{
	"name":"mae03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"Maeo_1392 Ribonuclease P, Rpp29\tK03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]"
				},
				{
					"name":"Maeo_0913 Ribonuclease P-related\tK03537 POP5; ribonuclease P\/MRP protein subunit POP5 [EC:3.1.26.5]"
				},
				{
					"name":"Maeo_1310 Ribonuclease P\tK03539 RPP1; ribonuclease P\/MRP protein subunit RPP1 [EC:3.1.26.5]"
				},
				{
					"name":"Maeo_0671 RNAse P, Rpr2\/Rpp21 subunit\tK03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"Maeo_0727 ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors"
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex",
				"children":[
				{
					"name":"Maeo_0134 protein of unknown function UPF0027\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				},
				{
					"name":"Maeo_0129 protein of unknown function DUF101\tK24956 ZBTB8OS; protein archease"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"Maeo_0782 translation elongation factor EF-1, subunit alpha\tK03231 EEF1A; elongation factor 1-alpha"
				}
				]
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"Maeo_1110 glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"Maeo_0234 prolyl-tRNA synthetase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"Maeo_0945 isoleucyl-tRNA synthetase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"Maeo_0233 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"Maeo_0619 methionyl-tRNA synthetase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"Maeo_1102 arginyl-tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"Maeo_0621 alanyl-tRNA synthetase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"Maeo_1294 glycyl-tRNA synthetase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]"
				},
				{
					"name":"Maeo_1189 threonyl-tRNA synthetase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"Maeo_1483 seryl-tRNA synthetase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"Maeo_1376 cysteinyl-tRNA synthetase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"Maeo_0944 valyl-tRNA synthetase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"Maeo_0030 histidyl-tRNA synthetase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"Maeo_1292 phenylalanyl-tRNA synthetase, alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"Maeo_1377 phenylalanyl-tRNA synthetase, beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"Maeo_0194 tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"Maeo_1485 tryptophanyl-tRNA synthetase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"Maeo_0733 Protein of unknown function DUF516\tK09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				}
				]
			},
			{
				"name":"AARS associated factors",
				"children":[
				{
					"name":"Maeo_0596 histidine triad (HIT) protein\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"Maeo_1188 MiaB-like tRNA modifying enzyme\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"Maeo_0624 N2,N2-dimethylguanosine tRNA methyltransferase\tK00555 TRMT1; tRNA (guanine26-N2\/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]"
				},
				{
					"name":"Maeo_0275 protein of unknown function Met10\tK15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"Maeo_0607 tRNA methyltransferase complex GCD14 subunit\tK07442 TRM61; tRNA (adenine57-N1\/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]"
				},
				{
					"name":"Maeo_0492 Wyosine base formation domain protein\tK15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]"
				},
				{
					"name":"Maeo_0636 protein of unknown function Met10\tK07055 TRM12; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]"
				},
				{
					"name":"Maeo_1057 Protein of unknown function DUF207\tK15450 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"Maeo_0158 tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"Maeo_1222 putative rRNA pseudouridine synthase\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"Maeo_0756 tRNA pseudouridine synthase D TruD\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"Maeo_1160 tRNA pseudouridine synthase D TruD\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"Maeo_1254 THUMP domain protein\tK07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]"
				}
				]
			},
			{
				"name":"Thiolation factors"
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Elongator complex",
				"children":[
				{
					"name":"Maeo_0279 histone acetyltransferase, ELP3 family\tK07739 ELP3; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]"
				}
				]
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"Maeo_1464 Sua5\/YciO\/YrdC\/YwlC family protein\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"Maeo_0724 selenide, water dikinase\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors"
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"Maeo_0950 Protein of unknown function UPF0278\tK09006 K09006; RNA-free ribonuclease P [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"Maeo_0727 ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"Maeo_1256 tRNA cytidylyltransferase\tK07558 K07558; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases",
				"children":[
