_10380 hypothetical protein\tK07172 mazE; antitoxin MazE"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"A0257_08665 hypothetical protein\tK06218 relE; mRNA interferase RelE\/StbE"
				}
				]
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"A0257_07895 toxin YoeB\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"A0257_09615 hypothetical protein\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"A0257_13090 hypothetical protein\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				},
				{
					"name":"A0257_22420 toxin HipA\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"A0257_00210 addiction module toxin RelE\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"A0257_01135 addiction module toxin RelE\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"A0257_04190 hypothetical protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"A0257_04845 addiction module toxin RelE\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"A0257_07425 hypothetical protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"A0257_22940 hypothetical protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"A0257_01140 transcriptional regulator\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"A0257_04850 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"A0257_07430 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"A0257_22935 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"A0257_07905 hypothetical protein\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"A0257_07920 DNA-binding protein\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"A0257_13620 hypothetical protein\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"A0257_00395 hypothetical protein\tK28275 vapC35S; ribonuclease VapC35\/45\/46\/47 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"A0257_09240 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"A0257_17295 rod shape-determining protein\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"A0257_02745 DNA topoisomerase IV\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"A0257_02735 DNA topoisomerase IV\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"A0257_14380 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"A0257_06205 cysteine desulfurase IscS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"A0257_14960 cysteine desulfurase IscS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"A0257_15570 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"A0257_14910 sulfurtransferase\tK19170 dndC; DNA sulfur modification protein DndC"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}