{
	"name":"mfo03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"Metfor_2647 RNase P\/RNase MRP subunit p29\tK03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]"
				},
				{
					"name":"Metfor_1159 RNase P\/RNase MRP subunit POP5\tK03537 POP5; ribonuclease P\/MRP protein subunit POP5 [EC:3.1.26.5]"
				},
				{
					"name":"Metfor_1158 RNase P\/RNase MRP subunit p30\tK03539 RPP1; ribonuclease P\/MRP protein subunit RPP1 [EC:3.1.26.5]"
				},
				{
					"name":"Metfor_1086 RNase P subunit RPR2\tK03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"Metfor_1625 ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors"
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex",
				"children":[
				{
					"name":"Metfor_1326 hypothetical protein\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				},
				{
					"name":"Metfor_1327 hypothetical protein\tK24956 ZBTB8OS; protein archease"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors",
				"children":[
				{
					"name":"Metfor_2512 translation elongation factor EF-1 alpha\tK03231 EEF1A; elongation factor 1-alpha"
				}
				]
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"Metfor_0500 glutamyl-tRNA synthetase, archaeal and eukaryotic family\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"Metfor_0989 prolyl-tRNA synthetase, family I\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"Metfor_0393 isoleucyl-tRNA synthetase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"Metfor_1041 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"Metfor_1266 protein containing C-terminal region\/beta chain of methionyl-tRNA synthetase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"Metfor_2841 arginyl-tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"Metfor_0330 lysyl-tRNA synthetase (class II)\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"Metfor_2041 alanine--tRNA ligase\/alanyl-tRNA synthetase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"Metfor_2218 glycyl-tRNA synthetase, dimeric type\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]"
				},
				{
					"name":"Metfor_2142 threonyl-tRNA synthetase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"Metfor_1727 seryl-tRNA synthetase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"Metfor_2466 cysteinyl-tRNA synthetase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"Metfor_1278 valyl-tRNA synthetase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"Metfor_1292 histidyl-tRNA synthetase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"Metfor_2550 phenylalanyl-tRNA synthetase, alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"Metfor_2549 phenylalanyl-tRNA synthetase, beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"Metfor_0185 tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"Metfor_2551 tryptophanyl-tRNA synthetase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"Metfor_0400 hypothetical protein\tK09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				}
				]
			},
			{
				"name":"AARS associated factors"
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"Metfor_2686 MiaB-like tRNA modifying enzyme\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"Metfor_1131 tRNA(guanine-26,N2-N2) methyltransferase\tK00555 TRMT1; tRNA (guanine26-N2\/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]"
				},
				{
					"name":"Metfor_0026 putative methyltransferase\tK15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"Metfor_2209 putative methyltransferase\tK15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"Metfor_1148 tRNA(1-methyladenosine) methyltransferase-like methyltransferase\tK07442 TRM61; tRNA (adenine57-N1\/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]"
				},
				{
					"name":"Metfor_2842 wyosine biosynthesis protein TYW1\tK15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]"
				},
				{
					"name":"Metfor_1346 putative methyltransferase\tK07055 TRM12; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"Metfor_2897 pseudouridylate synthase I\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"Metfor_2674 rRNA pseudouridine synthase, putative\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"Metfor_2278 tRNA pseudouridine synthase, TruD family\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"Metfor_1111 TIGR01213 family protein\tK07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"Metfor_2456 cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Elongator complex",
				"children":[
				{
					"name":"Metfor_0996 histone acetyltransferase, ELP3 family\tK07739 ELP3; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]"
				}
				]
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"Metfor_0970 Sua5\/YciO\/YrdC\/YwlC family protein\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"Metfor_0392 hypothetical protein\tK10761 THG1; tRNA(His) guanylyltransferase [EC:2.7.7.79]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors"
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"Metfor_1668 Archaeal RNase P\tK01978 rnpB; RNase P catalytic RNA component"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"Metfor_1625 ribonuclease Z\tK00784 rnz; ribonuclease Z [EC:3.1.26.11]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"Metfor_1190 CCA-adding enzyme\tK07558 K07558; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases",
				"children":[
				{
					"name":"Metfor_2552 tRNA intron endonuclease\tK01170 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16]"
				}
				]
			},
			{
				"name":"tRNA splicing ligases",
				"children":[
