{
	"name":"kpse03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III"
			},
			{
				"name":"Cytochrome c oxidase"
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase"
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"IP581_20470 infB; translation initiation factor IF-2\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"IP581_09910 infC; translation initiation factor IF-3\tK02520 infC; translation initiation factor IF-3"
				},
				{
					"name":"IP581_04090 tsf; elongation factor Ts\tK02357 tsf; elongation factor Ts"
				},
				{
					"name":"IP581_01100 tuf; elongation factor Tu\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"IP581_21210 tuf; elongation factor Tu\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"IP581_14335 fusA; elongation factor G\tK02355 fusA; elongation factor G"
				},
				{
					"name":"IP581_21215 fusA; elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP"
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"IP581_16955 era; GTPase Era\tK03595 era; GTPase"
				},
				{
					"name":"IP581_10245 tyrS; tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"IP581_06445 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"IP581_13625 aspS; aspartate--tRNA ligase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"IP581_13665 argS; arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors"
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"IP581_01555 ssb1; single-stranded DNA-binding protein SSB1\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors"
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex"
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"IP581_04125 bamA; outer membrane protein assembly factor BamA\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex"
			},
			{
				"name":"TIM8\/13 complex"
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex"
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex"
			},
			{
				"name":"TIM23 complex"
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors"
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"IP581_03445 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"IP581_17300 grpE; nucleotide exchange factor GrpE\tK03687 GRPE; molecular chaperone GrpE"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"IP581_01990 groL; chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"IP581_01985 co-chaperone GroES\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"IP581_03450 dnaJ; molecular chaperone DnaJ\tK03686 dnaJ; molecular chaperone DnaJ"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"IP581_14335 fusA; elongation factor G\tK02355 fusA; elongation factor G"
				},
				{
					"name":"IP581_21215 fusA; elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"IP581_10880 nifS; cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"IP581_16820 iscS; cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"IP581_03445 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"IP581_16805 hscB; co-chaperone HscB\tK04082 hscB; molecular chaperone HscB"
				},
				{
					"name":"IP581_10165 Grx4 family monothiol glutaredoxin\tK07390 grxD; monothiol glutaredoxin"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis"
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors",
				"children":[
				{
					"name":"IP581_14950 apbC; iron-sulfur cluster carrier protein ApbC\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				}
				]
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors"
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"IP581_05100 cyoE; protoheme IX farnesyltransferase\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"IP581_23180 yidC; membrane protein insertase YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				}
				]
			},
			{
				"name":"Complex-V assembly factors"
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors"
			},
			{
				"name":"Actin cytoskeleton organization"
			},
			{
				"name":"Mitochondrial movement"
			},
			{
				"name":"Retention of mitochondria"
			},
			{
				"name":"Morphogenesis factors"
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins"
			},
			{
				"name":"Parkin-dependent mechanism factors"
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"IP581_05435 htpG; molecular chaperone HtpG\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors"
			}
			]
		}
		]
	}
	]
}