{
	"name":"lpn03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P"
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"lpg2848 ribonuclease, T2 family\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"lpg2742 tRNA nucleotidyltransferase\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex",
				"children":[
				{
					"name":"lpg2201 replication factor C subunit (activator I)\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				},
				{
					"name":"lpg2202 hypothetical protein\tK24956 ZBTB8OS; protein archease"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"lpg1911 gltX; glutamate tRNA synthetase catalytic subunit\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"lpg0694 proS; prolyl-tRNA synthase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"lpg0937 ileS; isoleucyl tRNA synthetase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"lpg1348 leuS; leucyl tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"lpg2882 metG_1; methionyl tRNA synthetase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"lpg1306 glnS; glutaminyl-tRNA synthetase\tK01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]"
				},
				{
					"name":"lpg2031 argS; arginyl tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"lpg1777 lysU; lysine tRNA synthetase, heat inducible\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]"
				},
				{
					"name":"lpg1478 aspartyl tRNA synthetase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"lpg1799 alaS; alanyl tRNA synthetase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"lpg2282 asnS; asparaginyl tRNA synthetase\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				},
				{
					"name":"lpg2714 thrS; threonyl tRNA synthase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"lpg0513 serS; seryl tRNA synthetase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"lpg1307 cysS; cysteinyl-tRNA synthetase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"lpg0719 valS; valyl tRNA synthase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"lpg1544 hisS; histidyl tRNA synthetase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"lpg2711 pheS; phenylalanyl tRNA synthetase, alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"lpg2710 pheT; phenylalanyl tRNA synthetase, beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"lpg0568 tyrS; tyrosyl tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"lpg1444 trpS; tryptophanyl tRNA synthetase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"lpg1844 dtD; D-tyrosyl-tRNA\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				}
				]
			},
			{
				"name":"AARS associated factors",
				"children":[
				{
					"name":"lpg2765 hit; HIT family hydrolase\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"lpg1334 tRNA thiotransferase\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"lpg0481 S-adenosylmethionine-dependent methyltransferase\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"lpg1302 tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"lpg2770 tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"lpg1623 hydrogenase\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"lpg1746 iscS; cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Elongator complex"
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"lpg2972 SUA5\/yciO\/yrdC family:Sua5\/YciO\/YrdC\/YwlC protein family\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"lpg2696 miaA; tRNA delta(2)-isopentenylpyrophosphate transferase\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"lpg3001 thdF; GTP binding protein in thiophene and furan oxidation (GTPase)\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"lpg2889 gidA; glucose inhibited division protein A\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors"
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"lpg3004 rnpA; ribonuclease P protein component\tK03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"lpg2964 rnt; ribonuclease T\tK03683 rnt; ribonuclease T [EC:3.1.13.-]"
				},
				{
					"name":"lpg2012 rph; ribonuclease PH\tK00989 rph; ribonuclease PH [EC:2.7.7.56]"
				},
				{
					"name":"lpg2848 ribonuclease, T2 family\tK01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"lpg2742 tRNA nucleotidyltransferase\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases"
			},
			{
				"name":"tRNA splicing ligases",
				"children":[
				{
					"name":"lpg2201 replication factor C subunit (activator I)\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"lpg2491 hypothetical protein\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"lpg0703 ABC transporter, ABC binding protein\tK06020 ettA; energy-dependent translational throttle protein EttA"
				}
				]
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"lpg1348 leuS; leucyl tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"lpg0694 proS; prolyl-tRNA synthase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"lpg0568 tyrS; tyrosyl tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"lpg1444 trpS; tryptophanyl tRNA synthetase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"lpg2714 thrS; threonyl tRNA synthase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"lpg0937 ileS; isoleucyl tRNA synthetase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"lpg1777 lysU; lysine tRNA synthetase, heat inducible\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]"
				},
				{
					"name":"lpg1799 alaS; alanyl tRNA synthetase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"lpg0719 valS; valyl tRNA synthase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"lpg2882 metG_1; methionyl tRNA synthetase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"lpg0513 serS; seryl tRNA synthetase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"lpg1478 aspartyl tRNA synthetase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"lpg1840 glyQ; glycyl tRNA synthetase, alpha subunit\tK01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]"
