{
	"name":"moh02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins"
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins"
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system"
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"IHQ72_29090 site-specific DNA-methyltransferase\tK13581 ccrM; modification methylase [EC:2.1.1.72]"
				},
				{
					"name":"IHQ72_29605 DNA cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system"
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"IHQ72_32765 type II toxin-antitoxin system HipA family toxin\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA",
				"children":[
				{
					"name":"IHQ72_06125 CcdB family protein\tK19163 ccdB; toxin CcdB"
				},
				{
					"name":"IHQ72_06130 type II toxin-antitoxin system CcdA family antitoxin\tK19164 ccdA; antitoxin CcdA"
				}
				]
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"IHQ72_12660 type II toxin-antitoxin system RelE\/ParE family toxin\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"IHQ72_19920 type II toxin-antitoxin system RelE\/ParE family toxin\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"IHQ72_11950 hypothetical protein\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"IHQ72_12665 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"IHQ72_16825 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"IHQ72_19925 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"IHQ72_25515 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"IHQ72_30560 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"IHQ72_30575 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"IHQ72_26635 type II toxin-antitoxin system death-on-curing family toxin\tK07341 doc; death on curing protein"
				},
				{
					"name":"IHQ72_24795 type II toxin-antitoxin system Phd\/YefM family antitoxin\tK19165 phd; antitoxin Phd"
				}
				]
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"IHQ72_07920 type II toxin-antitoxin system HigB family toxin\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"IHQ72_07915 transcriptional regulator\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"IHQ72_14595 HigA family addiction module antidote protein\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA",
				"children":[
				{
					"name":"IHQ72_01395 type II toxin-antitoxin system MqsA family antitoxin\tK13655 mqsA; HTH-type transcriptional regulator \/ antitoxin MqsA"
				}
				]
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"IHQ72_10060 type II toxin-antitoxin system VapC family toxin\tK28279 vapC22; ribonuclease VapC22 [EC:3.1.-.-]"
				},
				{
					"name":"IHQ72_24740 type II toxin-antitoxin system prevent-host-death family antitoxin\tK28280 vapB22; antitoxin VapB22"
				},
				{
					"name":"IHQ72_34660 type II toxin-antitoxin system prevent-host-death family antitoxin\tK28280 vapB22; antitoxin VapB22"
				},
				{
					"name":"IHQ72_32325 PIN domain-containing protein\tK28143 vapC24S; ribonuclease VapC24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48 [EC:3.1.-.-]"
				},
				{
					"name":"IHQ72_32320 CopG family transcriptional regulator\tK28144 vapB24S; antitoxin VapB24\/25\/29\/31\/33\/37\/38\/39\/41\/43\/44\/48"
				},
				{
					"name":"IHQ72_09825 type II toxin-antitoxin system VapC family toxin\tK19686 vapC28S; ribonuclease VapC28\/30\/34\/36\/42 [EC:3.1.-.-]"
				},
				{
					"name":"IHQ72_25480 type II toxin-antitoxin system VapC family toxin\tK19686 vapC28S; ribonuclease VapC28\/30\/34\/36\/42 [EC:3.1.-.-]"
				},
				{
					"name":"IHQ72_26120 type II toxin-antitoxin system VapC family toxin\tK19686 vapC28S; ribonuclease VapC28\/30\/34\/36\/42 [EC:3.1.-.-]"
				},
				{
					"name":"IHQ72_00745 type II toxin-antitoxin system VapB family antitoxin\tK19687 vapB28S; antitoxin VapB28\/30\/34\/36\/42"
				},
				{
					"name":"IHQ72_12650 type II toxin-antitoxin system VapB family antitoxin\tK19687 vapB28S; antitoxin VapB28\/30\/34\/36\/42"
				},
				{
					"name":"IHQ72_26115 type II toxin-antitoxin system VapB family antitoxin\tK19687 vapB28S; antitoxin VapB28\/30\/34\/36\/42"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA",
				"children":[
				{
					"name":"IHQ72_02410 type II toxin-antitoxin system VapC family toxin\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				},
				{
					"name":"IHQ72_02415 plasmid stabilization protein\tK21495 fitA; antitoxin FitA"
				},
				{
					"name":"IHQ72_09815 plasmid stabilization protein\tK21495 fitA; antitoxin FitA"
				},
				{
					"name":"IHQ72_09820 hypothetical protein\tK21495 fitA; antitoxin FitA"
				}
				]
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"IHQ72_08925 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"IHQ72_16915 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"IHQ72_24485 parC; DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"IHQ72_19695 parE; DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"IHQ72_20020 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				},
				{
					"name":"IHQ72_20725 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"IHQ72_19905 succinate dehydrogenase assembly factor 2\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"IHQ72_02070 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"IHQ72_23600 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"IHQ72_34260 nifS; cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"IHQ72_35560 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}