{
	"name":"llu01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"AKJ09_10968 Tetracycline efflux protein TetA\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases",
				"children":[
				{
					"name":"AKJ09_01684 Ribosomal RNA large subunit methyltransferase N\tK15632 cfr; 23S rRNA (adenine-C8)-methyltransferase [EC:2.1.1.224]"
				}
				]
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"AKJ09_11105 hypothetical protein\tK18235 vgb; virginiamycin B lyase [EC:4.2.99.-]"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"AKJ09_04088 Bicyclomycin resistance protein\tK18552 cmlA; MFS transporter, DHA1 family, chloramphenicol\/florfenicol resistance protein"
				}
				]
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase",
				"children":[
				{
					"name":"AKJ09_01684 Ribosomal RNA large subunit methyltransferase N\tK15632 cfr; 23S rRNA (adenine-C8)-methyltransferase [EC:2.1.1.224]"
				}
				]
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"AKJ09_01757 Transcriptional repressor, BlaI\/MecI family\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"AKJ09_03514 Beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"AKJ09_03636 Osmosensitive K+ channel histidine kinase KdpD\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"AKJ09_02404 D-alanyl-D-alanine carboxypeptidase family\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"AKJ09_02610 D-alanyl-D-alanine carboxypeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"AKJ09_02402 putative two-component system sensor kinase\tK18351 vanSAc; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]"
				},
				{
					"name":"AKJ09_02403 Vancomycin response regulator VanR\tK18352 vanRAc; two-component system, OmpR family, response regulator VanR"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"AKJ09_00255 putative Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_01802 putative RND efflux membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_03744 putative Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_03811 putative Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_04714 putative Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_04819 putative Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_04963 putative Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_06488 putative RND efflux membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_06937 putative Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_07115 putative Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_07423 putative RND efflux membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_10297 RND efflux system, membrane fusion protein CmeA\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_10636 putative Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_11173 putative Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_11469 RND efflux system, membrane fusion protein CmeA\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_00254 Cobalt-zinc-cadmium resistance protein CzcA\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_01803 RND multidrug efflux transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_03743 Cobalt-zinc-cadmium resistance protein CzcA\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_03812 RND multidrug efflux transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_04715 RND multidrug efflux transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_04818 Cobalt-zinc-cadmium resistance protein CzcA\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_04964 RND efflux system, inner membrane transporter CmeB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_06489 RND efflux system, inner membrane transporter CmeB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_06938 Cobalt-zinc-cadmium resistance protein CzcA\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_07424 RND multidrug efflux transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_10298 RND efflux system, inner membrane transporter CmeB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_10637 RND multidrug efflux transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_11172 RND multidrug efflux transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_11470 RND efflux system, inner membrane transporter CmeB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"AKJ09_02151 Heavy metal RND efflux outer membrane protein, CzcC family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_04965 RND efflux system, outer membrane lipoprotein, NodT family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_11471 RND efflux system, outer membrane lipoprotein CmeC\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"AKJ09_01964 Transcriptional regulator, TetR family\tK18301 mexL; TetR\/AcrR family transcriptional regulator, mexJK operon transcriptional repressor"
				},
				{
					"name":"AKJ09_02151 Heavy metal RND efflux outer membrane protein, CzcC family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_04965 RND efflux system, outer membrane lipoprotein, NodT family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_11471 RND efflux system, outer membrane lipoprotein CmeC\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"AKJ09_02151 Heavy metal RND efflux outer membrane protein, CzcC family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_04965 RND efflux system, outer membrane lipoprotein, NodT family\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"AKJ09_11471 RND efflux system, outer membrane lipoprotein CmeC\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"AKJ09_01651 Transcriptional regulator, MerR family\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"AKJ09_01949 transcriptional regulator, MerR family\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"AKJ09_02383 Heavy metal resistance transcriptional regulator HmrR\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"AKJ09_02894 MerR-family transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"AKJ09_05869 Mercuric resistance operon regulatory protein\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"AKJ09_00256 Outer membrane protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_01801 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_02605 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_03262 Outer membrane protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_03745 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_04387 Heavy metal RND efflux outer membrane protein, CzcC family\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_06939 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_07457 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_08351 Heavy metal RND efflux outer membrane protein, CzcC family\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_08745 outer membrane efflux protein, putative\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_08746 Heavy metal RND efflux outer membrane protein, CzcC family\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_10263 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"AKJ09_00256 Outer membrane protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_01801 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_02605 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_03262 Outer membrane protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_03745 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_04387 Heavy metal RND efflux outer membrane protein, CzcC family\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_06939 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_07457 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_08351 Heavy metal RND efflux outer membrane protein, CzcC family\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_08745 outer membrane efflux protein, putative\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_08746 Heavy metal RND efflux outer membrane protein, CzcC family\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"AKJ09_10263 outer membrane efflux protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}