{
	"name":"lsv03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)",
				"children":[
				{
					"name":"111899851 LOC111899851; origin of replication complex subunit 1A\tK02603 ORC1; origin recognition complex subunit 1"
				},
				{
					"name":"111876197 ORC2; origin recognition complex second largest subunit 2\tK02604 ORC2; origin recognition complex subunit 2"
				},
				{
					"name":"111921208 ORC3; origin recognition complex subunit 3 isoform X1\tK02605 ORC3; origin recognition complex subunit 3"
				},
				{
					"name":"111894287 ORC4; origin recognition complex subunit 4\tK02606 ORC4; origin recognition complex subunit 4"
				},
				{
					"name":"111902671 ORC5; origin recognition complex protein 5\tK02607 ORC5; origin recognition complex subunit 5"
				},
				{
					"name":"111896106 ORC6; origin recognition complex protein 6\tK02608 ORC6; origin recognition complex subunit 6"
				},
				{
					"name":"111881188 LOC111881188; CDT1-like protein a, chloroplastic\tK10727 CDT1; chromatin licensing and DNA replication factor 1"
				},
				{
					"name":"111881249 CDT1A; CDT1-like protein A\tK10727 CDT1; chromatin licensing and DNA replication factor 1"
				},
				{
					"name":"111921201 LOC111921201; CDT1-like protein b\tK10727 CDT1; chromatin licensing and DNA replication factor 1"
				},
				{
					"name":"111880061 LOC111880061; cell division control protein 6 homolog B\tK02213 CDC6; cell division control protein 6"
				},
				{
					"name":"111912362 MCM2; minichromosome maintenance (MCM2\/3\/5) family protein\tK02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"
				},
				{
					"name":"111890880 MCM3; minichromosome maintenance (MCM2\/3\/5) family protein\tK02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]"
				},
				{
					"name":"111912453 MCM4; minichromosome maintenance (MCM2\/3\/5) family protein\tK02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]"
				},
				{
					"name":"111908347 MCM5; minichromosome maintenance (MCM2\/3\/5) family protein\tK02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]"
				},
				{
					"name":"111893406 MCM6; minichromosome maintenance (MCM2\/3\/5) family protein\tK02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]"
				},
				{
					"name":"111914339 PRL; minichromosome maintenance (MCM2\/3\/5) family protein\tK02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]"
				}
				]
			},
			{
				"name":"CDK (cyclin dependent kinase)",
				"children":[
				{
					"name":"111877127 LOC111877127; cyclin-A3-2\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"111889133 LOC111889133; G2\/mitotic-specific cyclin C13-1\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"111890706 LOC111890706; G2\/mitotic-specific cyclin C13-1\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"111895651 CYCA1;1; cyclin A1;1 isoform X1\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"111913039 LOC111913039; cyclin-A2-1\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"111917187 LOC111917187; cyclin-A2-1\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"111918945 CYCA2;4; cyclin A2;4\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"111878510 LOC111878510; cell division control protein 2 homolog A\tK02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]"
				},
				{
					"name":"111878923 LOC111878923; cell division control protein 2 homolog\tK02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]"
				},
				{
					"name":"111920245 LOC111920245; cell division control protein 2 homolog A\tK02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]"
				}
				]
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)",
				"children":[
				{
					"name":"111905122 LOC111905122; protein kinase superfamily protein isoform X1\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"GINS complex",
				"children":[
				{
					"name":"111910217 PSF1; partner of SLD five 1\tK10732 GINS1; GINS complex subunit 1"
				},
				{
					"name":"111899476 PSF2; PSF2\tK10733 GINS2; GINS complex subunit 2"
				},
				{
					"name":"111911267 LOC111911267; DNA replication complex GINS protein PSF3\tK10734 GINS3; GINS complex subunit 3"
				},
				{
					"name":"111900625 SLD5; DNA replication protein-like protein\tK10735 GINS4; GINS complex subunit 4"
				}
				]
			},
			{
				"name":"Other initiation factors",
				"children":[
				{
					"name":"111892018 LOC111892018; transcription coactivator\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
				},
				{
					"name":"111911871 MEI1; transcription coactivator isoform X1\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
				},
				{
					"name":"111906266 LOC111906266; DEAD\/DEAH box RNA helicase family protein\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
				},
				{
					"name":"111907653 CDC45; cell division cycle 45\tK06628 CDC45; cell division control protein 45"
				},
				{
					"name":"111893105 MCM8; minichromosome maintenance 8\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
				},
				{
					"name":"111899088 MCM9; minichromosome maintenance 9 isoform X1\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
				},
				{
					"name":"111899627 MCM10; minichromosome maintenance 10\tK10736 MCM10; minichromosome maintenance protein 10"
				},
				{
					"name":"111919666 ETG1; E2F target protein 1 (ETG1)\tK28390 MCMBP; minichromosome maintenance complex-binding protein"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex",
