{
	"name":"lei03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P"
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"C2U54_20730 ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"C2U54_00955 multifunctional CCA addition\/repair protein\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex",
				"children":[
				{
					"name":"C2U54_06100 RNA-splicing ligase RtcB\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"C2U54_21620 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"C2U54_09220 proS; proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"C2U54_08420 isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"C2U54_11080 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"C2U54_20155 metG; methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"C2U54_11225 glutamine--tRNA ligase\tK01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]"
				},
				{
					"name":"C2U54_19035 arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"C2U54_00150 lysS; lysine--tRNA ligase\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]"
				},
				{
					"name":"C2U54_18995 aspS; aspartate--tRNA ligase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"C2U54_23065 alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"C2U54_12650 asparagine--tRNA ligase\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				},
				{
					"name":"C2U54_14710 threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"C2U54_12475 serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"C2U54_10340 cysS; cysteine--tRNA ligase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"C2U54_02140 valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"C2U54_22030 histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"C2U54_14735 phenylalanine--tRNA ligase subunit alpha\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"C2U54_14740 phenylalanine--tRNA ligase subunit beta\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"C2U54_15160 tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"C2U54_02890 trpS; tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"C2U54_04460 dtd; D-tyrosyl-tRNA(Tyr) deacylase\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				}
				]
			},
			{
				"name":"AARS associated factors",
				"children":[
				{
					"name":"C2U54_13630 histidine triad nucleotide-binding protein\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"C2U54_11145 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"C2U54_00570 tRNA (guanosine(46)-N7)-methyltransferase TrmB\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				},
				{
					"name":"C2U54_09225 tsaA; tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO\tK22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"C2U54_20950 tRNA pseudouridine(38-40) synthase TruA\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"C2U54_01890 tRNA pseudouridine(55) synthase TruB\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"C2U54_23350 tRNA pseudouridine(13) synthase TruD\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"C2U54_22125 IscS subfamily cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Elongator complex"
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"C2U54_02510 L-threonylcarbamoyladenylate synthase type 1 TsaC\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"C2U54_06855 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"C2U54_04845 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"C2U54_04700 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"C2U54_14495 selenide, water dikinase SelD\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors",
				"children":[
				{
					"name":"C2U54_07060 3'(2'),5'-bisphosphate nucleotidase CysQ\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]"
				}
				]
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"C2U54_04860 ribonuclease P protein component\tK03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]"
				},
				{
					"name":"C2U54_01755 rnpB; RNase P RNA component class A\tK01978 rnpB; RNase P catalytic RNA component"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"C2U54_20730 ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				},
				{
					"name":"C2U54_15075 ribonuclease T\tK03683 rnt; ribonuclease T [EC:3.1.13.-]"
				},
				{
					"name":"C2U54_05390 ribonuclease PH\tK00989 rph; ribonuclease PH [EC:2.7.7.56]"
				},
				{
					"name":"C2U54_10975 ribonuclease I\tK01169 rna; ribonuclease I (enterobacter ribonuclease) [EC:4.6.1.21]"
				},
				{
					"name":"C2U54_17890 exoribonuclease II\tK01147 rnb; exoribonuclease II [EC:3.1.13.1]"
				},
				{
					"name":"C2U54_18665 ribonuclease D\tK03684 rnd; ribonuclease D [EC:3.1.13.5]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"C2U54_00955 multifunctional CCA addition\/repair protein\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases"
			},
			{
				"name":"tRNA splicing ligases",
				"children":[
				{
					"name":"C2U54_06100 RNA-splicing ligase RtcB\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"C2U54_08985 RNA 2',3'-cyclic phosphodiesterase\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"C2U54_08245 energy-dependent translational throttle protein EttA\tK06020 ettA; energy-dependent translational throttle protein EttA"
				}
				]
