{
	"name":"lcz01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"LCAZH_0560 ABC transporter ATPase\tK19350 lsa; lincosamide and streptogramin A transport system ATP-binding\/permease protein"
				},
				{
					"name":"LCAZH_0914 major facilitator superfamily permease\tK08217 mef; MFS transporter, DHA3 family, macrolide efflux protein"
				},
				{
					"name":"LCAZH_1409 major facilitator superfamily permease\tK08217 mef; MFS transporter, DHA3 family, macrolide efflux protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]"
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]",
				"children":[
				{
					"name":"LCAZH_0737 D-alanine-activating enzyme\tK03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]"
				},
				{
					"name":"LCAZH_0738 D-alanyl transfer protein\tK03739 dltB; membrane protein involved in D-alanine export"
				},
				{
					"name":"LCAZH_0739 D-alanyl carrier protein\tK14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]"
				},
				{
					"name":"LCAZH_0740 D-alanyl transfer protein\tK03740 dltD; D-alanine transfer protein"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"LCAZH_2238 lysyl-tRNA synthetase\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"LCAZH_2942 Cu(I)-responsive transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]"
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]"
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]",
				"children":[
				{
					"name":"LCAZH_2092 multidrug ABC transporter ATPase\/permease\tK18104 abcA; ATP-binding cassette, subfamily B, bacterial AbcA\/BmrA [EC:7.6.2.2]"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}