{
	"name":"len02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"LEP3755_33810 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"LEP3755_33830 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"LEP3755_33720 DEAD\/DEAH box helicase-like protein\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"LEP3755_33800 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"LEP3755_33790 CRISPR-associated Cas family protein\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"LEP3755_33800 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"LEP3755_33800 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"LEP3755_33780 hypothetical protein\tK19120 csc1; CRISPR-associated protein Csc1"
				},
				{
					"name":"LEP3755_33770 hypothetical protein\tK19121 csc2; CRISPR-associated protein Csc2"
				},
				{
					"name":"LEP3755_33760 hypothetical protein\tK19122 csc3; CRISPR-associated protein Csc3"
				},
				{
					"name":"LEP3755_33800 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"LEP3755_33790 CRISPR-associated Cas family protein\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"LEP3755_33800 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors",
				"children":[
				{
					"name":"LEP3755_30700 hypothetical protein\tK19076 cmr2; CRISPR-associated protein Cmr2"
				},
				{
					"name":"LEP3755_30690 hypothetical protein\tK09127 cmr3; CRISPR-associated protein Cmr3"
				},
				{
					"name":"LEP3755_30680 hypothetical protein\tK09000 cmr4; CRISPR-associated protein Cmr4"
				}
				]
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"LEP3755_07180 type I restriction-modification system R subunit\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"LEP3755_35690 type I site-specific deoxyribonuclease, HsdR family\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"LEP3755_57690 hypothetical protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"LEP3755_64540 hypothetical protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"LEP3755_65420 type I restriction enzyme R protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"LEP3755_07120 type I restriction-modification\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"LEP3755_35740 type I restriction-modification system S subunit\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"LEP3755_64570 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"LEP3755_65460 restriction modification system DNA specificity subunit\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"LEP3755_07110 type I restriction-modification system M subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"LEP3755_35810 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"LEP3755_35820 type I restriction-modification system, M subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"LEP3755_64550 putative RNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"LEP3755_64560 type I restriction-modification system, M subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"LEP3755_65520 type I restriction enzyme M protein\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases",
				"children":[
				{
					"name":"LEP3755_46750 type II site-specific deoxyribonuclease\tK01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]"
				},
				{
					"name":"LEP3755_63490 unknown protein\tK01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]"
				}
				]
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"LEP3755_17470 D12 class N6 adenine-specific DNA methyltransferase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"LEP3755_24740 site-specific DNA-methyltransferase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"LEP3755_61670 putative DNA methyltransferase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"LEP3755_56840 cytosine specific DNA methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"LEP3755_46500 Mrr restriction system protein\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"LEP3755_11860 PemK-like protein\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_29670 transcriptional modulator of MazE\/toxin, MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_46420 hypothetical protein\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_58380 putative PemK-like protein\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_62080 transcriptional modulator of MazE\/toxin MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_22300 cell growth regulatory protein MazE\tK07172 mazE; antitoxin MazE"
				},
				{
					"name":"LEP3755_29680 transcriptional regulator\/antitoxin, MazE\tK07172 mazE; antitoxin MazE"
				},
				{
					"name":"LEP3755_62070 hypothetical protein\tK07172 mazE; antitoxin MazE"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF",
				"children":[
				{
					"name":"LEP3755_24500 hypothetical protein\tK19156 prlF; antitoxin PrlF"
				}
				]
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"LEP3755_05520 hypothetical protein\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"LEP3755_13880 plasmid stabilization system protein like protein\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"LEP3755_20230 hypothetical protein\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"LEP3755_38530 plasmid stabilization system protein like protein\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"LEP3755_56110 cytotoxic translational repressor of toxin-antitoxin stability system\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"LEP3755_57150 hypothetical protein\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"LEP3755_57160 hypothetical protein\tK28297 relB_F; antitoxin RelB\/F"
				}
				]
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"LEP3755_04270 addiction module toxin, Txe\/YoeB family\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_36940 addiction module toxin, Txe\/YoeB\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_61740 addiction module toxin, Txe\/YoeB\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_04280 prevent-host-death family protein\tK19159 yefM; antitoxin YefM"
				},
				{
					"name":"LEP3755_36930 prevent-host-death protein\tK19159 yefM; antitoxin YefM"
				},
				{
					"name":"LEP3755_41020 hypothetical protein\tK19159 yefM; antitoxin YefM"
				},
				{
					"name":"LEP3755_46330 hypothetical protein\tK19159 yefM; antitoxin YefM"
				},
				{
					"name":"LEP3755_61750 prevent-host-death protein\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"LEP3755_57000 plasmid stabilization system\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"LEP3755_57010 hypothetical protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"LEP3755_30380 death-on-curing family protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"LEP3755_33690 hypothetical protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_42290 hypothetical protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_50070 hypothetical protein\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_47990 addiction module toxin, RelE\/StbE family\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"LEP3755_15350 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"LEP3755_33680 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"LEP3755_42280 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"LEP3755_50080 transcription regulator with HTH domain protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"LEP3755_52590 transcriptional regulator containing helix turn helix domain protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"LEP3755_14840 virulence-associated protein VapC\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_53380 PilT protein domain protein\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_37120 unknown protein\tK28280 vapB22; antitoxin VapB22"
				},
				{
					"name":"LEP3755_53370 prevent-host-death protein\tK28280 vapB22; antitoxin VapB22"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA",
				"children":[
				{
					"name":"LEP3755_47910 plasmid stabilization protein\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				},
				{
					"name":"LEP3755_24720 putative plasmid stability protein\tK21495 fitA; antitoxin FitA"
				}
				]
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"LEP3755_49890 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"LEP3755_36880 rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"LEP3755_09320 glutamyl-tRNA synthetase GltX\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA",
				"children":[
				{
					"name":"LEP3755_33750 hypothetical protein\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"LEP3755_33740 hypothetical protein\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				}
				]
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"LEP3755_24200 aminotransferase class V\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"LEP3755_57530 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"LEP3755_44720 DGQHR domain protein\tK19169 dndB; DNA sulfur modification protein DndB"
			},
			{
				"name":"LEP3755_44740 unknown protein\tK19170 dndC; DNA sulfur modification protein DndC"
			},
			{
				"name":"LEP3755_44800 hypothetical protein\tK19170 dndC; DNA sulfur modification protein DndC"
			},
			{
				"name":"LEP3755_44680 hypothetical protein\tK19171 dndD; DNA sulfur modification protein DndD"
			},
			{
				"name":"LEP3755_44750 hypothetical protein\tK19171 dndD; DNA sulfur modification protein DndD"
			},
			{
				"name":"LEP3755_44760 unknown protein\tK19172 dndE; DNA sulfur modification protein DndE"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}