{
	"name":"kph01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]",
				"children":[
				{
					"name":"KPNIH24_26690 beta-lactamase TEM\tK18698 blaTEM; beta-lactamase class A TEM [EC:3.5.2.6]"
				},
				{
					"name":"KPNIH24_15650 beta-lactamase TEM\tK18699 blaSHV; beta-lactamase class A SHV [EC:3.5.2.6]"
				},
				{
					"name":"KPNIH24_27130 beta-lactamase TEM\tK18699 blaSHV; beta-lactamase class A SHV [EC:3.5.2.6]"
				},
				{
					"name":"KPNIH24_26630 beta-lactamase\tK18768 blaKPC; beta-lactamase class A KPC [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases",
				"children":[
				{
					"name":"KPNIH24_26565 aminoglycoside phosphotransferase\tK19276 aac3-IV; aminoglycoside 3-N-acetyltransferase IV [EC:2.3.1.81]"
				},
				{
					"name":"KPNIH24_26780 aminoglycoside adenylyltransferase\tK19278 aac6-Ib; aminoglycoside 6'-N-acetyltransferase Ib [EC:2.3.1.82]"
				},
				{
					"name":"KPNIH24_27070 aminoglycoside adenylyltransferase\tK19278 aac6-Ib; aminoglycoside 6'-N-acetyltransferase Ib [EC:2.3.1.82]"
				}
				]
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases",
				"children":[
				{
					"name":"KPNIH24_17325 adenylyltransferase\tK00984 aadA; streptomycin 3\\\"-adenylyltransferase [EC:2.7.7.47]"
				},
				{
					"name":"KPNIH24_26870 adenylyltransferase\tK00984 aadA; streptomycin 3\\\"-adenylyltransferase [EC:2.7.7.47]"
				},
				{
					"name":"KPNIH24_27460 adenylyltransferase\tK00984 aadA; streptomycin 3\\\"-adenylyltransferase [EC:2.7.7.47]"
				},
				{
					"name":"KPNIH24_27470 adenylyltransferase\tK00984 aadA; streptomycin 3\\\"-adenylyltransferase [EC:2.7.7.47]"
				}
				]
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"KPNIH24_26570 hydrogenase expression protein HypB\tK18817 hph; hygromycin-B 4-O-kinase [EC:2.7.1.163]"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"KPNIH24_26555 macrolide transporter\tK08217 mef; MFS transporter, DHA3 family, macrolide efflux protein"
				},
				{
					"name":"KPNIH24_20225 multidrug transporter\tK08160 mdfA; MFS transporter, DHA1 family, multidrug\/chloramphenicol efflux transport protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"KPNIH24_26475 macrolide 2'-phosphotransferase\tK06979 mph; macrolide phosphotransferase"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"KPNIH24_27465 MFS transporter\tK18552 cmlA; MFS transporter, DHA1 family, chloramphenicol\/florfenicol resistance protein"
				}
				]
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"KPNIH24_13425 chloramphenicol acetyltransferase\tK19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28]"
				},
				{
					"name":"KPNIH24_27420 chloramphenicol acetyltransferase\tK19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase",
				"children":[
				{
					"name":"KPNIH24_17315 dihydropteroate synthase\tK18974 sul1; dihydropteroate synthase type 1 [EC:2.5.1.15]"
				},
				{
					"name":"KPNIH24_26880 dihydropteroate synthase\tK18974 sul1; dihydropteroate synthase type 1 [EC:2.5.1.15]"
				}
				]
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases",
				"children":[
				{
					"name":"KPNIH24_26865 dihydrofolate reductase\tK18590 dfrA12; dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]"
				}
				]
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"KPNIH24_14170 methyl viologen resistance protein SmvA\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases",
				"children":[
				{
					"name":"KPNIH24_03110 glutathione transferase\tK21265 fosA5; glutathione S-transferase fosA5 [EC:2.5.1.18]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"KPNIH24_03015 histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"KPNIH24_27690 histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"KPNIH24_27775 histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"KPNIH24_03010 transcriptional regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"KPNIH24_27695 transcriptional regulatory protein PcoR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"KPNIH24_27770 transcriptional regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]"
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]",
				"children":[
				{
					"name":"KPNIH24_18505 sensor protein PhoQ\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
				},
				{
					"name":"KPNIH24_18500 transcriptional regulator\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				}
				]
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"KPNIH24_21820 RND transporter MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KPNIH24_22865 multidrug transporter\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KPNIH24_25910 acriflavine resistance protein E\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KPNIH24_21815 multidrug RND transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"KPNIH24_22870 multidrug transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"KPNIH24_25915 multidrug transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"KPNIH24_10445 multidrug resistance outer membrane protein MdtQ\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KPNIH24_16285 transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KPNIH24_25920 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"KPNIH24_12820 TetR family transcriptional regulator\tK18301 mexL; TetR\/AcrR family transcriptional regulator, mexJK operon transcriptional repressor"
				},
				{
					"name":"KPNIH24_10445 multidrug resistance outer membrane protein MdtQ\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KPNIH24_16285 transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KPNIH24_25920 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"KPNIH24_10445 multidrug resistance outer membrane protein MdtQ\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KPNIH24_16285 transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KPNIH24_25920 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"KPNIH24_22755 transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]",
				"children":[
				{
					"name":"KPNIH24_13205 histidine kinase\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
				},
				{
					"name":"KPNIH24_13210 chemotaxis protein CheY\tK18144 adeR; two-component system, OmpR family, response regulator AdeR"
				},
				{
					"name":"KPNIH24_13220 acriflavine resistance protein B\tK18146 adeB; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"KPNIH24_04800 transcriptional regulator\tK18140 envR; TetR\/AcrR family transcriptional regulator, acrEF\/envCD operon repressor"
				},
				{
					"name":"KPNIH24_04795 multidrug transporter\tK18141 acrE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KPNIH24_04790 multidrug transporter\tK18142 acrF; multidrug efflux pump"
				},
				{
					"name":"KPNIH24_06005 membrane protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"KPNIH24_05840 transcriptional regulator\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
				},
				{
					"name":"KPNIH24_06005 membrane protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"KPNIH24_08600 transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KPNIH24_11300 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KPNIH24_16570 transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KPNIH24_17065 transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KPNIH24_18255 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]",
				"children":[
				{
					"name":"KPNIH24_17180 quinolone resistance protein\tK08170 norB; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"KPNIH24_14170 methyl viologen resistance protein SmvA\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]",
				"children":[
				{
					"name":"KPNIH24_15550 transcriptional regulator\tK13632 marA; AraC family transcriptional regulator, mar-sox-rob regulon activator"
				},
				{
					"name":"KPNIH24_19585 membrane protein\tK09476 ompF; outer membrane pore protein F"
				}
				]
			}
			]
		}
		]
	}
	]
}