				{
					"name":"Maeo_1014 tRNA intron endonuclease\tK01170 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16]"
				}
				]
			},
			{
				"name":"tRNA splicing ligases",
				"children":[
				{
					"name":"Maeo_0134 protein of unknown function UPF0027\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"Maeo_0987 2'-5' RNA ligase\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"Maeo_0233 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"Maeo_0215 lysyl-tRNA synthetase\tK04566 lysK; lysyl-tRNA synthetase, class I [EC:6.1.1.6]"
				},
				{
					"name":"Maeo_0234 prolyl-tRNA synthetase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"Maeo_0194 tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"Maeo_1485 tryptophanyl-tRNA synthetase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"Maeo_1189 threonyl-tRNA synthetase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"Maeo_0945 isoleucyl-tRNA synthetase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"Maeo_0621 alanyl-tRNA synthetase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"Maeo_0944 valyl-tRNA synthetase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"Maeo_0619 methionyl-tRNA synthetase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"Maeo_1483 seryl-tRNA synthetase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"Maeo_1376 cysteinyl-tRNA synthetase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"Maeo_1110 glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"Maeo_1102 arginyl-tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"Maeo_1292 phenylalanyl-tRNA synthetase, alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"Maeo_1377 phenylalanyl-tRNA synthetase, beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"Maeo_0030 histidyl-tRNA synthetase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"Maeo_0028 aspartyl-tRNA synthetase\tK09759 aspC; nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23]"
				},
				{
					"name":"Maeo_1060 O-phosphoseryl-tRNA(Cys) synthetase\tK07587 sepRS; O-phosphoseryl-tRNA synthetase [EC:6.1.1.27]"
				},
				{
					"name":"Maeo_0681 Sep-tRNA\tK06868 sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"Maeo_0733 Protein of unknown function DUF516\tK09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"Maeo_1188 MiaB-like tRNA modifying enzyme\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"Maeo_0071 RNA methyltransferase, TrmH family, group 1\tK02533 lasT; tRNA\/rRNA methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"Maeo_0669 protein of unknown function DUF358\tK16317 trmY; tRNA (pseudouridine54-N1)-methyltransferase [EC:2.1.1.257]"
				},
				{
					"name":"Maeo_1457 putative RNA methylase, NOL1\/NOP2\/sun family\tK22901 trm4; tRNA (cytosine40_48-C5)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"Maeo_0667 putative RNA methylase\tK07446 trm-G10; tRNA (guanine10-N2)-dimethyltransferase [EC:2.1.1.213]"
				},
				{
					"name":"Maeo_1410 protein of unknown function DUF127\tK07254 atrm56; tRNA (cytidine56-2'-O)-methyltransferase [EC:2.1.1.206]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"Maeo_0158 tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"Maeo_1222 putative rRNA pseudouridine synthase\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"Maeo_0756 tRNA pseudouridine synthase D TruD\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"Maeo_1160 tRNA pseudouridine synthase D TruD\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"Maeo_0855 SirA family protein\tK04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex",
				"children":[
				{
					"name":"Maeo_1198 putative metalloendopeptidase, glycoprotease family\tK15904 kae1-bud32; bifunctional N6-L-threonylcarbamoyladenine synthase \/ protein kinase Bud32 [EC:2.3.1.234 2.7.11.1]"
				},
				{
					"name":"Maeo_0176 conserved hypothetical protein\tK09741 pcc1; KEOPS complex subunit Pcc1"
				}
				]
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"Maeo_0772 exsB protein\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"Maeo_0632 6-pyruvoyl tetrahydropterin synthase\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"Maeo_0834 Radical SAM domain protein\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"Maeo_0724 selenide, water dikinase\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				},
				{
					"name":"Maeo_0928 Rhodanese domain protein\tK06917 selU; tRNA 2-selenouridine synthase [EC:2.9.1.3]"
				},
				{
					"name":"Maeo_0929 conserved hypothetical protein\tK06917 selU; tRNA 2-selenouridine synthase [EC:2.9.1.3]"
				},
				{
					"name":"Maeo_0878 archaeosine tRNA-ribosyltransferase\tK18779 tgtA; 7-cyano-7-deazaguanine tRNA-ribosyltransferase [EC:2.4.2.48]"
				},
				{
					"name":"Maeo_0796 thiamine biosynthesis\/tRNA modification protein ThiI\tK03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]"
				},
				{
					"name":"Maeo_0755 domain of unknown function DUF1743\tK06932 tiaS; tRNA(Ile2)-agmatinylcytidine synthase [EC:6.3.4.22]"
				},
				{
					"name":"Maeo_1464 Sua5\/YciO\/YrdC\/YwlC family protein\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors"
		}
		]
	}
	]
}