{
	"name":"mbs03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III",
				"children":[
				{
					"name":"MRBBS_0754 petB; Cytochrome b\tK00412 CYTB; ubiquinol-cytochrome c reductase cytochrome b subunit"
				}
				]
			},
			{
				"name":"Cytochrome c oxidase"
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase"
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"MRBBS_3337 infB; Translation initiation factor IF-2\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"MRBBS_2530 infC; Translation initiation factor IF-3\tK02520 infC; translation initiation factor IF-3"
				},
				{
					"name":"MRBBS_1155 tsf; Elongation factor Ts\tK02357 tsf; elongation factor Ts"
				},
				{
					"name":"MRBBS_0597 tuf; Elongation factor Tu\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"MRBBS_0608 tuf; Elongation factor Tu\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"MRBBS_0607 fusA; Elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP"
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"MRBBS_2650 era; GTPase Era\tK03595 era; GTPase"
				},
				{
					"name":"MRBBS_0594 tyrS; Tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"MRBBS_2728 leuS; Leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"MRBBS_2319 aspS; Aspartyl-tRNA synthetase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"MRBBS_0687 argS; Arginyl-tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"MRBBS_2276 gatA; Glutamyl-tRNA(Gln) amidotransferase subunit A\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"MRBBS_2285 putative Glutamyl-tRNA(Gln) amidotransferase subunit A\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"MRBBS_2711 gatA; Glutamyl-tRNA(Gln) amidotransferase subunit A\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"MRBBS_2712 gatB; Aspartyl\/glutamyl-tRNA(Asn\/Gln) amidotransferase subunit B\tK02434 gatB; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"MRBBS_2710 gatC; Aspartyl\/glutamyl-tRNA(Asn\/Gln) amidotransferase subunit C\tK02435 gatC; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors"
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"MRBBS_0639 ssb; Single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors"
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex"
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"MRBBS_1162 yaeT; Outer membrane protein assembly factor yaeT\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex"
			},
			{
				"name":"TIM8\/13 complex"
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex"
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex"
			},
			{
				"name":"TIM23 complex"
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors"
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"MRBBS_3352 dnaK; Chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"MRBBS_3353 grpE; Protein grpE\tK03687 GRPE; molecular chaperone GrpE"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"MRBBS_0963 groL; 60 kDa chaperonin\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"MRBBS_0962 groS; 10 kDa chaperonin\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"MRBBS_3351 dnaJ; Chaperone protein DnaJ\tK03686 dnaJ; molecular chaperone DnaJ"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"MRBBS_0607 fusA; Elongation factor G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"MRBBS_1673 iscS; Cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"MRBBS_3352 dnaK; Chaperone protein DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"MRBBS_0936 grxD; Glutaredoxin-4\tK07390 grxD; monothiol glutaredoxin"
				},
				{
					"name":"MRBBS_1949 Glutaredoxin-related protein\tK07390 grxD; monothiol glutaredoxin"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis"
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors",
				"children":[
				{
					"name":"MRBBS_0308 hypothetical protein\tK18159 NDUFAF1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1"
				},
				{
					"name":"MRBBS_1451 mrp; Protein mrp\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				},
				{
					"name":"MRBBS_1947 nubpl; Iron-sulfur protein NUBPL\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				},
				{
					"name":"MRBBS_3430 mrp; Mrp\/NBP35 family protein\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				}
				]
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors"
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"MRBBS_0068 cyoE; Protoheme IX farnesyltransferase\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"MRBBS_0067 ctaA; Heme A synthase\tK02259 COX15; heme a synthase [EC:1.17.99.9]"
				},
				{
					"name":"MRBBS_3886 oxaA; Inner membrane protein oxaA\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				},
				{
					"name":"MRBBS_0065 hypothetical protein\tK14998 SURF1; surfeit locus 1 family protein"
				},
				{
					"name":"MRBBS_0069 scoP; Putative copper-binding protein\tK07152 SCO1; protein SCO1"
				},
				{
					"name":"MRBBS_1011 scoP; Putative copper-binding protein\tK07152 SCO1; protein SCO1"
				},
				{
					"name":"MRBBS_3157 hypothetical protein\tK07152 SCO1; protein SCO1"
				}
				]
			},
			{
				"name":"Complex-V assembly factors"
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors"
			},
			{
				"name":"Actin cytoskeleton organization"
			},
			{
				"name":"Mitochondrial movement"
			},
			{
				"name":"Retention of mitochondria"
			},
			{
				"name":"Morphogenesis factors"
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins"
			},
			{
				"name":"Parkin-dependent mechanism factors"
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"MRBBS_1546 htpG; Chaperone protein htpG\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors"
			}
			]
		}
		]
	}
	]
}