{
	"name":"mft02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)"
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)",
			"children":[
			{
				"name":"XA26_52170 PhoR-like protein\tK07768 senX3; two-component system, OmpR family, sensor histidine kinase SenX3 [EC:2.7.13.3]"
			},
			{
				"name":"XA26_52160 SphR-like protein\tK07776 regX3; two-component system, OmpR family, response regulator RegX3"
			}
			]
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)"
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)"
		},
		{
			"name":"RstB-RstA"
		},
		{
			"name":"CpxA-CpxR (envelope stress response)"
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)"
		},
		{
			"name":"BaeS-BaeR (envelope stress response)"
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)"
		},
		{
			"name":"QseC-QseB (quorum sensing)"
		},
		{
			"name":"KdpD-KdpE (potassium transport)",
			"children":[
			{
				"name":"XA26_48060 Osmosensitive K+ channel histidine kinase KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			},
			{
				"name":"XA26_48070 kdpE; KdpE\tK07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE"
			}
			]
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)"
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)",
			"children":[
			{
				"name":"XA26_49170 Osmosensitive K+ channel histidine kinase KdpD\tK07653 mprB; two-component system, OmpR family, sensor histidine kinase MprB [EC:2.7.13.3]"
			},
			{
				"name":"XA26_49180 Two-component response regulator\tK07669 mprA; two-component system, OmpR family, response regulator MprA"
			}
			]
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)",
			"children":[
			{
				"name":"XA26_18910 Sensor histidine kinase MtrB\tK07654 mtrB; two-component system, OmpR family, sensor histidine kinase MtrB [EC:2.7.13.3]"
			},
			{
				"name":"XA26_18900 DNA-binding response regulator mtrA\tK07670 mtrA; two-component system, OmpR family, response regulator MtrA"
			}
			]
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)",
			"children":[
			{
				"name":"XA26_01960 sensor histidine kinase\tK07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3]"
			},
			{
				"name":"XA26_12090 Sensor-type histidine kinase prrB\tK07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3]"
			},
			{
				"name":"XA26_27070 sensor histidine kinase\tK07655 prrB; two-component system, OmpR family, sensor histidine kinase PrrB [EC:2.7.13.3]"
			},
			{
				"name":"XA26_01940 TrcR-like protein\tK07671 prrA; two-component system, OmpR family, response regulator PrrA"
			},
			{
				"name":"XA26_12100 DNA-binding response regulator\tK07671 prrA; two-component system, OmpR family, response regulator PrrA"
			}
			]
		},
		{
			"name":"TrcS-TrcR",
			"children":[
			{
				"name":"XA26_51020 Two-component system, sensor protein\tK07656 trcS; two-component system, OmpR family, sensor histidine kinase TrcS [EC:2.7.13.3]"
			},
			{
				"name":"XA26_51030 TrcR-like protein\tK07672 trcR; two-component system, OmpR family, response regulator TrcR"
			}
			]
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR"
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"XA26_09760 PhoR-like protein\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"XA26_43980 sensor histidine kinase\tK02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"XA26_09750 DNA-binding response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"XA26_43990 putative two-component system response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)",
			"children":[
			{
				"name":"XA26_00930 DNA-binding response regulator, LuxR family protein\tK07684 narL; two-component system, NarL family, nitrate\/nitrite response regulator NarL"
			}
			]
		},
		{
			"name":"NarQ-NarP (nitrate respiration)"
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)"
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)"
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)"
		},
		{
			"name":"DegS-DegU (multicellular behavior control)"
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)"
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)",
			"children":[
			{
				"name":"XA26_46760 devS; DevS\tK07682 devS; two-component system, NarL family, sensor histidine kinase DevS [EC:2.7.13.3]"
			},
			{
				"name":"XA26_46780 devR; DevR\tK07695 devR; two-component system, NarL family, response regulator DevR"
			}
			]
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"XA26_00940 hypothetical protein\tK02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"XA26_09280 sensor kinase, two-component system\tK02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"XA26_36610 Signal transduction histidine kinase CitA regulating citrate metabolism\tK02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)"
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)"
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"XA26_45880 lytS; LytS\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"XA26_45890 algR; alginate biosynthesis regulatory protein AlgR\tK02477 K02477; two-component system, LytTR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)"
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)"
		},
		{
			"name":"HydH-HydG (metal tolerance)"
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)"
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)"
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)"
		},
		{
			"name":"KinB-AlgB (alginate production)"
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"XA26_13460 Protein-glutamate methylesterase\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)"
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)"
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)"
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)"
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)"
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)"
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)"
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)"
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)"
		},
		{
			"name":"PdtaS-PdtaR",
			"children":[
			{
				"name":"XA26_19240 Signal transduction histidine kinase, subgroup 2\tK00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]"
			},
			{
				"name":"XA26_31050 response regulator\tK22010 pdtaR; two-component system, response regulator PdtaR"
			}
			]
		},
		{
			"name":"NasS-NasT"
		},
		{
			"name":"Unclassified"
		}
		]
	}
	]
}