{
	"name":"iel03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)",
				"children":[
				{
					"name":"124155697 Orc1; origin recognition complex subunit 1 isoform X1\tK02603 ORC1; origin recognition complex subunit 1"
				},
				{
					"name":"124168480 Orc2; origin recognition complex subunit 2 isoform X1\tK02604 ORC2; origin recognition complex subunit 2"
				},
				{
					"name":"124164107 Orc4; origin recognition complex subunit 4\tK02606 ORC4; origin recognition complex subunit 4"
				},
				{
					"name":"124163973 Orc5; origin recognition complex subunit 5 isoform X1\tK02607 ORC5; origin recognition complex subunit 5"
				},
				{
					"name":"124156503 Orc6; origin recognition complex subunit 6\tK02608 ORC6; origin recognition complex subunit 6"
				},
				{
					"name":"124163469 dup; chromatin licensing and DNA replication factor double parked\tK10727 CDT1; chromatin licensing and DNA replication factor 1"
				},
				{
					"name":"124155405 Cdc6; cell division cycle 6\tK02213 CDC6; cell division control protein 6"
				},
				{
					"name":"124158478 Mcm2; DNA replication licensing factor Mcm2\tK02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"
				},
				{
					"name":"124164519 Mcm3; minichromosome maintenance 3\tK02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]"
				},
				{
					"name":"124156525 dpa; disc proliferation abnormal\tK02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]"
				},
				{
					"name":"124167917 Mcm5; minichromosome maintenance 5 isoform X1\tK02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]"
				},
				{
					"name":"124159549 Mcm6; minichromosome maintenance 6\tK02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]"
				},
				{
					"name":"124160755 Mcm7; minichromosome maintenance 7\tK02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]"
				}
				]
			},
			{
				"name":"CDK (cyclin dependent kinase)",
				"children":[
				{
					"name":"124162236 CycA; cyclin A isoform X1\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"124162658 CycE; cyclin E isoform X1\tK06626 CCNE; G1\/S-specific cyclin-E1"
				}
				]
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)",
				"children":[
				{
					"name":"124165420 LOC124165420; cell division cycle 7-related protein kinase isoform X1\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"GINS complex",
				"children":[
				{
					"name":"124157697 LOC124157697; DNA replication complex GINS protein PSF1\tK10732 GINS1; GINS complex subunit 1"
				},
				{
					"name":"124159432 Psf2; DNA replication complex GINS protein PSF2-like protein\tK10733 GINS2; GINS complex subunit 2"
				},
				{
					"name":"124158692 Psf3; DNA replication complex GINS protein Psf3\tK10734 GINS3; GINS complex subunit 3"
				},
				{
					"name":"124160440 Sld5; DNA replication complex GINS protein Sld5\tK10735 GINS4; GINS complex subunit 4"
				}
				]
			},
			{
				"name":"Other initiation factors",
				"children":[
				{
					"name":"124157507 RecQ4; recQ4 helicase\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
				},
				{
					"name":"124155762 Cdc45; cell division cycle protein 45\tK06628 CDC45; cell division control protein 45"
				},
				{
					"name":"124157860 rec; minichromosome maintenance 8 factor recombination-defective\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
				},
				{
					"name":"124167030 LOC124167030; uncharacterized protein LOC124167030 isoform X1\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
				},
				{
					"name":"124156060 Mcm10; minichromosome maintenance 10 homolog isoform X1\tK10736 MCM10; minichromosome maintenance protein 10"
				},
				{
					"name":"124154061 LOC124154061; mini-chromosome maintenance complex-binding protein\tK28390 MCMBP; minichromosome maintenance complex-binding protein"
				},
				{
					"name":"124154483 LOC124154483; cyclin-dependent kinase 2-interacting protein\tK26052 CINP; cyclin-dependent kinase 2-interacting protein"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex",
				"children":[
				{
					"name":"124160679 PolA1; DNA polymerase alpha catalytic subunit\tK02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]"
				},
				{
					"name":"124167959 PolA2; DNA polymerase alpha subunit B isoform X1\tK02321 POLA2; DNA polymerase alpha subunit B"
				},
				{
					"name":"124164112 Prim1; DNA primase small subunit\tK02684 PRI1; DNA primase small subunit [EC:2.7.7.102]"
				},
				{
					"name":"124153598 LOC124153598; uncharacterized protein LOC124153598 isoform X1\tK02685 PRI2; DNA primase large subunit"
				},
				{
					"name":"124156123 LOC124156123; DNA primase large subunit\tK02685 PRI2; DNA primase large subunit"
				}
				]
			},
			{
				"name":"DNA polymerase epsilon complex",
				"children":[
				{
					"name":"124167833 PolE1; DNA polymerase epsilon catalytic subunit 1\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"124167873 PolE2; DNA polymerase epsilon subunit 2\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