				"children":[
				{
					"name":"111876728 ICU2; DNA-directed DNA polymerase\tK02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]"
				},
				{
					"name":"111881585 POLA2; DNA polymerase alpha 2\tK02321 POLA2; DNA polymerase alpha subunit B"
				},
				{
					"name":"111918788 POLA3; DNA primase POLA3\tK02684 PRI1; DNA primase small subunit [EC:2.7.7.102]"
				},
				{
					"name":"111909695 EMB2813; DNA primase, large subunit family\tK02685 PRI2; DNA primase large subunit"
				}
				]
			},
			{
				"name":"DNA polymerase epsilon complex",
				"children":[
				{
					"name":"111896626 LOC111896626; DNA polymerase epsilon catalytic subunit A\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"111905407 LOC111905407; DNA polymerase epsilon catalytic subunit A isoform X1\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"111893810 DPB2; DNA polymerase epsilon subunit B2\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
				},
				{
					"name":"111917504 LOC111917504; DNA polymerase II subunit B4\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"DNA polymerase delta complex",
				"children":[
				{
					"name":"111897619 LOC111897619; DNA polymerase delta subunit 1\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"111908879 POLD2; DNA polymerase delta small subunit\tK02328 POLD2; DNA polymerase delta subunit 2"
				},
				{
					"name":"111913871 POLD3; DNA-directed DNA polymerase\tK03504 POLD3; DNA polymerase delta subunit 3"
				},
				{
					"name":"111921207 POLD4; polymerase delta 4\tK03505 POLD4; DNA polymerase delta subunit 4"
				}
				]
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)"
			},
			{
				"name":"RPA (replication protein A)",
				"children":[
				{
					"name":"111892538 RPA1A; replication protein A 1A\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"111905201 LOC111905201; replication protein A 70 kDa DNA-binding subunit A\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"111910499 RPA70B; RPA70-kDa subunit B\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"111892174 LOC111892174; replication protein A 32 kDa subunit A\tK10739 RFA2; replication factor A2"
				},
				{
					"name":"111909598 LOC111909598; replication protein A 32 kDa subunit B\tK10739 RFA2; replication factor A2"
				},
				{
					"name":"111920046 LOC111920046; replication protein A 32 kDa subunit B\tK10739 RFA2; replication factor A2"
				},
				{
					"name":"111897084 LOC111897084; replication protein A 14 kDa subunit B\tK10740 RPA3; replication factor A3"
				}
				]
			},
			{
				"name":"RFC (replication factor C)",
				"children":[
				{
					"name":"111914702 RFC1; replication factor C1 isoform X1\tK10754 RFC1; replication factor C subunit 1"
				},
				{
					"name":"111905574 EMB1968; ATPase family associated with various cellular activities (AAA)\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"111920799 RFC2; replication factor C 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"111884448 LOC111884448; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"111899159 LOC111899159; uncharacterized protein LOC111899159\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"111899774 EMB2775; ATPase family associated with various cellular activities (AAA)\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"111906008 LOC111906008; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"111916276 LOC111916276; polynucleotidyl transferase, ribonuclease H-like superfamily protein\tK10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]"
				},
				{
					"name":"111897279 LOC111897279; ribonuclease H2 subunit B\tK10744 RNASEH2B; ribonuclease H2 subunit B"
				},
				{
					"name":"111902901 LOC111902901; ribonuclease H2 subunit C-like protein\tK10745 RNASEH2C; ribonuclease H2 subunit C"
				}
				]
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"111880340 LOC111880340; DNA sliding clamp PCNA\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"111916510 LOC111916510; DNA sliding clamp PCNA\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"111919730 LOC111919730; DNA sliding clamp PCNA\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"111891830 EMB2411; DNA replication helicase\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
				},
				{
					"name":"111892034 LOC111892034; 5'-3' exonuclease family protein\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"111880618 LOC111880618; 5'-3' exonuclease family protein isoform X1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
				},
				{
					"name":"111915137 LOC111915137; 5'-3' exonuclease family protein\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
				},
				{
					"name":"111883288 LOC111883288; SNF2 domain-containing protein \/ helicase domain-containing protein \/ HNH endonuclease domain-containing protein\tK25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]"
				},
				{
					"name":"111886023 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
				},
				{
