{
	"name":"mhx02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"MHH_c16490 cas1; CRISPR-associated endonuclease Cas1, subtype I-C\/DVULG\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"MHH_c16500 cas2; CRISPR-associated endoribonuclease Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"MHH_c23760 Cas3-like CRISPR-associated protein\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"MHH_c16470 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"MHH_c16470 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"MHH_c16450 cas8c; CRISPR-associated protein Cas8c\/Csd1, subtype I-C\/DVULG\tK19117 csd1; CRISPR-associated protein Csd1"
				},
				{
					"name":"MHH_c16460 cas7; CRISPR-associated protein Cas7\/Csd2, subtype I-C\/DVULG\tK19118 csd2; CRISPR-associated protein Csd2"
				},
				{
					"name":"MHH_c16470 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"MHH_c16440 cas5; CRISPR-associated protein Cas5, subtype I-C\/DVULG\tK19119 cas5d; CRISPR-associated protein Cas5d"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"MHH_c16470 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"MHH_c16470 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"MHH_c01680 HsdR-like host restriction; endonuclease\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"MHH_c24310 putative hsdR-like endonuclease HindVIIP\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"MHH_c01720 hsdS1; specificity determinant HsdS\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"MHH_c01740 hsdS2; specificity determinant HsdS\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"MHH_c12120 putative HsdS-like type I specificity\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"MHH_c12130 putative HsdS-like type I specificity\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"MHH_c24300 putative hsdS-like specificity determinant HindVIIP\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"MHH_c01690 HsdM-like host modification; DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"MHH_c12110 putative HsdM-like methyltransferase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"MHH_c24290 putative hsdM-like DNA methylase HindVIIP\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"MHH_c27130 dam; DNA adenine methylase Dam\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"MHH_c08200 eco57IBM; site-specific modification DNA-methyltransferase Eco57IBM\tK07317 K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"MHH_c15350 Dam-like adenine-specific DNA methylase\tK07318 K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"MHH_c20220 type III restriction protein res subunit\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"MHH_c23800 res; type III restriction-modification system protein Res\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"MHH_c23810 mod; type III restriction-modification system protein Mod\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system"
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS",
				"children":[
				{
					"name":"MHH_c02820 pemK; PemK toxin of the PemK-PemI toxin-antitoxin system\tK18841 chpB; mRNA interferase ChpB [EC:3.1.-.-]"
				},
				{
					"name":"MHH_c02810 pemI; PemI toxin of the PemK-PemI toxin-antitoxin system\tK18842 chpS; antitoxin ChpS"
				}
				]
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"MHH_c10960 putative RelE-like phage protein\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"MHH_c12860 prevent-host-death family protein\tK18923 stbD; antitoxin StbD"
				}
				]
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"MHH_c02370 toxin of the YafQ-DinJ toxin-antitoxin system\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"MHH_c25730 toxin YafQ\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"MHH_c02380 putative RelB-antitoxin and DNA-binding transcriptional repressor\tK07473 dinJ; DNA-damage-inducible protein J"
				},
				{
					"name":"MHH_c25720 DinJ-like antitoxin\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"MHH_c14830 HipA-like domain-containing protein\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				},
				{
					"name":"MHH_c22220 HipA-like protein\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"HicA-HicB",
				"children":[
				{
					"name":"MHH_c17280 hypothetical protein\tK07339 hicA; mRNA interferase HicA [EC:3.1.-.-]"
				},
				{
					"name":"MHH_c18050 hypothetical protein\tK07339 hicA; mRNA interferase HicA [EC:3.1.-.-]"
				},
				{
					"name":"MHH_c17270 hypothetical protein UPF0150\tK18843 hicB; antitoxin HicB"
				},
				{
					"name":"MHH_c18040 hicB; antitoxin HicB\tK18843 hicB; antitoxin HicB"
				}
				]
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"MHH_c02940 putative plasmid stabilization protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"MHH_c14980 plasmid stabilization system protein\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"MHH_c02930 putative addiction module antidote protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"MHH_c20950 putative addiction module antidote protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"MHH_c17680 plasmid maintenance system killer\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"MHH_c17690 putative HTH domain-containing virulence-associated protein\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"MHH_c10840 vapC; ribonuclease VapC\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"MHH_c10830 vagC; putative virulence protein VagC\tK18829 mvpT; antitoxin VapB"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"MHH_c00840 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"MHH_c23530 mreB; Rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"MHH_c19730 parC; DNA topoisomerase 4 - subunit A ParC\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"MHH_c25990 parE; DNA topoisomerase 4 - subunit B ParE\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"MHH_c00880 gltX; glutamyl-tRNA synthetase GltX\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system",
				"children":[
				{
					"name":"MHH_c22770 hypothetical protein\tK19167 abiQ; protein AbiQ"
				}
				]
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"MHH_c07330 hypothetical protein\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"MHH_c15630 iscS; cysteine desulfurase IscS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}