				},
				{
					"name":"124164489 Chrac-14; DNA polymerase epsilon subunit 3 Chrac-14\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"DNA polymerase delta complex",
				"children":[
				{
					"name":"124161927 PolD1; DNA polymerase delta 1, catalytic subunit\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"124156614 PolD2; DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
				},
				{
					"name":"124153574 LOC124153574; uncharacterized protein LOC124153574\tK03504 POLD3; DNA polymerase delta subunit 3"
				},
				{
					"name":"124153438 LOC124153438; DNA polymerase delta subunit 4\tK03505 POLD4; DNA polymerase delta subunit 4"
				}
				]
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)",
				"children":[
				{
					"name":"124159101 PolG1; DNA polymerase gamma, catalytic subunit tam\tK02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]"
				},
				{
					"name":"124168174 PolG2; DNA polymerase subunit gamma-2, mitochondrial isoform X1\tK02333 POLG2; DNA polymerase gamma 2"
				}
				]
			},
			{
				"name":"RPA (replication protein A)",
				"children":[
				{
					"name":"124156000 RPA1; replication protein A 70\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"124169596 RPA2; replication protein A2\tK10739 RFA2; replication factor A2"
				},
				{
					"name":"124159519 LOC124159519; replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
				}
				]
			},
			{
				"name":"RFC (replication factor C)",
				"children":[
				{
					"name":"124163362 Gnf1; germ line transcription factor 1\tK10754 RFC1; replication factor C subunit 1"
				},
				{
					"name":"124159022 RfC4; replication factor C subunit RfC4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"124165756 LOC124165756; replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"124156395 RfC38; replication factor C subunit RfC38\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"124158642 RfC3; replication factor C subunit RfC3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"124157485 LOC124157485; ribonuclease H isoform X1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				},
				{
					"name":"124169343 LOC124169343; uncharacterized protein LOC124169343 isoform X1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				},
				{
					"name":"124155973 LOC124155973; ribonuclease H2 subunit A\tK10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]"
				},
				{
					"name":"124160968 LOC124160968; ribonuclease H2 subunit B isoform X1\tK10744 RNASEH2B; ribonuclease H2 subunit B"
				},
				{
					"name":"124167309 LOC124167309; uncharacterized protein LOC124167309 isoform X1\tK10745 RNASEH2C; ribonuclease H2 subunit C"
				}
				]
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"124160817 PCNA; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"124170642 LOC124170642; PCNA-associated factor\tK28763 PCLAF; PCNA-associated factor"
				},
				{
					"name":"124155333 Dna2; DNA replication helicase\/nuclease 2 isoform X1\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
				},
				{
					"name":"124155518 Fen1; flap structure-specific endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"124157574 tos; exonuclease tos\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
				},
				{
					"name":"124165307 DNAlig1; DNA ligase 1 isoform X1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"124168904 LOC124168904; DNA (cytosine-5)-methyltransferase 1.S isoform X1\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"124168377 LOC124168377; DNA (cytosine-5)-methyltransferase 3B\tK17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors",
				"children":[
				{
					"name":"124159178 geminin; geminin DNA replication inhibitor\tK10749 GMNN; geminin"
				},
				{
					"name":"124165489 CycB; cyclin B\tK21770 CCNB2; G2\/mitotic-specific cyclin-B2"
				},
				{
					"name":"124168053 CycB3; cyclin B3\tK21771 CCNB3; G2\/mitotic-specific cyclin-B3"
				},
				{
					"name":"124160533 Cdk1; cyclin-dependent kinase 1\tK02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]"
				}
				]
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex"
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"124159369 Smg6; smg6 nonsense mediated mRNA decay factor isoform X1\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
				},
				{
					"name":"124167231 Smg5; smg5 nonsense mediated mRNA decay factor\tK11125 SMG5; protein SMG5"
				},
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"124161051 Gar1; gar1 ribonucleoprotein\tK11128 GAR1; H\/ACA ribonucleoprotein complex subunit 1"
					},
					{
						"name":"124153959 NHP2; NHP2 ribonucleoprotein\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"124158970 Nop60B; dyskerin pseudouridine synthase 1 Nop60B\tK11131 DKC1; H\/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"Sm core complex",
					"children":[
					{
