{
	"name":"mesa03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"MLASG1_1474 rnp; Ribonuclease P protein component 1\tK03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]"
				},
				{
					"name":"MLASG1_1591 rnp; Ribonuclease P protein component 2\tK03537 POP5; ribonuclease P\/MRP protein subunit POP5 [EC:3.1.26.5]"
				},
				{
					"name":"MLASG1_0739 rnp; Ribonuclease P protein component 3\tK03539 RPP1; ribonuclease P\/MRP protein subunit RPP1 [EC:3.1.26.5]"
				},
				{
					"name":"MLASG1_1343 rnp; Ribonuclease P protein component 4\tK03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"MLASG1_0685 rnz; Ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors"
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex",
				"children":[
				{
					"name":"MLASG1_0517 Protein archease\tK24956 ZBTB8OS; protein archease"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"MLASG1_1143 tuf; Elongation factor 1-alpha\tK03231 EEF1A; elongation factor 1-alpha"
				}
				]
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"MLASG1_1495 gltX; Glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"MLASG1_0483 proS; Proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"MLASG1_1360 ileS; Isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"MLASG1_0099 leuS; Leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"MLASG1_0504 metG; Methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"MLASG1_0038 argS; Arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"MLASG1_0285 alaS; Alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"MLASG1_0044 glyS; Glycine--tRNA ligase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]"
				},
				{
					"name":"MLASG1_0709 thrS; Threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"MLASG1_1168 serS; Type-2 serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"MLASG1_0553 valS; Valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"MLASG1_0289 hisS; Histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"MLASG1_1598 pheS; Phenylalanine--tRNA ligase alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"MLASG1_0320 pheT; Phenylalanine--tRNA ligase beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"MLASG1_1302 tyrS; Tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"MLASG1_0609 trpS; Tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"MLASG1_0882 dtdA; D-aminoacyl-tRNA deacylase\tK09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				}
				]
			},
			{
				"name":"AARS associated factors",
				"children":[
				{
					"name":"MLASG1_0759 Histidine triad (HIT) protein\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"MLASG1_0758 putative threonylcarbamoyladenosine tRNA methylthiotransferase\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"MLASG1_1362 trm; tRNA (guanine(26)-N(2))-dimethyltransferase\tK00555 TRMT1; tRNA (guanine26-N2\/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]"
				},
				{
					"name":"MLASG1_0829 trm5b; tRNA (guanine(37)-N1)-methyltransferase Trm5b\tK15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"MLASG1_0749 trmI; tRNA (adenine(57)-N(1)\/adenine(58)-N(1))-methyltransferase TrmI\tK07442 TRM61; tRNA (adenine57-N1\/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]"
				},
				{
					"name":"MLASG1_1131 taw; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase\tK15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]"
				},
				{
					"name":"MLASG1_0757 taw; tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase\tK07055 TRM12; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]"
				},
				{
					"name":"MLASG1_0560 taw; tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase\tK15450 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"MLASG1_0574 truA; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"MLASG1_0243 truB; putative tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"MLASG1_0301 truD; putative tRNA pseudouridine synthase D 2\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"MLASG1_0931 truD; putative tRNA pseudouridine synthase D 1\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"MLASG1_0872 pus; tRNA pseudouridine synthase Pus10\tK07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]"
				}
				]
			},
			{
				"name":"Thiolation factors"
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Elongator complex",
				"children":[
				{
					"name":"MLASG1_0736 N-acetyltransferase domain-containing protein\tK07739 ELP3; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]"
				}
				]
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"MLASG1_0375 Putative threonylcarbamoyl-AMP synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"MLASG1_0863 selD; Selenide, water dikinase\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				},
				{
					"name":"MLASG1_0128 THUMP domain protein\tK06963 TAN1; tRNA acetyltransferase TAN1"
				},
				{
					"name":"MLASG1_0498 THUMP domain protein\tK06963 TAN1; tRNA acetyltransferase TAN1"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors"
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"MLASG1_MISCRNA2 RNaseP_arch\tK01978 rnpB; RNase P catalytic RNA component"
				},
				{
					"name":"MLASG1_1357 conserved protein of unknown function\tK09006 K09006; RNA-free ribonuclease P [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"MLASG1_0685 rnz; Ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"MLASG1_0868 cca; CCA-adding enzyme\tK07558 K07558; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases",
