{
	"name":"lhl03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair"
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"LBHH_1412 Uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"LBHH_0126 Putative 3-methyladenine DNA glycosylase\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"LBHH_0891 Endonuclease III\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex"
					},
					{
						"name":"DNA polymerase epsilon complex"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex"
					},
					{
						"name":"Cul4-DDB2 complex"
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex"
					},
					{
						"name":"Cul4-CSA complex"
					},
					{
						"name":"Other TCR factor"
					}
					]
				},
				{
					"name":"TFIIH complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Other NER factors"
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"MutL homologs"
				},
				{
					"name":"DNA polymerase delta complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other MMR factors"
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex"
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex"
				},
				{
					"name":"BRCA complex"
				},
				{
					"name":"RecA family proteins"
				},
				{
					"name":"Rad52 family proteins"
				},
				{
					"name":"Rad54 family proteins"
				},
				{
					"name":"RecQ family DNA helicases"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Protein phosphatase 4"
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex"
				},
				{
					"name":"Other HR factors"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex"
				},
				{
					"name":"MRX complex"
				},
				{
					"name":"DNA Ligase 4 complex"
				},
				{
					"name":"X-family DNA polymerases"
				},
				{
					"name":"Other NHEJ factors"
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors"
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"B-family DNA polymerases"
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group"
			},
			{
				"name":"Other TLS factors"
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex"
			},
			{
				"name":"HRAD17(Rad24)-RFC complex"
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex"
			},
			{
				"name":"FPC (fork protection complex)"
			},
			{
				"name":"Triple T complex"
			},
			{
				"name":"BAG6-UBL4A-GET4 complex"
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases"
			},
			{
				"name":"Nucleases"
			},
			{
				"name":"Helicases"
			},
			{
				"name":"PSO4 complex"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"LBHH_0481 MutT\/NUDIX family protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"LBHH_0867 mutT; NUDIX family hydrolase\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"LBHH_1246 Hydrolase, MutT\/Nudix family protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"LBHH_0328 DUTPase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"LBHH_0129 6-O-methylguanine DNA methyltransferase, DNA binding domain protein\tK13531 adaB; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"LBHH_1412 Uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"LBHH_0793 Uracil-DNA glycosylase family protein\tK21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"LBHH_0126 Putative 3-methyladenine DNA glycosylase\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"LBHH_0162 DNA-3-methyladenine glycosylase I\tK01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]"
					},
					{
						"name":"LBHH_0561 Formamidopyrimidine-DNA glycosylase\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"LBHH_0891 Endonuclease III\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"LBHH_0078 Exodeoxyribonuclease A\tK01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"RecJ",
					"children":[
					{
						"name":"LBHH_0829 Single-stranded-DNA-specific exonuclease RecJ\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"LBHH_1586 DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"DNA polymerase I",
					"children":[
					{
						"name":"LBHH_0560 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"LBHH_1049 Excinuclease ABC subunit A-like protein\tK03701 uvrA; excinuclease ABC subunit A"
					},
					{
						"name":"LBHH_1431 Excision endonuclease subunit UvrA\tK03701 uvrA; excinuclease ABC subunit A"
					},
					{
						"name":"LBHH_1432 Excision endonuclease subunit UvrB\tK03702 uvrB; excinuclease ABC subunit B"
					},
					{
						"name":"LBHH_1163 uvrC; Excision endonuclease subunit UvrC\tK03703 uvrC; excinuclease ABC subunit C"
					},
					{
						"name":"LBHH_1587 ATP-dependent DNA helicase PcrA\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"LBHH_1704 ATP-dependent helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"LBHH_0560 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					},
					{
						"name":"LBHH_1586 DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)",
						"children":[
						{
							"name":"LBHH_0270 rpoB; DNA-directed RNA polymerase subunit beta\tK03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]"
						},
						{
							"name":"LBHH_0271 DNA-directed RNA polymerase subunit beta'\tK03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]"
						},
						{
							"name":"LBHH_0303 DNA-directed RNA polymerase subunit alpha\tK03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]"
						},
						{
							"name":"LBHH_0226 DNA-directed RNA polymerase sigma subunit RpoE\tK03048 rpoE; DNA-directed RNA polymerase subunit delta"
						},
						{
							"name":"LBHH_0758 DNA-directed RNA polymerase subunit omega\tK03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]"
						}
						]
					},
					{
						"name":"TRCF (transcription-repair coupling factor)",
						"children":[
						{
							"name":"LBHH_0258 Transcriptional repair coupling factor\tK03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]"
						}
						]
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"LBHH_0388 DNA mismatch repair protein mutS\tK03555 mutS; DNA mismatch repair protein MutS"
					},
					{
						"name":"LBHH_0402 MutS2 protein\tK07456 mutS2; DNA mismatch repair protein MutS2"
					}
					]
				},
				{
					"name":"Molecular matchmaker",
					"children":[
					{
						"name":"LBHH_0389 mutL; DNA mismatch repair protein mutL\tK03572 mutL; DNA mismatch repair protein MutL"
					}
					]
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases",
					"children":[
					{
						"name":"LBHH_0751 xseA; Exodeoxyribonuclease 7 large subunit\tK03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]"
					},
					{
						"name":"LBHH_0752 Exodeoxyribonuclease 7 small subunit\tK03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]"
					}
					]
				},
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"LBHH_1154 DNA-directed DNA polymerase III alpha subunit\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"LBHH_0811 DNA polymerase subunit III\tK03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]"