						"name":"124156220 SmB; small ribonucleoprotein particle protein SmB\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"124164433 SmD1; small ribonucleoprotein particle protein SmD1\tK11087 SNRPD1; small nuclear ribonucleoprotein D1"
					},
					{
						"name":"124157266 SmD2; small ribonucleoprotein particle protein SmD2 isoform X1\tK11096 SNRPD2; small nuclear ribonucleoprotein D2"
					},
					{
						"name":"124155183 SmD3; small ribonucleoprotein particle protein SmD3\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"124164260 LOC124164260; small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"124165322 LOC124165322; small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"124174097 SNRPG; small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					}
					]
				}
				]
			},
			{
				"name":"ELG1-RFC complex",
				"children":[
				{
					"name":"124159022 RfC4; replication factor C subunit RfC4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"124165756 LOC124165756; replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"124156395 RfC38; replication factor C subunit RfC38\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"124158642 RfC3; replication factor C subunit RfC3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"MRN complex",
				"children":[
				{
					"name":"124166548 mre11; double strand break repair nuclease mre11 isoform X1\tK10865 MRE11; double-strand break repair protein MRE11"
				},
				{
					"name":"124160243 rad50; DNA repair protein rad50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
				}
				]
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"124170798 LOC124170798; serine-protein kinase ATM\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"124159437 LOC124159437; bifunctional 3'-5' exonuclease\/ATP-dependent helicase WRN\tK10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]"
				},
				{
					"name":"124157656 Blm; Bloom syndrome helicase isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
				},
				{
					"name":"124162866 LOC124162866; DNA-dependent protein kinase catalytic subunit isoform X1\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
				},
				{
					"name":"124167147 mei-9; DNA repair endonuclease XPF mei-9\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				},
				{
					"name":"124153800 Parp1; poly-(ADP-ribose) polymerase\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
				},
				{
					"name":"124155535 Tnks; tankyrase\tK10799 TNKS; tankyrase [EC:2.4.2.30]"
				},
				{
					"name":"124162478 Rtel1; regulator of telomere elongation helicase 1 isoform X1\tK11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]"
				},
				{
					"name":"124162620 LOC124162620; telomerase RNA component interacting RNase-like\tK01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]"
				},
				{
					"name":"124170527 LOC124170527; uncharacterized protein LOC124170527\tK01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]"
				},
				{
					"name":"124164268 Pif1; pif1 DNA helicase\tK15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]"
				},
				{
					"name":"124167366 Pur-alpha; purine-rich binding protein-alpha isoform X1\tK21772 PURA; transcriptional activator protein Pur-alpha"
				},
				{
					"name":"124161079 WDR79; telomerase Cajal body protein 1 homolog\tK23314 WRAP53; telomerase Cajal body protein 1"
				},
				{
					"name":"124160734 LOC124160734; splicing regulator SDE2\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"124162386 LOC124162386; replication termination factor 2\tK25186 RTF2; replication termination factor 2"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"124165596 Top1; DNA topoisomerase 1 isoform X1\tK03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"124156618 Top2; DNA topoisomerase 2 isoform X1\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"124162306 Top3beta; DNA topoisomerase 3-beta\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			},
			{
				"name":"124167853 Top3alpha; topoisomerase 3-alpha isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"124161878 mtSSB; mitochondrial single stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"124157485 LOC124157485; ribonuclease H isoform X1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"124169343 LOC124169343; uncharacterized protein LOC124169343 isoform X1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors"
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"124157485 LOC124157485; ribonuclease H isoform X1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"124169343 LOC124169343; uncharacterized protein LOC124169343 isoform X1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"124155333 Dna2; DNA replication helicase\/nuclease 2 isoform X1\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
					},
					{
						"name":"124155518 Fen1; flap structure-specific endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"124165307 DNAlig1; DNA ligase 1 isoform X1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	}
	]
}