{
	"name":"msem02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"GMB29_20835 PAS domain-containing protein\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_20840 response regulator\tK07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)"
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)"
		},
		{
			"name":"RstB-RstA"
		},
		{
			"name":"CpxA-CpxR (envelope stress response)"
		},
		{
			"name":"CssS-CssR (secretion stress response)",
			"children":[
			{
				"name":"GMB29_23300 HAMP domain-containing protein\tK07650 cssS; two-component system, OmpR family, sensor histidine kinase CssS [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_23295 response regulator\tK07770 cssR; two-component system, OmpR family, response regulator CssR"
			}
			]
		},
		{
			"name":"CreC-CreB (phosphate regulation)"
		},
		{
			"name":"BaeS-BaeR (envelope stress response)"
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)"
		},
		{
			"name":"QseC-QseB (quorum sensing)"
		},
		{
			"name":"KdpD-KdpE (potassium transport)",
			"children":[
			{
				"name":"GMB29_05480 sensor histidine kinase KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)"
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)",
			"children":[
			{
				"name":"GMB29_16785 HAMP domain-containing protein\tK07651 resE; two-component system, OmpR family, sensor histidine kinase ResE [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_16790 response regulator\tK07775 resD; two-component system, OmpR family, response regulator ResD"
			}
			]
		},
		{
			"name":"VicK-VicR (cell wall metabolism)",
			"children":[
			{
				"name":"GMB29_26690 walK; cell wall metabolism sensor histidine kinase WalK\tK07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_26695 response regulator\tK07668 vicR; two-component system, OmpR family, response regulator VicR"
			}
			]
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)",
			"children":[
			{
				"name":"GMB29_26475 sensor histidine kinase\tK11629 bceS; two-component system, OmpR family, bacitracin resistance sensor histidine kinase BceS [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_26470 response regulator\tK11630 bceR; two-component system, OmpR family, bacitracin resistance response regulator BceR"
			}
			]
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)",
			"children":[
			{
				"name":"GMB29_23720 sensor histidine kinase\tK11633 yxdK; two-component system, OmpR family, sensor histidine kinase YxdK [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_23725 response regulator\tK11634 yxdJ; two-component system, OmpR family, response regulator YxdJ"
			}
			]
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR"
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)",
			"children":[
			{
				"name":"GMB29_24765 HAMP domain-containing protein\tK18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_24770 response regulator\tK18941 arlR; two-component system, OmpR family, response regulator ArlR"
			}
			]
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"GMB29_22435 response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)"
		},
		{
			"name":"NarQ-NarP (nitrate respiration)"
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)"
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)"
		},
		{
			"name":"ComP-ComA (competence)",
			"children":[
			{
				"name":"GMB29_22815 histidine kinase\tK07680 comP; two-component system, NarL family, sensor histidine kinase ComP [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_22810 response regulator\tK07691 comA; two-component system, NarL family, competent response regulator ComA"
			}
			]
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)"
		},
		{
			"name":"DegS-DegU (multicellular behavior control)",
			"children":[
			{
				"name":"GMB29_24575 histidine kinase\tK07777 degS; two-component system, NarL family, sensor histidine kinase DegS [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_24570 response regulator\tK07692 degU; two-component system, NarL family, response regulator DegU"
			}
			]
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)",
			"children":[
			{
				"name":"GMB29_22235 sensor histidine kinase\tK07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_02490 response regulator\tK07693 desR; two-component system, NarL family, response regulator DesR"
			},
			{
				"name":"GMB29_22240 response regulator\tK07693 desR; two-component system, NarL family, response regulator DesR"
			}
			]
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)",
			"children":[
			{
				"name":"GMB29_26020 sensor histidine kinase\tK11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_26015 response regulator\tK11618 liaR; two-component system, NarL family, response regulator LiaR"
			}
			]
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)"
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)",
			"children":[
			{
				"name":"GMB29_08130 STAS domain-containing protein\tK02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_16915 PAS domain S-box protein\tK02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_24485 PAS domain S-box protein\tK02491 kinA; two-component system, sporulation sensor kinase A [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_04115 GHKL domain-containing protein\tK07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_11550 sensor histidine kinase\tK07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_22720 GHKL domain-containing protein\tK07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_26550 sensor histidine kinase\tK07697 kinB; two-component system, sporulation sensor kinase B [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_14960 PAS domain S-box protein\tK13533 kinE; two-component system, sporulation sensor kinase E [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_25735 response regulator\tK02490 spo0F; two-component system, response regulator, stage 0 sporulation protein F"
			},
			{
				"name":"GMB29_19065 spo0A; sporulation transcription factor Spo0A\tK07699 spo0A; two-component system, response regulator, stage 0 sporulation protein A"
			}
			]
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)",
			"children":[
			{
				"name":"GMB29_04630 GHKL domain-containing protein\tK11637 citS; two-component system, CitB family, sensor histidine kinase CitS [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_04635 response regulator\tK11638 K11638; two-component system, CitB family, response regulator CitT"
