{
	"name":"mbr03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)",
				"children":[
				{
					"name":"MONBRDRAFT_28822 hypothetical protein\tK02603 ORC1; origin recognition complex subunit 1"
				},
				{
					"name":"MONBRDRAFT_26897 hypothetical protein\tK02604 ORC2; origin recognition complex subunit 2"
				},
				{
					"name":"MONBRDRAFT_33414 hypothetical protein\tK02605 ORC3; origin recognition complex subunit 3"
				},
				{
					"name":"MONBRDRAFT_21200 hypothetical protein\tK02606 ORC4; origin recognition complex subunit 4"
				},
				{
					"name":"MONBRDRAFT_16039 hypothetical protein\tK02607 ORC5; origin recognition complex subunit 5"
				},
				{
					"name":"MONBRDRAFT_28402 hypothetical protein\tK02213 CDC6; cell division control protein 6"
				},
				{
					"name":"MONBRDRAFT_36175 hypothetical protein\tK02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"
				},
				{
					"name":"MONBRDRAFT_38861 hypothetical protein\tK02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]"
				},
				{
					"name":"MONBRDRAFT_25497 hypothetical protein\tK02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]"
				},
				{
					"name":"MONBRDRAFT_27771 hypothetical protein\tK02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]"
				},
				{
					"name":"MONBRDRAFT_25214 hypothetical protein\tK02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]"
				},
				{
					"name":"MONBRDRAFT_14950 hypothetical protein\tK02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]"
				}
				]
			},
			{
				"name":"CDK (cyclin dependent kinase)",
				"children":[
				{
					"name":"MONBRDRAFT_14677 cycA; cyclin A\tK06627 CCNA; cyclin-A"
				}
				]
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)"
			},
			{
				"name":"GINS complex",
				"children":[
				{
					"name":"MONBRDRAFT_32908 hypothetical protein\tK10732 GINS1; GINS complex subunit 1"
				},
				{
					"name":"MONBRDRAFT_22745 hypothetical protein\tK10735 GINS4; GINS complex subunit 4"
				}
				]
			},
			{
				"name":"Other initiation factors",
				"children":[
				{
					"name":"MONBRDRAFT_9177 hypothetical protein\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
				},
				{
					"name":"MONBRDRAFT_31140 hypothetical protein\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
				},
				{
					"name":"MONBRDRAFT_25659 hypothetical protein\tK06628 CDC45; cell division control protein 45"
				},
				{
					"name":"MONBRDRAFT_9453 hypothetical protein\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
				},
				{
					"name":"MONBRDRAFT_32709 hypothetical protein\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
				},
				{
					"name":"MONBRDRAFT_32446 hypothetical protein\tK10736 MCM10; minichromosome maintenance protein 10"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex",
				"children":[
				{
					"name":"MONBRDRAFT_107 hypothetical protein\tK02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]"
				},
				{
					"name":"MONBRDRAFT_29731 hypothetical protein\tK02321 POLA2; DNA polymerase alpha subunit B"
				},
				{
					"name":"MONBRDRAFT_39071 hypothetical protein\tK02684 PRI1; DNA primase small subunit [EC:2.7.7.102]"
				},
				{
					"name":"MONBRDRAFT_32834 hypothetical protein\tK02685 PRI2; DNA primase large subunit"
				}
				]
			},
			{
				"name":"DNA polymerase epsilon complex",
				"children":[
				{
					"name":"MONBRDRAFT_15015 hypothetical protein\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"MONBRDRAFT_25230 hypothetical protein\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"DNA polymerase delta complex",
				"children":[
				{
					"name":"MONBRDRAFT_27827 hypothetical protein\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"MONBRDRAFT_29660 hypothetical protein\tK02328 POLD2; DNA polymerase delta subunit 2"
				},
				{
					"name":"MONBRDRAFT_23443 hypothetical protein\tK03504 POLD3; DNA polymerase delta subunit 3"
				},
				{
					"name":"MONBRDRAFT_5881 hypothetical protein\tK03505 POLD4; DNA polymerase delta subunit 4"
				}
				]
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)",
				"children":[
				{
					"name":"MONBRDRAFT_624 hypothetical protein\tK02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"RPA (replication protein A)",
				"children":[
				{
					"name":"MONBRDRAFT_451 hypothetical protein\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"MONBRDRAFT_36751 hypothetical protein\tK10739 RFA2; replication factor A2"
				}
				]
			},
			{
				"name":"RFC (replication factor C)",
				"children":[
				{
					"name":"MONBRDRAFT_16219 hypothetical protein\tK10754 RFC1; replication factor C subunit 1"
				},
				{
					"name":"MONBRDRAFT_21527 hypothetical protein\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"MONBRDRAFT_23144 hypothetical protein\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"MONBRDRAFT_30540 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"MONBRDRAFT_38211 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"MONBRDRAFT_25972 hypothetical protein\tK10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]"
				},
				{