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"C2U54_11080 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"C2U54_09220 proS; proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"C2U54_15160 tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"C2U54_02890 trpS; tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"C2U54_14710 threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"C2U54_08420 isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"C2U54_00150 lysS; lysine--tRNA ligase\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]"
				},
				{
					"name":"C2U54_23065 alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"C2U54_02140 valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"C2U54_20155 metG; methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"C2U54_12475 serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"C2U54_18995 aspS; aspartate--tRNA ligase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"C2U54_05730 glyQ; glycine--tRNA ligase subunit alpha\tK01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]"
				},
				{
					"name":"C2U54_05735 glycine--tRNA ligase subunit beta\tK01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]"
				},
				{
					"name":"C2U54_10340 cysS; cysteine--tRNA ligase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"C2U54_21620 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"C2U54_11225 glutamine--tRNA ligase\tK01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]"
				},
				{
					"name":"C2U54_19035 arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"C2U54_14735 phenylalanine--tRNA ligase subunit alpha\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"C2U54_14740 phenylalanine--tRNA ligase subunit beta\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"C2U54_22030 histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"C2U54_12650 asparagine--tRNA ligase\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				},
				{
					"name":"C2U54_08970 tRNA glutamyl-Q(34) synthetase GluQRS\tK01894 gluQ; glutamyl-Q tRNA(Asp) synthetase [EC:6.1.1.-]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"C2U54_04460 dtd; D-tyrosyl-tRNA(Tyr) deacylase\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				},
				{
					"name":"C2U54_10225 Cys-tRNA(Pro) deacylase\tK03976 ybaK; Cys-tRNA(Pro)\/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases",
				"children":[
				{
					"name":"C2U54_22255 tRNA adenosine(34) deaminase TadA\tK11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]"
				}
				]
			},
			{
				"name":"Dihydorouridine synthases",
				"children":[
				{
					"name":"C2U54_06210 tRNA dihydrouridine(20\/20a) synthase DusA\tK05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]"
				},
				{
					"name":"C2U54_02395 tRNA dihydrouridine synthase DusB\tK05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]"
				},
				{
					"name":"C2U54_20275 tRNA dihydrouridine(16) synthase DusC\tK05541 dusC; tRNA-dihydrouridine synthase C [EC:1.-.-.-]"
				}
				]
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"C2U54_11145 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"C2U54_19015 carboxy-S-adenosyl-L-methionine synthase CmoA\tK15256 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"C2U54_19020 tRNA 5-methoxyuridine(34)\/uridine 5-oxyacetic acid(34) synthase CmoB\tK15257 cmoB; tRNA (mo5U34)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"C2U54_12595 tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM\tK06219 smtA; tRNA 5-carboxymethoxyuridine methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"C2U54_08310 tRNA\/rRNA methyltransferase\tK02533 lasT; tRNA\/rRNA methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"C2U54_03995 trmA; tRNA (uridine(54)-C5)-methyltransferase TrmA\tK00557 trmA; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]"
				},
				{
					"name":"C2U54_00570 tRNA (guanosine(46)-N7)-methyltransferase TrmB\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				},
				{
					"name":"C2U54_22520 trmD; tRNA (guanosine(37)-N1)-methyltransferase TrmD\tK00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"C2U54_04845 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"C2U54_22375 tRNA\/rRNA methyltransferase\tK03214 yfiF; RNA methyltransferase, TrmH family [EC:2.1.1.-]"
				},
				{
					"name":"C2U54_05265 tRNA (guanosine(18)-2'-O)-methyltransferase TrmH\tK00556 trmH; tRNA (guanosine-2'-O-)-methyltransferase [EC:2.1.1.34]"
				},
				{
					"name":"C2U54_22135 tRNA (cytosine(32)\/uridine(32)-2'-O)-methyltransferase TrmJ\tK15396 trmJ; tRNA (cytidine32\/uridine32-2'-O)-methyltransferase [EC:2.1.1.200]"
				},
				{
					"name":"C2U54_05555 tRNA (uridine(34)\/cytosine(34)\/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase TrmL\tK03216 trmL; tRNA (cytidine\/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]"
				},
				{
					"name":"C2U54_09225 tsaA; tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO\tK22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"C2U54_22355 tRNA (adenosine(37)-N6)-methyltransferase TrmM\tK15460 yfiC; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"C2U54_20950 tRNA pseudouridine(38-40) synthase TruA\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"C2U54_01890 tRNA pseudouridine(55) synthase TruB\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"C2U54_23510 tRNA pseudouridine(65) synthase TruC\tK06175 truC; tRNA pseudouridine65 synthase [EC:5.4.99.26]"