				"children":[
				{
					"name":"MLASG1_0180 endA; tRNA-splicing endonuclease\tK01170 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16]"
				}
				]
			},
			{
				"name":"tRNA splicing ligases"
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"MLASG1_0614 RNA 2',3'-cyclic phosphodiesterase\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"MLASG1_0099 leuS; Leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"MLASG1_0149 lysS; Lysine--tRNA ligase\tK04566 lysK; lysyl-tRNA synthetase, class I [EC:6.1.1.6]"
				},
				{
					"name":"MLASG1_0483 proS; Proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"MLASG1_1302 tyrS; Tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"MLASG1_0609 trpS; Tryptophan--tRNA ligase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"MLASG1_0709 thrS; Threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"MLASG1_1360 ileS; Isoleucine--tRNA ligase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"MLASG1_0285 alaS; Alanine--tRNA ligase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"MLASG1_0553 valS; Valine--tRNA ligase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"MLASG1_0504 metG; Methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"MLASG1_1168 serS; Type-2 serine--tRNA ligase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"MLASG1_1495 gltX; Glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"MLASG1_0038 argS; Arginine--tRNA ligase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"MLASG1_1598 pheS; Phenylalanine--tRNA ligase alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"MLASG1_0320 pheT; Phenylalanine--tRNA ligase beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"MLASG1_0289 hisS; Histidine--tRNA ligase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"MLASG1_1284 aspS; Aspartate--tRNA(Asp\/Asn) ligase\tK09759 aspC; nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23]"
				},
				{
					"name":"MLASG1_0675 sepS; O-phosphoserine--tRNA(Cys) ligase\tK07587 sepRS; O-phosphoseryl-tRNA synthetase [EC:6.1.1.27]"
				},
				{
					"name":"MLASG1_0578 O-phospho-L-seryl-tRNA:Cys-tRNA synthase\tK06868 sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"MLASG1_0882 dtdA; D-aminoacyl-tRNA deacylase\tK09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"MLASG1_0758 putative threonylcarbamoyladenosine tRNA methylthiotransferase\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"MLASG1_1021 trmY; tRNA (pseudouridine(54)-N(1))-methyltransferase\tK16317 trmY; tRNA (pseudouridine54-N1)-methyltransferase [EC:2.1.1.257]"
				},
				{
					"name":"MLASG1_0519 trm; tRNA (cytosine(48)-C(5))-methyltransferase\tK22901 trm4; tRNA (cytosine40_48-C5)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"MLASG1_1003 trm; tRNA (guanine(6)-N2)-methyltransferase\tK16318 trm14; tRNA (guanine6-N2)-methyltransferase [EC:2.1.1.256]"
				},
				{
					"name":"MLASG1_0918 protein of unknown function\tK07446 trm-G10; tRNA (guanine10-N2)-dimethyltransferase [EC:2.1.1.213]"
				},
				{
					"name":"MLASG1_1381 tRNA (cytidine(56)-2'-O)-methyltransferase\tK07254 atrm56; tRNA (cytidine56-2'-O)-methyltransferase [EC:2.1.1.206]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"MLASG1_0574 truA; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"MLASG1_0243 truB; putative tRNA pseudouridine synthase B\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"MLASG1_0301 truD; putative tRNA pseudouridine synthase D 2\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"MLASG1_0931 truD; putative tRNA pseudouridine synthase D 1\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"MLASG1_0825 tRNA-5-methyluridine(54) 2-sulfurtransferase\tK21947 ttuA; tRNA-5-methyluridine54 2-sulfurtransferase [EC:2.8.1.15]"
				},
				{
					"name":"MLASG1_0232 SirA family protein\tK04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex",
				"children":[
				{
					"name":"MLASG1_0147 tRNA N6-adenosine threonylcarbamoyltransferase \/ Serine\/threonine-protein kinase Bud32\tK15904 kae1-bud32; bifunctional N6-L-threonylcarbamoyladenine synthase \/ protein kinase Bud32 [EC:2.3.1.234 2.7.11.1]"
				},
				{
					"name":"MLASG1_0807 putative KEOPS complex subunit Pcc1\tK09741 pcc1; KEOPS complex subunit Pcc1"
				}
				]
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"MLASG1_0369 queC; 7-cyano-7-deazaguanine synthase\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"MLASG1_1206 queD; Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"MLASG1_0548 queE; 7-carboxy-7-deazaguanine synthase\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"MLASG1_0863 selD; Selenide, water dikinase\tK01008 selD; selenide, water dikinase [EC:2.7.9.3]"
				},
				{
					"name":"MLASG1_0814 Rhodanese domain protein\tK06917 selU; tRNA 2-selenouridine synthase [EC:2.9.1.3]"
				},
				{
					"name":"MLASG1_0815 ATPase-like protein\tK06917 selU; tRNA 2-selenouridine synthase [EC:2.9.1.3]"
				},
				{
					"name":"MLASG1_1060 tgtA; tRNA-guanine(15) transglycosylase\tK18779 tgtA; 7-cyano-7-deazaguanine tRNA-ribosyltransferase [EC:2.4.2.48]"
				},
				{
					"name":"MLASG1_0879 thiI; putative tRNA sulfurtransferase\tK03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]"
				},
				{
					"name":"MLASG1_0384 tiaS; tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS\tK06932 tiaS; tRNA(Ile2)-agmatinylcytidine synthase [EC:6.3.4.22]"
				},
				{
					"name":"MLASG1_0375 Putative threonylcarbamoyl-AMP synthase\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors"
		}
		]
	}
	]
}