					"name":"MONBRDRAFT_7704 hypothetical protein\tK10744 RNASEH2B; ribonuclease H2 subunit B"
				}
				]
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"MONBRDRAFT_37444 hypothetical protein\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"MONBRDRAFT_29430 hypothetical protein\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"MONBRDRAFT_29551 hypothetical protein\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
				},
				{
					"name":"MONBRDRAFT_26139 hypothetical protein\tK25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors",
				"children":[
				{
					"name":"MONBRDRAFT_8459 cycB; cyclin B\tK21770 CCNB2; G2\/mitotic-specific cyclin-B2"
				}
				]
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex"
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins",
					"children":[
					{
						"name":"MONBRDRAFT_1942 hypothetical protein\tK11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"MONBRDRAFT_24824 hypothetical protein\tK11127 TEP1; telomerase protein component 1"
				},
				{
					"name":"MONBRDRAFT_36329 hypothetical protein\tK11127 TEP1; telomerase protein component 1"
				},
				{
					"name":"MONBRDRAFT_7351 hypothetical protein\tK11127 TEP1; telomerase protein component 1"
				},
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"MONBRDRAFT_9945 hypothetical protein\tK11128 GAR1; H\/ACA ribonucleoprotein complex subunit 1"
					},
					{
						"name":"MONBRDRAFT_34007 hypothetical protein\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"MONBRDRAFT_14965 hypothetical protein\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
					},
					{
						"name":"MONBRDRAFT_17370 hypothetical protein\tK11131 DKC1; H\/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"Sm core complex",
					"children":[
					{
						"name":"MONBRDRAFT_3442 hypothetical protein\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"MONBRDRAFT_13527 hypothetical protein\tK11096 SNRPD2; small nuclear ribonucleoprotein D2"
					},
					{
						"name":"MONBRDRAFT_32618 hypothetical protein\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"MONBRDRAFT_33682 hypothetical protein\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"MONBRDRAFT_13957 hypothetical protein\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					}
					]
				}
				]
			},
			{
				"name":"ELG1-RFC complex",
				"children":[
				{
					"name":"MONBRDRAFT_21527 hypothetical protein\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"MONBRDRAFT_23144 hypothetical protein\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"MONBRDRAFT_30540 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"MONBRDRAFT_38211 hypothetical protein\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"MRN complex",
				"children":[
				{
					"name":"MONBRDRAFT_25241 hypothetical protein\tK10865 MRE11; double-strand break repair protein MRE11"
				},
				{
					"name":"MONBRDRAFT_14089 hypothetical protein\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
				}
				]
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"MONBRDRAFT_34416 ATM; hypothetical protein\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"MONBRDRAFT_29065 hypothetical protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
				},
				{
					"name":"MONBRDRAFT_30238 hypothetical protein\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
				},
				{
					"name":"MONBRDRAFT_13638 hypothetical protein\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				},
				{
					"name":"MONBRDRAFT_26401 hypothetical protein\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
				},
				{
					"name":"MONBRDRAFT_27847 hypothetical protein\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
				},
				{
					"name":"MONBRDRAFT_12449 hypothetical protein\tK10799 TNKS; tankyrase [EC:2.4.2.30]"
				},
				{
					"name":"MONBRDRAFT_39174 hypothetical protein\tK10799 TNKS; tankyrase [EC:2.4.2.30]"
				},
				{
					"name":"MONBRDRAFT_39339 hypothetical protein\tK11135 PINX1; Pin2-interacting protein X1"
				},
				{
					"name":"MONBRDRAFT_27129 hypothetical protein\tK11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]"
				},
				{
					"name":"MONBRDRAFT_31367 hypothetical protein\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"MONBRDRAFT_11919 hypothetical protein\tK23314 WRAP53; telomerase Cajal body protein 1"
				},
				{
					"name":"MONBRDRAFT_26511 hypothetical protein\tK25186 RTF2; replication termination factor 2"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"MONBRDRAFT_26912 hypothetical protein\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			},
			{
				"name":"MONBRDRAFT_32733 hypothetical protein\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)"
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H"
				},
				{
					"name":"Other elongation factors"
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H"
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"MONBRDRAFT_29430 hypothetical protein\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"MONBRDRAFT_15735 hypothetical protein\tK03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]"
			}
			]
		}
		]
	}
	]
}