					"name":"111920004 LOC111920004; P-loop containing nucleoside triphosphate hydrolases superfamily protein\tK26118 ATAD5; ATPase family AAA domain-containing protein 5"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"111876994 LOC111876994; DNA (cytosine-5)-methyltransferase CMT2 isoform X1\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"111878393 LOC111878393; DNA (cytosine-5)-methyltransferase 1B isoform X1\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"111887753 CMT3; chromomethylase 3\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"111891835 LOC111891835; putative DNA (cytosine-5)-methyltransferase CMT1\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"111905319 LOC111905319; putative DNA (cytosine-5)-methyltransferase CMT1\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"111884521 LOC111884521; tudor\/PWWP\/MBT superfamily protein\tK17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors",
				"children":[
				{
					"name":"111883320 LOC111883320; G2\/mitotic-specific cyclin S13-7 isoform X1\tK21777 CCNB; G2\/mitotic-specific cyclin-B, other"
				},
				{
					"name":"111884954 CYCB3;1; cyclin b3;1\tK21777 CCNB; G2\/mitotic-specific cyclin-B, other"
				},
				{
					"name":"111889445 LOC111889445; G2\/mitotic-specific cyclin S13-7\tK21777 CCNB; G2\/mitotic-specific cyclin-B, other"
				},
				{
					"name":"111891045 LOC111891045; G2\/mitotic-specific cyclin S13-6\tK21777 CCNB; G2\/mitotic-specific cyclin-B, other"
				},
				{
					"name":"111901170 LOC111901170; G2\/mitotic-specific cyclin-2 isoform X1\tK21777 CCNB; G2\/mitotic-specific cyclin-B, other"
				},
				{
					"name":"111902543 LOC111902543; G2\/mitotic-specific cyclin-2\tK21777 CCNB; G2\/mitotic-specific cyclin-B, other"
				},
				{
					"name":"111915509 LOC111915509; G2\/mitotic-specific cyclin-2 isoform X1\tK21777 CCNB; G2\/mitotic-specific cyclin-B, other"
				},
				{
					"name":"111917727 SDS; cyclin family protein\tK21777 CCNB; G2\/mitotic-specific cyclin-B, other"
				}
				]
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex",
					"children":[
					{
						"name":"111876523 LOC111876523; uncharacterized protein LOC111876523 isoform X1\tK11111 TERF2; telomeric repeat-binding factor 2"
					},
					{
						"name":"111881057 LOC111881057; uncharacterized protein LOC111881057\tK11111 TERF2; telomeric repeat-binding factor 2"
					}
					]
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)",
					"children":[
					{
						"name":"111884534 LOC111884534; CST complex subunit STN1\tK23312 STN1; CST complex subunit STN1"
					},
					{
						"name":"111921672 LOC111921672; CST complex subunit STN1\tK23312 STN1; CST complex subunit STN1"
					},
					{
						"name":"111881958 MDO1; telomere-capping, CST complex subunit isoform X1\tK23313 TEN1; CST complex subunit TEN1"
					}
					]
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"111901173 TERT; telomerase reverse transcriptase\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"111904088 LOC111904088; H\/ACA ribonucleoprotein complex subunit 1-like protein 2\tK11128 GAR1; H\/ACA ribonucleoprotein complex subunit 1"
					},
					{
						"name":"111917701 LOC111917701; H\/ACA ribonucleoprotein complex subunit 1-like protein 2\tK11128 GAR1; H\/ACA ribonucleoprotein complex subunit 1"
					},
					{
						"name":"111882552 LOC111882552; H\/ACA ribonucleoprotein complex subunit 2-like protein\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"111915717 LOC111915717; H\/ACA ribonucleoprotein complex subunit 2-like protein\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"111881322 LOC111881322; H\/ACA ribonucleoprotein complex subunit 3-like protein\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
					},
					{
						"name":"111891565 LOC111891565; H\/ACA ribonucleoprotein complex subunit 3-like protein\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
					},
					{
						"name":"111884937 LOC111884937; H\/ACA ribonucleoprotein complex subunit 4\tK11131 DKC1; H\/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]"
					},
					{
						"name":"111920080 LOC111920080; H\/ACA ribonucleoprotein complex subunit 4\tK11131 DKC1; H\/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"111901173 TERT; telomerase reverse transcriptase\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Sm core complex",
					"children":[
					{
						"name":"111882531 LOC111882531; uncharacterized protein LOC111882531\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"111898104 LOC111898104; uncharacterized protein LOC111898104\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"111913215 LOC111913215; uncharacterized protein LOC111913215\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"111884756 LOC111884756; small nuclear ribonucleoprotein SmD1a\tK11087 SNRPD1; small nuclear ribonucleoprotein D1"
					},
					{
						"name":"111886435 LOC111886435; small nuclear ribonucleoprotein SmD1a\tK11087 SNRPD1; small nuclear ribonucleoprotein D1"
					},
					{
						"name":"111883104 LOC111883104; uncharacterized protein LOC111883104\tK11096 SNRPD2; small nuclear ribonucleoprotein D2"
					},
					{
						"name":"111878448 LOC111878448; small nuclear ribonucleoprotein SmD3b\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"111908477 LOC111908477; small nuclear ribonucleoprotein SmD3b\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"111910382 LOC111910382; uncharacterized protein LOC111910382\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"111913910 LOC111913910; uncharacterized protein LOC111913910 isoform X1\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"111899763 LOC111899763; putative small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"111899764 LOC111899764; putative small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"111882600 LOC111882600; putative small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					}