				},
				{
					"name":"C2U54_23350 tRNA pseudouridine(13) synthase TruD\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"C2U54_08565 bifunctional tRNA pseudouridine(32) synthase\/23S rRNA pseudouridine(746) synthase RluA\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]"
				},
				{
					"name":"C2U54_22690 RNA pseudouridine synthase\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"C2U54_14040 mnmA; tRNA 2-thiouridine(34) synthase MnmA\tK00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]"
				},
				{
					"name":"C2U54_17625 tRNA 2-thiocytidine(32) synthetase TtcA\tK14058 ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA"
				},
				{
					"name":"C2U54_03330 sulfurtransferase TusA\tK04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]"
				},
				{
					"name":"C2U54_02745 sulfurtransferase complex subunit TusB\tK07237 tusB; tRNA 2-thiouridine synthesizing protein B"
				},
				{
					"name":"C2U54_02750 sulfurtransferase complex subunit TusC\tK07236 tusC; tRNA 2-thiouridine synthesizing protein C"
				},
				{
					"name":"C2U54_02755 sulfurtransferase complex subunit TusD\tK07235 tusD; tRNA 2-thiouridine synthesizing protein D [EC:2.8.1.-]"
				},
				{
					"name":"C2U54_12825 sulfurtransferase TusE\tK11179 tusE; tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-]"
				},
				{
					"name":"C2U54_22115 iron-sulfur cluster assembly protein IscA\tK13628 iscA; iron-sulfur cluster assembly protein"
				},
				{
					"name":"C2U54_22125 IscS subfamily cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"C2U54_00190 tRNA-modifying protein YgfZ\tK06980 ygfZ; tRNA-modifying protein YgfZ"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"C2U54_04700 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"C2U54_06855 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"C2U54_07385 miaE; tRNA isopentenyl-2-thiomethyl-A-37 hydroxylase MiaE\tK06169 miaE; tRNA 2-(methylsulfanyl)-N6-isopentenyladenosine37 hydroxylase [EC:1.14.99.69]"
				},
				{
					"name":"C2U54_20980 bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD\/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC\tK15461 mnmC; tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein [EC:2.1.1.61 1.5.-.-]"
				},
				{
					"name":"C2U54_09810 queA; tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA\tK07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]"
				},
				{
					"name":"C2U54_10010 7-cyano-7-deazaguanine synthase QueC\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"C2U54_23425 queD; 6-carboxytetrahydropterin synthase QueD\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"C2U54_23445 7-carboxy-7-deazaguanine synthase QueE\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"C2U54_23525 NADPH-dependent 7-cyano-7-deazaguanine reductase QueF\tK06879 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]"
				},
				{
					"name":"C2U54_06830 queG; tRNA epoxyqueuosine(34) reductase QueG\tK18979 queG; epoxyqueuosine reductase [EC:1.17.99.6]"
				},
				{
					"name":"C2U54_14495 selenide, water dikinase SelD\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				},
				{
					"name":"C2U54_10300 tRNA 2-selenouridine(34) synthase MnmH\tK06917 selU; tRNA 2-selenouridine synthase [EC:2.9.1.3]"
				},
				{
					"name":"C2U54_09815 tRNA guanosine(34) transglycosylase Tgt\tK00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]"
				},
				{
					"name":"C2U54_09900 tRNA 4-thiouridine(8) synthase ThiI\tK03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]"
				},
				{
					"name":"C2U54_09185 tRNA lysidine(34) synthetase TilS\tK04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]"
				},
				{
					"name":"C2U54_21840 tRNA cytosine(34) acetyltransferase TmcA\tK06957 tmcA; tRNA(Met) cytidine acetyltransferase [EC:2.3.1.193]"
				},
				{
					"name":"C2U54_18680 tsaB; tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB\tK14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB"
				},
				{
					"name":"C2U54_02510 L-threonylcarbamoyladenylate synthase type 1 TsaC\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"C2U54_01035 tsaD; tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD\tK25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]"
				},
				{
					"name":"C2U54_06840 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE\tK06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE"
				},
				{
					"name":"C2U54_23580 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA\tK22132 tcdA; tRNA threonylcarbamoyladenosine dehydratase"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"C2U54_06895 ribonuclease R\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
			},
			{
				"name":"C2U54_01880 pnp; polyribonucleotide nucleotidyltransferase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
			},
			{
				"name":"C2U54_05150 VapC toxin family PIN domain ribonuclease\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
			},
			{
				"name":"C2U54_07185 VapC toxin family PIN domain ribonuclease\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
			},
			{
				"name":"C2U54_24465 PIN domain-containing protein\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
			}
			]
		}
		]
	}
	]
}