				},
				{
					"name":"lpg1839 glyS; glycyl tRNA synthetase, beta subunit\tK01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]"
				},
				{
					"name":"lpg1307 cysS; cysteinyl-tRNA synthetase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"lpg1911 gltX; glutamate tRNA synthetase catalytic subunit\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"lpg1306 glnS; glutaminyl-tRNA synthetase\tK01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]"
				},
				{
					"name":"lpg2031 argS; arginyl tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"lpg2711 pheS; phenylalanyl tRNA synthetase, alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"lpg2710 pheT; phenylalanyl tRNA synthetase, beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"lpg1544 hisS; histidyl tRNA synthetase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"lpg2282 asnS; asparaginyl tRNA synthetase\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"lpg1844 dtD; D-tyrosyl-tRNA\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				},
				{
					"name":"lpg1207 hypothetical protein\tK19055 prdX; Ala-tRNA(Pro) deacylase [EC:3.1.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases",
				"children":[
				{
					"name":"lpg1721 yfhC; deaminase\tK11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]"
				}
				]
			},
			{
				"name":"Dihydorouridine synthases",
				"children":[
				{
					"name":"lpg1462 zinc binding TIM barrel protein, YjbN family\tK05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]"
				},
				{
					"name":"lpg2861 nitrogen regulation protein\tK05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]"
				}
				]
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"lpg1334 tRNA thiotransferase\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"lpg0481 S-adenosylmethionine-dependent methyltransferase\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				},
				{
					"name":"lpg0396 trmD; tRNA (guanine N1) methyltransferase\tK00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"lpg3001 thdF; GTP binding protein in thiophene and furan oxidation (GTPase)\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"lpg1747 RNA methyltransferase\tK15396 trmJ; tRNA (cytidine32\/uridine32-2'-O)-methyltransferase [EC:2.1.1.200]"
				},
				{
					"name":"lpg2496 RNA methyltransferase TrmH family, group 2\tK03216 trmL; tRNA (cytidine\/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"lpg1302 tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"lpg2770 tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"lpg1623 hydrogenase\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"lpg1389 tRNA (5 methylaminomethyl-2-thiouridylate) methyltransferase\tK00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]"
				},
				{
					"name":"lpg0698 hypothetical protein\tK14058 ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA"
				},
				{
					"name":"lpg1744 ydiC; HesB family protein\tK13628 iscA; iron-sulfur cluster assembly protein"
				},
				{
					"name":"lpg1746 iscS; cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"lpg1579 glycine cleavage T protein\tK06980 ygfZ; tRNA-modifying protein YgfZ"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"lpg2889 gidA; glucose inhibited division protein A\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"lpg2696 miaA; tRNA delta(2)-isopentenylpyrophosphate transferase\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"lpg1550 tRNA-(ms(2)io(6)a)-hydrolase(tRNA hydroxylase)\tK06169 miaE; tRNA 2-(methylsulfanyl)-N6-isopentenyladenosine37 hydroxylase [EC:1.14.99.69]"
				},
				{
					"name":"lpg1532 putative peptidase\tK15461 mnmC; tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein [EC:2.1.1.61 1.5.-.-]"
				},
				{
					"name":"lpg2004 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase\tK07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]"
				},
				{
					"name":"lpg2886 ExsB protein\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"lpg2865 6-pyruvoyl tetrahydropterin synthase, putative\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"lpg2041 radical activating enzyme\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"lpg2740 hypothetical protein\tK09765 queH; epoxyqueuosine reductase [EC:1.17.99.6]"
				},
				{
					"name":"lpg2003 tgt; queuine tRNA-ribosyltransferase\tK00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]"
				},
				{
					"name":"lpg2727 tgt; queuine\/archaeosine tRNA-ribosyltransferase\tK00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]"
				},
				{
					"name":"lpg0786 mesJ; cell cycle protein MesJ\tK04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]"
				},
				{
					"name":"lpg1921 glycoprotease (O-sialoglycoprotein endopeptidase)\tK14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB"
				},
				{
					"name":"lpg2972 SUA5\/yciO\/yrdC family:Sua5\/YciO\/YrdC\/YwlC protein family\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"lpg2357 gcp; O-sialoglycoprotein endopeptidase\tK25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]"
				},
				{
					"name":"lpg2699 ATPase or kinase\tK06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"lpg0092 vacB; (exo)ribonuclease R\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
			},
			{
				"name":"lpg2768 pnp; polyribonucleotide nucleotidyltransferase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
			}
			]
		}
		]
	}
	]
}