{
	"name":"kpo01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]",
				"children":[
				{
					"name":"KPN2242_10850 beta-lactamase TEM\tK18699 blaSHV; beta-lactamase class A SHV [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"KPN2242_07195 multidrug efflux system translocase MdfA\tK08160 mdfA; MFS transporter, DHA1 family, multidrug\/chloramphenicol efflux transport protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"KPN2242_13030 putative chloramphenicol acetyltransferase\tK19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"KPN2242_12305 methyl viologen resistance protein SmvA\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases",
				"children":[
				{
					"name":"KPN2242_01920 putative glyoxalase\/bleomycin resistance protein\/dioxygenase\tK21265 fosA5; glutathione S-transferase fosA5 [EC:2.5.1.18]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"KPN2242_01835 sensor kinase CusS\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"KPN2242_25406 sensor kinase CusS\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"KPN2242_25501 copper resistant sensor kinase PcoS\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"KPN2242_01830 DNA-binding transcriptional activator CusR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"KPN2242_25411 DNA-binding transcriptional activator CusR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"KPN2242_25496 Transcriptional regulatory protein pcoR\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]"
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]",
				"children":[
				{
					"name":"KPN2242_08755 sensor protein PhoQ\tK07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]"
				},
				{
					"name":"KPN2242_08760 DNA-binding transcriptional regulator PhoP\tK07660 phoP; two-component system, OmpR family, response regulator PhoP"
				}
				]
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"KPN2242_04625 acriflavine resistance protein A\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KPN2242_05635 putative secretion protein HlyD\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KPN2242_23270 putative secretion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KPN2242_04620 multidrug efflux system protein AcrB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"KPN2242_05640 RND transporter, hydrophobe\/amphiphile efflux-1 (HAE1) family protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"KPN2242_23275 acridine efflux pump\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"KPN2242_10210 putative outer membrane efflux protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KPN2242_23280 RND efflux system, outer membrane lipoprotein, NodT family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"KPN2242_13680 putative TetR-family trancriptional regulatory protein\tK18301 mexL; TetR\/AcrR family transcriptional regulator, mexJK operon transcriptional repressor"
				},
				{
					"name":"KPN2242_10210 putative outer membrane efflux protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KPN2242_23280 RND efflux system, outer membrane lipoprotein, NodT family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"KPN2242_10210 putative outer membrane efflux protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KPN2242_23280 RND efflux system, outer membrane lipoprotein, NodT family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"KPN2242_04735 MerR family transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]",
				"children":[
				{
					"name":"KPN2242_13295 sensor histidine protein kinase (RstA regulator)\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
				},
				{
					"name":"KPN2242_13290 response regulator\tK18144 adeR; two-component system, OmpR family, response regulator AdeR"
				},
				{
					"name":"KPN2242_13280 acridine efflux pump\tK18146 adeB; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"KPN2242_21385 DNA-binding transcriptional regulator EnvR\tK18140 envR; TetR\/AcrR family transcriptional regulator, acrEF\/envCD operon repressor"
				},
				{
					"name":"KPN2242_21390 transmembrane protein affecting septum formation and cell membrane permeability\tK18141 acrE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KPN2242_21395 integral transmembrane protein; acridine resistance\tK18142 acrF; multidrug efflux pump"
				},
				{
					"name":"KPN2242_20325 tolC; outer membrane channel protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"KPN2242_19560 DNA-binding transcriptional activator EvgA\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
				},
				{
					"name":"KPN2242_19680 DNA-binding transcriptional activator EvgA\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
				},
				{
					"name":"KPN2242_19700 DNA-binding transcriptional activator EvgA\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
				},
				{
					"name":"KPN2242_20485 DNA-binding transcriptional activator EvgA\tK07690 evgA; two-component system, NarL family, response regulator EvgA"
				},
				{
					"name":"KPN2242_20325 tolC; outer membrane channel protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"KPN2242_09035 putative LysR-family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KPN2242_09725 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KPN2242_09885 putative LysR-family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KPN2242_17810 putative LysR-family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]",
				"children":[
				{
					"name":"KPN2242_09610 major facilitator superfamily MFS_1\tK08170 norB; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"KPN2242_12305 methyl viologen resistance protein SmvA\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]",
				"children":[
				{
					"name":"KPN2242_10950 DNA-binding transcriptional activator MarA\tK13632 marA; AraC family transcriptional regulator, mar-sox-rob regulon activator"
				},
				{
					"name":"KPN2242_15250 DNA-binding transcriptional activator MarA\tK13632 marA; AraC family transcriptional regulator, mar-sox-rob regulon activator"
				},
				{
					"name":"KPN2242_07850 outer membrane protein 1A\/OmpK35 porin\tK09476 ompF; outer membrane pore protein F"
				}
				]
			}
			]
		}
		]
	}
	]
}