				{
					"name":"Metfor_1326 hypothetical protein\tK14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate\/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]"
				}
				]
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"Metfor_1189 2'-5' RNA ligase\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"Metfor_1041 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"Metfor_0989 prolyl-tRNA synthetase, family I\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"Metfor_0185 tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"Metfor_2551 tryptophanyl-tRNA synthetase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"Metfor_2142 threonyl-tRNA synthetase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"Metfor_0393 isoleucyl-tRNA synthetase\tK01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]"
				},
				{
					"name":"Metfor_0330 lysyl-tRNA synthetase (class II)\tK04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]"
				},
				{
					"name":"Metfor_2041 alanine--tRNA ligase\/alanyl-tRNA synthetase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"Metfor_1278 valyl-tRNA synthetase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"Metfor_1266 protein containing C-terminal region\/beta chain of methionyl-tRNA synthetase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"Metfor_1727 seryl-tRNA synthetase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"Metfor_2466 cysteinyl-tRNA synthetase\tK01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]"
				},
				{
					"name":"Metfor_0500 glutamyl-tRNA synthetase, archaeal and eukaryotic family\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"Metfor_2841 arginyl-tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"Metfor_2550 phenylalanyl-tRNA synthetase, alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"Metfor_2549 phenylalanyl-tRNA synthetase, beta subunit\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"Metfor_1292 histidyl-tRNA synthetase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"Metfor_0232 aspartyl-tRNA synthetase, archaeal type\tK09759 aspC; nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23]"
				},
				{
					"name":"Metfor_2843 O-phosphoseryl-tRNA(Cys) synthetase\tK07587 sepRS; O-phosphoseryl-tRNA synthetase [EC:6.1.1.27]"
				},
				{
					"name":"Metfor_1987 Sep-tRNA:Cys-tRNA synthase\tK06868 sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73]"
				},
				{
					"name":"Metfor_2473 Sep-tRNA:Cys-tRNA synthase\tK06868 sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"Metfor_0400 hypothetical protein\tK09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"Metfor_2686 MiaB-like tRNA modifying enzyme\tK15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase [EC:2.8.4.5]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"Metfor_0045 methylase involved in ubiquinone\/menaquinone biosynthesis\tK15256 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"Metfor_2141 RNA methyltransferase, TrmH family, group 1\tK02533 lasT; tRNA\/rRNA methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"Metfor_1110 hypothetical protein\tK16317 trmY; tRNA (pseudouridine54-N1)-methyltransferase [EC:2.1.1.257]"
				},
				{
					"name":"Metfor_1651 putative DNA modification methylase\tK07446 trm-G10; tRNA (guanine10-N2)-dimethyltransferase [EC:2.1.1.213]"
				},
				{
					"name":"Metfor_2030 hypothetical protein\tK07254 atrm56; tRNA (cytidine56-2'-O)-methyltransferase [EC:2.1.1.206]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"Metfor_2897 pseudouridylate synthase I\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"Metfor_2674 rRNA pseudouridine synthase, putative\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"Metfor_2278 tRNA pseudouridine synthase, TruD family\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"Metfor_2456 cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex",
				"children":[
				{
					"name":"Metfor_2873 metallohydrolase, glycoprotease\/Kae1 family\tK15904 kae1-bud32; bifunctional N6-L-threonylcarbamoyladenine synthase \/ protein kinase Bud32 [EC:2.3.1.234 2.7.11.1]"
				},
				{
					"name":"Metfor_0181 hypothetical protein\tK09119 cgi121; KEOPS complex subunit Cgi121"
				},
				{
					"name":"Metfor_1164 hypothetical protein\tK09741 pcc1; KEOPS complex subunit Pcc1"
				}
				]
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"Metfor_2837 queuosine biosynthesis protein QueC\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"Metfor_2835 6-pyruvoyl-tetrahydropterin synthase\tK01737 queD; 6-pyruvoyltetrahydropterin\/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]"
				},
				{
					"name":"Metfor_2836 organic radical activating enzyme\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"Metfor_1670 tRNA-guanine transglycosylase\tK18779 tgtA; 7-cyano-7-deazaguanine tRNA-ribosyltransferase [EC:2.4.2.48]"
				},
				{
					"name":"Metfor_2004 thiazole biosynthesis\/tRNA modification protein ThiI\tK03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]"
				},
				{
					"name":"Metfor_2478 thiazole biosynthesis\/tRNA modification protein ThiI\tK03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]"
				},
				{
					"name":"Metfor_2916 putative DNA-binding protein containing a Zn-ribbon domain\tK06932 tiaS; tRNA(Ile2)-agmatinylcytidine synthase [EC:6.3.4.22]"
				},
				{
					"name":"Metfor_0970 Sua5\/YciO\/YrdC\/YwlC family protein\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"Metfor_2808 exoribonuclease R\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
			}
			]
		}
		]
	}
	]
}