					},
					{
						"name":"LBHH_0002 DNA polymerase III Beta chain\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"LBHH_1266 DNA-directed DNA polymerase III delta subunit\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"LBHH_0360 DNA polymerase III, delta subunit\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"LBHH_1409 DNA polymerase III alpha chain\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"LBHH_1667 DNA polymerase III\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"LBHH_0354 DNA polymerase III\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"LBHH_1586 DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"LBHH_1587 ATP-dependent DNA helicase PcrA\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"LBHH_1704 ATP-dependent helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"LBHH_0008 Single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins",
					"children":[
					{
						"name":"LBHH_1279 Exodeoxyribonuclease V alpha chain\tK03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]"
					},
					{
						"name":"LBHH_1447 recA; Recombinase A\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"LBHH_0390 ruvA; Holliday junction ATP-dependent DNA helicase ruvA\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"LBHH_0391 ruvB; Holliday junction ATP-dependent DNA helicase ruvB\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					},
					{
						"name":"LBHH_0759 Primosomal protein N' (ATP-dependent helicase priA) (Replication factor Y)\tK04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"RecFOR pathway proteins",
					"children":[
					{
						"name":"LBHH_1447 recA; Recombinase A\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"LBHH_0329 DNA repair protein radA\tK04485 radA; DNA repair protein RadA\/Sms"
					},
					{
						"name":"LBHH_0004 recF; DNA replication and repair protein recF\tK03629 recF; DNA replication and repair protein RecF"
					},
					{
						"name":"LBHH_0771 DNA helicase RecG\tK03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]"
					},
					{
						"name":"LBHH_0829 Single-stranded-DNA-specific exonuclease RecJ\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
					},
					{
						"name":"LBHH_0861 DNA repair protein recO\tK03584 recO; DNA repair protein RecO (recombination protein O)"
					},
					{
						"name":"LBHH_0356 recR; Recombination protein recR\tK06187 recR; recombination protein RecR"
					},
					{
						"name":"LBHH_0755 RecN ATPase involved in DNA repair\tK03631 recN; DNA repair protein RecN (Recombination protein N)"
					},
					{
						"name":"LBHH_0893 recU; Holliday junction resolvase recU\tK03700 recU; recombination protein U"
					},
					{
						"name":"LBHH_0390 ruvA; Holliday junction ATP-dependent DNA helicase ruvA\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"LBHH_0391 ruvB; Holliday junction ATP-dependent DNA helicase ruvB\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"AddAB pathway proteins",
					"children":[
					{
						"name":"LBHH_0886 ATP-dependent helicase\/nuclease subunit A\tK16898 addA; ATP-dependent helicase\/nuclease subunit A [EC:5.6.2.4 3.1.-.-]"
					},
					{
						"name":"LBHH_0885 ATP-dependent helicase\/deoxyribonuclease subunit B\tK16899 addB; ATP-dependent helicase\/nuclease subunit B [EC:5.6.2.4 3.1.-.-]"
					}
					]
				},
				{
					"name":"Other HR factor",
					"children":[
					{
						"name":"LBHH_0549 Putative uncharacterized protein\tK15342 cas1; CRISP-associated protein Cas1"
					}
					]
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator",
						"children":[
						{
							"name":"LBHH_0006 DNA topoisomerase (ATP-hydrolyzing) subunit A\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
						},
						{
							"name":"LBHH_0005 DNA gyrase subunit B\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
						},
						{
							"name":"LBHH_1127 DNA topoisomerase I\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
						}
						]
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"LBHH_1140 Integration host factor, beta subunit\tK03530 hupB; DNA-binding protein HU-beta"
						}
						]
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway",
						"children":[
						{
							"name":"LBHH_0829 Single-stranded-DNA-specific exonuclease RecJ\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
						},
						{
							"name":"LBHH_0861 DNA repair protein recO\tK03584 recO; DNA repair protein RecO (recombination protein O)"
						},
						{
							"name":"LBHH_0356 recR; Recombination protein recR\tK06187 recR; recombination protein RecR"
						},
						{
							"name":"LBHH_1586 DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
						}
						]
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"LBHH_1110 ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
						},
						{
							"name":"LBHH_1049 Excinuclease ABC subunit A-like protein\tK03701 uvrA; excinuclease ABC subunit A"
						},
						{
							"name":"LBHH_1431 Excision endonuclease subunit UvrA\tK03701 uvrA; excinuclease ABC subunit A"
						},
						{
							"name":"LBHH_1432 Excision endonuclease subunit UvrB\tK03702 uvrB; excinuclease ABC subunit B"
						}
						]
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"LBHH_1447 recA; Recombinase A\tK03553 recA; recombination protein RecA"
				},
				{
					"name":"LBHH_0795 LexA repressor\tK01356 lexA; repressor LexA [EC:3.4.21.88]"
				},
				{
					"name":"LBHH_0755 RecN ATPase involved in DNA repair\tK03631 recN; DNA repair protein RecN (Recombination protein N)"
				},
				{
					"name":"LBHH_0008 Single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"LBHH_1479 recX; Regulatory protein RecX\tK03565 recX; regulatory protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases",
				"children":[
				{
					"name":"LBHH_0887 ATP-dependent DNA helicase DinG\tK03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]"
				},
				{
					"name":"LBHH_1621 lhr; Lhr-like helicase\tK03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"LBHH_0481 MutT\/NUDIX family protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"LBHH_0867 mutT; NUDIX family hydrolase\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"LBHH_1246 Hydrolase, MutT\/Nudix family protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"LBHH_0328 DUTPase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"LBHH_1881 ribonucleotide-diphosphate reductase subunit alpha\tK00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]"
				},
				{
					"name":"LBHH_1883 nrdF; Ribonucleoside-diphosphate reductase 2 alpha subunit\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"LBHH_0394 Phosphoesterase, DHH family protein\tK06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]"
				}
				]
			}
			]
		}
		]
	}
	]
}