					]
				}
				]
			},
			{
				"name":"ELG1-RFC complex",
				"children":[
				{
					"name":"111905574 EMB1968; ATPase family associated with various cellular activities (AAA)\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"111920799 RFC2; replication factor C 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"111884448 LOC111884448; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"111899159 LOC111899159; uncharacterized protein LOC111899159\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"111899774 EMB2775; ATPase family associated with various cellular activities (AAA)\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"111906008 LOC111906008; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"MRN complex",
				"children":[
				{
					"name":"111895473 MRE11; DNA repair and meiosis protein (Mre11) isoform X1\tK10865 MRE11; double-strand break repair protein MRE11"
				},
				{
					"name":"111895839 NBS1; nijmegen breakage syndrome 1 isoform X1\tK10867 NBN; nibrin"
				}
				]
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"111913545 ATM; serine\/Threonine-kinase ATM-like protein isoform X1\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"111880001 RECQSIM; RECQ helicase SIM\tK10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]"
				},
				{
					"name":"111877989 LOC111877989; ATP-dependent DNA helicase Q-like 4A isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
				},
				{
					"name":"111888247 LOC111888247; ATP-dependent DNA helicase Q-like 4A isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
				},
				{
					"name":"111894227 RECQL3; DEAD\/DEAH box RNA helicase family protein isoform X4\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
				},
				{
					"name":"111907385 UVH1; restriction endonuclease, type II-like superfamily protein isoform X1\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				},
				{
					"name":"111881230 PARP1; poly(ADP-ribose) polymerase 2\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
				},
				{
					"name":"111892784 PARP2; poly(ADP-ribose) polymerase\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
				},
				{
					"name":"111884229 LOC111884229; G-patch domain-containing protein 1\tK11135 PINX1; Pin2-interacting protein X1"
				},
				{
					"name":"111886488 LOC111886488; D111\/G-patch domain-containing protein\tK11135 PINX1; Pin2-interacting protein X1"
				},
				{
					"name":"111878128 LOC111878128; RAD3-like DNA-binding helicase protein\tK11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]"
				},
				{
					"name":"111880521 EMB2423; telomere length regulation TEL2 family protein\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"111881913 LOC111881913; uncharacterized protein LOC111881913\tK11138 RIF1; telomere-associated protein RIF1"
				},
				{
					"name":"111898627 LOC111898627; purin-rich alpha 1\tK21772 PURA; transcriptional activator protein Pur-alpha"
				},
				{
					"name":"111902722 LOC111902722; transcription factor Pur-alpha 1\tK21772 PURA; transcriptional activator protein Pur-alpha"
				},
				{
					"name":"111906778 LOC111906778; transducin\/WD40 repeat-like superfamily protein\tK23314 WRAP53; telomerase Cajal body protein 1"
				},
				{
					"name":"111894558 LOC111894558; ubiquitin-like superfamily protein\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"111905364 LOC111905364; RTF2 RING-finger protein\tK25186 RTF2; replication termination factor 2"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"111896260 LOC111896260; DNA topoisomerase 1 beta\tK03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"111920094 LOC111920094; DNA topoisomerase 1 beta\tK03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"111908304 TOPII; topoisomerase II isoform X1\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"111888272 LOC111888272; DNA topoisomerase, type IA, core isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			},
			{
				"name":"111909794 TOP3A; topoisomerase 3alpha\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"111895877 LOC111895877; nucleic acid-binding, OB-fold-like protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H"
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"111920154 LOC111920154; DNA polymerase I A, chloroplastic\/mitochondrial\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					}
					]
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H"
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"111891830 EMB2411; DNA replication helicase\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
					},
					{
						"name":"111892034 LOC111892034; 5'-3' exonuclease family protein\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"111886023 LIG1; DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"111909688 GYRA; DNA GYRASE A\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
			},
			{
				"name":"111889396 LOC111889396; DNA gyrase subunit B, chloroplastic\/mitochondrial\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
			},
			{
				"name":"111879428 LOC111879428; DNA topoisomerase 6 subunit B\tK03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]"
			},
			{
				"name":"111899829 TOP6B; topoisomerase 6 subunit B\tK03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]"
			}
			]
		}
		]
	}
	]
}