			}
			]
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)",
			"children":[
			{
				"name":"GMB29_22570 GHKL domain-containing protein\tK11691 K11691; two-component system, CitB family, sensor histidine kinase DctS [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_22575 response regulator\tK11692 K11692; two-component system, CitB family, response regulator DctR"
			}
			]
		},
		{
			"name":"MalK-MalR (malate transport)",
			"children":[
			{
				"name":"GMB29_07500 dcuS; two-component system sensor histidine kinase DcuS\tK11614 yufL; two-component system, CitB family, sensor histidine kinase MalK [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_10710 dcuS; two-component system sensor histidine kinase DcuS\tK11614 yufL; two-component system, CitB family, sensor histidine kinase MalK [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_07505 response regulator\tK11615 malR; two-component system, CitB family, response regulator MalR"
			},
			{
				"name":"GMB29_10715 response regulator\tK11615 malR; two-component system, CitB family, response regulator MalR"
			}
			]
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"GMB29_23610 GHKL domain-containing protein\tK02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_23605 response regulator\tK02475 K02475; two-component system, CitB family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR",
			"children":[
			{
				"name":"GMB29_22300 sensor histidine kinase\tK07704 lytS; two-component system, LytTR family, sensor histidine kinase LytS [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_22295 response regulator\tK07705 lytT; two-component system, LytTR family, response regulator LytT"
			}
			]
		},
		{
			"name":"AlgZ-AlgR (alginate production)"
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)"
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)"
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)"
		},
		{
			"name":"HydH-HydG (metal tolerance)",
			"children":[
			{
				"name":"GMB29_07180 GHKL domain-containing protein\tK07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)"
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)"
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)"
		},
		{
			"name":"KinB-AlgB (alginate production)"
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"GMB29_02585 response regulator\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_14110 response regulator\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_17305 chemotaxis protein CheA\tK03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_14265 response regulator\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"GMB29_17355 response regulator\tK03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY"
			},
			{
				"name":"GMB29_17310 cheB; chemotaxis-specific protein-glutamate methyltransferase CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"GMB29_16880 response regulator\tK03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)"
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)"
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)"
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)"
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)"
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)"
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)"
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)",
			"children":[
			{
				"name":"GMB29_04670 GHKL domain-containing protein\tK07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_07970 GHKL domain-containing protein\tK07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_09045 GHKL domain-containing protein\tK07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_04665 response regulator\tK07719 glnL; two-component system, response regulator GlnL"
			},
			{
				"name":"GMB29_07975 response regulator\tK07719 glnL; two-component system, response regulator GlnL"
			},
			{
				"name":"GMB29_09050 response regulator\tK07719 glnL; two-component system, response regulator GlnL"
			}
			]
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN",
			"children":[
			{
				"name":"GMB29_01965 HAMP domain-containing protein\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_03505 HAMP domain-containing protein\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_05550 HAMP domain-containing protein\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_06175 HAMP domain-containing protein\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_06465 HAMP domain-containing protein\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_06590 HAMP domain-containing protein\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_08030 HAMP domain-containing protein\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_08915 hypothetical protein\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_12370 HAMP domain-containing protein\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_15340 HAMP domain-containing protein\tK07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]"
			},
			{
				"name":"GMB29_01960 response regulator\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_03450 response regulator\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_03500 response regulator\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_05545 response regulator\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_06180 response regulator\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_06470 response regulator\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_06595 response regulator\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_08920 response regulator\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_09645 AraC family transcriptional regulator\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_11750 helix-turn-helix domain-containing protein\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_12365 response regulator\tK07720 yesN; two-component system, response regulator YesN"
			},
			{
				"name":"GMB29_15335 response regulator\tK07720 yesN; two-component system, response regulator YesN"
			}
			]
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)"
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)"
		},
		{
			"name":"PdtaS-PdtaR"
		},
		{
			"name":"NasS-NasT"
		},
		{
			"name":"Unclassified"
		}
		]
	}
	]
}